Torsten Goldmann

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. pmc Triggering receptor expressed on myeloid cells-1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis
    Tobias van Bremen
    Medical Clinic III, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck 23538, Germany
    Diagn Pathol 8:24. 2013
  2. pmc Virtual slides in peer reviewed, open access medical publication
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 6:124. 2011
  3. pmc CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
    Dmitri V Pechkovsky
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    Respir Res 6:75. 2005
  4. pmc To be at the right place at the right time
    Klaus Kayser
    Institute of Pathology, Charite, Chariteplatz 1, D 10118 Berlin, Germany
    Diagn Pathol 6:2-9. 2011
  5. pmc Image standards in tissue-based diagnosis (diagnostic surgical pathology)
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 3:17. 2008
  6. pmc On the significance of Surfactant Protein-A within the human lungs
    Torsten Goldmann
    Division for Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany
    Diagn Pathol 4:8. 2009
  7. pmc The human placenta releases substances that drive lung cancer into apoptosis
    Sebastian Marwitz
    Research Center Borstel, Clinical and Experimental Pathology, Parkallee 3a, D 23845, Borstel, Germany
    Diagn Pathol 4:27. 2009
  8. ncbi request reprint Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffin-embedded tissues
    T Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Germany
    Pathol Res Pract 198:91-5. 2002
  9. ncbi request reprint Cost-effective gel documentation using a web-cam
    T Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1 40, D 23845 Borstel, Germany
    J Biochem Biophys Methods 50:91-5. 2001
  10. ncbi request reprint Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material
    Torsten Goldmann
    Research Center Borstel, Clinical and Experimental Pathology, Germany
    Pathol Res Pract 201:599-602. 2005

Detail Information

Publications60

  1. pmc Triggering receptor expressed on myeloid cells-1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis
    Tobias van Bremen
    Medical Clinic III, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck 23538, Germany
    Diagn Pathol 8:24. 2013
    ..Bacterial sepsis induced immunsuppression via antigen hyporesponsibility increases the risk of nosokomial infections and mortality. Pattern recognition receptors (PRR) might have a central role in the pathophysiology of hyporesponsibility...
  2. pmc Virtual slides in peer reviewed, open access medical publication
    Klaus Kayser
    Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 6:124. 2011
    ....
  3. pmc CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
    Dmitri V Pechkovsky
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    Respir Res 6:75. 2005
    ....
  4. pmc To be at the right place at the right time
    Klaus Kayser
    Institute of Pathology, Charite, Chariteplatz 1, D 10118 Berlin, Germany
    Diagn Pathol 6:2-9. 2011
    ..To include the theory of hierarchic order of structures and aspects of thermodynamically open systems, especially entropy, structural entropy and entropy flow...
  5. pmc Image standards in tissue-based diagnosis (diagnostic surgical pathology)
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Berlin, Germany
    Diagn Pathol 3:17. 2008
    ..Progress in automated image analysis, virtual microscopy, hospital information systems, and interdisciplinary data exchange require image standards to be applied in tissue-based diagnosis...
  6. pmc On the significance of Surfactant Protein-A within the human lungs
    Torsten Goldmann
    Division for Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany
    Diagn Pathol 4:8. 2009
    ....
  7. pmc The human placenta releases substances that drive lung cancer into apoptosis
    Sebastian Marwitz
    Research Center Borstel, Clinical and Experimental Pathology, Parkallee 3a, D 23845, Borstel, Germany
    Diagn Pathol 4:27. 2009
    ..As even sterile-filtrated medium caused the mentioned effects we hypothesize one or more soluble mediators. The detailed way of promoting apoptosis and nature of these mediators need to be elucidated in further studies...
  8. ncbi request reprint Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffin-embedded tissues
    T Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Germany
    Pathol Res Pract 198:91-5. 2002
    ..To sum up, these initial results, obtained with the novel HOPE-fixative, are promising as regards the enhancement of the capabilities of in situ hybridization in the future...
  9. ncbi request reprint Cost-effective gel documentation using a web-cam
    T Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1 40, D 23845 Borstel, Germany
    J Biochem Biophys Methods 50:91-5. 2001
    ....
