- Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literatureE Reinhold-Keller
Department of Rheumatology, Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Germany
Clin Exp Rheumatol 19:541-9. 2001..The authors report 3 young patients with biopsy-proven active generalized WG who were consistently negative for ANCA over observation times ranging from 58 to 114 months...
- Effect of Wegener's granulomatosis on work disability, need for medical care, and quality of life in patients younger than 40 years at diagnosisEva Reinhold-Keller
Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Lubeck, Germany
Arthritis Rheum 47:320-5. 2002..To evaluate the effects of Wegener's granulomatosis (WG) on employment status, work disability, and need for medical care of 60 consecutive WG patients aged < or = 40 years at diagnosis...
- High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexateEva Reinhold-Keller
Medical University of Lubeck, Lubeck, Germany
Arthritis Rheum 47:326-32. 2002....
- Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decadesJulia U Holle
University Hospital Schleswig Holstein Campus Lübeck, Lubeck, Germany
Arthritis Rheum 63:257-66. 2011..To determine the long-term outcome in patients with Wegener's granulomatosis (WG) over 4 decades in an academic hospital unit specializing in rheumatology...
- Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosisPeter Lamprecht
Department of Rheumatology, University of Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
Arthritis Res Ther 5:R25-31. 2003..CCR5 and CCR3 expression on CD4+ and CD8+ memory T cells indicates a potential to respond to chemotactic gradients and might be important in T cell migration contributing to granuloma formation and vasculitis in WG...
- Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosisPeter Lamprecht
Department of Rheumatology, University Hospital of Schleswig Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany
Clin Immunol 108:1-7. 2003..Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation...
- [How long should cyclophosphamide therapy of Wegener's granulomatosis continue?]Eva Reinhold-Keller
Poliklinik fur Rheumatologie, Universitätsklinikum zu Lübeck, Germany
Dtsch Med Wochenschr 127:1909-10. 2002