Research Topics
Genomes and Genes | Silke FeuerriegelSummaryAffiliation: Research Center Borstel Country: Germany Publications
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Detail Information
Publications
Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence settingSilke Feuerriegel
Molecular Mycobacteriology, Research Center Borstel, Germany
BMC Microbiol 12:90. 2012..Of the strains investigated 50 were either mono- or poly-resistant to isoniazid, rifampin, streptomycin, ethambutol and pyrazinamide or MDR and 47 fully susceptible strains served as controls...
Role of global regulator Rma for multidrug efflux-mediated fluoroquinolone resistance in SalmonellaSilke Feuerriegel
Pharmaceutical Biology and Microbiology, University of Hamburg, Bundesstrasse, Hamburg, Germany
Microb Drug Resist 14:259-63. 2008..Thus, the global regulator Rma is important in Salmonella concerning elevated expression of several mdr efflux pumps and hence resulting increase in antibiotic resistance...
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatmentSilke Feuerriegel
Research Center Borstel, National Reference Center for Mycobacteria, Parkallee 18, 23845 Borstel, Germany
Antimicrob Agents Chemother 53:3353-6. 2009..The mechanisms that confer amikacin resistance in this setting remain unclear...
embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutationClaudia Plinke
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
J Antimicrob Chemother 65:1359-67. 2010..Here, other mutations in the embCAB operon are suggested to be involved in resistance development...
Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824Silke Feuerriegel
Molecular Mycobacteriology, Research Center Borstel, Parkallee 18, 23845 Borstel, Germany
Antimicrob Agents Chemother 55:5718-22. 2011..canettii infections. This finding has implications for the design of multiple ongoing clinical trials...
rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strainsPatrick Beckert
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
Antimicrob Agents Chemother 56:2743-5. 2012....
Thr202Ala in thyA is a marker for the Latin American Mediterranean lineage of the Mycobacterium tuberculosis complex rather than para-aminosalicylic acid resistanceSilke Feuerriegel
Molecular Mycobacteriology, Research Center Borstel, Parkallee 1, Borstel, Germany
Antimicrob Agents Chemother 54:4794-8. 2010..These findings challenge some of the previous understanding of PAS resistance and, as a consequence, warrant further in-depth investigations of the genetic variation in PAS-resistant clinical isolates and spontaneous mutants...
High resolution discrimination of clinical Mycobacterium tuberculosis complex strains based on single nucleotide polymorphismsSusanne Homolka
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
PLoS ONE 7:e39855. 2012..High throughput assays can be established which will be needed for large association studies that are mandatory for detailed investigation of host-pathogen-interaction during TB infection...