  10. ncbi request reprint Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material
    Torsten Goldmann
    Research Center Borstel, Clinical and Experimental Pathology, Germany
    Pathol Res Pract 201:599-602. 2005
    ....
  11. ncbi request reprint The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry
    T Goldmann
    Research Center Borstel, Parkallee 3, 23845 Borstel, Germany
    Arch Dermatol Res 293:115-20. 2001
    ..3%, a specificity of 87.0% and an efficiency of 73.6%. This kind of combined risk-factor score might be used to more accurately detect patients at high risk of metastasis...
  12. pmc The TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae
    Daniel Drömann
    Medical Clinic III, University of Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Germany
    Respir Res 11:67. 2010
    ..Few data are available regarding the influence of acute and persistent infection on tissue remodelling and repair factors such as transforming growth factor (TGF)-beta...
  13. pmc Proteomics out of the archive: Two-dimensional electrophoresis and mass spectrometry using HOPE-fixed, paraffin-embedded tissues
    Daniel Kähler
    Research Center Borstel, Germany
    J Histochem Cytochem 58:221-8. 2010
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  14. doi request reprint Effect of steroids, acetyl-cysteine and calcium-activated chloride channel inhibitors on allergic mucin expression in sinus mucosa
    Hans Peter Hauber
    From the Medical Clinic, Research Center Borstel, Borstel, Germany
    Laryngoscope 118:1528-33. 2008
    ..Our goal was to investigate the effect of glucocorticosteroids, acetyl-cysteine (ACC), and calcium-activated chloride channel (CLCA) inhibitors in a model of Th2 type cytokine induced mucin expression in human airway mucosa...
  15. ncbi request reprint LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors
    Hans Peter Hauber
    Medical Clinic, Research Center Borstel, Borstel, Germany
    J Endotoxin Res 13:109-16. 2007
    ..Therefore, we tested the hypothesis that hCLCA1 may be involved in lipopolysaccharide (LPS) induced mucin up-regulation in human airways. We also investigated the effect of NFA and MSI-2216 on LPS-induced mucin up-regulation...
  16. doi request reprint Expression of the acute phase protein haptoglobin in human lung cancer and tumor-free lung tissues
    Mahdi Abdullah
    Research Center Borstel, Clinical and Experimental Pathology, Borstel, Germany
    Pathol Res Pract 205:639-47. 2009
    ..Due to the known immunomodulatory effects of haptoglobin, its broad expression and synthesis within human lung tissues strongly suggests a function as a fundamental pulmonary local defense element...
  17. doi request reprint Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways
    Lisa Sprenger
    Division of Pathophysiology of Inflammation, Research Center Borstel, Borstel, Germany
    Pulm Pharmacol Ther 24:232-9. 2011
    ..Infection with Pseudomonas aeruginosa (PA) induces mucus hypersecretion in airways. Therapeutic options to attenuate excessive mucus expression are sparse...
  18. pmc Effect of low tidal volume ventilation on lung function and inflammation in mice
    Hans P Hauber
    Division of Pathophysiology of Inflammation, Research Center Borstel, Borstel, Germany
    BMC Pulm Med 10:21. 2010
    ..In contrast data on very short term effects of low tidal volume ventilation are sparse. Therefore we investigated the functional and structural effects of low tidal volume ventilation in mice...
  19. pmc A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy
    Dagmar S Lang
    Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany
    Respir Res 8:43. 2007
    ..The purpose of the present study was the development of a human ex vivo tissue culture model and the analysis of the effects of conventional chemotherapy, which then can serve as a tool to test new chemotherapeutical regimens in NSCLC...
  20. pmc HOPE-BAL: improved molecular diagnostics by application of a novel technique for fixation and paraffin embedding
    Sebastian Marwitz
    Research Center Borstel, Clinical and Experimental Pathology, Borstel, Germany
    J Histochem Cytochem 59:601-14. 2011
    ..Because of the excellent preservation of nucleic acids, protein, and morphologic structures, HOPE-BAL is a step forward into enhanced molecular diagnostics and biobanking in pulmonary medicine...
  21. doi request reprint Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis
    Malte U Hammer
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, Germany
    Biochem J 427:477-88. 2010
    ..Instead, differences in activity originated from the LPS-binding step, which could be demonstrated by NK-2 attachment to intact bacteria, and to solid-supported LPS bilayers on a surface acoustic wave biosensor...
