Holger Heine

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. ncbi request reprint The biology of endotoxin
    H Heine
    Research Center Borstel, Center for Medicine and Biosciences, Parkallee 22, D 23845 Borstel, Germany
    Mol Biotechnol 19:279-96. 2001
  2. pmc Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells
    Kimberley Kallsen
    Division of Innate Immunity, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
    PLoS ONE 7:e50000. 2012
  3. pmc S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection
    Ellen Andresen
    Division of Innate Immunity, Department of Immunology and Cell Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    BMC Pulm Med 11:10. 2011
  4. ncbi request reprint Recognition of bacterial products by toll-like receptors
    Holger Heine
    Department of Immunology and Cell Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Chem Immunol Allergy 86:99-119. 2005
  5. doi request reprint TLRs, NLRs and RLRs: innate sensors and their impact on allergic diseases--a current view
    Holger Heine
    Research Center Borstel Leibniz Center for Medicine and Biosciences, Division of Innate Immunity, Section of Immunoregulation, Parkallee 22, 23845 Borstel, Germany
    Immunol Lett 139:14-24. 2011
  6. ncbi request reprint Toll-like receptors and their function in innate and adaptive immunity
    Holger Heine
    Division of Innate Immunity, Research Center Borstel, Center for Medicine and Biosciences, Germany
    Int Arch Allergy Immunol 130:180-92. 2003
  7. ncbi request reprint CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex
    Holger Heine
    Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
    Eur J Immunol 33:1399-408. 2003
  8. doi request reprint Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
    Kay Vogel
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008
  9. ncbi request reprint TLR1- and TLR6-independent recognition of bacterial lipopeptides
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 281:9049-57. 2006
  10. doi request reprint TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
    Ulrich Zahringer
    Division of Immunochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    Immunobiology 213:205-24. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint The biology of endotoxin
    H Heine
    Research Center Borstel, Center for Medicine and Biosciences, Parkallee 22, D 23845 Borstel, Germany
    Mol Biotechnol 19:279-96. 2001
    ..The knowledge about the molecular basis for the responses to endotoxin may eventually lead to the development of new drugs to fight the fatal effects of bacterial infections...
  2. pmc Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells
    Kimberley Kallsen
    Division of Innate Immunity, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
    PLoS ONE 7:e50000. 2012
    ..Taken together, our data reveal epigenetic mechanisms which are the basis of the maintenance of the constitutive gene expression of human beta defensin 1...
  3. pmc S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection
    Ellen Andresen
    Division of Innate Immunity, Department of Immunology and Cell Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    BMC Pulm Med 11:10. 2011
    ..We hypothesized that S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD...
  4. ncbi request reprint Recognition of bacterial products by toll-like receptors
    Holger Heine
    Department of Immunology and Cell Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Chem Immunol Allergy 86:99-119. 2005
    ..This review focuses on the current knowledge about the different molecules that are recognized by Toll receptors in mammalian cells...
  5. doi request reprint TLRs, NLRs and RLRs: innate sensors and their impact on allergic diseases--a current view
    Holger Heine
    Research Center Borstel Leibniz Center for Medicine and Biosciences, Division of Innate Immunity, Section of Immunoregulation, Parkallee 22, 23845 Borstel, Germany
    Immunol Lett 139:14-24. 2011
    ..This current view describes our present knowledge about these three main innate immune receptor families and their importance for adaptive immune responses such as asthma and allergy...
  6. ncbi request reprint Toll-like receptors and their function in innate and adaptive immunity
    Holger Heine
    Division of Innate Immunity, Research Center Borstel, Center for Medicine and Biosciences, Germany
    Int Arch Allergy Immunol 130:180-92. 2003
    ....
  7. ncbi request reprint CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex
    Holger Heine
    Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
    Eur J Immunol 33:1399-408. 2003
    ..Finally, through FRET analysis we could demonstrate LPS-induced clustering of CD55 and CD11/CD18 in human monocytes. Our results imply a new functional role of CD55 as a member of a multimeric LPS receptor complex...
