Elvira Richter

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. pmc Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence setting
    Silke Feuerriegel
    Molecular Mycobacteriology, Research Center Borstel, Germany
    BMC Microbiol 12:90. 2012
  2. pmc Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations
    Judit Barniol
    Section Clinical Tropical Medicine, Department for Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    BMC Infect Dis 9:197. 2009
  3. pmc RIDOM: comprehensive and public sequence database for identification of Mycobacterium species
    Dag Harmsen
    Institut fur Hygiene, Universitat Munster, Munster, Germany
    BMC Infect Dis 3:26. 2003
  4. pmc Usefulness of the GenoType MTBC assay for differentiating species of the Mycobacterium tuberculosis complex in cultures obtained from clinical specimens
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, 23845 Borstel, Germany
    J Clin Microbiol 42:4303-6. 2004
  5. pmc Evaluation of genotype MTBC assay for differentiation of clinical Mycobacterium tuberculosis complex isolates
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 41:2672-5. 2003
  6. ncbi request reprint Mycobacterium holsaticum sp. nov
    Elvira Richter
    Forschungszentrum Borstel, National Reference Centre for Mycobacteria, D 23845 Borstel, Germany
    Int J Syst Evol Microbiol 52:1991-6. 2002
  7. pmc Mycobacterium avium subsp. paratuberculosis infection in a patient with HIV, Germany
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
    Emerg Infect Dis 8:729-31. 2002
  8. pmc Mycobacterium alsiense, a novel, slowly growing species isolated from two patients with pulmonary disease
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, 23845, Borstel, Germany
    J Clin Microbiol 45:3837-9. 2007
  9. ncbi request reprint Drug-susceptibility testing in TB: current status and future prospects
    Elvira Richter
    Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Parkallee 18, D 23845 Borstel, Germany
    Expert Rev Respir Med 3:497-510. 2009
  10. pmc Identification of Mycobacterium kansasii by using a DNA probe (AccuProbe) and molecular techniques
    E Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
    J Clin Microbiol 37:964-70. 1999

Collaborators

Detail Information

Publications45

  1. pmc Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence setting
    Silke Feuerriegel
    Molecular Mycobacteriology, Research Center Borstel, Germany
    BMC Microbiol 12:90. 2012
    ..Of the strains investigated 50 were either mono- or poly-resistant to isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide or MDR and 47 fully susceptible strains served as controls...
  2. pmc Transmission dynamics of pulmonary tuberculosis between autochthonous and immigrant sub-populations
    Judit Barniol
    Section Clinical Tropical Medicine, Department for Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    BMC Infect Dis 9:197. 2009
    ..Besides, we assessed transmission in relation to social mixing using an innovative tool that measures the integration of immigrants into the local social environment...
  3. pmc RIDOM: comprehensive and public sequence database for identification of Mycobacterium species
    Dag Harmsen
    Institut fur Hygiene, Universitat Munster, Munster, Germany
    BMC Infect Dis 3:26. 2003
    ..However, reliable sequence-based identification is hampered by many faulty and some missing sequence entries in publicly accessible databases...
  4. pmc Usefulness of the GenoType MTBC assay for differentiating species of the Mycobacterium tuberculosis complex in cultures obtained from clinical specimens
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, 23845 Borstel, Germany
    J Clin Microbiol 42:4303-6. 2004
    ..bovis [5 strains], and Mycobacterium africanum subtype I [1 strain]) results were identical to conventional results. The sensitivity was slightly higher for this test than for the AccuProbe assay...
  5. pmc Evaluation of genotype MTBC assay for differentiation of clinical Mycobacterium tuberculosis complex isolates
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 41:2672-5. 2003
    ..M. bovis subsp. bovis, M. bovis subsp. caprae, M. bovis BCG, M. africanum subtype I, and M. microti were unequivocally identified. M. tuberculosis, M. canetti, and M. africanum subtype II showed a unique hybridization pattern...
  6. ncbi request reprint Mycobacterium holsaticum sp. nov
    Elvira Richter
    Forschungszentrum Borstel, National Reference Centre for Mycobacteria, D 23845 Borstel, Germany
    Int J Syst Evol Microbiol 52:1991-6. 2002
    ..Another strain of M. holsaticum sp. nov., strain 5050, which differed in the internal transcribed spacer sequence, was deposited as DSM 44479 ( = CCUG 46267)...
  7. pmc Mycobacterium avium subsp. paratuberculosis infection in a patient with HIV, Germany
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
    Emerg Infect Dis 8:729-31. 2002
    ..We report the first case of human infection with MAP in a patient with HIV; infection was confirmed by obtaining isolates from several different specimen types...
