Wolfgang Gaebel

Summary

Affiliation: Rhine Clinic Bonn
Country: Germany

Publications

  1. pmc Relapse prevention in schizophrenia and schizoaffective disorder with risperidone long-acting injectable vs quetiapine: results of a long-term, open-label, randomized clinical trial
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Germany
    Neuropsychopharmacology 35:2367-77. 2010
  2. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
  3. doi request reprint Remission and recovery and their predictors in schizophrenia spectrum disorder: results from a 1-year follow-up naturalistic trial
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychiatr Q 83:187-207. 2012
  4. doi request reprint Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, D 40629 Düsseldorf, Germany
    J Clin Psychiatry 72:205-18. 2011
  5. doi request reprint Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 13:30-8. 2012
  6. doi request reprint Predictors of relapse in the year after hospital discharge among patients with schizophrenia
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstreet 7, 80336 Munich, Germany
    Psychiatr Serv 63:87-90. 2012
  7. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
  8. doi request reprint Quality of life and subjective well-being in schizophrenia and schizophrenia spectrum disorders: valid predictors of symptomatic response and remission?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:729-38. 2010
  9. doi request reprint Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:985-97. 2008
  10. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012

Collaborators

Detail Information

Publications90

  1. pmc Relapse prevention in schizophrenia and schizoaffective disorder with risperidone long-acting injectable vs quetiapine: results of a long-term, open-label, randomized clinical trial
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Germany
    Neuropsychopharmacology 35:2367-77. 2010
    ..Both antipsychotics were generally well tolerated...
  2. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  3. doi request reprint Remission and recovery and their predictors in schizophrenia spectrum disorder: results from a 1-year follow-up naturalistic trial
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Psychiatr Q 83:187-207. 2012
    ..0113) were found to be significantly predictive of recovery. Our results underline the need to implement more specific treatment strategies to improve long-term outcome...
  4. doi request reprint Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, D 40629 Düsseldorf, Germany
    J Clin Psychiatry 72:205-18. 2011
    ..The current study was therefore designed to compare prospectively the relapse preventive efficacy of further maintenance treatment and targeted intermittent treatment in patients with ICD-10-diagnosed first-episode schizophrenia...
  5. doi request reprint Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: comparing treatment with risperidone and haloperidol
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 13:30-8. 2012
    ..To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol...
  6. doi request reprint Predictors of relapse in the year after hospital discharge among patients with schizophrenia
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstreet 7, 80336 Munich, Germany
    Psychiatr Serv 63:87-90. 2012
    ..Relapse and its predictors were examined among patients with schizophrenia in the year after hospital discharge...
  7. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  8. doi request reprint Quality of life and subjective well-being in schizophrenia and schizophrenia spectrum disorders: valid predictors of symptomatic response and remission?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 11:729-38. 2010
    ..To examine quality of life and subjective well-being as predictors of symptomatic treatment outcome...
  9. doi request reprint Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:985-97. 2008
    ..Risperidone has better extrapyramidal tolerability and treatment retention rate than the equivalent dose of haloperidol in these patients...
  10. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  11. doi request reprint Response trajectories in "real-world" naturalistically treated schizophrenia patients
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 139:218-24. 2012
    ..To date, research has identified distinct antipsychotic response trajectories yet focussing on data from randomized-controlled trials (RCTs). Therefore, the heterogeneity of response in "real-world" schizophrenia patients is still unknown...
  12. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  13. doi request reprint Clinical predictors of response and remission in inpatients with depressive syndromes
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Affect Disord 133:137-49. 2011
    ..We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated for 53.62 ± 47.5 days...
  14. pmc Neurophysiological correlates of impaired facial affect recognition in individuals at risk for schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, University of Dusseldorf, Dusseldorf, Germany
    Schizophr Bull 38:1021-9. 2012
    ..Such characterization should add to the question whether the neural processes underlying facial affect recognition deficits might be part of a basic neural dysfunction reflecting a vulnerability factor of schizophrenia...
  15. doi request reprint Predictors of response and remission in the acute treatment of first-episode schizophrenia patients--is it all about early response?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Neuropsychopharmacol 21:370-8. 2011
    ..To evaluate the predictive validity of early response compared to other well-known predictor variables in acutely ill first-episode patients...
  16. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  17. ncbi request reprint Akathisia and suicidal ideation in first-episode schizophrenia
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J Clin Psychopharmacol 32:694-8. 2012
    ..The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES...
  18. doi request reprint Evaluating depressive symptoms in schizophrenia: a psychometric comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale
    Rebecca Schennach
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Psychopathology 45:276-85. 2012
    ....
  19. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  20. doi request reprint The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Int J Neuropsychopharmacol 12:181-9. 2009
    ..g. use of specific co-medications, supportive psychotherapy and continuous medical attendance by nursing staff) might be beneficial...
  21. doi request reprint Outcomes of 1014 naturalistically treated inpatients with major depressive episode
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Eur Neuropsychopharmacol 20:346-55. 2010
    ..Of those who ultimately achieved response more than 40% did so within the first 2weeks. An individualized naturalistic inpatient treatment approach appears to be beneficial in terms of effectiveness...
  22. ncbi request reprint Stability of emotional dysfunctions? A long-term fMRI study in first-episode schizophrenia
    Martina Reske
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Psychiatr Res 41:918-27. 2007
    ..This study aimed at determining changes of mood-related neural correlates under standardized pharmacological therapy in first-episode schizophrenia...
  23. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  24. doi request reprint A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:117-24. 2012
    ..Our findings suggest a role of SHANK1 in working memory deficits in schizophrenia, which may arise from neurodevelopmental changes to prefrontal cortical areas...
  25. ncbi request reprint Does clinical judgment of baseline severity and changes in psychopathology depend on the patient population? Results of a CGI and PANSS linking analysis in a naturalistic study
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
    J Clin Psychopharmacol 30:726-31. 2010
    ..Furthermore, these linking results were compared with those derived from randomized controlled trials to examine if the baseline severity might influence the linking results...
  26. doi request reprint Novel schizophrenia risk gene TCF4 influences verbal learning and memory functioning in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychobiology 63:131-6. 2011
    ..Thus, we hypothesized that the disease-associated C allele of the rs9960767 polymorphism of the TCF4 gene led to impaired VDM functioning in schizophrenia patients...
  27. doi request reprint Do efficacy and effectiveness samples differ in antidepressant treatment outcome? An analysis of eligibility criteria in randomized controlled trials
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany
    J Clin Psychiatry 71:1425-33. 2010
    ..Because of strict inclusion and exclusion criteria, results drawn from placebo-controlled randomized antidepressant efficacy trials may not be transferable to real-world patients...
  28. doi request reprint A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  29. doi request reprint Attitude towards adherence in patients with schizophrenia at discharge
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    J Psychiatr Res 43:1294-301. 2009
    ....
  30. doi request reprint The relation of regional cerebral perfusion and atrophy in mild cognitive impairment (MCI) and early Alzheimer's dementia
    Christian Luckhaus
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Duesseldorf, Germany
    Psychiatry Res 183:44-51. 2010
    ..The data also support the concept of functional compensatory brain activation and the diaschisis hypothesis as relevant in incipient and early AD...
  31. doi request reprint Response and remission criteria in major depression--a validation of current practice
    Michael Riedel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 44:1063-8. 2010
    ..91) and a decrease of 47% for the BDI baseline score (AUC: 0.78) best corresponded CGI response criteria. Our data largely confirmed currently used remission and response criteria in naturalistically treated patients...
  32. doi request reprint An early improvement threshold to predict response and remission in first-episode schizophrenia
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, Muenchen 80336, Germany
    Br J Psychiatry 196:460-6. 2010
    ..Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding...
  33. doi request reprint Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Germany
    Eur Neuropsychopharmacol 18:768-72. 2008
    ..008). Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia...
  34. doi request reprint Does early improvement triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression
    Verena Henkel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Affect Disord 115:439-49. 2009
    ..Patients were treated with various antidepressants and co-medication according to the protocol based on evidence-based clinical guidelines...
  35. ncbi request reprint Evaluation of factors influencing medication compliance in inpatient treatment of psychotic disorders
    Birgit Janssen
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Duesseldorf, Bergische Landstr 2, 40629 Duesseldorf, Germany
    Psychopharmacology (Berl) 187:229-36. 2006
    ..Short- and long-term compliance to prescribed antipsychotic drugs is of particular concern in regard to medication choice and treatment outcome in the care of psychotic disorders...
  36. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  37. doi request reprint Prediction of psychosis by mismatch negativity
    Mitja Bodatsch
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Biol Psychiatry 69:959-66. 2011
    ..To this aim, mismatch negativity (MMN) was investigated in a sample clinically at high risk, comparing individuals with and without subsequent conversion to psychosis...
  38. doi request reprint Sick leave and depression - determining factors and clinical effect in outpatient care
    Isaac Bermejo
    Department of Psychiatry and Psychotherapy, University Medical Centre of Freiburg, Germany
    Psychiatry Res 180:68-73. 2010
    ..For a targeted implementation of sick leave as therapeutic measure predictors for effectiveness should be defined...
  39. doi request reprint Drug attitude as predictor for effectiveness in first-episode schizophrenia: Results of an open randomized trial (EUFEST)
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Rhineland State Clinics Düsseldorf, Germany
    Eur Neuropsychopharmacol 20:310-6. 2010
    ..DAI scores could also serve as an (differential) indicator for the need of enhanced treatment monitoring. These findings have to be validated in other (first-episode) samples...
  40. doi request reprint No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression
    Richard Musil
    Department of Psychiatry and Psychotherapy, Psychiatric Clinic, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 263:405-12. 2013
    ..However, results showed a tendency towards significance. At this stage, we cannot support an influence of these three polymorphisms. Further studies in larger patient samples to increase sample sizes of subgroups are warranted...
  41. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  42. doi request reprint Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode
    Richard Musil
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Neuropsychopharmacol 23:663-74. 2013
    ..The small number of cases warrants replication in larger patient samples. Lack of a placebo control group hampers definite conclusions on an association with antidepressive treatment...
  43. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...
  44. doi request reprint The effects of combined acamprosate and integrative behaviour therapy in the outpatient treatment of alcohol dependence: a randomized controlled trial
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Drug Alcohol Depend 118:417-22. 2011
    ..The aim of this randomized, controlled, multisite trial was to evaluate the efficacy of combined treatment with integrative behaviour therapy (IBT) and acamprosate on drinking behaviour in detoxified alcohol-dependent patients...
  45. doi request reprint Clomipramine-induced serum prolactin as a marker for serotonin and dopamine turnover: results of an open label study
    Joachim Cordes
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 261:567-73. 2011
    ..We conclude that monoamine changes in relation to prolactin response after clomipramine challenge may be suitable for characterizing the relationship between central serotonergic and dopaminergic function...
  46. doi request reprint Effects of 10 Hz repetitive transcranial magnetic stimulation (rTMS) on clinical global impression in chronic schizophrenia
    Joachim Cordes
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Bergische Landstr 2, D 40629 Düsseldorf, Germany
    Psychiatry Res 177:32-6. 2010
    ..However, in our study this beneficial effect was restricted to subjects with pronounced negative symptoms...
  47. doi request reprint Improving outpatient care of depression by implementing practice guidelines: a controlled clinical trial
    Isaac Bermejo
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstr 5, 79104 Freiburg, Germany
    Int J Qual Health Care 21:29-36. 2009
    ..The aim of the study was to implement clinical practice guidelines for outpatient care of depression using a practice-oriented and interdisciplinary approach...
  48. ncbi request reprint Revisiting the relapse predictive validity of prodromal symptoms in schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Germany
    Schizophr Res 95:19-29. 2007
    ..yielded other relevant 'early signs'. It is concluded that the relapse predictive validity of prodromal symptoms has to be enhanced e.g. by supplement of other clinical parameters with predictive potential or by closer monitoring...
  49. doi request reprint Defining and predicting functional outcome in schizophrenia and schizophrenia spectrum disorders
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 113:210-7. 2009
    ..To assess criteria and to identify predictive factors for functional outcome. The criteria should cover all domains proposed by the Remission in Schizophrenia Working Group...
  50. ncbi request reprint Adherence to guidelines for treatment of depression in in-patients
    Frank Schneider
    Department of Psychiatry and Psychotherapy, University of Aachen RWTH, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Psychiatry 187:462-9. 2005
    ..Adherence to treatment guidelines enhances treatment outcome. However, in clinical practice many patients with depression do not receive appropriate treatment...
  51. doi request reprint Randomized controlled multicentre trial of cognitive behaviour therapy in the early initial prodromal state: effects on social adjustment post treatment
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Early Interv Psychiatry 1:71-8. 2007
    ....
  52. doi request reprint Psychotic disorders in ICD-11
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Asian J Psychiatr 6:263-5. 2013
    ..The proposals for ICD-11 are compared with those for the corresponding DSM-5 chapter...
  53. ncbi request reprint Evaluation of the German WPA "program against stigma and discrimination because of schizophrenia--Open the Doors": results from representative telephone surveys before and after three years of antistigma interventions
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, D 40629 Düsseldorf, Germany
    Schizophr Res 98:184-93. 2008
    ..Several measures to tackle the stigma in certain target populations have been proven successful, but the effectiveness of the program on the general population level has not yet been examined...
  54. doi request reprint Classifying psychosis--challenges and opportunities
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Int Rev Psychiatry 24:538-48. 2012
    ....
  55. doi request reprint The DGPPN research project on mental healthcare utilization in Germany: inpatient and outpatient treatment of persons with depression by different disciplines
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, LVR Klinikum Düsseldorf, Bergische Landstr 2, 40629 Düsseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 262:S51-5. 2012
    ..Specialists for psychosomatic medicine and psychological psychotherapists predominantly treated cases of mild and moderate depression, whereas severe cases were mostly cared for by psychiatrists or psychiatric departments...
  56. doi request reprint Preventing progression to first-episode psychosis in early initial prodromal states
    A Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Br J Psychiatry 200:22-9. 2012
    ....
  57. pmc The impact of antipsychotic drugs on food intake and body weight and on leptin levels in blood and hypothalamic ob-r leptin receptor expression in wistar rats
    Martina von Wilmsdorff
    LVR Klinikum Düsseldorf, Kliniken der Heinrich Heine Universität, Dusseldorf, Germany
    Clinics (Sao Paulo) 65:885-94. 2010
    ..The aim of our study was to investigate the impact of typical and atypical antipsychotic drugs on leptin concentration in blood and changes in the receptor expression in the hypothalamus of male Wistar rats...
  58. doi request reprint Electrophysiological correlates of planning and monitoring in first episode schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Medical Faculty, University of Dusseldorf, Dusseldorf, Germany
    Psychiatry Res 203:83-8. 2012
    ..Thus, poorer performance in schizophrenia seems to be attributable to impaired planning behavior based on hypoactivity of prefrontal areas, involved in the temporal scheduling of deliberate actions as well as visuomotor integration...
  59. pmc Integrative etiopathogenetic models of psychotic disorders: methods, evidence and concepts
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, LVR Klinikum Düsseldorf, Bergische Landstrasse 2, D 40629 Düsseldorf, Germany
    Schizophr Bull 37:S5-12. 2011
    ....
  60. doi request reprint Future classification of psychotic disorders
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S213-8. 2009
    ..Given the rapid progress in these fields, regular updates of the classification criteria at shorter intervals than in the past may become necessary...
  61. doi request reprint Prevention of rehospitalization in schizophrenia: results of an integrated care project in Germany
    Christian Schmidt-Kraepelin
    LVR Klinikum Düsseldorf, Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S205-12. 2009
    ..The model project described is an important step to gain evidence and experience with integrated care for patients with schizophrenia...
  62. doi request reprint Mental health quality, outcome measurement, and improvement in Germany
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Dusseldorf, Germany
    Curr Opin Psychiatry 22:636-42. 2009
    ..This review describes the most recent results of quality assurance programs from Germany as identified by a systematic literature search covering the time span 1 January 2008 until 1 June 2009...
  63. pmc The German Research Network on Schizophrenia--impact on the management of schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Postbox 12 05 10, D 40605 Düsseldorf, Germany
    Dialogues Clin Neurosci 8:115-21. 2006
    ....
