Hans Georg Rammensee

Summary

Country: Germany

Publications

  1. pmc HLA ligandome tumor antigen discovery for personalized vaccine approach
    Hans Georg Rammensee
    Department of Immunology, Institute of Cell Biology, and German Cancer Consortium DKTK, German Cancer Research Center DKFZ Partner Site Tübingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Expert Rev Vaccines 12:1211-7. 2013
  2. pmc The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules
    R Obst
    Department of Immunology, Institute for Cell Biology, University of Tubingen, D 72076 Tubingen, Germany
    J Exp Med 191:805-12. 2000
  3. ncbi request reprint SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
  4. ncbi request reprint Towards patient-specific tumor antigen selection for vaccination
    Hans Georg Rammensee
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Immunol Rev 188:164-76. 2002
  5. ncbi request reprint Some considerations on the use of peptides and mRNA for therapeutic vaccination against cancer
    Hans Georg Rammensee
    Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Eberhard Karls Universitat, Tubingen, Germany
    Immunol Cell Biol 84:290-4. 2006
  6. ncbi request reprint Identification of C-met oncogene as a broadly expressed tumor-associated antigen recognized by cytotoxic T-lymphocytes
    Kerstin Schag
    Department of Hematology, Oncology and Immunology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 10:3658-66. 2004
  7. ncbi request reprint Induction of adipophilin-specific cytotoxic T lymphocytes using a novel HLA-A2-binding peptide that mediates tumor cell lysis
    Susanne M Schmidt
    University of Tubingen, Department of Hematology, Tuebingen, Germany
    Cancer Res 64:1164-70. 2004
  8. ncbi request reprint Immunostimulating capacities of stabilized RNA molecules
    Birgit Scheel
    CureVac GmbH, Tubingen, Germany
    Eur J Immunol 34:537-47. 2004
  9. ncbi request reprint MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue
    Björn F Krämer
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    Cancer Biol Ther 4:943-8. 2005
  10. ncbi request reprint Integrated functional genomics approach for the design of patient-individual antitumor vaccines
    Toni Weinschenk
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    Cancer Res 62:5818-27. 2002