  8. pmc Mycobacterium alsiense, a novel, slowly growing species isolated from two patients with pulmonary disease
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, 23845, Borstel, Germany
    J Clin Microbiol 45:3837-9. 2007
    ..The isolates showed unique 16S rRNA internal transcribed spacers and hsp65 sequences: the 16S rRNA was most closely related to Mycobacterium szulgai and Mycobacterium malmoense...
  9. ncbi request reprint Drug-susceptibility testing in TB: current status and future prospects
    Elvira Richter
    Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Parkallee 18, D 23845 Borstel, Germany
    Expert Rev Respir Med 3:497-510. 2009
    ..Among the molecular tests, line-probe assays seem to be the most promising tools for a rapid and very specific and sensitive detection of multidrug-resistant M. tuberculosis...
  10. pmc Identification of Mycobacterium kansasii by using a DNA probe (AccuProbe) and molecular techniques
    E Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
    J Clin Microbiol 37:964-70. 1999
    ..Since the M. kansasii strains that are missed are rare and all M. gastri strains are correctly negative, the new formulated AccuProbe provides a useful tool for the identification of M. kansasii...
  11. pmc Evaluation of the GenoType MTBDRplus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens
    Doris Hillemann
    Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Parkallee 18, D 23845 Borstel, Germany
    J Clin Microbiol 45:2635-40. 2007
    ..2%) among the 41 specimens containing INH-resistant strains. Thus, the new GenoType MTBDRplus assay represents a reliable and upgraded tool for the detection of INH and RMP resistance in strains or directly from smear-positive specimens...
  12. pmc Feasibility of the GenoType MTBDRsl assay for fluoroquinolone, amikacin-capreomycin, and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens
    Doris Hillemann
    Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Parkallee 18, D 23845 Borstel, Germany
    J Clin Microbiol 47:1767-72. 2009
    ..In combination with a molecular test for detection of rifampin and isoniazid resistance, the potential for the detection of extensively resistant tuberculosis within 1 to 2 days can be postulated...
  13. pmc Evaluation of the GenoType Mycobacterium Assay for identification of mycobacterial species from cultures
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D 23845 Borstel, Germany
    J Clin Microbiol 44:1769-75. 2006
    ..Concordant results were obtained for 137 (92.6%) of 148 mycobacterial strains with the CM assay and 133 (89.9%) of 148 mycobacterial strains with the AS assay, and all three non-Mycobacterium species were identified...
  14. pmc rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains
    Patrick Beckert
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    Antimicrob Agents Chemother 56:2743-5. 2012
    ....
  15. pmc Use of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis complex isolates
    Doris Hillemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D 23845 Borstel, Germany
    J Clin Microbiol 43:3699-703. 2005
    ..In conclusion, the MTBDR assay is a rapid and easy-to-perform test for the detection of the most common mutations found in MDR M. tuberculosis strains that can readily be included in a routine laboratory work flow...
  16. pmc IS6110 fingerprinting of drug-resistant Mycobacterium tuberculosis strains isolated in Germany during 1995
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Germany
    J Clin Microbiol 35:3015-20. 1997
    ..tuberculosis strains were presumably carried over from the former Soviet Union to Germany by immigrants...
  17. ncbi request reprint Biochemical and genetic evidence for the transfer of Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999 to the species Mycobacterium bovis Karlson and Lessel 1970 (approved lists 1980) as Mycobacterium bovis subsp. caprae comb. nov
    Stefan Niemann
    Forschungszentrum Borstel, National Reference Centre for Mycobacteria, Germany
    Int J Syst Evol Microbiol 52:433-6. 2002
    ..tuberculosis subsp. caprae is misleading and not correct in light of the biochemical and genetic characteristics and propose that the accurate designation of isolates of this subtype is M. bovis subsp. caprae...
  18. pmc Thr202Ala in thyA is a marker for the Latin American Mediterranean lineage of the Mycobacterium tuberculosis complex rather than para-aminosalicylic acid resistance
    Silke Feuerriegel
    Molecular Mycobacteriology, Research Center Borstel, Parkallee 1, Borstel, Germany
    Antimicrob Agents Chemother 54:4794-8. 2010
    ..These findings challenge some of the previous understanding of PAS resistance and, as a consequence, warrant further in-depth investigations of the genetic variation in PAS-resistant clinical isolates and spontaneous mutants...
  19. pmc Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpert MTB/RIF system
    Doris Hillemann
    Nationales Referenzzentrum für Mykobakterien, Forschungszentrum Borstel, Parkallee 18, 23845 Borstel, Germany
    J Clin Microbiol 49:1202-5. 2011
    ..0% (20 out of 29 culture-positive cases detected), 100% sensitivity was found with the urine and stool specimens. The combined sensitivity and specificity of the Xpert assay were calculated to be 77.3% and 98.2%, respectively...
