Affiliation: Research Center Borstel
- Human lung cancer cells express functionally active Toll-like receptor 9Daniel Droemann
Medical Clinic, Research Center Borstel, D 23845 Borstel, Germany
Respir Res 6:1. 2005..TLR9 expression by malignant tumor cells, would affect treatment approaches using CpG-ODN on the one hand, and, on the other hand, provide additional novel information about the role of tumor cells in tumor-immunology...
- Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patientsDaniel Droemann
Medical Clinic, Research Center Borstel, 23845 Borstel, Germany
Respir Res 6:68. 2005..In the present study we characterized the expression of Toll-like receptor (TLR)- 2, TLR4 and CD14 on human AM compared to autologous monocytes obtained from patients with COPD, healthy smokers and non-smokers...
- Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary diseaseDaniel Droemann
Medical Clinic, Research Center Borstel, Parkallee 35, D 23845 Borstel, Germany
Am J Respir Crit Care Med 175:791-7. 2007..Chlamydia pneumoniae (Cpn) infection may play a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Few data are available comparing persistent and acute infection of this pathogen in the human respiratory tract...
- Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lungDaniel Droemann
Medical Clinic, Research Center Borstel, Parkallee 35, Germany
Histochem Cell Biol 119:103-8. 2003..Expression of mRNA was verified by RT-PCR and DNA sequencing. These results indicate a potential mechanism of increased immunosurveillance at the alveolar level controlling the localized infection...
- A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapyDagmar S Lang
Clinical and Experimental Pathology, Research Center Borstel, Borstel, Germany
Respir Res 8:43. 2007..The purpose of the present study was the development of a human ex vivo tissue culture model and the analysis of the effects of conventional chemotherapy, which then can serve as a tool to test new chemotherapeutical regimens in NSCLC...
- Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infectionJan Rupp
Institute of Medical Microbiology and Hygiene, University of Luebeck, Ratzeburger Allee 160, 23538, Germany
FEMS Immunol Med Microbiol 41:197-203. 2004..We conclude that target cells differ in acute and chronic chlamydial infection and suggest the ACIM as a novel tool to analyze the host-pathogen-interactions in acute respiratory infections...