Research Topics
| Knuth RassSummaryCountry: Germany Publications
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Detail Information
Publications
[Systemic treatment of melanoma. Current clinical trials]A Hauschild
Schwerpunktbereich Dermato Onkologie und Operative Dermatologie, Klinik fur Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Deutschland
Hautarzt 59:484-91. 2008..This overview delineates the most important clinical trials currently conducted or planned in the adjuvant and palliative setting of melanoma treatment...
[Experimental treatment of malignant melanoma and its rationale]K Rass
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421, Homburg, Deutschland
Hautarzt 59:475-83. 2008..It will be challenging for the future to identify and characterize more precisely those patients who might most benefit from a certain treatment approach...
Treatment of melanoma and nonmelanoma skin cancerKnuth Rass
Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
Adv Exp Med Biol 624:296-318. 2008....
UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancerKnuth Rass
Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, 66421 Homburg Saar, Germany
Adv Exp Med Biol 624:162-78. 2008....
Chemotherapeutics, chemoresistance and the management of melanomaK Rass
Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg, Germany
G Ital Dermatol Venereol 144:61-78. 2009..The development of drugs targeting those mechanisms and their administration in combination with chemotherapy is currently one of the fascinating novel treatment approaches in melanoma...
Venoarterial flow index steadily improves after endovenous laser treatment of the great saphenous veinKnuth Rass
Department of Dermatology, Venereology, and Allergology, Saarland University Hospital, Homburg, Germany
Dermatol Surg 36:1691-9. 2010..The venous arterial flow index (VAFI) represents a quantitative duplex ultrasound parameter to characterize venous hemodynamics, which has not been investigated in EVLT so far...
Construction and evaluation of a multidimensional score to assess varicose vein severity - the Homburg Varicose Vein Severity Score (HVVSS)Knuth Rass
Department of Dermatology, Venerology and Allergology, Saarland University Hospital, 66421 Homburg, Germany
Eur J Dermatol 21:577-84. 2011..977 and 0.950 pre- and postoperatively (p<0.001). HVVSS is a suitable and reliable tool to assess disease severity in varicose vein patients and to quantify therapeutic effects of varicose vein treatment...
Comparable effectiveness of endovenous laser ablation and high ligation with stripping of the great saphenous vein: two-year results of a randomized clinical trial (RELACS study)Knuth Rass
Department of Dermatology, Venerology and Allergology, Saarland University Hospital, 66421 Homburg, Germany
Arch Dermatol 148:49-58. 2012..To compare the clinical efficacy and safety of endovenous laser treatment (EVLT) with high ligation and stripping (HLS) as standard treatment for great saphenous vein (GSV) insufficiency...
High-throughput miRNA profiling of human melanoma blood samplesPetra Leidinger
Institute of Human Genetics, Medical School, Saarland University, Building 60, 66421 Homburg Saar, Germany
BMC Cancer 10:262. 2010..MicroRNA (miRNA) signatures are not only found in cancer tissue but also in blood of cancer patients. Specifically, miRNA detection in blood offers the prospect of a non-invasive analysis tool...
[Therapy of malignant melanoma. First-, second- and pathogenesis-oriented third-line therapies]K Rass
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, 66421 Homburg
Hautarzt 57:773-84. 2006..First clinical experiences are encouraging, but results from controlled trials have to be awaited...
Prospective randomized multicenter adjuvant dermatologic cooperative oncology group trial of low-dose interferon alfa-2b with or without a modified high-dose interferon alfa-2b induction phase in patients with lymph node-negative melanomaAxel Hauschild
Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, D 24105 Kiel, Germany
J Clin Oncol 27:3496-502. 2009..2% (arm A) and 82.9% (arm B). CONCLUSION The addition of a 4-week modified HDI induction phase to a 2-year low-dose adjuvant IFN-alpha-2b treatment schedule did not improve the clinical outcome...
Reciprocal responses of fibroblasts and melanocytes to α-MSH depending on MC1R polymorphismsHedwig Stanisz
Department of Dermatology, Venerology and Allergology University Hospital of Saarland Homburg, Germany
Dermatoendocrinol 3:259-65. 2011..Thus, the MC1R seems to be not solely important for the skin pigmentary system, but also for the fibroblast function, and might influence different processes of the dermal compartment like wound healing, fibrosis and keloid formation...
Frequency of colour vision deficiencies in melanoma patients: results of a prospective comparative screening study with the Farnsworth panel D 15 test including 300 melanoma patients and 100 healthy controlsClaudia Pföhler
Department of Dermatology, The Saarland University Hospital bInstitute for Medical Biometry, Epidemiology and Medical Informatics, Homburg Saar, Germany
Melanoma Res 16:413-21. 2006..For the use of blue vision deficiency in melanoma patients without predisposing diseases, a diligent test performance and interpretation is very important...
[Differential diagnosis of verrucous skin changes. When wild warts grow rapidly...]K Rass
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg
MMW Fortschr Med 147:59-61. 2005..This article gives and overview of the various types of verrucous skin changes (viral warts, seborrheic warts)...
DNA mismatch repair enzyme hMSH2 in malignant melanoma: increased immunoreactivity as compared to acquired melanocytic nevi and strong mRNA expression in melanoma cell linesK Rass
Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany
Histochem J 33:459-67. 2001..In conclusion, our findings indicate that hMSH-2 may be of importance for genetic stability, tumorigenesis and progression of malignant melanoma...
Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3N Booken
Department of Dermatology, Venereology and Allergology, University Medical Centre Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany
Leukemia 22:393-9. 2008..Furthermore, CDO1 catalyzes taurine synthesis and taurine inhibits apoptosis and promotes chemoprotection. In summary, CDO1 and DNM3 may improve the diagnosis of SS and open novel clues to its pathogenesis...
[Modern aspects of varicose vein surgery]K Rass
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg
Hautarzt 56:448-56. 2005..This report delineates current developments in varicose vein surgery and provides information on principles, effectiveness and side effect profiles of endovascular therapy procedures...