  22. doi request reprint Modulation of the inflammatory response to Streptococcus pneumoniae in a model of acute lung tissue infection
    Feng Xu
    Medical Clinic III, Campus Lubeck, University of Schleswig Holstein, Lubeck, Germany
    Am J Respir Cell Mol Biol 39:522-9. 2008
    ..p38 MAPK holds a major role in pathogen-induced pulmonary cytokine release and is a potential molecular target to modulate overwhelming lung inflammation...
  23. ncbi request reprint Pulmonary responses to overventilation in late multiple organ failure
    Ulrike Uhlig
    Division of Pulmonary Pharmacology, Research Center Borstel, Borstel, Germany
    Anesthesiology 105:1192-200. 2006
    ..However, most studies have focused on the onset and the early phase of MOF. It was the aim of the current study to investigate the effect of ventilation in the course of MOF...
  24. ncbi request reprint Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary disease
    Daniel Droemann
    Medical Clinic, Research Center Borstel, Parkallee 35, D 23845 Borstel, Germany
    Am J Respir Crit Care Med 175:791-7. 2007
    ..Chlamydia pneumoniae (Cpn) infection may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Few data are available comparing persistent and acute infection of this pathogen in the human respiratory tract...
  25. pmc Comparison of the effect of LPS and PAM3 on ventilated lungs
    Hans P Hauber
    Pathophysiology of Inflammation, Research Center Borstel, Borstel, Germany
    BMC Pulm Med 10:20. 2010
    ..Therefore the effect of LPS and a lipopetide from Gram-positive bacteria, PAM3, on ventilated lungs were investigated...
  26. ncbi request reprint Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung
    Daniel Droemann
    Medical Clinic, Research Center Borstel, Parkallee 35, Germany
    Histochem Cell Biol 119:103-8. 2003
    ..Expression of mRNA was verified by RT-PCR and DNA sequencing. These results indicate a potential mechanism of increased immunosurveillance at the alveolar level controlling the localized infection...
  27. pmc Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors
    Lena Heinbockel
    Division of Biophysics, Research Center Borstel, Borstel, Germany
    Antimicrob Agents Chemother 57:1480-7. 2013
    ..This broad neutralization efficiency and the additive action of the peptide with common antibiotics makes it an exceptionally appropriate drug candidate against bacterial sepsis and also offers multiple other medication opportunities...
  28. pmc Human lung cancer cells express functionally active Toll-like receptor 9
    Daniel Droemann
    Medical Clinic, Research Center Borstel, D 23845 Borstel, Germany
    Respir Res 6:1. 2005
    ..TLR9 expression by malignant tumor cells, would affect treatment approaches using CpG-ODN on the one hand, and, on the other hand, provide additional novel information about the role of tumor cells in tumor-immunology...
  29. pmc S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection
    Ellen Andresen
    Division of Innate Immunity, Department of Immunology and Cell Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
    BMC Pulm Med 11:10. 2011
    ..We hypothesized that S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD...
  30. pmc LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification
    Dagmar S Lang
    Clinical and Experimental Pathology, Research Center Borstel, Parkallee 3, Borstel, Germany
    Diagn Pathol 3:49. 2008
    ....
  31. pmc Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients
    Daniel Droemann
    Medical Clinic, Research Center Borstel, 23845 Borstel, Germany
    Respir Res 6:68. 2005
    ..In the present study we characterized the expression of Toll-like receptor (TLR)- 2, TLR4 and CD14 on human AM compared to autologous monocytes obtained from patients with COPD, healthy smokers and non-smokers...
  32. pmc Multiple peptide resistance factor (MprF)-mediated Resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol
    Jörg Andrä
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, D 23845 Borstel, Germany
    J Biol Chem 286:18692-700. 2011
    ..Altogether, our data support and underline the significance of lysyl-PG for S. aureus resistance to AMPs...
  33. pmc Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes
    Bernhard Schaaf
    Medical Clinic III, University of Schleswig Holstein, , , Germany
    Diagn Pathol 4:12. 2009
    ..Death is associated with downregulation of TLR2 and CD14 expression on monocytes correlating with reduced cytokine inducibility. We suggest that CD14 and TLR2 are a key factor in monocyte hyporesponsibility during severe sepsis...
  34. ncbi request reprint The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    Antje Blumenthal
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Blood 108:965-73. 2006
    ..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections...
  35. ncbi request reprint HOPE fixation of cytospin preparations of human cells for in situ hybridization and immunocytochemistry
    Oliver Umland
    Departments of Immunology and Cell Biology, Research Center Borstel, Parkallee 3, D 23845 Borstel, Germany
    J Histochem Cytochem 51:977-80. 2003
    ..HOPE can be used with cells and tissues and with a broad spectrum of immunohistocytochemical and molecular techniques...
  36. ncbi request reprint The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues
    Torsten Goldmann
    Clinical and Experimental Pathology, Research Center Borstel, Parkallee 3, 23845 Borstel, Germany
    Pathol Res Pract 200:511-5. 2004
    ..In addition, by detecting GAPDH and high mobility group protein gene B1 (HMGB1)-specific transcripts, we were able to demonstrate that RNA from HOPE-fixed tissue can also be used for Northern blot hybridization...
  37. doi request reprint Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients
    Kai Schmengler
    Division of Immunochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 4a, 23845 Borstel, Germany
    Eur J Cell Biol 89:25-33. 2010
    ..Together with the Western blot results mAb S60-4-14 displays a potential diagnostic tool for the specific identification of P. aeruginosa in infected lungs of CF...
  38. ncbi request reprint Phosphoinositide 3-OH kinase inhibition prevents ventilation-induced lung cell activation
    Ulrike Uhlig
    Research Center Borstel, Borstel, Germany
    Am J Respir Crit Care Med 169:201-8. 2004
    ....
  39. ncbi request reprint Structure and mode of action of the antimicrobial peptide arenicin
    Jörg Andrä
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 10, 23845 Borstel, Germany
    Biochem J 410:113-22. 2008
    ..Our results strongly suggest that membrane interaction plays a pivotal role in the antibacterial activity of arenicin...
  40. ncbi request reprint Effect of dexamethasone and ACC on bacteria-induced mucin expression in human airway mucosa
    Hans Peter Hauber
    Medical Clinic, Research Center Borstel, Research Center Borstel, Borstel, Germany
    Am J Respir Cell Mol Biol 37:606-16. 2007
    ..ACC alone may increase mucin expression in noninfected mucosa, but it decreased bacteria-induced mucin expression. Further studies are warranted to evaluate whether the effect of DEX or ACC is clinically relevant...
  41. doi request reprint Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
    Kay Vogel
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008
    ..Because of their small size and thereby their potential for deposition in lower airways of small children, bacterial spores may be candidates for such allergy-protective effects...
  42. ncbi request reprint Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A
    Andreas Busche
    Division of Immunotherapy, Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    Hum Gene Ther 17:135-46. 2006
    ..Our data demonstrate that MICA overexpression can function as NK cell-mediated immunotherapy in experimental lung cancer...
  43. ncbi request reprint Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2
    Ingo Fricke
    Division of Immunotherapy, Research Center Borstel, Parkallee 1 40, 23845 Borstel, Germany
    J Immunol 176:5173-82. 2006
    ....
  44. doi request reprint I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Blood 116:2665-75. 2010
    ..Thus, I787 provides nonredundant signals for c-Kit internalization and functionality...
  45. pmc Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung
    Mahdi Abdullah
    Clinical and Experimental Pathology, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Parkallee 3, D 23845, Borstel, Germany
    Diagn Pathol 7:158. 2012
    ..We conclude that the presented data shows that pHp is a native part of the surfactant system in the human lung. VIRTUAL SLIDES: http://www.diagnosticpathology.diagnomx.eu/vs/2563584738239912...
  46. ncbi request reprint Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
    Jörg Andrä
    Forschungszentrum Borstel, Leibniz Zentrum für Medizin und Biowissenschaften, Parkallee 10, D 23845 Borstel, Germany
    J Biol Chem 282:14719-28. 2007
    ....
  47. ncbi request reprint Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ
    Wolfgang M Kuebler
    Division of Pulmonary Pharmacology, Research Center Borstel, Borstel, Germany
    Am J Respir Crit Care Med 168:1391-8. 2003
    ....
