Ulf R Rapp

Summary

Country: Germany

Publications

  1. ncbi request reprint Oncogene-induced plasticity and cancer stem cells
    Ulf R Rapp
    Institute für Medizinische Strahlenkunde und Zellforschung MSZ, Bayerisches Krebsforschungszentrum, Julius Maximilians University, Wurzburg, Germany
    Cell Cycle 7:45-51. 2008
  2. doi request reprint Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages
    Arnold R Sienerth
    Institut fur Medizinische Strahlenkunde und Zellforschung, Wurzburg, Germany
    Immunol Cell Biol 89:812-6. 2011
  3. ncbi request reprint Tumor induction by activated JNK occurs through deregulation of cellular growth
    Ulrike Rennefahrt
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, University of Wurzburg, Wurzburg, Germany
    Cancer Lett 215:113-24. 2004
  4. doi request reprint Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma
    Roland Houben
    Klinik fur Dermatologie, Venerologie und Allergologie, Julius Maximilians Universitat, Wurzburg, Germany
    J Invest Dermatol 128:2003-12. 2008
  5. ncbi request reprint Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
    Fatih Ceteci
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Versbacher Strasse 5, 97078, Wurzburg, Germany
    Cancer Cell 12:145-59. 2007
  6. ncbi request reprint Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases
    Ulf R Rapp
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, 97078 Wurzburg, Germany
    Biochim Biophys Acta 1644:149-58. 2004
  7. pmc Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure
    Boris W Kramer
    Universitäts Kinderklinik Würzburg, D 97080 Wurzburg, Germany
    BMC Cancer 4:24. 2004
  8. ncbi request reprint BAD association with membranes is regulated by Raf kinases and association with 14-3-3 proteins
    Ulf R Rapp
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Versbacher Str 5, 97078 Wurzburg, Germany
    Adv Enzyme Regul 47:281-5. 2007
  9. pmc B-Raf specific antibody responses in melanoma patients
    Joachim Fensterle
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, University Clinics of Würzburg, Versbacher Str 5, 97078 Wurzburg, Germany
    BMC Cancer 4:62. 2004
  10. pmc BAG-1 haplo-insufficiency impairs lung tumorigenesis
    Rudolf Götz
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Germany
    BMC Cancer 4:85. 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Oncogene-induced plasticity and cancer stem cells
    Ulf R Rapp
    Institute für Medizinische Strahlenkunde und Zellforschung MSZ, Bayerisches Krebsforschungszentrum, Julius Maximilians University, Wurzburg, Germany
    Cell Cycle 7:45-51. 2008
    ..In this perspective article we will summarize the experimental evidence that illustrates our concept and discuss its implications for tumor formation and tumor therapy...
  2. doi request reprint Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages
    Arnold R Sienerth
    Institut fur Medizinische Strahlenkunde und Zellforschung, Wurzburg, Germany
    Immunol Cell Biol 89:812-6. 2011
    ..Our results identify Bmi1 as a repressor of IL-10 expression during macrophage activation...
  3. ncbi request reprint Tumor induction by activated JNK occurs through deregulation of cellular growth
    Ulrike Rennefahrt
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, University of Wurzburg, Wurzburg, Germany
    Cancer Lett 215:113-24. 2004
    ..In vitro studies and analysis of tumor material support the conclusion that oncogenic JNK primarily transforms through its effects on cell proliferation and tumor vascularization but does not affect cell survival...
  4. doi request reprint Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma
    Roland Houben
    Klinik fur Dermatologie, Venerologie und Allergologie, Julius Maximilians Universitat, Wurzburg, Germany
    J Invest Dermatol 128:2003-12. 2008
    ..Our findings suggest that mitogen-activated protein kinase (MAPK) activity is subject to regulation even in BRAF/NRAS mutant melanoma cells and that high MAPK pathway signaling may be important only in distinct subsets of tumor cells...
  5. ncbi request reprint Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
    Fatih Ceteci
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Versbacher Strasse 5, 97078, Wurzburg, Germany
    Cancer Cell 12:145-59. 2007
    ..In vivo, lung tumor cells with disrupted E-cadherin expressed beta-catenin target genes normally found in other endodermal lineages suggesting that reprogramming may be involved in metastatic progression...
  6. ncbi request reprint Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases
    Ulf R Rapp
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, 97078 Wurzburg, Germany
    Biochim Biophys Acta 1644:149-58. 2004
    ..Within the scope of this review, we will discuss the contribution of Bcl-2-dependent signaling pathways to cell survival by Raf kinases and also address the underlying mechanisms...
