H M Reichardt

Summary

Country: Germany

Publications

  1. pmc Glucocorticoids in T cell apoptosis and function
    M J Herold
    Molecular Immunology, Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Cell Mol Life Sci 63:60-72. 2006
  2. ncbi request reprint Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis
    Holger M Reichardt
    University of Wurzburg, Molecular Immunology, Institute for Virology and Immunobiology, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Expert Rev Neurother 6:1657-70. 2006
  3. ncbi request reprint Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targeting
    H M Reichardt
    Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Strasse 7, 97078, Germany
    Curr Pharm Des 10:2797-805. 2004
  4. ncbi request reprint Molecular and cellular mechanisms of T cell development
    U Bommhardt
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Cell Mol Life Sci 61:263-80. 2004
  5. pmc Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cell Biol 20:9009-17. 2000
  6. pmc Feedback control of glucocorticoid production is established during fetal development
    H M Reichardt
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Mol Med 2:735-44. 1996
  7. ncbi request reprint DNA binding of the glucocorticoid receptor is not essential for survival
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Cell 93:531-41. 1998
  8. ncbi request reprint Mutagenesis of the glucocorticoid receptor in mice
    C Kellendonk
    Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    J Steroid Biochem Mol Biol 69:253-9. 1999
  9. pmc CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responses
    H Voigt
    Department of Dermatology, Julius Maximilians Univerity, Wurzburg, Germany
    Clin Exp Immunol 143:93-102. 2006
  10. ncbi request reprint Absence of glucocorticoid receptor-beta in mice
    C Otto
    Division Molecular Biology of the Cell I, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 272:26665-8. 1997

Collaborators

Detail Information

Publications21

  1. pmc Glucocorticoids in T cell apoptosis and function
    M J Herold
    Molecular Immunology, Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Cell Mol Life Sci 63:60-72. 2006
    ..Although our knowledge in this field has substantially increased during recent years, we are still far from a comprehensive picture of the role that GCs play in T lymphocytes...
  2. ncbi request reprint Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis
    Holger M Reichardt
    University of Wurzburg, Molecular Immunology, Institute for Virology and Immunobiology, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Expert Rev Neurother 6:1657-70. 2006
    ..With this knowledge in mind, we should be able to further improve the management of multiple sclerosis using this class of drugs...
  3. ncbi request reprint Immunomodulatory activities of glucocorticoids: insights from transgenesis and gene targeting
    H M Reichardt
    Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Strasse 7, 97078, Germany
    Curr Pharm Des 10:2797-805. 2004
    ..Many new and exciting findings have thereby been generated but despite the enormous efforts of several laboratories, a complete picture on the role of GR in the immune system is only just emerging...
  4. ncbi request reprint Molecular and cellular mechanisms of T cell development
    U Bommhardt
    Institute of Virology and Immunobiology, University of Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany
    Cell Mol Life Sci 61:263-80. 2004
    ....
  5. pmc Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cell Biol 20:9009-17. 2000
    ..Furthermore, they may explain differences in the susceptibility of humans to inflammatory diseases and stress, depending on individual prenatal and postnatal experiences known to influence the expression of the glucocorticoid receptor...
  6. pmc Feedback control of glucocorticoid production is established during fetal development
    H M Reichardt
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Mol Med 2:735-44. 1996
    ....
  7. ncbi request reprint DNA binding of the glucocorticoid receptor is not essential for survival
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Cell 93:531-41. 1998
    ..In contrast to GR-/- mice, these mutants termed GRdim are viable, revealing the in vivo relevance of DNA-binding-independent activities of the GR...
  8. ncbi request reprint Mutagenesis of the glucocorticoid receptor in mice
    C Kellendonk
    Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    J Steroid Biochem Mol Biol 69:253-9. 1999
    ....
  9. pmc CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responses
    H Voigt
    Department of Dermatology, Julius Maximilians Univerity, Wurzburg, Germany
    Clin Exp Immunol 143:93-102. 2006
    ..This suggests that CD28-mediated costimulatory signals are essential for differentiation of functional tumour-specific CD8+ T-effector cells despite having no impact on the homing of primed CD8+ T cells...
  10. ncbi request reprint Absence of glucocorticoid receptor-beta in mice
    C Otto
    Division Molecular Biology of the Cell I, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 272:26665-8. 1997
    ..Since GRbeta is not conserved across species its physiological significance in humans appears questionable...
  11. ncbi request reprint Analysis of glucocorticoid signalling by gene targeting
    H M Reichardt
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    J Steroid Biochem Mol Biol 65:111-5. 1998
    ..However neither in the lung nor the adrenals were any histological abnormalities found. In conclusion GR(dim)-mice represent a valuable tool to further analyse mechanisms of physiological effects of the GR...
  12. pmc Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
    H M Reichardt
    Division of Molecular Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany
    EMBO J 20:7168-73. 2001
    ..The only defect of immune suppression detected so far concerns the induced apoptosis of thymocytes and T lymphocytes...
  13. pmc Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory
    M S Oitzl
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, P O Box 9503, Leiden University Medical Center, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 98:12790-5. 2001
    ..Although it cannot be excluded that both processes are involved in a coordinated way, interrupting the DNA-binding capacity of the receptor is sufficient to induce impairment...
  14. ncbi request reprint Mammary gland development and lactation are controlled by different glucocorticoid receptor activities
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Endocrinol 145:519-27. 2001
    ..CONCLUSIONS: The present study has demonstrated that GR plays an important role in the mammary gland and that it uses different molecular modes of action to control development and milk protein synthesis...
  15. pmc Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice
    P Gass
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    EMBO Rep 1:447-51. 2000
    ..These MR-related alterations may participate in the pathogenesis of hippocampal changes observed in ageing, chronic stress and affective disorders...
  16. ncbi request reprint Genetic dissection of glucocorticoid receptor function in mice
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany
    Curr Opin Genet Dev 8:532-8. 1998
    ..Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions...
  17. ncbi request reprint The Cre/loxP system--a versatile tool to study glucocorticoid signalling in mice
    H M Reichardt
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Biochem Soc Trans 27:78-83. 1999
  18. ncbi request reprint Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day...
  19. pmc The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
    J P Tuckermann
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Cell Biol 147:1365-70. 1999
    ..Thus, these data suggest that the DNA binding-independent function of the GR is dispensable for repression of AP-1 activity in vivo and responsible for the antitumor promoting activity of GCs...
  20. pmc The glucocorticoid receptor is required for stress erythropoiesis
    A Bauer
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Genes Dev 13:2996-3002. 1999
    ..A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo...
  21. ncbi request reprint Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
    H Karst
    Inst Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Nat Neurosci 3:977-8. 2000
    ..Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers...