Michaell Ranke

Summary

Country: Germany

Publications

  1. ncbi Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Trends Endocrinol Metab 16:190-7. 2005
  2. ncbi Growth and development are similar in VLBW children born appropriate and small for gestational age: an interim report on 97 preschool children
    Michael B Ranke
    Paediatric Endocrinology Section, University Hospital for Children and Adolescents, Tuebingen, Germany
    J Pediatr Endocrinol Metab 20:1017-26. 2007
  3. ncbi Clinical considerations in using growth hormone therapy in growth hormone deficiency
    Michael B Ranke
    University Children s Hospital, Paediatric Endocrinology and Diabetes, Tubingen, Germany
    Endocr Dev 18:83-91. 2010
  4. ncbi Increased response, but lower responsiveness, to growth hormone (GH) in very young children (aged 0-3 years) with idiopathic GH Deficiency: analysis of data from KIGS
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:1966-71. 2005
  5. ncbi Insulin-like growth factors as diagnostic tools in growth hormone deficiency during childhood and adolescence: the KIGS experience
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 62:17-25. 2004
  6. ncbi Final height in children with medulloblastoma treated with growth hormone
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 64:28-34. 2005
  7. ncbi Treatment of dwarfism with recombinant human insulin-like growth factor-1
    Michael B Ranke
    Universitätsklinik für Kinder und Jugendmedizin, Sektion Pädiatrische Endokrinologie, Tubingen
    Dtsch Arztebl Int 106:703-9. 2009
  8. ncbi Defining insulin-like growth factor-I deficiency
    Michael B Ranke
    Paediatric Endocrinology Section, University Children's Hospital, University of Tuebingen, Tuebingen, Germany
    Horm Res 65:9-14. 2006
  9. ncbi Sensitivity to IGF-I in short children born small for gestational age
    M B Ranke
    Section Pediatric Endocrinology, Children s Hospital, Tuebingen, Germany
    J Endocrinol Invest 29:21-6. 2006
  10. ncbi Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Pediatr Res 61:105-10. 2007

Detail Information

Publications64

  1. ncbi Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Trends Endocrinol Metab 16:190-7. 2005
    ..Further studies on IGF-I metabolic effects and growing understanding of the IGF-I-IGF-binding protein system could open new therapeutic avenues...
  2. ncbi Growth and development are similar in VLBW children born appropriate and small for gestational age: an interim report on 97 preschool children
    Michael B Ranke
    Paediatric Endocrinology Section, University Hospital for Children and Adolescents, Tuebingen, Germany
    J Pediatr Endocrinol Metab 20:1017-26. 2007
    ..To investigate growth and development in a cohort of children born with very low birth weight (VLBW) treated at a single tertiary neonatal unit...
  3. ncbi Clinical considerations in using growth hormone therapy in growth hormone deficiency
    Michael B Ranke
    University Children s Hospital, Paediatric Endocrinology and Diabetes, Tubingen, Germany
    Endocr Dev 18:83-91. 2010
    ..This approach not only optimizes the outcomes but also the cost of treatment. Further efforts are needed to incorporate the existing evidence into the diagnostic procedure and treatment of GH deficiency...
  4. ncbi Increased response, but lower responsiveness, to growth hormone (GH) in very young children (aged 0-3 years) with idiopathic GH Deficiency: analysis of data from KIGS
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:1966-71. 2005
    ..The early detection and GH treatment of congenital GHD is advantageous as a cost-effective strategy for achieving greater improvement of absolute height and growth velocity...
  5. ncbi Insulin-like growth factors as diagnostic tools in growth hormone deficiency during childhood and adolescence: the KIGS experience
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 62:17-25. 2004
    ....
  6. ncbi Final height in children with medulloblastoma treated with growth hormone
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 64:28-34. 2005
    ..Height in general is severely compromised in survivors. The present study is an extension of the investigation by the author's group of the effect of exogenous growth hormone (GH) among medulloblastoma patients...
  7. ncbi Treatment of dwarfism with recombinant human insulin-like growth factor-1
    Michael B Ranke
    Universitätsklinik für Kinder und Jugendmedizin, Sektion Pädiatrische Endokrinologie, Tubingen
    Dtsch Arztebl Int 106:703-9. 2009
    ..In primary disturbances of IGF-1 production, short stature can only be treated with recombinant human IGF-1 (rhIGF-1). rhIGF-1 was recently approved for this indication but can also be used to treat other conditions...
  8. ncbi Defining insulin-like growth factor-I deficiency
    Michael B Ranke
    Paediatric Endocrinology Section, University Children's Hospital, University of Tuebingen, Tuebingen, Germany
    Horm Res 65:9-14. 2006
  9. ncbi Sensitivity to IGF-I in short children born small for gestational age
    M B Ranke
    Section Pediatric Endocrinology, Children s Hospital, Tuebingen, Germany
    J Endocrinol Invest 29:21-6. 2006
    ..Adequate additional therapies could in future result in positive effects on co-morbidities associated with IGF-I insensitivity in SGA children in addition to height gain...
  10. ncbi Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Pediatr Res 61:105-10. 2007
    ..Evidently, height at GH start (the taller, the better), age at GH start (the younger, the better), the responsiveness to GH (the higher, the better) and age at puberty (the later, the better) determine NAH...
  11. ncbi Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 68:53-62. 2007
    ..To develop methods to identify factors associated with a favorable outcome in GH-treated children with idiopathic short stature (ISS)...
  12. ncbi KIGS: 20 years
    Michaell Ranke
    Department of Pediatrics and Endocrinology, University Children's Hospital of Tuebingen, Tuebingen, Germany
    Horm Res 68:40. 2007
  13. ncbi Prediction models for short children born small for gestational age (SGA) covering the total growth phase. Analyses based on data from KIGS (Pfizer International Growth Database)
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    BMC Med Inform Decis Mak 11:38. 2011
    ..The aims of this study were to compile existing prediction models for short children born SGA (SGA), to develop new models and to validate the algorithms...
  14. ncbi Predicting growth in response to growth hormone treatment
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    Growth Horm IGF Res 19:1-11. 2009
    ..While all aspects of model development bear continued scrutiny and improvement, the incorporation of more predictors is key if treatment outcomes are to be optimized in terms of efficacy, safety and cost...
  15. ncbi [Considerations of growth hormone treatment during the transition from adolescence to adulthood]
    M B Ranke
    Universitätsklinik für Kinder und Jugendmedizin, Pädiatrische Endokrinologie und Diabetologie, Universitat Tubingen
    Dtsch Med Wochenschr 134:1117-20. 2009
    ..0 SDS). GH treatment during the transition phase should be monitored by an endocrinologist with expertise in dealing with adolescent and adult patients, as well as having experience in structuring treatment and documentation...
  16. ncbi Noonan syndrome: growth to growth hormone - the experience of observational studies
    Michael B Ranke
    Department of Pediatrics, University of Tubingen, Germany
    Horm Res 72:36-40. 2009
    ..Both case studies and observational studies are necessary in order to obtain further evidence about the efficacy and safety of GH treatment in NS...
  17. ncbi Observed and predicted growth responses in prepubertal children with growth disorders: guidance of growth hormone treatment by empirical variables
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strasse 1, Tuebingen D 72076, Germany
    J Clin Endocrinol Metab 95:1229-37. 2010
    ..7; P < 0.001). Conclusions: Decisions on GH therapy regimens should be made using both traditional (HV or DeltaHt SDS) and prediction model-derived (SR) indices of growth response...
  18. ncbi Height at start, first-year growth response and cause of shortness at birth are major determinants of adult height outcomes of short children born small for gestational age and Silver-Russell syndrome treated with growth hormone: analysis of data from KIG
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res Paediatr 74:259-66. 2010
    ..There is limited information about adult height (AH) outcomes and the factors influencing outcomes of growth hormone (GH) therapy in short children born small for gestational age (SGA)...
  19. ncbi IGF-I and IGF binding protein-3 levels during initial GH dosage step-up are indicators of GH sensitivity in GH-deficient children and short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 64:68-76. 2005
    ..A stepwise increment of the GH dose is an approach aimed at avoiding adverse events. We investigated GH sensitivity by studying IGF-I and IGFBP-3 concentrations during the initial phase of GH treatment...
  20. ncbi Reference levels of insulin-like growth factor I in the serum of healthy adults: comparison of four immunoassays
    Michael Bernd Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 41:1329-34. 2003
    ....
  21. ncbi Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database)
    Michael B Ranke
    Sektion Pädiatrische Endokrinologie, Universitatsklinikum Tubingen, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:125-31. 2003
    ..Furthermore, this model can be used to provide patients with a realistic expectation of treatment and may help to identify compliance problems or other underlying causes of treatment failure...
  22. ncbi New paradigms for growth hormone treatment in the 21st century: prediction models
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 13:1365-9. 2000
    ..Growth prediction models will facilitate realistic expectations and will permit stepwise goals to be set and monitored...
  23. ncbi A growth prediction model for short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children's Hospital, , Germany
    J Pediatr Endocrinol Metab 15:1273. 2002
  24. ncbi Early-onset idiopathic growth hormone deficiency within KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:18-21. 2003
    ..Thus, it is suggested that early diagnosis and initiation of treatment in GH-deficient patients is strongly needed to achieve the maximum effects from therapy...
  25. ncbi Prediction model of total pubertal growth in idiopathic growth hormone deficiency: analysis of data from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, University Children's Hospital, , Germany
    Horm Res 60:58-9. 2003
  26. ncbi The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen D 72076 Germany
    J Clin Endocrinol Metab 88:4748-53. 2003
    ..The use of a higher GH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment...
  27. ncbi The potential of prediction models based on data from KIGS as tools to measure responsiveness to growth hormone. Pharmacia International Growth Database
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 55:44-8. 2001
    ..This will improve the efficacy and safety of GH treatment as well as reducing the costs involved...
  28. ncbi Predicting the response to recombinant human growth hormone in Turner syndrome: KIGS models. KIGS International Board. Kabi International Growth Study
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Acta Paediatr Suppl 88:122-5. 1999
    ....
  29. ncbi Long-term treatment of growth hormone insensitivity syndrome with IGF-I. Results of the European Multicentre Study. The Working Group on Growth Hormone Insensitivity Syndromes
    M B Ranke
    University Children s Hospitals of Tübingen, Germany
    Horm Res 51:128-34. 1999
    ..If treatment is started at an early age, there is considerable potential for achieving height normalisation. The treatment modalities need to be optimized with respect to the growth-promoting and metabolic effects of IFG-I...
  30. ncbi Catch-up growth: new lessons for the clinician
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1257-66. 2002
    ....
  31. ncbi Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants
    Martin W Elmlinger
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 68:124-31. 2007
    ..The results provide further evidence that IGFBP-2 and IGF-II in breast milk are relevant factors for the early development of preterm infants...
  32. ncbi Growth during the first two years predicts pre-school height in children born with very low birth weight (VLBW): results of a study of 1,320 children in Germany
    Branko Trebar
    Paediatric Endocrinology Section, University Children s Hospital, D 72076 Tuebingen, Germany
    Pediatr Res 62:209-14. 2007
    ..65 SDS): 1st yr Ht SDS; change (2nd yr) in Ht and weight SDS; MPH SDS; 1st yr weight SDS; birth weight SDS. Thus, some AGA and SGA children born VLBW remain short and preventive strategies need to be developed for those at risk...
  33. ncbi Prevalence of autoantibodies associated with thyroid and celiac disease in Ullrich-Turner syndrome in relation to adult height after growth hormone treatment
    Markus Bettendorf
    University Children s Hospital, Heidelberg, Germany
    J Pediatr Endocrinol Metab 19:149-54. 2006
    ..Therefore, medical care for patients with UTS should routinely include screening for these autoimmune disorders in order to assure early detection and appropriate treatment...
  34. ncbi Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children
    Roland Schweizer
    Paediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076, Tubingen, Germany
    Bone 41:875-81. 2007
    ..Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength...
  35. ncbi Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition
    Roland Schweizer
    Pediatric Endocrinology Section, University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:2978-83. 2008
    ..They also face a high risk of the metabolic syndrome developing after childhood. It is not known whether low muscle mass influences muscle function...
  36. ncbi Age-dependency of insulin-like growth factors, insulin-like growth factor-binding proteins, and acid labile subunit in plasma and wounds of surgical patients
    Corinna Wicke
    Department of Surgery, Pediatric Endocrinology Section of the Children s Hospital, and BG Trauma Center, University of Tubingen, Tubingen, Germany
    Wound Repair Regen 10:360-5. 2002
    ..The current data adds to accumulating evidence that a decline in the IGF system in aged patients contributes to the healing deficits observed in the elderly...
  37. ncbi Screening for insulin-like growth factor-I receptor mutations in patients with Silver-Russell syndrome
    Gerhard Binder
    University Children s Hospital and Growth Research Center, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1167-71. 2002
    ..Our data do not support the suggestion that the IGF-I receptor is frequently involved in the pathogenesis of SRS...
  38. ncbi IGFs, IGFBPs, IGF-binding sites and biochemical markers of bone metabolism during differentiation in human pulp fibroblasts
    Katharina M Reichenmiller
    Department of Conservative Dentistry, School of Dental Medicine at the University of Tübingen, Germany
    Horm Res 62:33-9. 2004
    ..To investigate the role of the insulin-like growth factors (IGF) system during the differentiation of human pulp-derived fibroblasts (HPF)...
  39. ncbi SHOX haploinsufficiency and Leri-Weill dyschondrosteosis: prevalence and growth failure in relation to mutation, sex, and degree of wrist deformity
    Gerhard Binder
    Section of Pediatric Endocrinology, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 89:4403-8. 2004
    ..No statistically significant effects of type of mutation, age of menarche, or sex on height were observed. The effect of GH therapy varied between individuals and needs to be examined in controlled studies...
  40. ncbi Predicting the response to growth hormone treatment in short children with chronic kidney disease
    Otto Mehls
    Division of Pediatric Nephrology, University Hospital for Children and Adolescents, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 95:686-92. 2010
    ..The model will help in identifying nonresponders and to tailor treatment strategies...
  41. ncbi Ketoacidosis at onset of type 1 diabetes mellitus in children--frequency and clinical presentation
    Andreas Neu
    University of Tuebingen, University Children s Hospital, Hoppe Seyler Str 1, 72076, Tubingen, Germany
    Pediatr Diabetes 4:77-81. 2003
    ..Since 1987, patients with newly diagnosed diabetes mellitus type 1 under 15 yr of age have been registered in Baden-Wuerttemberg (BW), Germany...
  42. ncbi Growth hormone-induced increases in skeletal muscle mass alleviates the associated insulin resistance in short children born small for gestational age, but not with growth hormone deficiency
    David D Martin
    University Children s Hospital, Tubingen, Germany
    Horm Res 72:38-45. 2009
    ....
  43. ncbi Insulin tolerance test causes hypokalaemia and can provoke cardiac arrhythmias
    Gerhard Binder
    University Children s Hospital, Tubingen, Germany
    Horm Res 62:84-7. 2004
    ..In addition, in the case of a comatose child during ITT the determination of the glucose and potassium level as well as adequate treatment are necessary...
  44. ncbi Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)
    Martin W Elmlinger
    Pediatric Endocrinology, University Children s Hospital, Tuebingen, Germany
    Clin Chem Lab Med 42:654-64. 2004
    ..5th centile. In conclusion, the automated IMMULITE IGF-I and IGFBP-3 assays are reliable tools in the diagnosis of pathologies of the GH/IGF axis and in the follow-up of their therapies...
  45. ncbi The endocrine phenotype in silver-russell syndrome is defined by the underlying epigenetic alteration
    Gerhard Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Str 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 93:1402-7. 2008
    ..Around 50% of children with Silver-Russell syndrome (SRS) carry a hypomethylation of the imprinting control region 1 at the IGF2/H19 locus on 11p15, the functional significance of which is unknown...
  46. ncbi Assessment of relevant hepatic steatosis in obese adolescents by rapid fat-selective GRE imaging with spatial-spectral excitation: a quantitative comparison with spectroscopic findings
    Fabian Springer
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Eur Radiol 21:816-22. 2011
    ..To test the feasibility of fat-selective GRE imaging using a spectral-spatial excitation technique for determination of intrahepatic lipid content (IHL) in obese adolescents...
  47. ncbi Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adul
    Martin W Elmlinger
    University Children s Hospital, Paediatric Endocrinology Section, Tuebingen, Germany
    Clin Chem Lab Med 40:1151-60. 2002
    ..Our findings agree with earlier studies. The calculated reference intervals can be used to assess the development of children, particularly for measurements performed by the Immulite and Immulite 2000 chemiluminescence assay systems...
  48. ncbi Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0-20 years
    Andreas Neu
    University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Pediatr Diabetes 10:468-73. 2009
    ....
  49. ncbi The early dehydroepiandrosterone sulfate rise of adrenarche and the delay of pubarche indicate primary ovarian failure in Turner syndrome
    David D Martin
    University Children's Hospital, D-72076 Tuebingen, Germany
    J Clin Endocrinol Metab 89:1164-8. 2004
    ..These data demonstrate that normal timing of adrenarche is dependent on gonadal function and suggest that normal pubarche is the clinical manifestation of the ovarian conversion of DHEAS to active androgens...
  50. ncbi Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome
    Gerhard Binder
    University Children s Hospital Tuebingen, Pediatric Endocrinology Section, Tuebingen, Germany
    Clin Endocrinol (Oxf) 68:567-72. 2008
    ..Here, we studied the long-term effect of GH therapy in Turner syndrome in correlation to this polymorphism...
  51. ncbi Pilot study of elevated levels of insulin-like growth factor-binding protein-2 as indicators of hepatocellular carcinoma
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 60:174-80. 2003
    ..Our aim was to evaluate the role of IGFBP-2 levels together with insulin-like growth factor (IGF)-I, IGF-II and IGFBP-3 in the diagnostic work-up of patients with hepatocellular carcinoma (HCC)...
  52. ncbi Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: results of the German IGLU Follow-up Study 2001
    Helmuth G Doerr
    University Hospital for Children and Adolescents, Erlangen, Germany
    Hum Reprod 20:1418-21. 2005
    ..To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment...
  53. ncbi Incidence of diabetes mellitus among children of Italian migrants substantiates the role of genetic factors in the pathogenesis of type 1 diabetes
    Stefan Ehehalt
    University Hospital for Children and Adolescents, Hoppe Seyler Strasse 1, 72076 Tuebingen, Germany
    Eur J Pediatr 168:613-7. 2009
    ....
  54. ncbi Central laboratory reassessment of IGF-I, IGF-binding protein-3, and GH serum concentrations measured at local treatment centers in growth-impaired children: implications for the agreement between outpatient screening and the results of somatotropic axis
    Berthold P Hauffa
    Division of Pediatric Endocrinology and Diabetology, University Children s Hospital, Heidelberg, Germany
    Eur J Endocrinol 157:597-603. 2007
    ....
  55. ncbi Total pubertal growth and markers of puberty onset in adolescents with GHD: comparison between mathematical growth analysis and pubertal staging methods
    David D Martin
    Paediatric Endocrinology Section, University Children's Hospital, Hoppe-Seyler-Strasse 1, DE-72076 Tubingen, Germany
    Horm Res 63:95-101. 2005
    ..In our study, 40% of TPG occurred before "breast stage B2" was attained in GHD girls; whereas 23% of TPG occurred before "testes >3 ml" in GHD boys...
  56. ncbi Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry
    Johannes Roth
    University Children s Hospital, Tuebingen, Germany
    Arthritis Rheum 50:1277-85. 2004
    ..This study was undertaken to obtain a more detailed understanding of the musculoskeletal system in JIA by analyzing bone density, bone geometry, and muscle force as the most important factor in bone development...
  57. ncbi Structural analysis of human growth hormone with respect to the dominant expression of growth hormone (GH) mutations in isolated GH deficiency type II
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen Germany
    Endocrinology 146:1411-7. 2005
    ..The inhibitory effect of GH mutants on heterologously expressed, non-GH proteins suggests that the dominant negative effect is not limited to GH or to proteins of the regulated secretory pathway, but may depend on expression levels...
  58. ncbi In vitro analysis of hGH secretion in the presence of mutations of amino acids involved in zinc binding
    Daniel I Iliev
    Pediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    J Mol Endocrinol 39:163-7. 2007
    ..Our in vitro data do not support the hypothesis of disturbed Zn(2+) binding as a major pathogenetic mechanism in dominantly transmitted GH deficiency...
  59. ncbi Central reassessment of GH concentrations measured at local treatment centers in children with impaired growth: consequences for patient management
    Berthold P Hauffa
    Department of Pediatric Hematology Oncology and Endocrinology, University Children s Hospital, Essen, Germany
    Eur J Endocrinol 150:291-7. 2004
    ....
  60. ncbi Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature
    Gerhard Binder
    University Children s Hospital, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 88:4891-6. 2003
    ..Our observations suggest that it is rational to limit SHOX mutation screening to children with an extremities-trunk ratio less than 1.95 + 1/2 height (m) and to add a critical judgment of the hand radiography...
  61. ncbi Automatic determination of left- and right-hand bone age in the First Zurich Longitudinal Study
    David D Martin
    University Children s Hospital, Tubingen, Germany
    Horm Res Paediatr 74:50-5. 2010
    ..The aim was to study the average difference of automated BoneXpert BA determination (left- vs. right-hand) for normal children, examine the precision of automatic BA and provide a BA reference for normal Caucasian children...
  62. ncbi MR imaging and spectroscopy of a tuber cinereum hamartoma in a patient with growth hormone deficiency and hypogonadotropic hypogonadism
    David D Martin
    Section for Pediatric Endocrinology, University of Tubingen, 72076 Tubingen, Germany
    AJNR Am J Neuroradiol 24:1177-80. 2003
    ..This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used...
  63. ncbi Clinical application of automated Greulich-Pyle bone age determination in children with short stature
    David D Martin
    Paediatric Endocrinology Section, University Children s Hospital, Tuebingen, Germany
    Pediatr Radiol 39:598-607. 2009
    ..Bone age (BA) rating is time consuming and highly rater dependent...
  64. ncbi IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T
    Klaus W Frommer
    Pediatric Endocrinology Section, University Children s Hospital, 72076 Tuebingen, Germany
    J Mol Endocrinol 37:13-23. 2006
    ..Our results suggest that IGFBP-2-induced gene expressions are of functional significance for proliferation, cell adhesion, cell migration and apoptosis, and showed that IGFBP-2 can promote apoptosis in tumor cells independent of IGF...