  64. ncbi request reprint Remediation of impairments in facial affect recognition in schizophrenia: efficacy and specificity of a new training program
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, University of Duesseldorf, Rhineland State Clinics, Bergische Landstrasse 2, D 40629 Duesseldorf, Germany
    Schizophr Res 80:295-303. 2005
    ..The present study investigates the efficacy and specificity of a new training program for the remediation of such impairments...
  65. ncbi request reprint Validation of polypharmacy process measures in inpatient schizophrenia care
    Birgit Janssen
    Department of Psychiatry and Psychotherapy, University of Duesseldorf, Germany
    Schizophr Bull 30:1023-33. 2004
    ..The rising trend toward polypharmacy in schizophrenia care, which is not supported by current guideline recommendations, warrants critical appraisal...
  66. ncbi request reprint Switching antipsychotics in inpatient schizophrenia care: predictors and outcomes
    Stefan Weinmann
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    J Clin Psychiatry 65:1099-105. 2004
    ..The primary aim was to assess factors associated with antipsychotic switching and to compare disease course with regard to mental state and social functioning...
  67. doi request reprint Abnormal neuroendocrine response to clomipramine in hereditary affective psychosis
    Joachim Cordes
    Department of Psychiatry, Heinrich Heine University, Dusseldorf, Germany
    Depress Anxiety 26:E111-9. 2009
    ..In this study, the neuroendocrine responses to clomipramine were assessed in remitted patients suffering from hereditary depression...
  68. doi request reprint Schizophrenia guidelines across the world: a selective review and comparison
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, LVR Klinikum Düsseldorf, Heinrich Heine University Dusseldorf, Germany
    Int Rev Psychiatry 23:379-87. 2011
    ..Nevertheless, core guideline recommendations should be adapted to regional conditions using available tools for adaptation...
  69. doi request reprint Measuring the stigma of psychiatry and psychiatrists: development of a questionnaire
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S119-23. 2011
    ..It is available in several languages (Arab, English, German, Japanese, Polish, and Spanish) and can easily be adapted for utilization in other medical specialties...
  70. ncbi request reprint Improving quality of care for depression: the German Action Programme for the implementation of evidence-based guidelines
    Martin Härter
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    Int J Qual Health Care 18:113-9. 2006
    ..Throughout the 1990s, educational initiatives were started for implementing guidelines. Evidence-based guidelines on depression have been formulated in many countries...
  71. ncbi request reprint Facial expressivity in the course of schizophrenia and depression
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Duesseldorf Rheinische Kliniken Duesseldorf, Bergische Landstrasse 2, 40629 Duesseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 254:335-42. 2004
    ....
  72. doi request reprint [Benchmarking in psychiatric acute care--a demonstration project in a hospitals network]
    Birgit Janssen
    LVR Klinikum Düsseldorf, Kliniken der Heinrich Heine Universität Düsseldorf
    Z Evid Fortbild Qual Gesundhwes 105:371-5. 2011
    ..Future projects should focus on the conformance with treatment guidelines by defining both structural and process measures as a starting point and evaluation criterion...
  73. ncbi request reprint Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man
    Rolf Larisch
    Department of Nuclear Medicine, Heinrich Heine University of Dusseldorf, Moorenstr 5, Dusseldorf, Germany
    Behav Brain Res 139:21-9. 2003
    ..The paradigm might, thus, be useful to estimate serotonin release in vivo. Pretreatment with serotonergic antidepressants reduces the effect of clomipramine...
  74. doi request reprint Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging
    Christian Luckhaus
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Bergische Landstrasse 2, D 40629, Duesseldorf, Germany
    Neuroimage 40:495-503. 2008
    ..This method may thus be useful in both research and clinical applications to detect early functional brain changes in the pathogenesis of dementias...
  75. pmc Sex-dependent behavioral effects and morphological changes in the hippocampus after prenatal invasive interventions in rats: implications for animal models of schizophrenia
    Martina von Wilmsdorff
    LVR Klinikum Düsseldorf, Kliniken der Heinrich Heine Universität Düs seldorf Germany
    Clinics (Sao Paulo) 65:209-19. 2010
    ..Although schizophrenia affects both human genders, there are gender-dependent differences with respect to age of onset, clinical characteristics, course and prognosis of the disease...
  76. ncbi request reprint [Reason for encounter and diagnosis of depression in patients in general practice]
    Sandra Kratz
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat Dusseldorf, Rheinische Kliniken Düsseldorf
    Z Arztl Fortbild Qualitatssich 97:50-6. 2003
    ..Hence, the study underlines the need for training in criteria-orientated diagnosis and the application of suitable screening instruments for depressive disorders in general practice...
  77. ncbi request reprint Pharmacological long-term treatment strategies in first episode schizophrenia--study design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, 40629 Duesseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 254:129-40. 2004
    ..In conclusion, treatment in first episode schizophrenia is effective under both (further on blinded) neuroleptics; however these patients are at high risk for treatment drop-out. This emphasizes the need for a special support program...
  78. doi request reprint Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatment
    Jens Kuhn
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S135-41. 2009
    ..It suggests some additional requirements for ethically justifiable therapeutic research employing DBS in psychiatric patients...
  79. ncbi request reprint Schizophrenia practice guidelines: international survey and comparison
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Germany
    Br J Psychiatry 187:248-55. 2005
    ..Schizophrenia guidelines differ considerably in methodology and content...
  80. doi request reprint Modern modularity and the road towards a modular psychiatry
    Jurgen Zielasek
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:60-5. 2008
    ....
  81. doi request reprint The DSM-V initiative "deconstructing psychosis" in the context of Kraepelin's concept on nosology
    Wolfgang Gaebel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Heinrich Heine Universitat, Rheinische Kliniken Düsseldorf, Bergische Landstr 2, 40629, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:41-7. 2008
    ....
  82. doi request reprint Atypical symptoms in hospitalised patients with major depressive episode: frequency, clinical characteristics, and internal validity
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Affect Disord 108:271-8. 2008
    ....
  83. ncbi request reprint Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Schizophr Res 89:198-210. 2007
    ....
  84. ncbi request reprint Interventions to reduce the stigma associated with severe mental illness: experiences from the open the doors program in Germany
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Dusseldorf, Bergische Landstrasse 2, 40629 Düsseldorf, Germany
    Can J Psychiatry 48:657-62. 2003
    ..Improved knowledge should in turn abolish prejudice and negative perceptions and facilitate the social reintegration of those suffering from mental illness...
  85. pmc Deconstructing Psychosis conference February 2006: the validity of schizophrenia and alternative approaches to the classification of psychosis
    Judith Allardyce
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Rhineland State Clinics, Germany
    Schizophr Bull 33:863-7. 2007
    ..We conclude by proposing potential alternative approaches to refining the classification of psychosis...
  86. ncbi request reprint Impaired Trail-Making Test-B performance in patients with acute schizophrenia is related to inefficient sequencing of planning and acting
    Wolfgang Wolwer
    Department of Psychiatry, Heinrich Heine University, Bergische Landstrasse 2, POB 12 05 10, D 40605 Düsseldorf, Germany
    J Psychiatr Res 36:407-16. 2002
    ....
  87. ncbi request reprint Oxcarbazepine--efficacy and tolerability during treatment of alcohol withdrawal: a double-blind, randomized, placebo-controlled multicenter pilot study
    Dagmar Koethe
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Alcohol Clin Exp Res 31:1188-94. 2007
    ..Oxcarbazepine (OXC), a newer anticonvulsive drug, has a favorable safety profile over carbamazepine (CBZ) and other older AEDs due to its excellent efficacy and better side-effect profile...
  88. ncbi request reprint German research network on schizophrenia-bridging the gap between research and care
    Wolfgang Wolwer
    German Research Network on Schizophrenia, Department of Psychiatry, Heinrich Heine University, Bergische Landstrasse 2, 12 05 10, 40605 Düsseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 253:321-9. 2003
    ..The network is mainly funded by the German Ministry for Research spanning a period of 5 years...
  89. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  90. ncbi request reprint Trait characteristic of impaired visuomotor integration during Trail-Making Test B performance in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Neuropsychobiology 48:59-67. 2003
    ..Thus, the abnormalities in the process of TMT-B performance proved to be reliable and stable trait characteristics in schizophrenia...