Research Topics
| H M ReichardtSummaryCountry: Germany Publications
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Detail Information
Publications
Glucocorticoids in T cell apoptosis and functionM J Herold
Molecular Immunology, Institute for Virology and Immunobiology, , Versbacher Strasse 7, , Germany
Cell Mol Life Sci 63:60-72. 2006..Although our knowledge in this field has substantially increased during recent years, we are still far from a comprehensive picture of the role that GCs play in T lymphocytes...
Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitisHolger M Reichardt
University of Wurzburg, Molecular Immunology, Institute for Virology and Immunobiology, Versbacher Strasse 7, 97078 Wurzburg, Germany
Expert Rev Neurother 6:1657-70. 2006..With this knowledge in mind, we should be able to further improve the management of multiple sclerosis using this class of drugs...- Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targetingH M Reichardt
Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Strasse 7, 97078, Germany
Curr Pharm Des 10:2797-805. 2004..Many new and exciting findings have thereby been generated but despite the enormous efforts of several laboratories, a complete picture on the role of GR in the immune system is only just emerging... - Molecular and cellular mechanisms of T cell developmentU Bommhardt
Institute of Virology and Immunobiology, , Versbacher Strasse 7, , Germany
Cell Mol Life Sci 61:263-80. 2004.... - Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shockH M Reichardt
Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
Mol Cell Biol 20:9009-17. 2000..Furthermore, they may explain differences in the susceptibility of humans to inflammatory diseases and stress, depending on individual prenatal and postnatal experiences known to influence the expression of the glucocorticoid receptor... - Feedback control of glucocorticoid production is established during fetal developmentH M Reichardt
Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
Mol Med 2:735-44. 1996.... - DNA binding of the glucocorticoid receptor is not essential for survivalH M Reichardt
Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
Cell 93:531-41. 1998..In contrast to GR-/- mice, these mutants termed GRdim are viable, revealing the in vivo relevance of DNA-binding-independent activities of the GR... - Mutagenesis of the glucocorticoid receptor in miceC Kellendonk
Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
J Steroid Biochem Mol Biol 69:253-9. 1999.... - CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responsesH Voigt
Department of Dermatology, Julius-Maximilians-Univerity, , Germany
Clin Exp Immunol 143:93-102. 2006..This suggests that CD28-mediated costimulatory signals are essential for differentiation of functional tumour-specific CD8+ T-effector cells despite having no impact on the homing of primed CD8+ T cells... - Absence of glucocorticoid receptor-beta in miceC Otto
Division Molecular Biology of the Cell I, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
J Biol Chem 272:26665-8. 1997..Since GRbeta is not conserved across species its physiological significance in humans appears questionable... - Analysis of glucocorticoid signalling by gene targetingH M Reichardt
Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
J Steroid Biochem Mol Biol 65:111-5. 1998..However neither in the lung nor the adrenals were any histological abnormalities found. In conclusion GR(dim)-mice represent a valuable tool to further analyse mechanisms of physiological effects of the GR... - Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptorH M Reichardt
Division of Molecular Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
EMBO J 20:7168-73. 2001..The only defect of immune suppression detected so far concerns the induced apoptosis of thymocytes and T lymphocytes... - Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memoryM S Oitzl
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, P O Box 9503, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
Proc Natl Acad Sci U S A 98:12790-5. 2001..Although it cannot be excluded that both processes are involved in a coordinated way, interrupting the DNA-binding capacity of the receptor is sufficient to induce impairment... - Mammary gland development and lactation are controlled by different glucocorticoid receptor activitiesH M Reichardt
Division of Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Eur J Endocrinol 145:519-27. 2001..CONCLUSIONS: The present study has demonstrated that GR plays an important role in the mammary gland and that it uses different molecular modes of action to control development and milk protein synthesis... - Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult miceP Gass
Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
EMBO Rep 1:447-51. 2000..These MR-related alterations may participate in the pathogenesis of hippocampal changes observed in ageing, chronic stress and affective disorders... - Genetic dissection of glucocorticoid receptor function in miceF Tronche
Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany
Curr Opin Genet Dev 8:532-8. 1998..Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions... - The Cre/loxP system--a versatile tool to study glucocorticoid signalling in miceH M Reichardt
Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
Biochem Soc Trans 27:78-83. 1999 - Resetting of circadian time in peripheral tissues by glucocorticoid signalingA Balsalobre
, Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
Science 289:2344-7. 2000..In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day... - The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skinJ P Tuckermann
Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
J Cell Biol 147:1365-70. 1999..Thus, these data suggest that the DNA binding-independent function of the GR is dispensable for repression of AP-1 activity in vivo and responsible for the antitumor promoting activity of GCs... - The glucocorticoid receptor is required for stress erythropoiesisA Bauer
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Genes Dev 13:2996-3002. 1999..A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo... - Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimersH Karst
Inst Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
Nat Neurosci 3:977-8. 2000..Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers...