S Ehlers

Summary

Affiliation: Research Center Borstel
Country: Germany

Publications

  1. ncbi request reprint Mycobacterium tuberculosis-induced cell death of primary human monocytes and macrophages is not significantly modulated by tumor necrosis factor-targeted biologicals
    Norbert Reiling
    Division of Molecular Infection Biology, Department of Biochemical Microbiology, Research Center Borstel, Borstel, Germany
    J Investig Dermatol Symp Proc 12:26-33. 2007
  2. ncbi request reprint Towards a comprehensive view of the bacterial cell wall
    Boris Dmitriev
    N F Gamaleya Institute for Epidemiology and Microbiology, Gamaleya Str 18, Moscow 123098, Russia
    Trends Microbiol 13:569-74. 2005
  3. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: lifestyle changes affecting the host-environment interface
    S Ehlers
    Cluster of Excellence Inflammation at Interfaces, Research Center Borstel, Borstel, Germany
    Clin Exp Immunol 160:10-4. 2010
  4. ncbi request reprint [Pathomorphogenesis of tubercular histologic changes: mechanisms of granuloma formation, maintenance and necrosis]
    S Ehlers
    Abteilung Immunchemie und Biochemische Mikrobiologie, Forschungszentrum Borstel
    Internist (Berl) 44:1363-73. 2003
  5. ncbi request reprint Commentary: adaptive immunity in the absence of innate immune responses? The un-Tolled truth of the silent invaders
    Stefan Ehlers
    Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Eur J Immunol 34:1783-8. 2004
  6. ncbi request reprint Tumor necrosis factor and its blockade in granulomatous infections: differential modes of action of infliximab and etanercept?
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Clin Infect Dis 41:S199-203. 2005
  7. ncbi request reprint Why does tumor necrosis factor targeted therapy reactivate tuberculosis?
    Stefan Ehlers
    Molecular Infection Biology Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Rheumatol Suppl 74:35-9. 2005
  8. doi request reprint Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis
    S Ehlers
    Dept of Molecular Infection Biology, Research Center Borstel, Germany
    Infection 37:87-95. 2009
  9. doi request reprint Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
    Stefan Ehlers
    Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
    Immunobiology 214:674-82. 2009
  10. doi request reprint DC-SIGN and mannosylated surface structures of Mycobacterium tuberculosis: a deceptive liaison
    Stefan Ehlers
    Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany
    Eur J Cell Biol 89:95-101. 2010

Detail Information

Publications63

  1. ncbi request reprint Mycobacterium tuberculosis-induced cell death of primary human monocytes and macrophages is not significantly modulated by tumor necrosis factor-targeted biologicals
    Norbert Reiling
    Division of Molecular Infection Biology, Department of Biochemical Microbiology, Research Center Borstel, Borstel, Germany
    J Investig Dermatol Symp Proc 12:26-33. 2007
    ....
  2. ncbi request reprint Towards a comprehensive view of the bacterial cell wall
    Boris Dmitriev
    N F Gamaleya Institute for Epidemiology and Microbiology, Gamaleya Str 18, Moscow 123098, Russia
    Trends Microbiol 13:569-74. 2005
    ..Here, we illustrate why the scaffold concept of murein architecture provides a more comprehensive representation of bacterial cell wall physiology than previous models...
  3. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: lifestyle changes affecting the host-environment interface
    S Ehlers
    Cluster of Excellence Inflammation at Interfaces, Research Center Borstel, Borstel, Germany
    Clin Exp Immunol 160:10-4. 2010
    ..Controversial viewpoints and gaps in current knowledge were examined and new concepts for prevention and treatment of CID were formulated...
  4. ncbi request reprint [Pathomorphogenesis of tubercular histologic changes: mechanisms of granuloma formation, maintenance and necrosis]
    S Ehlers
    Abteilung Immunchemie und Biochemische Mikrobiologie, Forschungszentrum Borstel
    Internist (Berl) 44:1363-73. 2003
    ..g. administration of anti-TNF monoclonal antibodies, may result in reactivation of tuberculosis...
  5. ncbi request reprint Commentary: adaptive immunity in the absence of innate immune responses? The un-Tolled truth of the silent invaders
    Stefan Ehlers
    Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Eur J Immunol 34:1783-8. 2004
    ....
  6. ncbi request reprint Tumor necrosis factor and its blockade in granulomatous infections: differential modes of action of infliximab and etanercept?
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    Clin Infect Dis 41:S199-203. 2005
    ....
  7. ncbi request reprint Why does tumor necrosis factor targeted therapy reactivate tuberculosis?
    Stefan Ehlers
    Molecular Infection Biology Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Rheumatol Suppl 74:35-9. 2005
    ....
  8. doi request reprint Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis
    S Ehlers
    Dept of Molecular Infection Biology, Research Center Borstel, Germany
    Infection 37:87-95. 2009
    ..However, if minimal intermittent recrudescence were to take place within the alveolar space, this would contradict the very definition of latency, which implies that no access of Mtb to the airways exists during latency...
  9. doi request reprint Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis
    Stefan Ehlers
    Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
    Immunobiology 214:674-82. 2009
    ..These results suggest that targeting selectin ligand function during treatment of chronic inflammatory disorders may run the risk of accelerating TB disease progression...
  10. doi request reprint DC-SIGN and mannosylated surface structures of Mycobacterium tuberculosis: a deceptive liaison
    Stefan Ehlers
    Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany
    Eur J Cell Biol 89:95-101. 2010
    ..The dominant Mtb-derived ligands for DC-SIGN are presently unknown, and a major role of DC-SIGN in the immune response to Mtb infection may lie in its capacity to maintain a balanced inflammatory state during chronic TB...
  11. doi request reprint TB or not TB? Fishing for Molecules Making Permissive granulomas
    Stefan Ehlers
    Cluster of Excellence Inflammation at Interfaces, Microbial Inflammation Research, Research Center Borstel, Parkallee 1, D 23845 Borstel, Germany
    Cell Host Microbe 7:6-8. 2010
    ..In transparent zebrafish larvae infected with Mycobacterium marinum, Volkman et al. demonstrate an interaction of mycobacteria with epithelial cells that helps recruit macrophages to the granuloma as "feeder cells."..
  12. doi request reprint Infection, inflammation, and chronic diseases: consequences of a modern lifestyle
    Stefan Ehlers
    Cluster of Excellence Inflammation at Interfaces Borstel Kiel Lübeck Plön, Research Center Borstel, Microbial Inflammation Research, Parkallee 1, D 23845 Borstel, Germany
    Trends Immunol 31:184-90. 2010
    ....
  13. pmc Role of tumour necrosis factor (TNF) in host defence against tuberculosis: implications for immunotherapies targeting TNF
    S Ehlers
    Molecular Infection Biology, Research Centre Borstel, D 23845 Borstel, Germany
    Ann Rheum Dis 62:ii37-42. 2003
    ..However, conceivably, TNF targeting biological agents can be developed that because of their particular mode of action and their specific pharmacodynamics may be less likely to have this side effect...
  14. pmc Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Center for Medicine and Biosciences, D 23845 Borstel, Germany
    J Exp Med 194:1847-59. 2001
    ..In contrast, high mycobacterial load and extensive granulomatous infiltration per se are not sufficient to cause caseation, nor is granuloma necrosis linked to the induction of nitric oxide...
  15. pmc Mycobacterium avium infection in CD14-deficient mice fails to substantiate a significant role for CD14 in antimycobacterial protection or granulomatous inflammation
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Immunology 103:113-21. 2001
    ..avium in vitro, there is no evidence that CD14 plays a significant role in either the antibacterial defence or the chronic granulomatous reaction to M. avium infection in vivo...
  16. ncbi request reprint The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..tuberculosis infection as wild-type mice, these data demonstrate that signaling of LT alpha(1)beta(2) heterotrimers via the LT beta R is an essential prerequisite for containment of intracellular pathogens...
  17. ncbi request reprint Immunity to tuberculosis: a delicate balance between protection and pathology
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    FEMS Immunol Med Microbiol 23:149-58. 1999
    ..In mycobacterial infections, immunologically mediated protection is intrinsically associated with tissue damage in the form of granuloma formation. The implications of this finding for future vaccine design and evaluation are discussed...
  18. pmc Differential requirement for interferon-gamma to restrict the growth of or eliminate some recently identified species of nontuberculous mycobacteria in vivo
    S Ehlers
    Division of Molecular Infection Biology, Research Centre Borstel, Centre for Medicine and Biosciences, Borstel, Germany
    Clin Exp Immunol 124:229-38. 2001
    ..In conclusion, IFNgamma is a crucial determinant of infection outcome with most, but not all opportunistic mycobacterial species...
  19. pmc Gamma interferon is essential for clearing Mycobacterium genavense infection
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 68:3720-3. 2000
    ..Granulomatous lesions in the livers of GKO mice were diffuse, were composed of monocytes, neutrophils, and CD3(+) cells, and were histochemically negative for inducible nitric oxide synthase...
  20. ncbi request reprint Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 165:483-92. 2000
    ..In conclusion, granuloma disintegration in TNFRp55-/- mice is a lethal event that is dependent on IL-12 and that is mediated by an excess of T cells...
  21. ncbi request reprint Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis
    Norbert Reiling
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 169:3480-4. 2002
    ..tuberculosis in borderline situations, its function, and that of CD14 and TLR4, in initiating protective responses against naturally low-dose airborne infection is redundant...
  22. ncbi request reprint Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis
    Tanja Schreiber
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 176:1131-40. 2006
    ....
  23. pmc Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 67:3571-9. 1999
    ..In response to persistent mycobacterial infection, the absence of TNFRp55 causes the disregulation of T-cell-macrophage interactions and results in fatal granuloma necrosis even when adequate antibacterial functions are maintained...
  24. ncbi request reprint Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis
    S Aly
    Division of Molecular Infection Biology, Research Centre Borstel, D 23845 Borstel, Germany
    J Pathol 212:295-305. 2007
    ....
  25. ncbi request reprint Different types of pulmonary granuloma necrosis in immunocompetent vs. TNFRp55-gene-deficient mice aerogenically infected with highly virulent Mycobacterium avium
    J Benini
    Molecular Infection Biology, Research Center Borstel, Center for Medicine and Biosciences, Parkallee 22, D 23845 Borstel, Germany
    J Pathol 189:127-37. 1999
    ..Furthermore, the use of TNFRp55 gene-deficient mice in this model establishes a role for TNF in maintaining the integrity of a developing pulmonary granuloma...
  26. ncbi request reprint Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity
    N Reiling
    Department of Immunochemistry and Biochemical Microbiology and Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 167:3339-45. 2001
    ..In conclusion, M. avium-induced secretion of TNF-alpha and IL-10 by human macrophages is differentially regulated at the level of MAP kinase activity...
  27. ncbi request reprint Complex encounters at the macrophage-mycobacterium interface: studies on the role of the mannose receptor and CD14 in experimental infection models with Mycobacterium avium
    N Reiling
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    Immunobiology 204:558-71. 2001
    ....
  28. ncbi request reprint Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice
    S Aly
    Molecular Infection Biology, Research Centre Borstel, Borstel, Germany
    J Pathol 210:298-305. 2006
    ..These findings have important implications for the use of the mouse model of Mtb infection in developing eradication chemotherapy and for evaluating putative mechanisms of chronic persistence and latency of Mtb...
  29. pmc Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity
    Tanja Schreiber
    Infection Immunology Research, Research Center Borstel, Borstel, Germany
    J Immunol 183:1301-12. 2009
    ..Taken together, macrophage-derived IL-10 triggers aspects of alternative macrophage activation and promotes Mtb recrudescence independent of overt effects on anti-TB T cell immunity...
  30. doi request reprint MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis
    Norbert Reiling
    Microbial Interface Biology, Research Center Borstel, D 23845 Borstel, Germany
    Immunol Lett 116:15-23. 2008
    ..Disrupted IL-1R and/or IFN-gamma signaling pathways likely play a much more prominent role in explaining the exquisite susceptibility of MyD88-deficient mice to TB than the function of MyD88 as a TLR adaptor...
  31. ncbi request reprint Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    Immunobiology 210:217-27. 2005
    ..This phenotype probably reflects an IL-12p40-dependent effect on macrophage activation at the level of innate immunity...
  32. doi request reprint Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages
    Jan Neumann
    Division of Microbial Interface Biology, Research Center Borstel, Borstel, Germany
    FASEB J 24:4599-612. 2010
    ..The current data support the notion that evolutionarily conserved Wnt/Fzd signaling is involved in balancing the inflammatory response to microbial stimulation of innate immune cells of vertebrate origin...
  33. pmc Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics
    Antje Blumenthal
    Division of Molecular Infection Biology, Department of Immunochemistry and Biochemical Microbiology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Infect Immun 73:3330-41. 2005
    ..TMC724, a strain of avian origin, could not be classified by any one of these schemes, possibly indicating the limits of pathogen categorization solely by immune response signatures...
  34. doi request reprint Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 38:680-94. 2008
    ..Rather, MyD88, but not TLR2, TLR4 and TLR9, is critical for triggering macrophage effector mechanisms central to anti-mycobacterial defense...
  35. doi request reprint Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin
    Olivia Schreiber
    Department of Pulmonary Medicine, Research Center Borstel, Germany
    J Infect Dis 198:1044-54. 2008
    ..bovis BCG")...
  36. doi request reprint Mycobacteria-induced granuloma necrosis depends on IRF-1
    Sahar Aly
    Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Cell Mol Med 13:2069-82. 2009
    ..In summary, IRF-1, rather than being a mere transcription factor downstream of IFN-gamma, may be a master regulator of mycobacteria-induced immunopathology...
  37. pmc Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways
    Antje Blumenthal
    Department of Immunochemistry and Biochemical Microbiology, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 70:4961-7. 2002
    ..avium strains, but early ERK1/2 activation in infected macrophages is critically involved in controlling the growth of highly replicative M. avium strains...
  38. ncbi request reprint Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1
    Dominik Rückerl
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Immunobiology 211:427-36. 2006
    ..We therefore conclude from our study that IL-10, IL-4 and IL-27 collaborate in modulating macrophage activation by successive upregulation of the IL-4Ralpha and WSX-1 on alternatively activated macrophages...
  39. ncbi request reprint Resistance and susceptibility to tuberculosis analysed at the transcriptome level: lessons from mouse macrophages
    Christine Keller
    Molecular Infection Biology, Research Center Borstel, Parkallee 22, 23845, Germany
    Tuberculosis (Edinb) 84:144-58. 2004
    ....
  40. ncbi request reprint The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis
    Christoph Holscher
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:3534-44. 2005
    ..In conclusion, IL-27 both prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation...
  41. ncbi request reprint The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    Antje Blumenthal
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Blood 108:965-73. 2006
    ..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections...
  42. pmc Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes
    Christine Keller
    Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Infect Immun 74:4295-309. 2006
    ..tuberculosis significantly longer than control mice. We conclude that initially enhanced recruitment of granulocytes contributes to susceptibility to tuberculosis...
  43. ncbi request reprint Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells
    Alexandra Rausch
    Junior Research Group Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 36:1156-67. 2006
    ..Hence, our results implicate IL-15 and NKG2D as promising targets for modulating CD8+ T cell-mediated protection against tuberculosis...
  44. ncbi request reprint Rapid immunodiagnosis of tuberculosis in a woman receiving anti-TNF therapy
    Christoph Lange
    Medical Clinic, and Division of Clinical Infectious Diseases, Research Center Borstel, Germany
    Nat Clin Pract Rheumatol 3:528-34. 2007
    ..The patient had begun treatment with bi-weekly subcutaneous injections of adalimumab 5 weeks earlier...
  45. pmc Identification of promoter elements in mycobacteria: mutational analysis of a highly symmetric dual promoter directing the expression of replication genes of the Mycobacterium plasmid pAL5000
    P Stolt
    Division of Molecular Infection Biology, Research Centre Borstel, Parkallee 22, D 23845 Borstel, Germany
    Nucleic Acids Res 27:396-402. 1999
    ..These divergent promoters were studied through site-specific mutagenesis in a xylE reporter gene assay. The analysis furnished evidence supporting the existence of a distal as well as a proximal element in mycobacterial promoters...
  46. doi request reprint TGF-β1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells
    H Schafer
    Department of Internal Medicine I, Laboratory of Molecular Gastroenterology and Hepatology, UKSH Campus Kiel, Kiel, Germany
    Oncogene 32:180-9. 2013
    ..In conclusion, these data provide new insights into the mechanisms by which IBD promotes malignant transformation of intestinal epithelial cells and underscore the role of L1CAM and macrophages in this scenario...
  47. ncbi request reprint PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
    Rolf Göggel
    Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Nat Med 10:155-60. 2004
    ..Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury...
  48. pmc Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910
    Anne J Lenaerts
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Antimicrob Agents Chemother 51:3338-45. 2007
    ..These results show that this acellular rim may, therefore, be a primary location of persisting bacilli withstanding drug treatment...
  49. pmc A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival
    Joanne Turner
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 72:3759-68. 2004
    ..tuberculosis. This study identifies this lipoprotein as an important and potent inducer of protective T cells within the lungs of mice infected with M. tuberculosis and therefore as a possible target for vaccination...
  50. doi request reprint In vitro and in vivo characterization of a Mycobacterium tuberculosis mutant deficient in glycosyltransferase Rv1500
    Sven Malm
    Department of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Int J Med Microbiol 298:645-55. 2008
    ..We verified mRNA expression of Rv1500 in H37Rv and conclude that Rv1500 must serve a redundant role in viability and virulence of M. tuberculosis...