  8. doi request reprint Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
    Kay Vogel
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008
    ..Because of their small size and thereby their potential for deposition in lower airways of small children, bacterial spores may be candidates for such allergy-protective effects...
  9. ncbi request reprint TLR1- and TLR6-independent recognition of bacterial lipopeptides
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 281:9049-57. 2006
    ..Contrary to the current model, distinct lipopeptides are recognized by TLR2 in a TLR1- and TLR6-independent manner...
  10. doi request reprint TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
    Ulrich Zahringer
    Division of Immunochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    Immunobiology 213:205-24. 2008
    ..This finding implies that the activity of all other putative bacterial compounds so far reported as TLR2 agonists was most likely due to contaminating highly active natural lipoproteins and/or lipopeptides...
  11. ncbi request reprint Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization
    Jörg Andrä
    Forschungszentrum Borstel, Leibniz Zentrum for Medizin und Biowissenschaften, Parkallee 10, D 23845 Borstel, Germany
    Biol Chem 387:301-10. 2006
    ....
  12. ncbi request reprint Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans
    Klaus Brandenburg
    Forschungszentrum Borstel, Center for Medicine and Biosciences, Borstel, Germany
    Eur J Biochem 270:3271-9. 2003
    ....
  13. ncbi request reprint Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC
    Holger Heine
    Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
    Eur J Biochem 270:440-50. 2003
    ..Like other LPS, the chlamydial LPS used toll-like receptor TLR4 for signalling, but unlike other LPS activation was strictly CD14-dependent...
  14. ncbi request reprint Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1
    Maria Manukyan
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 35:911-21. 2005
    ..Thus, LP binding to CD14 is the first step in the LP recognition, inducing physical proximity of CD14 and LP with TLR2/TLR1 and formation of the TLR2 signaling complex...
  15. doi request reprint Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope
    Anna Hanuszkiewicz
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    Chemistry 14:10251-8. 2008
    ..lwoffii F78 LPS. Thus, an LPS was identified outside Chlamydiaceae that contains a Chlamydia-specific LPS epitope in its core region...
  16. doi request reprint Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide
    Sabine Riekenberg
    Cellular Immunology, Department of Immunology and Cell Biology, Research Center Borstel, Germany
    FEBS J 276:649-59. 2009
    ..Modulation of RGS1 and RGS2 by Toll-like receptor ligands plays an important role during inflammatory and immunological reactions after bacterial and viral infection...
  17. pmc Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease
    Ellen Andresen
    Section of Immunoregulation, Division of Innate Immunity, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    PLoS ONE 6:e21898. 2011
    ..Thus, expression of human DEFB1 is upregulated and related to the decrease in pulmonary function in patients with COPD...
  18. ncbi request reprint Lipopeptide structure determines TLR2 dependent cell activation level
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    FEBS J 272:6354-64. 2005
    ..Thus they might support the explanation of specific immuno-stimulatory potentials of different microorganisms and provide a basis for rational design of TLR2 specific adjuvants mediating immune activation to distinct levels...
  19. ncbi request reprint Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling
    Katja Farhat
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, Borstel, Germany
    J Leukoc Biol 83:692-701. 2008
    ....
  20. ncbi request reprint Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A
    Yingda Wu
    Department of Immunochemistry and Biochemical Microbiology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Am J Respir Cell Mol Biol 31:587-94. 2004
    ..The data suggest that anti-inflammatory effects of SP-A on LPS-challenged AMs are associated with a SP-A-mediated direct modulation of the IkappaB-alpha turnover in these cells...
  21. doi request reprint Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2
    Kathleen Fischer
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, D 23845 Borstel, Germany
    Glycobiology 21:1588-95. 2011
    ..This LTA preparation possesses Toll-like receptor 2- (TLR2) and TLR4-independent cytokine-inducing activities in human mononuclear cells...
  22. ncbi request reprint The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    Antje Blumenthal
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Blood 108:965-73. 2006
    ..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections...
  23. doi request reprint Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits
    Lore Brade
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Innate Immun 18:279-93. 2012
    ..The mimicked epitope likely shares common determinants with the WN1 222-5 epitope, yet differences with respect to either affinity or specificity do exist, as binding to smaller oligosaccharides of the inner core was not observed...
  24. ncbi request reprint The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121
    Kathleen Fischer
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, D 23845 Borstel, Germany
    Biol Chem 393:749-55. 2012
    ..The EC TA was a poly(glycosylglycerol phosphate) molecule with a repeating unit of -6)-[β-D-Glcp-(1→3)-][α-D-GlcpNAc-(1→4)-]α-D-GalpNAc-(1→3)-β-D-GlcpNAc-(1→2)-glycerol-(1-P-)...
  25. ncbi request reprint Induction of various immune modulatory molecules in CD34(+) hematopoietic cells
    Oliver Umland
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Leukoc Biol 75:671-9. 2004
    ....
  26. ncbi request reprint Investigation on the agonistic and antagonistic biological activities of synthetic Chlamydia lipid A and its use in in vitro enzymatic assays
    Holger Heine
    Leibniz Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany
    J Endotoxin Res 13:126-32. 2007
    ..coli, Chlamydia trachomatis and Chlamydophila psittaci as shown by in vitro assays and detection of the products by thin layer chromatography and immune staining with monoclonal antibody...
  27. ncbi request reprint Toll-like receptor 6-independent signaling by diacylated lipopeptides
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    Eur J Immunol 35:282-9. 2005
    ..Our results indicate that both the lipid and the N-terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand-receptor interaction on host cells...
  28. ncbi request reprint Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2
    Ingo Fricke
    Division of Immunotherapy, Research Center Borstel, Parkallee 1 40, 23845 Borstel, Germany
    J Immunol 176:5173-82. 2006
    ....
  29. pmc Biophysical characterization of triacyl monosaccharide lipid a partial structures in relation to bioactivity
    Klaus Brandenburg
    Forschungszentrum Borstel, Division of Biophysics, D 23845 Borstel, Germany
    Biophys J 83:322-33. 2002
    ..Based on these data a model of the intra and intermolecular conformations is proposed which also extends the concept of "endotoxic conformation."..
  30. ncbi request reprint Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595
    Holger Janusch
    Research Center Borstel, Center for Medicine and Biosciences, Borstel, Germany
    J Endotoxin Res 8:343-56. 2002
    ....
  31. ncbi request reprint Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T
    Ulrich Zahringer
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    J Biol Chem 279:21046-54. 2004
    ..g. Legionella and Chlamydia), may provide the molecular basis for low endotoxic potency...
  32. ncbi request reprint Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties
    Jennifer Debarry
    Division of Innate Immunity, Research Center Borstel, Leibniz Center for Medicine, and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 119:1514-21. 2007
    ....
  33. ncbi request reprint The generalized endotoxic principle
    Ulrich Seydel
    Forschungszentrum Borstel, Germany
    Eur J Immunol 33:1586-92. 2003
    ..These results define a general endotoxic principle and, furthermore, provide new insights into an understanding of early steps of endotoxin action...
  34. ncbi request reprint Structural polymorphism and endotoxic activity of synthetic phospholipid-like amphiphiles
    K Brandenburg
    Forschungszentrum Borstel, Leibniz Institut für Medizin und Biowissenschaften, Parkallee 10, D 23845 Borstel, Germany
    Biochemistry 43:4039-46. 2004
    ....