  48. pmc What's cooking? detection of important biomarkers in HOPE-fixed, paraffin-embedded tissues eliminates the need for antigen retrieval
    Torsten Goldmann
    Am J Pathol 163:2638-40. 2003
  49. ncbi request reprint Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection
    Jan Rupp
    Institute of Medical Microbiology and Hygiene, University of Luebeck, Ratzeburger Allee 160, 23538, Germany
    FEMS Immunol Med Microbiol 41:197-203. 2004
    ..We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections...
  50. ncbi request reprint A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18
    Antje Prasse
    Department of Pneumology, University Hospital, Killianstr 5, 79106 Freiburg, Germany
    Am J Respir Crit Care Med 173:781-92. 2006
    ..Conclusions: Our findings suggest that AMs from patients with pulmonary fibrosis disclose a phenotype of alternative activation and might be a part of a positive feedback loop with lung fibroblasts perpetuating fibrotic processes...
  51. ncbi request reprint HOPE--a new fixing technique enables preservation and extraction of high molecular weight DNA and RNA of > 20 kb from paraffin-embedded tissues. Hepes-Glutamic acid buffer mediated Organic solvent Protection Effect
    Klaus Hermann Wiedorn
    Institut fur Pathologie, Klinikum Stuttgart, Kriegsbergstr 60, 70174 Stuttgart, Germany
    Pathol Res Pract 198:735-40. 2002
    ..This technique will most probably lead to new impacts on molecular pathology...
  52. doi request reprint CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy
    Torsten Goldmann
    Virchows Arch 452:347-8. 2008
  53. ncbi request reprint DNA methylation markers of surfactant proteins in lung cancer
    Zhenwu Lin
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Oncol 31:181-91. 2007
    ..We speculate that SP-A1 and SP-D are subject to methylation/demethylation regulatory mechanisms and are involved in lung cancer pathogenesis by virtue of their function in innate host defense and/or regulation of inflammation...
  54. ncbi request reprint HMGA2 overexpression in non-small cell lung cancer
    Britta Meyer
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Mol Carcinog 46:503-11. 2007
    ..05). The results presented herein indicate that HMGA2 overexpression is a common event in NSCLC and could serve as molecular marker for lung cancer...
  55. ncbi request reprint Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication
    Bastian Opitz
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Biol Chem 281:36173-9. 2006
    ..pneumophila in lung epithelial cells. In conclusion, we demonstrated a critical role of IPS-1, IRF3, and IFNbeta in Legionella infection of lung epithelium...
  56. pmc High-throughput DNA methylation profiling using universal bead arrays
    Marina Bibikova
    Illumina, Inc, San Diego, California 92121, USA
    Genome Res 16:383-93. 2006
    ..The technology should prove useful for DNA methylation analyses in large populations, with potential application to the classification and diagnosis of a broad range of cancers and other diseases...
  57. ncbi request reprint Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa
    Klaus Kayser
    UICC TPCC, Institute of Pathology, Charite, Schumann Str 20 21, D 10168 Berlin, Germany
    Lung Cancer 47:205-14. 2005
    ..The data suggest the hypothesis that preneoplastic lesions in the lung might be partly induced by the tumor itself...
  58. ncbi request reprint Direct and indirect in situ PCR
    Klaus Hermann Wiedorn
    Institut fur Pathologie, Katharinehospital Stuttgart, Germany
    Methods Mol Biol 226:433-44. 2003
  59. ncbi request reprint Inter-laboratory validation of PCR-based detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues
    Christiane Schewe
    Charite Campus Mitte, Institute of Pathology, Universitatsmedizin Berlin, Schumannstr 20 21, 10098 Berlin, Germany
    Virchows Arch 447:573-85. 2005
    ..oligene.com/). All molecular pathology laboratories are invited to participate in this quality assurance initiative...
  60. ncbi request reprint Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis
    Dmitri V Pechkovsky
    Department of Pneumology, Medical Center, Albert Ludwigs University, Freiburg, Germany
    FEMS Immunol Med Microbiol 46:30-8. 2006
    ..These findings indicate a possible role for AEC-II and AEC-II-derived IL-18 in pathomechanisms of granulomatous lung diseases...