  7. pmc Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure
    Boris W Kramer
    Universitäts Kinderklinik Würzburg, D 97080 Wurzburg, Germany
    BMC Cancer 4:24. 2004
    ..In this study the effect of the Raf kinase inhibitor BAY 43-9006 and of the MEK inhibitor CI-1040 (PD184352) on a Raf dependent lung tumor mouse model was analyzed in detail...
  8. ncbi request reprint BAD association with membranes is regulated by Raf kinases and association with 14-3-3 proteins
    Ulf R Rapp
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Versbacher Str 5, 97078 Wurzburg, Germany
    Adv Enzyme Regul 47:281-5. 2007
  9. pmc B-Raf specific antibody responses in melanoma patients
    Joachim Fensterle
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, University Clinics of Würzburg, Versbacher Str 5, 97078 Wurzburg, Germany
    BMC Cancer 4:62. 2004
    ....
  10. pmc BAG-1 haplo-insufficiency impairs lung tumorigenesis
    Rudolf Götz
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Germany
    BMC Cancer 4:85. 2004
    ....
  11. ncbi request reprint Use of the alpha-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain
    Ivaylo Gentschev
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Versbacher Str 5, D 97078 Wurzburg, Germany
    Int J Med Microbiol 294:363-71. 2004
    ..Therefore, the combination of the hemolysin secretion system and S. typhi Ty21a could form the basis for a new generation of live bacterial vaccines...
  12. pmc Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice
    Ivaylo Gentschev
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, University of Wuerzburg, D 97078 Wuerzburg, Germany
    BMC Cancer 5:15. 2005
    ..In this study we analyzed the functionality of a new live C-Raf vaccine based on an attenuated Salmonella enterica serovar Typhimurium aroA strain in two Raf dependent lung tumor mouse models...
  13. ncbi request reprint BuCy RAFs drive cells into MEK addiction
    Ulf R Rapp
    Institut fur Medizinische Strahlenkunde und Zellforschung, Versbacher Strasse 5, 97078 Wurzburg, Germany
    Cancer Cell 9:9-12. 2006
    ....
  14. doi request reprint Isoform-specific interaction of C-RAF with mitochondria
    Antoine Galmiche
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Wurzburg, Germany
    J Biol Chem 283:14857-66. 2008
    ....
  15. ncbi request reprint Ras signaling: PP2A puts Ksr and Raf in the right place
    Thomas Raabe
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Versbacherstr 5, 97078 Wurzburg, Germany
    Curr Biol 13:R635-7. 2003
  16. ncbi request reprint Raf kinases in lung tumor development
    Ulf R Rapp
    Institut für Medizinische, Strahlenkunde und Zellforschung MSZ, Bayerische Julius Maximilians Universität, Universitat Wurzburg, Versbacher Strasse 5, D 97078, Wurzburg, Germany
    Adv Enzyme Regul 43:183-95. 2003
  17. doi request reprint Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli
    Christian Hotz
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Wurzburg, Germany
    Int J Med Microbiol 299:109-19. 2009
    ..typhi strain secreting HlyA compared with the same strain without rfaH plasmid...
  18. ncbi request reprint KSR--a regulator and scaffold protein of the MAPK pathway
    Thomas Raabe
    University of W rzburg, Institut fuer Medizinische Strahlenkunde und Zellforschung MSZ, Versbacherstrasse 5, 97078 W rzburg, Germany
    Sci STKE 2002:pe28. 2002
    ..They focus on the adaptor kinase suppressor of Ras (KSR) and describe how the interactions between KSR and other proteins and the subcellular localization of KSR are regulated by phosphorylation...
  19. pmc BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling
    Lisa Polzien
    Department of Microbiology, Biocenter, University of Wurzburg, 97074 Wurzburg, Germany
    J Biol Chem 286:17934-44. 2011
    ..Collectively, our findings provide new insights into the regulation of BAD function by phosphorylation and its role in cancer signaling...
  20. pmc Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase
    Angela Baljuls
    Theodor Boveri Institute of Bioscience, Department of Microbiology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 286:16491-503. 2011
    ..In summary, we provide evidence that each of the basic residues within the RKTR motif is indispensable for correct RAF function...
  21. doi request reprint Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part
    Lisa Polzien
    Theodor Boveri Institute, Department of Microbiology, University of Wuerzburg, 97074 Wuerzburg, Germany
    Biochim Biophys Acta 1810:162-9. 2011
    ..Since the functional role of the BAD C-terminal part has not been considered so far, we have investigated here the interplay of the structure and function of this region...
  22. doi request reprint Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins
    Andreas Fischer
    Bayerisches Krebsforschungszentrum, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 284:3183-94. 2009
    ..Together, our results shed more light on the complex mechanism of RAF activation, particularly with respect to activation steps that are mediated by 14-3-3 proteins and prohibitin...
  23. ncbi request reprint Raf kinases: oncogenesis and drug discovery
    Ralf Schreck
    Institut fur Medizinische Strahlenkunde und Zellforschung, MSZ, Universitat Wurzburg, Wurzburg, Germany
    Int J Cancer 119:2261-71. 2006
    ....
  24. doi request reprint MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma
    Inês C Castro
    Biocenter, Department of Microbiology, University of Wurzburg, Wurzburg, Germany
    Mol Cancer Res 11:161-72. 2013
    ..Our results thus identify a novel epigenetic mechanism by which MYC activates GATA4 leading to metastasis in lung adenocarcinoma, suggesting novel potential targets for the development of antimetastatic therapy...
  25. pmc Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
    Matthias Becker
    Bayerisches Krebsforschungszentrum, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 4:e4230. 2009
    ..We have previously described a RAF oncogene driven transgenic mouse model for non small cell lung cancer (NSCLC). Here we examine whether tumor initiation and growth requires the stem cell self-renewal factor Bmi1...
  26. pmc Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum
    Verena Pfeiffer
    Institute for Medical Radiation and Cell Research MSZ, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e58259. 2013
    ....
  27. pmc Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression
    Katharina Galmbacher
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e9572. 2010
    ..TAM depletion was sustained and associated with complete tumor regression.These data support TAMs as useful targets for antitumor therapy and highlight attenuated bacterial pathogens as potential tools...
  28. pmc A-RAF kinase functions in ARF6 regulated endocytic membrane traffic
    Elena Nekhoroshkova
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 4:e4647. 2009
    ..RAF kinases direct ERK MAPK signaling to distinct subcellular compartments in response to growth factor stimulation...
  29. ncbi request reprint Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene
    Sabine Müller-Brüsselbach
    Institute of Molecular Biology and Tumor Research IMT, Philipps University, Marburg, Germany
    Int J Oncol 31:607-11. 2007
    ..These results are relevant with respect to the clinical application of drugs modulating the activity of PPARbeta or PPARgamma...
  30. ncbi request reprint Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling
    Anatoly Samoylenko
    University of Wurzburg, Section of Experimental Neurosurgery, Department of Neurosurgery, Josef Schneider St 11, 97080 Wurzburg, Germany
    Cell Signal 20:154-62. 2008
    ..Our data indicate that TPO via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity...
  31. ncbi request reprint Vivotif--a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens
    Ivaylo Gentschev
    Berna Biotech Ltd, Berne, Switzerland
    Chemotherapy 53:177-80. 2007
    ..Recently, we successfully used Ty21a for antigen delivery via the haemolysin secretion system of Escherichia coli, which allows efficient protein secretion from the carrier bacteria...
  32. pmc Negative regulation of mitochondrial VDAC channels by C-Raf kinase
    Véronique Le Mellay
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, 97078 Wurzburg, Germany
    BMC Cell Biol 3:14. 2002
    ..However, apoptosis suppression by C-Raf also occurs in cells lacking expression of Bad or Bcl-2...
  33. ncbi request reprint Ras oncogenes and their downstream targets
    Krishnaraj Rajalingam
    University of Wurzburg, Institut fur Medizinische Strahlenkunde und Zellforschung, Versbacherstr 5, D 97078 Wurzburg, Germany
    Biochim Biophys Acta 1773:1177-95. 2007
    ..Finally, we comment on the role of micro RNAs in modulating RAS expression, contribution of RAS to stem cell function and on high-throughput analyses of RAS signaling networks...
  34. ncbi request reprint Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates
    Angela Baljuls
    Institute for Medical Radiation and Cell Research, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 282:26575-90. 2007
    ..Considering this observation, we suggest that tyrosine 296, which is unique for A-RAF, is a major determinant of the low activating potency of this RAF isoform...
  35. ncbi request reprint B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding
    Andreas Fischer
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 282:26503-16. 2007
    ..Taken together, these data suggest that the activation of B-RAF, in contrast to C-RAF, may take place both at the plasma membrane and in the cytosolic environment...
  36. ncbi request reprint The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways
    Michele Caraglia
    Experimental Pharmacology Unit, Experimental Oncology Department, National Cancer Institute Fondazione G Pascale, Naples, Italy
    Int J Cancer 121:2317-30. 2007
    ....
  37. doi request reprint Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites
    Angela Baljuls
    Institute for Medical Radiation and Cell Research, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 283:27239-54. 2008
    ..Together, we provide here for the first time a detailed analysis of in vivo A-RAF phosphorylation status and demonstrate that regulation of A-RAF by phosphorylation exhibits unique features compared with B- and C-RAF...
  38. pmc Cortical migration defects in mice expressing A-RAF from the B-RAF locus
    Guadalupe Camarero
    Institut fur Medizinische Strahlenkunde und Zellforschung, Bayerische Julius Maximilians Universität, Versbacher Str 5, D 97078 Wurzburg, Germany
    Mol Cell Biol 26:7103-15. 2006
    ..Our data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions...
  39. ncbi request reprint Raf and the road to cell survival: a tale of bad spells, ring bearers and detours
    Jakob Troppmair
    Department of General and Transplantation Surgery, Daniel Swarovski Research Lab, University of Innsbruck, Innsbruck, Austria
    Biochem Pharmacol 66:1341-5. 2003
    ..They include the recruitment of novel effectors such as IAP and Bcl-2 proteins, key molecules in cell survival control, which interfere with the executions of the cell death at various levels, but also direct effects on metabolic events...
  40. ncbi request reprint Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch
    Lev M Fedorov
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Bayerische Julius Maximilians Universität, D 97078 Wurzburg, Germany
    Cancer Res 63:2268-77. 2003
    ..This mouse model for pulmonary adenoma and adenocarcinoma should be very helpful for a better understanding of pathogenesis and treatment of this most deadly human cancer...
  41. ncbi request reprint C-Raf controlled pathways in the protection of tumor cells from apoptosis
    Emily P Slater
    Institute of Molecular Biology and Tumor Research IMT Philipps University, Emil Mannkopff Strasse 2, 35033 Marburg, Germany
    Int J Cancer 104:425-32. 2003
    ....
  42. ncbi request reprint Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf
    Lev M Fedorov
    Institut fur Medizinische Strahlenkunde und Zellforschung, Bayerische Julius Maximilians Universität, D 97078 Wurzburg, Germany
    Cancer Res 62:6297-303. 2002
    ..These findings suggest that bcl-2 is a major susceptibility gene for development of lung cancer in mice and perhaps in humans...
  43. ncbi request reprint Regulation of glycolysis by Raf protein serine/threonine kinases
    Véronique Le Mellay
    Institut für Medizinische, Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Str 5, Germany
    Adv Enzyme Regul 42:317-32. 2002
  44. ncbi request reprint Constitutive JNK activation in NIH 3T3 fibroblasts induces a partially transformed phenotype
    Ulrike E E Rennefahrt
    Institut fur Medizinische Strahlenkunde und Zellforschung, Universitat Wurzburg, 97078 Wurzburg, Germany
    J Biol Chem 277:29510-8. 2002
    ..Our data suggest that constitutive JNK activation elicits major aspects of cellular transformation but is unable to induce the complete set of changes which are required to establish the fully transformed phenotype...
  45. ncbi request reprint Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling
    Troy Joseph
    Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10021, USA
    Oncogene 21:3651-8. 2002
    ..These data indicate that PLD signaling provides a novel survival signal that overcomes cell cycle arrest induced by high intensity Raf signaling...
  46. pmc Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways
    Manfred Kunz
    Department of Dermatology, University of Rostock, Augustenstr 80 84, 18055 Rostock, Germany
    Biochem J 366:299-306. 2002
    ..Functionally, H/R-induced MCP-1 production may contribute to tumour progression by committing selective pressure on tumour cells via chemoattraction and activation of tumour-infiltrating monocytes/macrophages...
  47. ncbi request reprint Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts
    Mirko Hekman
    Institut fuer Medizinische Strahlenkunde und Zellforschung MSZ, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 277:24090-102. 2002
    ..Thus Ras-Raf binding in response to activation of Ras-coupled receptors may utilize Raf protein that is already present at the membrane...
  48. ncbi request reprint B-Raf/Rap1 signaling, but not c-Raf-1/Ras, induces the histidine decarboxylase promoter in Helicobacter pylori infection
    Silja Wessler
    Max Planck Institut für Infektionsbiologie, Abt Molekulare Biologie, Berlin, Germany
    FASEB J 16:417-9. 2002
    ..pylori with gastric epithelial cells and help to define potential molecular targets for therapeutic interventions in the context of H. pylori-related gastric diseases...