  35. doi request reprint Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity
    Nicolas Gisch
    Department of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    Bioorg Med Chem Lett 21:3362-6. 2011
    ..All biotinylated compounds retained their ability to activate NOD2 in a cell-based test system and are therefore suitable for binding studies aimed at identifying the appropriate pattern recognition receptor(s)...
  36. doi request reprint Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster
    Christine Warmbold
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Immunol 190:366-71. 2013
    ..We conclude that the innate immune response to this allergen-mediated proteolytic cleavage represents an ancient type of danger signaling that may be highly relevant for the primary allergenicity of compounds such as Der p 1...
  37. ncbi request reprint Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells
    Jens Fleischer
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 169:770-7. 2002
    ..Taken together, our results show that specific binding of PF-4, resulting in the down-regulation of the IL-2-release correlates with the inhibition of functions in activated T cells...
  38. ncbi request reprint Decay-accelerating factor (DAF/CD55) is a functional active element of the LPS receptor complex
    H Heine
    Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany
    J Endotoxin Res 7:227-31. 2001
    ..Our results demonstrate a new functional role of CD55 as a molecule able to mediate LPS-induced activation of cells that may be part of a multimeric LPS receptor complex...
  39. ncbi request reprint The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide
    J DeBarry
    Division of Innate Immunity, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 22, Borstel, Germany
    Allergy 65:690-7. 2010
    ..In the present study, we further characterized one of these bacteria, namely Acinetobacter lwoffii F78, with regard to the bacteria-induced signaling and possible mechanisms of allergy protection...
  40. ncbi request reprint TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS
    Stefanie Zeuke
    Department of Medicine II, Medical University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany
    Cardiovasc Res 56:126-34. 2002
    ..While the adverse effects of cytokines on contractile function and myocardial cell integrity are well studied, little is known on whether cardiac cells are only targets or active players in these inflammatory reactions...
  41. ncbi request reprint LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide
    Yang Liu
    Department of Neurology, University of Gottingen, Germany
    Brain 128:1778-89. 2005
    ....
  42. ncbi request reprint Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:33645-53. 2003
    ..These data indicate that newly described ACG is involved in developing host immunity during Lyme disease and thus may be useful for diagnosis and vaccination...
  43. ncbi request reprint Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B
    Verena von Bulow
    Institute of Immunology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen University, Aachen, Germany
    J Immunol 179:4180-6. 2007
    ....
  44. ncbi request reprint Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent
    Martha Triantafilou
    Infection and Immunity Group, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    J Biol Chem 279:40882-9. 2004
    ..Similarly to lipopolysaccharide, LTA activation occurs at the cell surface, and the observed trafficking is independent of signaling...
  45. ncbi request reprint Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Charite University Medical Center, Humboldt University, Berlin, Germany
    J Immunol 173:2683-91. 2004
    ..These results support that LBP is a pattern recognition receptor transferring a variety of bacterial ligands including the two major types of lipopeptides to CD14 present in different receptor complexes...
  46. ncbi request reprint Synthesis of peptidoglycan fragments and evaluation of their biological activity
    Seiichi Inamura
    Department of Chemistry, Graduate School of Science, Osaka University, 1 1 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
    Org Biomol Chem 4:232-42. 2006
    ..Here we reveal that TLR2 was not stimulated by the series of synthetic PG partial structures, whereas Nod2 recognizes the partial structures containing the MDP moiety...
  47. ncbi request reprint Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease
    Silke Walter
    Department of Neurology, University of the Saarland, Homburg, Germany
    Cell Physiol Biochem 20:947-56. 2007
    ..Together, these observations provide the first evidence for a role of the key innate immune receptor, TLR4, in neuroinflammation in Alzheimer's disease...
  48. ncbi request reprint Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma
    William Vermi
    Department of Pathology and the Section of General Pathology and Immunology, University of Brescia, Italy
    Blood 107:454-62. 2006
    ..These findings suggest that the humoral immune response to B henselae initiates in the extrafollicular areas of infected lymph nodes and is regulated by DCs...