Zane Orinska

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. doi request reprint I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Blood 116:2665-75. 2010
  2. pmc A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    EMBO J 24:4260-70. 2005
  3. ncbi request reprint Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15
    Elena Bulanova
    Department of Immunology and Cell Biology and Immunochemistry and Biochemical Microbiology, Research Center Borstel, Borstel D 23845, Germany
    J Biol Chem 282:13167-79. 2007
  4. ncbi request reprint IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Nat Med 13:927-34. 2007
  5. ncbi request reprint Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions
    Erietta Stelekati
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunity 31:665-76. 2009
  6. doi request reprint Intracellular IL-15 controls mast cell survival
    Farhad Mirghomizadeh
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Exp Cell Res 315:3064-75. 2009
  7. pmc Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 25:9324-39. 2005
  8. pmc Transcriptional regulation of mouse mast cell protease-2 by interleukin-15
    Farhad Mirghomizadeh
    Division of Immunobiology, Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 284:32635-41. 2009
  9. pmc Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-γ-mediated suppressor activities
    Rajia Bahri
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    PLoS ONE 7:e45234. 2012
  10. ncbi request reprint TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment
    Zane Orinska
    Department of Immunology and Cellular Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Blood 106:978-87. 2005

Collaborators

Detail Information

Publications21

  1. doi request reprint I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Blood 116:2665-75. 2010
    ..Thus, I787 provides nonredundant signals for c-Kit internalization and functionality...
  2. pmc A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    EMBO J 24:4260-70. 2005
    ..Thus, IL-15-induced protection from TNFalpha-mediated cell death involves a hitherto unknown IL-15 receptor complex, consisting of IL-15Ralpha and Axl RTK, and requires their reciprocal activation initiated by ligand-induced IL-15Ralpha...
  3. ncbi request reprint Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15
    Elena Bulanova
    Department of Immunology and Cell Biology and Immunochemistry and Biochemical Microbiology, Research Center Borstel, Borstel D 23845, Germany
    J Biol Chem 282:13167-79. 2007
    ..Thus, a dual mechanism of sIL-15Ralpha generation exists in mice, giving rise to polypeptides with distinct properties, which regulate IL-15 function...
  4. ncbi request reprint IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Nat Med 13:927-34. 2007
    ..Our results identify an unexpected breach in MC-dependent innate immune defenses against sepsis and suggest that inhibiting intracellular IL-15 in MCs may improve survival from sepsis...
  5. ncbi request reprint Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions
    Erietta Stelekati
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunity 31:665-76. 2009
    ..Thus, MCs are important players in antigen-specific regulation of CD8(+) T cells...
  6. doi request reprint Intracellular IL-15 controls mast cell survival
    Farhad Mirghomizadeh
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Exp Cell Res 315:3064-75. 2009
    ..These findings suggest that intracellular IL-15 is a key regulator of pathways controlling primary mouse mast cell homeostasis...
  7. pmc Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 25:9324-39. 2005
    ..Upon immobilization, sAxl promoted cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. Thus, ADAM10-mediated generation of sAxl might play an important role in diverse biological processes...
  8. pmc Transcriptional regulation of mouse mast cell protease-2 by interleukin-15
    Farhad Mirghomizadeh
    Division of Immunobiology, Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 284:32635-41. 2009
    ..This suggests a novel model of cytokine-controlled protease transcription: non-CpG methylation maintains a chromosomal domain in an "open" configuration that is permissive for gene expression...
  9. pmc Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-γ-mediated suppressor activities
    Rajia Bahri
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    PLoS ONE 7:e45234. 2012
    ..These findings add evidence that the expression of ectoenzyme receptor family members positively correlates with suppressor functions and identifies CD8(+)CD38(high) T cells as potential inhibitors of excessive immune responses...
  10. ncbi request reprint TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment
    Zane Orinska
    Department of Immunology and Cellular Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Blood 106:978-87. 2005
    ..Mast-cell reconstitution of KitW/KitW-v mice normalizes the CD8+ T-cell influx. Thus, mast cells stimulated through engagement of TLR3 are potent regulators of CD8+ T-cell activities in vitro and in vivo...
  11. doi request reprint ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells
    Elena Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Leukoc Biol 85:692-702. 2009
    ..This finding highlights a novel level of complexity in the sophisticated biology of MCs and may facilitate the development of new therapeutic approaches to modulate MC activities...
  12. pmc Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b
    Niko Föger
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Exp Med 208:1777-87. 2011
    ..Thus, coronin proteins, and in turn the actin cytoskeleton, exhibit a functional dichotomy as differential regulators of degranulation versus cytokine secretion in MC biology...
  13. pmc How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    Erwin H Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 28:4851-61. 2008
    ....
  14. ncbi request reprint Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells
    Elena Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3880-90. 2005
    ....
  15. ncbi request reprint Mast cells in allergy: innate instructors of adaptive responses
    Erietta Stelekati
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Immunobiology 212:505-19. 2007
    ..In this review, we explore the hypothesis that mast cells serve as central mediators between innate and adaptive immunity, rather as pure effector cells, during allergic innate responses...
  16. ncbi request reprint Mast cells express novel functional IL-15 receptor alpha isoforms
    Elena Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5045-55. 2003
    ..Taken together, our data indicate that murine mast cells express novel, fully functional IL-15R alpha isoforms, which can explain the selective regulatory effects of IL-15 on these cells...
  17. ncbi request reprint Reverse signaling through membrane-bound interleukin-15
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    J Biol Chem 279:42192-201. 2004
    ..This fact highlights a new level of complexity in the biology of IL-15 and offers novel important insights into our understanding of the cellular responses modulated by this pleiotropic cytokine...
  18. ncbi request reprint Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation
    Orietta D'Orlando
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 43:194-208. 2013
    ..Finally, we show that these mice are a very useful tool for dissecting the role of STX11 in vesicular trafficking and secretion...
  19. doi request reprint Mechanisms of cytokine secretion: a portfolio of distinct pathways allows flexibility in cytokine activity
    Erwin Hans Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Eur J Cell Biol 90:476-83. 2011
    ....
  20. ncbi request reprint Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B
    Vadim Budagian
    Department of Immunology and Cellular Biology, Research Center Borstel, D 23845 Borstel, Germany
    J Biol Chem 278:1549-60. 2003
    ..Taken together, these results demonstrate the ability of extracellular ATP to activate multiple downstream signaling events in a human T-lymphoblastoid cell line...
  21. ncbi request reprint Novel B cell population producing functional IgG in the absence of membrane IgM expression
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 32:3472-80. 2002
    ..It remains an open question how the reactivity of these B cells is regulated and in which extent such B cells play a role in physiological and pathological processes such as autoantibody production and autoimmunity...