  51. ncbi request reprint IFN-gamma and NO in mycobacterial disease: new jobs for old hands
    Andrea M Cooper
    The Trudeau Institute, PO Box 59, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Microbiol 10:221-6. 2002
    ..avium infection, even leads to reduced bacterial growth...
  52. ncbi request reprint Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines
    Peter Seiler
    Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany
    Eur J Immunol 33:2676-86. 2003
    ..Hence, PMN play a central role in regulating the focal granulomatous response in the lung, and this early granuloma formation can be segregated from long-term protection against pulmonary M. tuberculosis infection...
  53. doi request reprint LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest
    Silvana K Rampini
    Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 32, CH 8006 Zurich, Switzerland
    Microbiology 154:2991-3001. 2008
    ..These observations demonstrate severe attenuation even in the presence of arrested phagosome maturation, and point to a role for the early phagosome in growth restriction of the M. tuberculosis lspA mutant...
  54. ncbi request reprint Sarcoidosis is associated with a truncating splice site mutation in BTNL2
    Ruta Valentonyte
    Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 12, 24105 Kiel, Germany
    Nat Genet 37:357-64. 2005
    ..The resulting protein lacks the C-terminal IgC domain and transmembrane helix, thereby disrupting the membrane localization of the protein, as shown in experiments using green fluorescent protein and V5 fusion proteins...
  55. ncbi request reprint Anaerobic arginine metabolism of Mycobacterium tuberculosis is mediated by arginine deiminase (arcA), but is not essential for chronic persistence in an aerogenic mouse model of infection
    Michael Sürken
    Department of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Int J Med Microbiol 298:657-61. 2008
    ..Following aerosol infection in mice, the DeltaarcA mutant and wild-type strain of M. tuberculosis multiplied and persisted in infected organs in a similar fashion...
  56. ncbi request reprint Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener
    Ying Lan Guo
    Abt Pharmazeutische Biochemie, Pharmazeutisches Institut, Universitat Tubingen, Morgenstelle 8, D 72076 Tubingen, Germany
    Mol Microbiol 57:667-77. 2005
    ..In vitro growth characteristics and in vivo organ infection and mortality were unaltered in the knockout strain indicating that AC Rv1625c alone is not a virulence factor...
  57. pmc Mycobacterium tuberculosis prevents inflammasome activation
    Sharon S Master
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cell Host Microbe 3:224-32. 2008
    ..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation...
  58. ncbi request reprint Tumor necrosis factor and granuloma biology: explaining the differential infection risk of etanercept and infliximab
    Robert S Wallis
    UMDNJ New Jersey Medical School, Newark, NJ, USA
    Semin Arthritis Rheum 34:34-8. 2005
    ..TNF is known to participate in the induction and maintenance of protective granulomas at multiple steps, and evidence supporting a differential inhibition of TNF bioactivity and signaling by the 2 drugs is discussed...
  59. ncbi request reprint Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection
    Martin Schaefer
    Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, Munich, Germany
    J Immunol 180:6836-45. 2008
    ..Based on our in vivo data, we propose that instead of favoring the immune evasion of mycobacteria, human DC-SIGN may have evolved as a pathogen receptor promoting protection by limiting tuberculosis-induced pathology...
  60. ncbi request reprint Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice
    Mrigank Srivastava
    Laboratory for Experimental Lung Research, Department of Pulmonary Medicine, Hannover School of Medicine, Hannover, Germany
    Cell Microbiol 9:738-52. 2007
    ..bovis BCG uptake in vivo...
  61. ncbi request reprint Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264
    Dorothea Dittrich
    Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
    Int J Med Microbiol 296:563-6. 2006
    ..Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence...
  62. ncbi request reprint Helminth-derived products inhibit the development of allergic responses in mice
    Claudia M Trujillo-Vargas
    Center for Infectious Diseases, University of Wurzburg, Wurzburg, Germany
    Am J Respir Crit Care Med 175:336-44. 2007
    ..Supporting this view is our published finding that infection with Nippostrongylus brasiliensis decreased ovalbumin-induced Th2 responses in the lung of mice...
  63. ncbi request reprint The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis
    Claudia Mailaender
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Staudtstr 5, D 91058 Erlangen, Germany
    Microbiology 150:853-64. 2004
    ..This study provides the first experimental evidence that porins are important for drug susceptibility of M. tuberculosis...