Andreas Reif

Summary

Country: Germany

Publications

  1. pmc Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes
    Sarah Kittel-Schneider
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Würzburg Würzburg, Germany
    Front Psychiatry 3:33. 2012
  2. doi request reprint A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
    Int J Neuropsychopharmacol 14:887-97. 2011
  3. doi request reprint Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
  4. doi request reprint A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Psychopharmacology (Berl) 214:239-48. 2011
  5. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
  6. doi request reprint COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control
    Sebastian Heinzel
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Cereb Cortex 23:1453-62. 2013
  7. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
  8. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
  9. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
  10. doi request reprint KCNIP4 as a candidate gene for personality disorders and adult ADHD
    Lena Weißflog
    Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Eur Neuropsychopharmacol 23:436-47. 2013

Detail Information

Publications69

  1. pmc Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes
    Sarah Kittel-Schneider
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Würzburg Würzburg, Germany
    Front Psychiatry 3:33. 2012
    ..Finally, neither Dat nor Nos3 RNA expression was detected in cultured astrocytes. Conclusion: These data provide further evidence for a role of astroglial cells in the molecular mechanisms of action of antidepressants...
  2. doi request reprint A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
    Int J Neuropsychopharmacol 14:887-97. 2011
    ..Our fNIRS data extend previous studies suggesting disturbed prefrontal functioning in schizophrenia and suggest that genetic variation of NOS1 has a role in cognitive dysfunction, probably by mediating glutamatergic tone...
  3. doi request reprint Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  4. doi request reprint A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Psychopharmacology (Berl) 214:239-48. 2011
    ..In line with this, we have previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders...
  5. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
    ..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders...
  6. doi request reprint COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control
    Sebastian Heinzel
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Cereb Cortex 23:1453-62. 2013
    ..Our findings might help to disentangle the genetic basis of dopaminergic mechanisms underlying prefrontal (dys)function...
  7. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
    ..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality...
  8. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  9. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
    ....
  10. doi request reprint KCNIP4 as a candidate gene for personality disorders and adult ADHD
    Lena Weißflog
    Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Eur Neuropsychopharmacol 23:436-47. 2013
    ..0079 to 0.049). Seven markers within the KCNIP4 gene showed an association with PD (p values from 0.0043 to 0.0437). The results of these studies suggest a role of KCNIP4 in the etiology of ADHD, PD and other co-morbid disorders...
  11. doi request reprint Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
    ..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT...
  12. doi request reprint NOS1 ex1f-VNTR polymorphism affects prefrontal oxygenation during response inhibition tasks
    Juliane Kopf
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Clinical and Molecular Psychobiology, Wuerzburg, Germany
    Hum Brain Mapp 33:2561-71. 2012
    ..Impairment of prefrontal control with consecutive failure of inhibitory processes might underlie association findings reported previously...
  13. ncbi request reprint Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  14. doi request reprint Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:786-93. 2012
    ..However, epigenetic mechanisms might obfuscate the genetic association, calling for ascertainment in larger samples as well as assessment of the MAOA promoter methylation status therein...
  15. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    ..We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH...
  16. doi request reprint The expression of the transcription factor FEV in adult human brain and its association with affective disorders
    Claudia B Kriegebaum
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    J Neural Transm 117:831-6. 2010
    ..FEV therefore might not account for the genetic risk towards depression or bipolar disorder. Furthermore, the specificity of FEV for the serotonergic system should be reconsidered...
  17. pmc Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 35:2193-202. 2010
    ....
  18. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...
  19. pmc Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e37651. 2012
    ..In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females...
  20. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  21. doi request reprint Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression
    Martin Schecklmann
    University of Regensburg, Department of Psychiatry and Psychotherapy, Regensburg, Germany
    Psychiatry Res 194:378-84. 2011
    ..However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions...
  22. ncbi request reprint Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  23. ncbi request reprint Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
    Claus Jürgen Scholz
    IZKF Laboratory for Microarray Applications, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:967-72. 2010
    ..Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities...
  24. pmc Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study
    Olga Rivero
    Unit of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e12254. 2010
    ..To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany...
  25. doi request reprint NOS1 ex1f-VNTR polymorphism influences prefrontal brain oxygenation during a working memory task
    Juliane Kopf
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
    Neuroimage 57:1617-23. 2011
    ..This suggests a potential compensatory mechanism, with task-related brain regions being more active in short allele carriers to compensate for reduced NOS1 expression...
  26. ncbi request reprint MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
    ....
  27. doi request reprint Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    J Neural Transm 119:981-5. 2012
    ..We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways...
  28. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  29. ncbi request reprint A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
    ..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity...
  30. doi request reprint The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Behav Brain Res 220:152-8. 2011
    ..Overall, our data indicate that this spatial learning task will be useful to characterize spatial memory in various genetic or pharmacological mouse models...
  31. pmc The BDNF Val66Met polymorphism modulates the generalization of cued fear responses to a novel context
    Andreas Mühlberger
    1 Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Wurzburg, Germany 2 Department of Experimental Psychology Clinical Psychology and Psychotherapy, University of Regensburg, Regensburg, Germany
    Neuropsychopharmacology 39:1187-95. 2014
    ..These are the first results to provide evidence in humans that BDNF modulates the generalization of fear responses. Such context-dependent generalization processes might predispose Met carriers for affective and anxiety disorders. ..
  32. pmc A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    Psychopharmacology (Berl) 224:573-9. 2012
    ..However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes...
  33. ncbi request reprint Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder?
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany
    Int J Neuropsychopharmacol 15:1217-28. 2012
    ..Future studies are warranted to replicate the present finding in independent samples, preferably in a longitudinal design...
  34. doi request reprint Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processing
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics, and PsychotherapyUniversity of Würzburg, Wurzburg, Germany
    Cogn Affect Behav Neurosci 9:168-72. 2009
    ..Specifically, Met/Met carriers respond more sensitively to unpleasant stimuli, as compared with Val/Val carriers. We did not find evidence that life stress moderates the effect of the COMT genotype on emotional stimuli processing...
  35. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  36. ncbi request reprint Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2375-83. 2007
    ..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior...
  37. pmc A novel approach to probabilistic biomarker-based classification using functional near-infrared spectroscopy
    Tim Hahn
    Department of Cognitive Psychology II, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt am Main, Germany
    Hum Brain Mapp 34:1102-14. 2013
    ..In addition, our approach can easily compensate for variable class priors, which is highly advantageous in making predictions in a wide range of clinical neuroimaging applications...
  38. ncbi request reprint PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Atten Defic Hyperact Disord 4:145-52. 2012
    ..Nevertheless, as all those conditions are comorbid, PPP2R2C might reflect a common underlying neurobiological risk factor...
  39. pmc Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing
    Stefanie C Biehl
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e28396. 2011
    ..They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes...
  40. pmc ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 37:759-69. 2012
    ..The present findings may eventually aid in improving primary and secondary prevention by sharpening the risk profiles of anxiety-prone individuals...
  41. doi request reprint Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Behav Brain Res 218:99-105. 2011
    ..These results challenge the comparability of not sufficiently standardized tests of anxiety-like behavior and emphasize the need for controlling environmental variables in behavioral phenotyping...
  42. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process...
  43. doi request reprint Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Alzheimers Dis 23:327-33. 2011
    ..As demonstrated, ex1f-VNTR interacted with the apolipoprotein E ε4 risk allele (OR in the presence of both risk alleles 3.63; 95% CI: 1.45-9.12). These findings provide further evidence for an association of NOS1 with AD...
  44. ncbi request reprint Further evidence for plasma progranulin as a biomarker in bipolar disorder
    Sarah Kittel-Schneider
    Bipolar Disorder Program, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Germany Electronic address
    J Affect Disord 157:87-91. 2014
    ..A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking...
  45. ncbi request reprint Neurogenesis and schizophrenia: dividing neurons in a divided mind?
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007
    ..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders...
  46. ncbi request reprint Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005
    ..In conclusion, we suggest that in females homocysteinemia is an unspecific risk factor for organic brain disorders like dementia, and possibly depression, but not for schizophrenia...
  47. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
    ..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia...
  48. ncbi request reprint Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
    Psychiatry Res 132:273-8. 2004
    ..We conclude that more extensive study of NoGo anteriorisation as a potential endophenotype of 22q11-DS patients at risk for 22q11-associated psychiatric conditions is warranted...
  49. doi request reprint Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 116:689-97. 2009
    ....
  50. ncbi request reprint Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Cereb Cortex 17:1160-3. 2007
    ....
  51. pmc Interaction of valproic acid and the antidepressant drugs doxepin and venlafaxine: analysis of therapeutic drug monitoring data under naturalistic conditions
    Stefan Unterecker
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wurzburg, Wurzburg, Germany
    Int Clin Psychopharmacol 29:206-11. 2014
    ..403±0.665 vs. 1.102±0.444, P<0.017). As a consequence, if a combination of valproic acid with doxepin or venlafaxine is administered, cautious dosing is advisable and TDM should be performed. ..
  52. ncbi request reprint Internalizing and externalizing behavior in adult ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 6:101-10. 2014
    ..Internalizing and externalizing behavior notably affected psychosocial status to a similar extent. The frequency of both internalizing and externalizing behavior in AADHD might reflect an underlying emotional regulation disorder. ..
  53. pmc Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle
    Evelyn Glotzbach-Schoon
    Department of Psychology I, Biological Psychology, Clinical Psychology, and Psychotherapy, University of Würzburg Würzburg, Germany
    Front Behav Neurosci 7:31. 2013
    ..explicit fear responses. Enhanced contextual fear conditioning as reflected in potentiated startle responses may be an endophenotype for anxiety disorders...
  54. ncbi request reprint Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
    ..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy...
  55. ncbi request reprint Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders
    Ann Christine Ehlis
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 32:162-70. 2007
    ..These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders...
  56. ncbi request reprint Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
    Christian P Jacob
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 30:1711-8. 2005
    ..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits...
  57. ncbi request reprint Facial affect decoding in schizophrenic disorders: a study using event-related potentials
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy at the University of Würzburg Füchsleinstr 15, 97080 Wurzburg, Germany
    Psychiatry Res 141:247-52. 2006
    ..Interestingly, schizophrenic patients had higher amplitudes in the neutral condition than did healthy controls. This effect was more pronounced in the paranoid subgroup of patients...
  58. pmc The Effect of Emotional Content on Brain Activation and the Late Positive Potential in a Word n-back Task
    Juliane Kopf
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg Germany
    PLoS ONE 8:e75598. 2013
    ..In this study, we used emotional words of different valence but with similar arousal levels in an n-back task...
  59. ncbi request reprint Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
    ..Finally, we attempt to identify future directions of genetic manipulation in animal models to advance our understanding of brain dysregulation characteristic of anxiety disorders...
  60. ncbi request reprint Morphological abnormalities in nitric-oxide-synthase-positive striatal interneurons of schizophrenic patients
    Martin Lauer
    Department of Psychiatry, Julius Maximilian University Würzburg, Fuchsleinstrasse 15, DE 97080 Würzburg, Germany
    Neuropsychobiology 52:111-7. 2005
    ..0001). Striatal nitrinergic interneurons might thus be involved in the pathogenesis of at least some forms of schizophrenia. Studies on larger samples are however needed to further corroborate this finding...
  61. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  62. doi request reprint Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Cereb Cortex 21:1659-66. 2011
    ..Additionally, our results may have important implications for functional brain imaging in which HRs are commonly used as a surrogate for neural activation...
  63. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  64. ncbi request reprint Duplication 15q14 --> pter: a rare chromosomal abnormality underlying bipolar affective disorder
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Psychiatry 19:179-81. 2004
    ..Possible implications of this rare chromosomal abnormality with regards to psychiatric disorders are discussed, with emphasis on recent evidence suggesting chromosome 15q13-15 as a susceptibility locus for psychosis...
  65. doi request reprint Major depression: a role for hippocampal neurogenesis?
    Margherita M Lee
    Department of Psychiatry Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Germany
    Curr Top Behav Neurosci 14:153-79. 2013
    ....
  66. doi request reprint Behavioral genetics of affective and anxiety disorders
    Katharina Domschke
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, D 97080, Wurzburg, Germany
    Curr Top Behav Neurosci 12:463-502. 2012
    ..Finally, there is some evidence for genetic factors potentially shared between affective and anxiety disorders pointing to a possible overlapping phenotype between anxiety disorders and depression...
  67. ncbi request reprint Toward a molecular architecture of personality
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstr 15, 97080, Wuerzburg, Germany
    Behav Brain Res 139:1-20. 2003
    ..The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders...
  68. ncbi request reprint Carbohydrate-deficient transferrin parallels disease severity in anorexia nervosa
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Psychiatry Res 137:143-6. 2005
    ..In anorexia nervosa patients, CDT is unsuitable as a marker of alcohol abuse, but it might serve as a parameter indicating prognosis and disease severity. However, case-control studies with larger samples are warranted...
  69. ncbi request reprint NADPH-diaphorase staining reveals new types of interneurons in human putamen
    Silvia Johannes
    Laboratory of Neurobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080, Wurzburg, Germany
    Brain Res 980:92-9. 2003
    ..Thus, we suggest at least three novel types of neostriatal interneurons. Furthermore, a special class of large neurons thought to be efferent in nature, stained NOS-positive...