  49. ncbi request reprint Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites
    Mirko Hekman
    Institute for Medical Radiation and Cell Research, University of Wuerzburg, 97078 Wuerzburg
    J Biol Chem 279:14074-86. 2004
    ..14-3-3 binding epitopes pS259 and pS621 and visualized for the first time the sequence of the essential C-Raf phosphorylation events in mammalian cells in response to growth factor stimulation...
  50. ncbi request reprint B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade
    Armin Robubi
    Department of Bioinformatics, University of Wuerzburg, D 97074 Wuerzburg, Germany
    Biol Chem 386:1165-71. 2005
    ....
  51. pmc Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
    Rudolf Götz
    Institut für Klinische Neurobiologie, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Nat Neurosci 8:1169-78. 2005
    ..Our data show that Bag1 is a physiological mediator of extracellular survival signals linked to the cellular mechanisms that prevent apoptosis in hematopoietic and neuronal progenitor cells...
  52. ncbi request reprint Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
    Krishnaraj Rajalingam
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Nat Cell Biol 7:837-43. 2005
    ..Our data show an unexpected role of prohibitin in the activation of the Ras-Raf signalling pathway and in modulating epithelial cell adhesion and migration...
  53. ncbi request reprint Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding
    Mirko Hekman
    Institute for Medical Radiation and Cell Research and Institute for Clinical Neurobiology, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 281:17321-36. 2006
    ..The dynamic interaction of BAD with membranes is tied to activation and membrane translocation of Bcl-XL...
  54. ncbi request reprint MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
    Jan Willem Voncken
    Research Institute Growth and Development, Molecular Genetics, Maastricht University, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    J Biol Chem 280:5178-87. 2005
    ..This suggests a novel mechanism by which a silenced gene status can be modulated and implicates PcG-mediated repression as a dynamically controlled process...
  55. ncbi request reprint Mitogen-activated 3p kinase is active in the nucleus
    Vera Zakowski
    Institut für Molekulare Medizin IMM, Heinrich Heine Universitat Dusseldorf, D 40225 Dusseldorf, Germany
    Exp Cell Res 299:101-9. 2004
    ..These data not only show that nuclear export of the kinase is mechanistically uncoupled from its activation, but also provide a novel mechanism by which cells may modulate enzyme activity toward a stimulus-specific response...
  56. ncbi request reprint Immunogenicity of constitutively active V599EBRaf
    Mads Hald Andersen
    Insitute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 64:5456-60. 2004
    ....
  57. ncbi request reprint Validation of a liquid chromatography assay for the quantification of the Raf kinase inhibitor BAY 43-9006 in small volumes of mouse serum
    Samar Afify
    Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius Maximilians Universität, Am Hubland, 97074 Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 809:99-103. 2004
    ..The lower limit of quantitation (LOQ) was 80 ng/ml with an accuracy of 105.8%. Thus, this method has been validated and can be applied for the drug monitoring or pharmacokinetic studies of BAY 43-9006 in small volumes of serum samples...
  58. pmc Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes
    Robert Kurzbauer
    Institute for Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 101:10984-9. 2004
    ..Taken together, the presented work provides insight into the spatial regulation of MAPK signaling, illustrating how p14 and MP1 collaborate as an endosomal adaptor/scaffold complex...
  59. ncbi request reprint Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice
    Veronika Olschläger
    Institut fur Immunologie, Bundesforschungsanstalt fur Viruskrankheiten der Tiere, Paul Ehrlich Str 28, Tubingen, Germany
    Oncogene 23:6639-46. 2004
    ..These findings disclose the possibility to use modified influenza virus for the therapy of tumors with an activated Ras/Raf signalling pathway...
  60. ncbi request reprint Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control
    Eugen Kerkhoff
    Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Universitat Wurzburg, Versbacher Strasse 5, D 97078 Wurzburg, Germany
    Biochim Biophys Acta 1589:151-9. 2002
    ..These results indicate a pro-oncogenic function of the Rac GTPase with respect to the deregulation of cell cycle control...
  61. ncbi request reprint Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation
    Mirko Hekman
    Institut fuer Medizinische Strahlenkunde und Zellforschung, University of Wuerzburg, 97078 Wuerzburg, Germany
    FEBS Lett 579:464-8. 2005
    ..Furthermore, we show here, using point mutant forms of C-Raf kinases with serine to alanine and serine to aspartic acid substitution, that serines 296 and 301 contribute to negative regulation of C-Raf...
  62. ncbi request reprint Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism
    Sybille Mazurek
    Institute of Biochemistry and Endocrinology, Veterinary Faculty, Justus Liebig University, Giessen, Germany
    Anticancer Res 27:3963-71. 2007
    ..High serine levels thus may be responsible for the activation of M2-PK in A-Raf transformed NIH3T3 cells...