Erez Raz

Summary

Country: Germany

Publications

  1. ncbi Regulation of zebrafish primordial germ cell migration by attraction towards an intermediate target
    Gilbert Weidinger
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Development 129:25-36. 2002
  2. pmc Specification of primordial germ cells in medaka (Oryzias latipes)
    Amaury Herpin
    Department of Physiological Chemistry I, University of Wuerzburg, Biozentrum, Am Hubland, D 97074 Wuerzburg, Germany
    BMC Dev Biol 7:3. 2007
  3. ncbi Attraction rules: germ cell migration in zebrafish
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Curr Opin Genet Dev 16:355-9. 2006
  4. ncbi Primordial germ cell development in zebrafish
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070, Gottingen, Germany
    Semin Cell Dev Biol 13:489-95. 2002
  5. ncbi Primordial germ-cell development: the zebrafish perspective
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Nat Rev Genet 4:690-700. 2003
  6. ncbi Guidance of primordial germ cell migration
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Curr Opin Cell Biol 16:169-73. 2004
  7. ncbi Transition from non-motile behaviour to directed migration during early PGC development in zebrafish
    Heiko Blaser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Cell Sci 118:4027-38. 2005
  8. pmc Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development
    Markus J Strasser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    BMC Dev Biol 8:58. 2008
  9. ncbi Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow
    Heiko Blaser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Dev Cell 11:613-27. 2006
  10. ncbi Autonomous modes of behavior in primordial germ cell migration
    Michal Reichman-Fried
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Dev Cell 6:589-96. 2004

Collaborators

Detail Information

Publications31

  1. ncbi Regulation of zebrafish primordial germ cell migration by attraction towards an intermediate target
    Gilbert Weidinger
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Development 129:25-36. 2002
    ..Our results indicate that zebrafish PGCs are guided by attraction towards two signaling centers, one of which may represent the somatic tissues of the gonad...
  2. pmc Specification of primordial germ cells in medaka (Oryzias latipes)
    Amaury Herpin
    Department of Physiological Chemistry I, University of Wuerzburg, Biozentrum, Am Hubland, D 97074 Wuerzburg, Germany
    BMC Dev Biol 7:3. 2007
    ....
  3. ncbi Attraction rules: germ cell migration in zebrafish
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Curr Opin Genet Dev 16:355-9. 2006
    ..In all of these stages, zebrafish germ cells respond as individual cells to alterations in the shape of the sdf-1a expression domain, by directed migration towards their target - the position where the gonad develops...
  4. ncbi Primordial germ cell development in zebrafish
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070, Gottingen, Germany
    Semin Cell Dev Biol 13:489-95. 2002
    ..This review summarizes studies aimed at understanding the development of this cell population in zebrafish and compares these results with those obtained in other model organisms...
  5. ncbi Primordial germ-cell development: the zebrafish perspective
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Nat Rev Genet 4:690-700. 2003
    ....
  6. ncbi Guidance of primordial germ cell migration
    Erez Raz
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Curr Opin Cell Biol 16:169-73. 2004
    ..The ability to visualize chemokine-guided migration at a high resolution in vivo in these model organisms provides a unique opportunity to study this process, which is relevant for many events in normal development and disease...
  7. ncbi Transition from non-motile behaviour to directed migration during early PGC development in zebrafish
    Heiko Blaser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Cell Sci 118:4027-38. 2005
    ..These distinctive morphological and molecular alterations could represent a general occurrence in similar processes critical for development and disease...
  8. pmc Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development
    Markus J Strasser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    BMC Dev Biol 8:58. 2008
    ..Little is known about the structure of these granules as well as their segregation in mitosis during early germ-cell development...
  9. ncbi Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow
    Heiko Blaser
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Dev Cell 11:613-27. 2006
    ..The biased formation of new protrusions in a particular region of the cell in response to SDF-1 defines the leading edge and the direction of cell migration...
  10. ncbi Autonomous modes of behavior in primordial germ cell migration
    Michal Reichman-Fried
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Dev Cell 6:589-96. 2004
    ..Together, these behavioral modes allow the cells to arrive at specific destinations with high fidelity and remain at their target site...
  11. ncbi Guidance of primordial germ cell migration by the chemokine SDF-1
    Maria Doitsidou
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Cell 111:647-59. 2002
    ..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs...
  12. doi Control of Dead end localization and activity--implications for the function of the protein in antagonizing miRNA function
    Krasimir Slanchev
    Max Planck Institute for Biophysical Chemistry, Germ Cell Development, Am Fassberg 11, 37070 Goettingen, Germany
    Mech Dev 126:270-7. 2009
    ..Based on molecular modeling, we identify the putative RNA binding domain of Dnd as a canonical RRM and propose that this domain is important for protein subcellular localization and function...
  13. ncbi Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration
    Sofia Minina
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, Gottingen, Germany
    Curr Biol 17:1164-72. 2007
    ....
  14. ncbi dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival
    Gilbert Weidinger
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany
    Curr Biol 13:1429-34. 2003
    ..We have identified dead end orthologs in other vertebrates including Xenopus, mouse, and chick, where they are expressed in germ plasm and germ-line cells, suggesting a role in germ-line development in these organisms as well...
  15. ncbi Signaling pathways controlling primordial germ cell migration in zebrafish
    Karin Dumstrei
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Gottingen, Germany
    J Cell Sci 117:4787-95. 2004
    ..We therefore conclude that Gi-dependent signaling is essential for directional migration, whereas the PI3K pathway is important for the actual motility of PGCs...
  16. pmc Development without germ cells: the role of the germ line in zebrafish sex differentiation
    Krasimir Slanchev
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 102:4074-9. 2005
    ..Our results demonstrate an unexpected role for the germ line in promoting female development because PGC-ablated fish invariably developed as males...
  17. ncbi Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12
    Jürg Stebler
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Dev Biol 272:351-61. 2004
    ..These findings suggest that SDF-1 is required for the PGCs to execute the final migration steps as they transmigrate through the blood vessel endothelium of the chick or the gut epithelium of the mouse...
  18. ncbi What is left behind--quality control in germ cell migration
    Bijan Boldajipour
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Sci STKE 2007:pe16. 2007
    ..In addition, these studies underscore the different functions a single signaling pathway can have in controlling cell survival, cell proliferation, and cell migration during different phases of development...
  19. ncbi Expression of a linker histone-like gene in the primordial germ cells in zebrafish
    Katja Müller
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Mech Dev 117:253-7. 2002
    ..H1M transcripts are uniformly distributed during blastula stages, but become restricted to the PGCs during gastrulation and remain visible in PGCs as they migrate towards the region of the gonad...
  20. ncbi Multiple levels of posttranscriptional control lead to germ line-specific gene expression in the zebrafish
    Uta Wolke
    Max Planck Institute for Biophysical Chemistry, Germ Cell Development, Am Fassberg 11, 37077, Gottingen, Germany
    Curr Biol 12:289-94. 2002
    ..In conclusion, we show that posttranscriptional degradation-protection mechanisms acting on RNA and protein function in a vertebrate to enrich for specific molecules in the PGCs...
  21. ncbi Primordial germ-cell development in zebrafish
    Erez Raz
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, Göttingen 37070, Germany
    Results Probl Cell Differ 40:166-79. 2002
  22. ncbi Found in translation: A new player in EMT
    Natalia C Mackenzie
    Germ Cell Development, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, Göttingen 37070, Germany
    Dev Cell 11:434-6. 2006
    ..Screening for genes mediating EMT and cancer metastasis, Waerner, Alacakaptan, and colleagues identified ILEI, a cytokine-like protein that plays an essential role in EMT, tumor growth, and late steps of metastasis...
  23. ncbi A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish
    Saskia Houwing
    Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
    Cell 129:69-82. 2007
    ..Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification...
  24. ncbi Germ cells: sex and repression in mice
    Erez Raz
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11 37070, Goettingen, Germany
    Curr Biol 15:R600-3. 2005
    ..The mouse Blimp1 gene encodes a transcriptional repressor that is essential for B-cell development. Recent studies have shown that the Blimp1 protein also plays a critical role in the specification of mouse primordial germ cells...
  25. doi Sequential SDF1a and b-induced mobility guides Medaka PGC migration
    Amaury Herpin
    University of Wuerzburg, Department of Physiological Chemistry I, Biozentrum, Am Hubland, D 97074 Wuerzburg, Germany
    Dev Biol 320:319-27. 2008
    ..In this process both SDF1 co-orthologues show only partly overlapping expression pattern and cooperate in the correct positioning of the PGCs...
  26. doi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
    ....
  27. ncbi RNA-binding protein Dnd1 inhibits microRNA access to target mRNA
    Martijn Kedde
    The Netherlands Cancer Institute, Division of Tumor Biology, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands
    Cell 131:1273-86. 2007
    ..These effects of Dnd1 are mediated through uridine-rich regions present in the miRNA-targeted mRNAs. Thus, our data unravel a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression...
  28. pmc CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells
    Elena Vasyutina
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Genes Dev 19:2187-98. 2005
    ..Our analysis reveals a role of SDF1/CXCR4 signaling in the development of migrating muscle progenitors and shows that a threshold number of progenitor cells is required to generate muscle of appropriate size...
  29. ncbi The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival
    Kathleen A Molyneaux
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 130:4279-86. 2003
    ..This demonstrates a high degree of evolutionary conservation of part of the mechanism, but also an area of evolutionary divergence...
  30. ncbi Involvement of Pax6 and Otx2 in the forebrain-specific regulation of the vertebrate homeobox gene ANF/Hesx1
    Derek Spieler
    AG Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, 37077 Gottingen, Germany
    Dev Biol 269:567-79. 2004
    ..However, a mutation of the Pax6 site did not abolish reporter activity from an electroporated vector. We conclude that Otx2 and Pax6 are key molecules involved in conserved mechanisms of ANF gene regulation...
  31. pmc Production of maternal-zygotic mutant zebrafish by germ-line replacement
    Brian Ciruna
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Proc Natl Acad Sci U S A 99:14919-24. 2002
    ..Furthermore, the ability to generate large clutches of purely mutant embryos will greatly facilitate embryological, genetic, genomic, and biochemical studies...