Research Topics
Genomes and Genes | Andreas ReifSummaryCountry: Germany Publications
| Collaborators
|
Detail Information
Publications
MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophreniaSandra Selch
Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
Biol Psychiatry 61:1211-4. 2007....- Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthaseA Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, D 97078 Wurzburg, Germany
Free Radic Biol Med 37:988-97. 2004..In conclusion, standard Clark-type ()NO electrodes are cross-sensitive to H(2)O(2) and therefore both SOD and catalase are absolutely required to specifically detect (.-)NO from NOS... - Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviourAndreas Reif
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
Eur J Neurosci 20:885-95. 2004..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis... - Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environmentAndreas Reif
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 32:2375-83. 2007..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior... - Encephalopathy and myoclonus triggered by valproic acidAndreas Reif
Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy... - Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndromeAndreas Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
Psychiatry Res 132:273-8. 2004..We conclude that more extensive study of NoGo anteriorisation as a potential endophenotype of 22q11-DS patients at risk for 22q11-associated psychiatric conditions is warranted... - A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorderAndreas Reif
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Int J Neuropsychopharmacol 9:13-20. 2006..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity... - Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychosesAndreas Reif
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005..In conclusion, we suggest that in females homocysteinemia is an unspecific risk factor for organic brain disorders like dementia, and possibly depression, but not for schizophrenia... - The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementiaA Reif
Department of Psychiatry and Psychotherapy, Section of Clinical and Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
Eur J Neurol 15:637-9. 2008..However, no significant differences were observed between patients and controls. Bearing in mind the caveat of the small patient sample size, our data nevertheless argue against a major genetic role of MAO-A polymorphism in FTD... - Carbohydrate-deficient transferrin parallels disease severity in anorexia nervosaAndreas Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
Psychiatry Res 137:143-6. 2005..In anorexia nervosa patients, CDT is unsuitable as a marker of alcohol abuse, but it might serve as a parameter indicating prognosis and disease severity. However, case-control studies with larger samples are warranted... - A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex functionA Reif
Department of Psychiatry and Psychotherapy Section for Clinical and Molecular Psychobiology and Laboratory for Psychophysiology and Functional Imaging, Julius Maximilians University Würzburg, Wurzburg, Germany
Mol Psychiatry 11:286-300. 2006..Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning... - Neurogenesis and schizophrenia: dividing neurons in a divided mind?Andreas Reif
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders... - Neural stem cell proliferation is decreased in schizophrenia, but not in depressionA Reif
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Wurzburg, Germany
Mol Psychiatry 11:514-22. 2006.... - Duplication 15q14 --> pter: a rare chromosomal abnormality underlying bipolar affective disorderAndreas Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
Eur Psychiatry 19:179-81. 2004..Possible implications of this rare chromosomal abnormality with regards to psychiatric disorders are discussed, with emphasis on recent evidence suggesting chromosome 15q13-15 as a susceptibility locus for psychosis... - Neuroleptic malignant syndrome in Kufs' diseaseA Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Germany
J Neurol Neurosurg Psychiatry 74:385-7. 2003..Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL... - Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable mannerA Reif
Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
Free Radic Biol Med 30:803-8. 2001..Thus, biologically formed NO(-) may function as an effective pro-oxidant unless scavenged by SOD and affect the apparent NADPH stoichiometry of the NOS reaction... - Delusional paralysis: an unusual variant of Cotard's syndromeAndreas Reif
Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, DE 97080 Würzburg, Germany
Psychopathology 36:218-20. 2003..Upon ECT, symptoms rapidly improved. Psychopathological implications and the nosological position of Cotard's syndrome are discussed... - Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthaseA Reif
Department of Pharmacology and Toxicology, Julius Maximilians University, Wurzburg, 97078 Germany
J Biol Chem 274:24921-9. 1999..In conclusion, we propose a role for H(4)Bip as a dimer-stabilizing factor of neuronal NOS during catalysis, possibly by interfering with enzyme destabilizing products... - Toward a molecular architecture of personalityAndreas Reif
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstr 15, 97080, Wuerzburg, Germany
Behav Brain Res 139:1-20. 2003..The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders... - Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humansAndreas Reif
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
Arch Gen Psychiatry 66:41-50. 2009..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies... - Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulationLise Gutknecht
Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
Int J Neuropsychopharmacol 10:309-20. 2007..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders... - A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorderChristian P Jacob
Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality... - Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNFSabrina Fritzen
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
Mol Cell Neurosci 35:261-71. 2007..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis... - DIRAS2 is associated with adult ADHD, related traits, and co-morbid disordersAndreas Reif
Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 36:2318-27. 2011..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders... - Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult lifeClaudia Kriegebaum
Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
Neurochem Int 57:512-7. 2010..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT... - A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophreniaAndreas Reif
Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
Int J Neuropsychopharmacol 14:887-97. 2011..Our fNIRS data extend previous studies suggesting disturbed prefrontal functioning in schizophrenia and suggest that genetic variation of NOS1 has a role in cognitive dysfunction, probably by mediating glutamatergic tone... - The expression of the transcription factor FEV in adult human brain and its association with affective disordersClaudia B Kriegebaum
Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
J Neural Transm 117:831-6. 2010..FEV therefore might not account for the genetic risk towards depression or bipolar disorder. Furthermore, the specificity of FEV for the serotonergic system should be reconsidered... - Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disordersAnn Christine Ehlis
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
Neuropsychopharmacology 32:162-70. 2007..These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders... - Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout miceLise Gutknecht
Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
J Neural Transm 115:1127-32. 2008..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation... - Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activityChristian P Jacob
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
Neuropsychopharmacology 30:1711-8. 2005..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits... - Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in miceYong Chen
Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
Mol Pain 6:13. 2010..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process... - Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHDHeike Weber
Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 36:2076-85. 2011..We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH... - Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depressionMartin Schecklmann
University of Regensburg, Department of Psychiatry and Psychotherapy, Regensburg, Germany University of Würzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wurzburg, Germany University of Würzburg, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Wurzburg, Germany
Psychiatry Res 194:378-84. 2011..However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions... - Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association studyOlga Rivero
Unit of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
PLoS ONE 5:e12254. 2010..To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany... - NOS1 ex1f-VNTR polymorphism influences prefrontal brain oxygenation during a working memory taskJuliane Kopf
University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
Neuroimage 57:1617-23. 2011..This suggests a potential compensatory mechanism, with task-related brain regions being more active in short allele carriers to compensate for reduced NOS1 expression... - Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processingMartin J Herrmann
Department of Psychiatry, Psychosomatics, and PsychotherapyUniversity of Würzburg, Wurzburg, Germany
Cogn Affect Behav Neurosci 9:168-72. 2009..Specifically, Met/Met carriers respond more sensitively to unpleasant stimuli, as compared with Val/Val carriers. We did not find evidence that life stress moderates the effect of the COMT genotype on emotional stimuli processing... - Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHDThomas Dresler
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
Neuropsychopharmacology 35:2193-202. 2010.... - Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivityBenedikt Klauke
Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
Depress Anxiety 28:1048-57. 2011..Thus, a gene-environment interaction (G × E) study was conducted with respect to anxiety sensitivity (AS) as a promising intermediate phenotype of anxiety disorders... - Human stiff-person syndrome IgG induces anxious behavior in ratsChristian Geis
Department of Neurology, University of Wurzburg, Wurzburg, Germany
PLoS ONE 6:e16775. 2011..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear... - The novel brain-specific tryptophan hydroxylase-2 gene in panic disorderRainald Mossner
Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Psychopharmacol 20:547-52. 2006..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia... - The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in miceAntonia M Post
Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Behav Brain Res 220:152-8. 2011..Overall, our data indicate that this spatial learning task will be useful to characterize spatial memory in various genetic or pharmacological mouse models... - Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral centerChristian P Jacob
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center... - Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohortAndreas Reif
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Alzheimers Dis 23:327-33. 2011..As demonstrated, ex1f-VNTR interacted with the apolipoprotein E ?4 risk allele (OR in the presence of both risk alleles 3.63; 95% CI: 1.45-9.12). These findings provide further evidence for an association of NOS1 with AD... - Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorderJobst Meyer
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
Int J Neuropsychopharmacol 8:495-504. 2005..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder... - Gene-environment interaction influences anxiety-like behavior in ethologically based mouse modelsAntonia M Post
Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
Behav Brain Res 218:99-105. 2011..These results challenge the comparability of not sufficiently standardized tests of anxiety-like behavior and emphasize the need for controlling environmental variables in behavioral phenotyping... - A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivityAndreas Reif
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
Psychopharmacology (Berl) 214:239-48. 2011..In line with this, we have previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders... - Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient miceMichael Karl Boettger
Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
Eur J Pain 11:810-8. 2007..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process... - Functional variants of TSPAN8 are associated with bipolar disorder and schizophreniaClaus Jürgen Scholz
IZKF Laboratory for Microarray Applications, University of Wurzburg, Wurzburg, Germany
Am J Med Genet B Neuropsychiatr Genet 153:967-72. 2010..Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities... - Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processingMartin J Herrmann
Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Cereb Cortex 17:1160-3. 2007.... - Life events in panic disorder-an update on "candidate stressors"Benedikt Klauke
Department of Psychiatry and Psychotherapy, University of Muenster, Germany
Depress Anxiety 27:716-30. 2010.... - Gender Differences in Associations of Glutamate Decarboxylase 1 Gene (GAD1) Variants with Panic DisorderHeike Weber
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
PLoS ONE 7:e37651. 2012..In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females... - Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studiesKlaus Peter Lesch
ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
J Neural Transm 115:1573-85. 2008..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability... - Facial affect decoding in schizophrenic disorders: a study using event-related potentialsMartin J Herrmann
Department of Psychiatry and Psychotherapy at the University of Würzburg Füchsleinstr 15, 97080 Wurzburg, Germany
Psychiatry Res 141:247-52. 2006..Interestingly, schizophrenic patients had higher amplitudes in the neutral condition than did healthy controls. This effect was more pronounced in the paranoid subgroup of patients... - Decreased anxiety in mice lacking the organic cation transporter 3Thomas Wultsch
Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
J Neural Transm 116:689-97. 2009.... - Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activityP Kotsonis
Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
Biochem J 340:745-52. 1999..Consistent with this, exogenous H2O2 also inhibited NOS activity during phase I. Thus during catalysis NOS is subject to complex autoinhibition by both enzyme-derived RNS and H2O2, differentially affecting enzyme activity... - Pterin interactions with distinct reductase activities of NO synthaseM M Pantke
Department of Pharmacology and Toxicology, , Versbacher Str. 9, , Germany
Biochem J 356:43-51. 2001.... - Morphological abnormalities in nitric-oxide-synthase-positive striatal interneurons of schizophrenic patientsMartin Lauer
Department of Psychiatry, , , , Germany
Neuropsychobiology 52:111-7. 2005..0001). Striatal nitrinergic interneurons might thus be involved in the pathogenesis of at least some forms of schizophrenia. Studies on larger samples are however needed to further corroborate this finding... - NO synthase-positive striatal interneurons are decreased in schizophreniaS Fritzen
Department of Psychiatry, Julius Maximilians University Würzburg, Germany
Eur Neuropsychopharmacol 17:595-9. 2007..Our results suggest that striatal nitrinergic interneurons are involved in the pathophysiology of at least some forms of schizophrenia, such as e.g. catatonic schizophrenia... - Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patientsA Reif
Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Germany
J Neural Transm 110:1401-11. 2003..9+/-3.8 micromol/l), especially in elderly subjects. We thus suggest that homocysteinemia, at least in females, is an unspecific risk factor for organic brain disorders, but not endogenous psychoses... - Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processingStefanie C Biehl
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
PLoS ONE 6:e28396. 2011..They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes... - Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibitionChristian Geis
Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
Brain 133:3166-80. 2010.... - Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variantTim Hahn
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
Cereb Cortex 21:1659-66. 2011..Additionally, our results may have important implications for functional brain imaging in which HRs are commonly used as a surrogate for neural activation... - Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytesSarah Kittel-Schneider
Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Würzburg Würzburg, Germany
Front Psychiatry 3:33. 2012..Finally, neither Dat nor Nos3 RNA expression was detected in cultured astrocytes. Conclusion: These data provide further evidence for a role of astroglial cells in the molecular mechanisms of action of antidepressants... - ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle ReflexKatharina Domschke
Department of Psychiatry, University of Muenster, Muenster, Germany
Neuropsychopharmacology 37:759-69. 2012..The present findings may eventually aid in improving primary and secondary prevention by sharpening the risk profiles of anxiety-prone individuals... - Anxiety-related traits in mice with modified genes of the serotonergic pathwayKlaus Peter Lesch
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
Eur J Pharmacol 480:185-204. 2003..Finally, we attempt to identify future directions of genetic manipulation in animal models to advance our understanding of brain dysregulation characteristic of anxiety disorders... - DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophreniasA J Fallgatter
Department of Psychiatry, University of Wuerzburg, Wuerzburg, Germany Fallgatter
Genes Brain Behav 9:489-97. 2010..An impact on fundamental processes of cognitive response control may be one mechanism by which DTNBP1 gene variants via glutamatergic transmission contribute to the pathophysiology underlying schizophrenic illnesses... - Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disordersChristian P Jacob
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
Am J Psychiatry 161:569-72. 2004..The authors analyzed the influence of 5-HTTLPR variants on personality disorders... - Behavioral genetics of affective and anxiety disordersKatharina Domschke
Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, D 97080, Wurzburg, Germany
Curr Top Behav Neurosci 12:463-502. 2012..Finally, there is some evidence for genetic factors potentially shared between affective and anxiety disorders pointing to a possible overlapping phenotype between anxiety disorders and depression... - Folie a deux versus genetically driven delusional disorder: case reports and nosological considerationsAndreas Reif
Department of Psychiatry and Psychotherapy, University of Würzberg, Fuchsleinstrasse 15, 97080 Würzberg, Germany
Compr Psychiatry 45:155-60. 2004..Thus, thorough psychopathological examination in suspected folie a deux settings can help to obtain valid diagnoses... - A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disordersC Hess
Department of Psychiatry and Psychotherapy, Clinical and Molecular Psychobiology, University of Wuerzburg, Wuerzburg, Germany
J Neural Transm 116:121-30. 2009.... - NADPH-diaphorase staining reveals new types of interneurons in human putamenSilvia Johannes
Laboratory of Neurobiology, Department of Psychiatry and Psychotherapy, , , D-97080, , Germany
Brain Res 980:92-9. 2003..Thus, we suggest at least three novel types of neostriatal interneurons. Furthermore, a special class of large neurons thought to be efferent in nature, stained NOS-positive... - Carbohydrate-deficient transferrin is elevated in catabolic female patientsA Reif
Department of Psychiatry and Psychotherapy, , , , Germany
Alcohol Alcohol 36:603-7. 2001..Possible biochemical mechanisms of this phenomenon are discussed. As a consequence of these findings, the measurement of CDT alone is not suitable to screen for alcohol misuse in catabolic subjects... - Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12M Romanos
ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
Mol Psychiatry 13:522-30. 2008..Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD... - Association of a NOS1 promoter repeat with Alzheimer's diseaseDaniela Galimberti
Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Neurobiol Aging 29:1359-65. 2008..83). Therefore, short alleles of the NOS1 exon 1f-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk... - Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthasesHans Matter
Sanofi-Aventis, Chemical Sciences, Drug Design, Building G 878, D-65926 Frankfurt am Main, Germany
J Med Chem 48:4783-92. 2005.... - Acute akinetic crisis with marked cognitive impairment due to Valproate treatmentAndreas Reif
Int J Geriatr Psychiatry 18:356-7. 2003 - Venlafaxine and reversible blepharoedemaAndreas Reif
Int J Neuropsychopharmacol 5:413-4. 2002 - In vitro detection of nitric oxide and nitroxyl by electron paramagnetic resonanceAndrei M Komarov
Department of Physiology and Experimental Medicine, George Washington University Medical Center, Washington, DC 20037, USA
Methods Enzymol 359:18-27. 2002