  20. pmc Evaluation of Mycobacterium tuberculosis typing methods in a 4-year study in Schleswig-Holstein, Northern Germany
    Andreas Roetzer
    Molecular Mycobacteriology, Forschungszentrum Borstel, Parkallee 18, D 23845 Borstel, Germany
    J Clin Microbiol 49:4173-8. 2011
    ....
  21. pmc First linezolid-resistant clinical isolates of Mycobacterium tuberculosis
    Elvira Richter
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D 23845 Borstel, Germany
    Antimicrob Agents Chemother 51:1534-6. 2007
    ..The MICs of linezolid were 4 microg/ml (one strain) and 8 microg/ml (three strains). Since no mutations were detected in potential target genes, the mechanism of resistance remains unclear...
  22. pmc Double infection with a resistant and a multidrug-resistant strain of Mycobacterium tuberculosis
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany
    Emerg Infect Dis 6:548-51. 2000
    ..Inappropriate treatment led to further drug resistance and unsuccessful therapy. Thus, additional infections with resistant M. tuberculosis strains should be considered when tuberculosis therapy fails...
  23. ncbi request reprint [Antibiotic drug-resistant tuberculosis]
    Ulf Greinert
    Klinische Infektiologie, Medizinische Klinik, Forschungszentrum Borstel
    Med Klin (Munich) 102:957-66. 2007
    ..Patient adherence to the therapy is essential. As adverse effects of MDR-TB therapy are common, treatment of these patients should be guided by experienced physicians...
  24. ncbi request reprint Application of the Capilia TB assay for culture confirmation of Mycobacterium tuberculosis complex isolates
    D Hillemann
    National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany
    Int J Tuberc Lung Dis 9:1409-11. 2005
    ..The overall sensitivity and specificity were 92.4% and 100%, respectively. In three of nine false-negative isolates a mutation in the mpb64 gene could be detected...
  25. pmc Two cases of Mycobacterium microti derived tuberculosis in HIV-negative immunocompetent patients
    S Niemann
    National Reference Center for Mycobacteria, Borstel, Germany
    Emerg Infect Dis 6:539-42. 2000
    ..The isolates were identified as M. microti of the llama and vole types, according to spoligotype patterns. Our data demonstrate that M. microti can cause severe pulmonary TB in immunocompetent patients...
  26. pmc Differentiation of clinical Mycobacterium tuberculosis complex isolates by gyrB DNA sequence polymorphism analysis
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 38:3231-4. 2000
    ..Based on these results, we present a clear diagnostic algorithm for the differentiation of species of the MTBC...
  27. ncbi request reprint The fate of bacillus Calmette-Guerin after intravesical instillation
    C Durek
    Department of Urology, , National Reference Center for Mycobacteria, Germany
    J Urol 165:1765-8. 2001
    ..Long lasting and persistent BCG DNA in the bladder wall may account for long-term immuno-activation. However, the remaining BCG may be a possible source of late systemic infections...
  28. pmc Differential requirement for interferon-gamma to restrict the growth of or eliminate some recently identified species of nontuberculous mycobacteria in vivo
    S Ehlers
    Division of Molecular Infection Biology, Research Centre Borstel, Centre for Medicine and Biosciences, Borstel, Germany
    Clin Exp Immunol 124:229-38. 2001
    ..In conclusion, IFNgamma is a crucial determinant of infection outcome with most, but not all opportunistic mycobacterial species...
  29. pmc Stability of Mycobacterium tuberculosis IS6110 restriction fragment length polymorphism patterns and spoligotypes determined by analyzing serial isolates from patients with drug-resistant tuberculosis
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 37:409-12. 1999
    ..Partial deletions, e.g., deletions induced by homologous recombination between the repetitive DR elements, could not be detected in this study...
  30. pmc Gamma interferon is essential for clearing Mycobacterium genavense infection
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 68:3720-3. 2000
    ..Granulomatous lesions in the livers of GKO mice were diffuse, were composed of monocytes, neutrophils, and CD3(+) cells, and were histochemically negative for inducible nitric oxide synthase...
  31. ncbi request reprint Application of the Genotype MTBDR assay directly on sputum specimens
    D Hillemann
    Forschungszentrum Borstel, Nationales Referenzzentrum für Mykobakterien, Borstel, Germany
    Int J Tuberc Lung Dis 10:1057-9. 2006
    ..The concordance between the MTBDR assay and conventional drug susceptibility testing was 100%...
  32. pmc Differentiation among members of the Mycobacterium tuberculosis complex by molecular and biochemical features: evidence for two pyrazinamide-susceptible subtypes of M. bovis
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 38:152-7. 2000
    ..bovis and M. africanum. Moreover, we describe two PZA-susceptible M. bovis subtypes and describe a method that facilitates an unambiguous differentiation of the two M. africanum subtypes...
  33. ncbi request reprint Real-time PCR assay for improved detection of Mycobacterium tuberculosis complex in paraffin-embedded tissues
    D Hillemann
    National Reference Center for Mycobacteria, Research Center Borstel, Germany
    Int J Tuberc Lung Dis 10:340-2. 2006
    ..To test the usefulness of a commercially available real-time polymerase chain reaction (PCR) kit for the detection of Mycobacterium tuberculosis complex (MTBC) in formalin-fixed, paraffin-embedded tissues...
  34. pmc Stability of IS6110 restriction fragment length polymorphism patterns of Mycobacterium tuberculosis strains in actual chains of transmission
    S Niemann
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, D 23845 Borstel, Germany
    J Clin Microbiol 38:2563-7. 2000
    ..tuberculosis strains. Furthermore, the data presented indicate that isolates with identical IS6110 DNA fingerprint patterns are a good indicator for the rate of recent transmission in a study population...
  35. pmc Whole Genome Sequencing Reveals Complex Evolution Patterns of Multidrug-Resistant Mycobacterium tuberculosis Beijing Strains in Patients
    Matthias Merker
    Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
    PLoS ONE 8:e82551. 2013
    ..Furthermore, high resolution WGS analysis is necessary to accurately detect exogenous re-infection as classical genotyping lacks discriminatory power in high incidence settings. ..
  36. pmc Use of the BACTEC Mycobacteria Growth Indicator Tube 960 automated system for recovery of Mycobacteria from 9,558 extrapulmonary specimens, including urine samples
    Doris Hillemann
    National Reference Center for Mycobacteria, Forschungszentrum Borstel, Parkallee 18, 23845 Borstel, Germany
    J Clin Microbiol 44:4014-7. 2006
    ..8% and 69.3%, respectively. However, the efficiency of the MGIT 960 system can be maximized with additional culture on solid media...
  37. ncbi request reprint Analysis of the Kveim-Siltzbach test reagent for bacterial DNA
    E Richter
    Research Centre Borstel, Medical Hospital, and National Reference Center for Mycobacteria, Borstel, Germany
    Am J Respir Crit Care Med 159:1981-4. 1999
    ..Because the KST reagent elicits granuloma, these results do not support the hypothesis of a bacterial cause of sarcoid granuloma...
  38. ncbi request reprint The Beijing genotype is a major cause of drug-resistant tuberculosis in Kazakhstan
    T Kubica
    Forschungszentrum Borstel, National Reference Centre for Mycobacteria, Borstel, Germany
    Int J Tuberc Lung Dis 9:646-53. 2005
    ..Nine Kazakhstan oblasts, 2001...
  39. doi request reprint Occurrence of rpoB Mutations in Isoniazid-Resistant but Rifampin-Susceptible Mycobacterium tuberculosis Isolates from Germany
    Sönke Andres
    National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany
    Antimicrob Agents Chemother 58:590-2. 2014
    ....
  40. pmc First Evaluation after Implementation of a Quality Control System for the Second Line Drug Susceptibility Testing of Mycobacterium tuberculosis Joint Efforts in Low and High Incidence Countries
    Doris Hillemann
    National Reference Laboratory for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany
    PLoS ONE 8:e76765. 2013
    ..Overall, we demonstrated the importance of developing inter-laboratory networks to establish quality assurance and improvement of SLD testing of M. tuberculosis. ..
  41. ncbi request reprint Clinical evaluation of the semiautomated BDProbeTec ET System for the detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens
    Sabine Rüsch-Gerdes
    Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee, Borstel, Germany
    Diagn Microbiol Infect Dis 48:265-70. 2004
    ..The data demonstrate that the BDProbeTec ET assay is a highly sensitive and specific technique for the rapid (within 5 h) detection of M. tuberculosis complex in respiratory and nonrespiratory specimens...
  42. pmc In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants
    Doris Hillemann
    Antimicrob Agents Chemother 52:800-1. 2008
  43. ncbi request reprint Isolated pituitary granuloma by atypical Mycobacterium in a nonimmunosuppressed woman
    Dimos Florakis
    Department of Endocrinology and Diabetic Center, G Gennimatas General Hospital of Athens, Athens, Greece
    Clin Endocrinol (Oxf) 56:123-6. 2002
    ..In conclusion, this is the first case of an isolated pituitary granuloma caused by an NTM infection in a nonimmunosuppressed patient...
  44. pmc Mycobacterium bohemicum and cervical lymphadenitis in children
    Julia Huber
    Emerg Infect Dis 14:1158-9. 2008
  45. ncbi request reprint Disseminated Mycobacterium haemophilum infection as initial manifestation of AIDS
    E Enno Stürenburg
    Institut für Infektionsmedizin, Zentrum für Klinisch Theoretische Medizin I, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Tuberculosis (Edinb) 84:341-5. 2004
    ..We describe the first case of a disseminated M. haemophilum infection as initial manifestation of AIDS in Europe...