Detail Information

Publications117 found, 100 shown here

  1. pmc HLA ligandome tumor antigen discovery for personalized vaccine approach
    Hans Georg Rammensee
    Department of Immunology, Institute of Cell Biology, and German Cancer Consortium DKTK, German Cancer Research Center DKFZ Partner Site Tübingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Expert Rev Vaccines 12:1211-7. 2013
    ..Such antigens, however, may specifically appear in very few patients or may be mutated appearing just in one patient. Therefore, to target these in a molecularly defined way, the approach has to be individualized. ..
  2. pmc The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules
    R Obst
    Department of Immunology, Institute for Cell Biology, University of Tubingen, D 72076 Tubingen, Germany
    J Exp Med 191:805-12. 2000
    ..In consequence, allorestricted, peptide-specific T cells (that are of interest for clinical applications) are easier to obtain if T cells and target cells express related MHC molecules...
  3. ncbi request reprint SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
    ..Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only...
  4. ncbi request reprint Towards patient-specific tumor antigen selection for vaccination
    Hans Georg Rammensee
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Immunol Rev 188:164-76. 2002
    ..The scope of the present review is to explore the possibilities and the formidable technical and logistical challenge for such individual patient-oriented antigen definition to be used for therapeutic immunization...
  5. ncbi request reprint Some considerations on the use of peptides and mRNA for therapeutic vaccination against cancer
    Hans Georg Rammensee
    Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Eberhard Karls Universitat, Tubingen, Germany
    Immunol Cell Biol 84:290-4. 2006
    ..The potential use of peptides as minimal essential T-cell antigens and of mRNA as a novel form of antigen with advantages is discussed, with special consideration of practical aspects...
  6. ncbi request reprint Identification of C-met oncogene as a broadly expressed tumor-associated antigen recognized by cytotoxic T-lymphocytes
    Kerstin Schag
    Department of Hematology, Oncology and Immunology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 10:3658-66. 2004
    ..Using a DNA chip analysis of tumor samples from patients with renal cell carcinoma and sequencing of peptides bound to the HLA-A*0201 molecules on tumor cells a peptide derived from the c-Met protein was identified recently...
  7. ncbi request reprint Induction of adipophilin-specific cytotoxic T lymphocytes using a novel HLA-A2-binding peptide that mediates tumor cell lysis
    Susanne M Schmidt
    University of Tubingen, Department of Hematology, Tuebingen, Germany
    Cancer Res 64:1164-70. 2004
    ..Our results demonstrate that this peptide might represent an interesting candidate for the development of cancer vaccines designed to target adipophilin-derived epitopes in a wide range of malignancies...
  8. ncbi request reprint Immunostimulating capacities of stabilized RNA molecules
    Birgit Scheel
    CureVac GmbH, Tubingen, Germany
    Eur J Immunol 34:537-47. 2004
    ..We postulate that phosphorothioate RNA, which mimics trans-stabilized RNA, is a new PAMP...
  9. ncbi request reprint MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue
    Björn F Krämer
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    Cancer Biol Ther 4:943-8. 2005
    ..Ligands from MAGED4 could thus be interesting tumor-associated antigens in a subset of RCC, even though the identified ligand is presented by a rather rare allele...
  10. ncbi request reprint Integrated functional genomics approach for the design of patient-individual antitumor vaccines
    Toni Weinschenk
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    Cancer Res 62:5818-27. 2002
    ..We envision the use of this novel integrated functional genomics approach for the design of antitumor vaccines tailored to suit the needs of each patient...
  11. ncbi request reprint Lessons to be learned from primary renal cell carcinomas: novel tumor antigens and HLA ligands for immunotherapy
    Tobias Krüger
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Cancer Immunol Immunother 54:826-36. 2005
    ..This underlines the advantage of a personalized therapeutic approach. Further analyses will contribute additional HLA ligands to this repertoire of universal as well as patient-individual tumor antigens...
  12. ncbi request reprint Toll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA
    Birgit Scheel
    CureVac GmbH, Tubingen, Germany
    Eur J Immunol 35:1557-66. 2005
    ..The studies presented here explain the capacity of protamine-RNA to act as a vaccine, and pave the way towards the development of safe and efficient mRNA-based immunotherapies...
  13. ncbi request reprint Unexpected abundance of HLA class II presented peptides in primary renal cell carcinomas
    Jörn Dengjel
    Immatics Biotechnologies GmbH, University of Tubingen, Germany
    Clin Cancer Res 12:4163-70. 2006
    ....
  14. ncbi request reprint Identification of HLA ligands and T-cell epitopes for immunotherapy of lung cancer
    Anneke Neumann
    Department of Immunology, Interfaculty Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, Tubingen, 72076, Germany
    Cancer Immunol Immunother 62:1485-97. 2013
    ..g. peptide vaccines that are able to induce a CTL response against the tumor, might be a promising approach...
  15. ncbi request reprint MICA/NKG2D-mediated immunogene therapy of experimental gliomas
    Manuel A Friese
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Cancer Res 63:8996-9006. 2003
    ..These data commend MICA immunogene therapy as a novel experimental treatment for human malignant gliomas...
  16. doi request reprint Results of the first phase I/II clinical vaccination trial with direct injection of mRNA
    Benjamin Weide
    Department of Dermatology, Institute for Cell Biology, University of Tubingen, Germany
    J Immunother 31:180-8. 2008
    ..However, a demonstration of clinical effectiveness of direct injection of copy mRNA for antitumor immunotherapy was not shown in this study and must be evaluated in subsequent trials...
  17. ncbi request reprint Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Mol Cell Proteomics 6:102-13. 2007
    ....
  18. ncbi request reprint T cell avidity determines the level of CTL activation
    Matthias Hofmann
    Institute for Cell Biology, Department of Immunology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 34:1798-806. 2004
    ..Our model system now allows analysis of whether T cells with identical specificities but different avidities influence each other during activation and homeostatic proliferation...
  19. ncbi request reprint Cutting edge: predetermined avidity of human CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheres
    Steffen Walter
    Department of Immunology, Institute for Cell Biology, Division of Hematology and Oncology, University of Tubingen, Tubingen, Germany
    J Immunol 171:4974-8. 2003
    ..We believe that the possibility to raise Ag-specific T cells with predetermined avidity will be crucial for the future use of aAPCs in immunotherapeutical settings...
  20. ncbi request reprint Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
    Stefan A Welte
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Tubingen, Germany
    Eur J Immunol 33:194-203. 2003
    ..UL16-mediated reduction of NKG2DL cell surface density diminished NK cytotoxicity. Thus, UL16 functions by capturing activating ligands for cytotoxic lymphocytes that are synthesized in response to HCMV infection...
  21. ncbi request reprint Quantitative analysis of prion-protein degradation by constitutive and immuno-20S proteasomes indicates differences correlated with disease susceptibility
    Stefan Tenzer
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    J Immunol 172:1083-91. 2004
    ....
  22. ncbi request reprint Identification and characterization of T-cell epitopes deduced from RGS5, a novel broadly expressed tumor antigen
    Cristina N Boss
    Department of Oncology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 13:3347-55. 2007
    ..Interestingly, RGS5 was recently shown to be involved in tumor angiogenesis...
  23. ncbi request reprint Supraagonistic, bispecific single-chain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo
    Ludger Grosse-Hovest
    Institute for Cell Biology, Department of Immunology, Eberhard Karls University Tubingen, Tubingen, Germany
    Int J Cancer 117:1060-4. 2005
    ....
  24. doi request reprint Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients
    Melanie Widenmeyer
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen 72076, Germany
    Int J Cancer 131:140-9. 2012
    ..Thus, this HLA-DR restricted epitope is broadly immunogenic and should be valuable for stimulating T helper cells in patients suffering from a wide range of tumors...
  25. doi request reprint Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas
    Sebastian Attig
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Cancer Res 69:8412-9. 2009
    ..Additionally, several populations of CD4(+) and CD8(+) regulatory T cells were identified that may synergize to locally dampen antitumor T-cell responses...
  26. doi request reprint Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 38:1503-10. 2008
    ..Features of peptides presented independently of TAP as well as proteasomal contribution to their generation provide an insight into basic immunological mechanisms...
  27. doi request reprint Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and β1 integrin
    Britta Janina Wagner
    1Department of Immunology, University of Tubingen, Germany
    Int J Oncol 39:1593-600. 2011
    ..As an example of adhesion molecule down-regulating drugs, simvastatin may provide a novel therapeutic approach to the prevention of peritoneal carcinomatosis...
  28. doi request reprint A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    Cancer Res 68:2447-54. 2008
    ..In the future, T cells directed against VEGF as a tumor-associated antigen may represent a possible way of combining peptide-based anti-VEGF immunotherapy with already existent anti-VEGF cancer therapies...
  29. ncbi request reprint Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
    Helmut Rainer Salih
    Department of Internal Medicine II, University Hospital, Eberhard Karls University, Tubingen, Germany
    Blood 102:1389-96. 2003
    ..In addition, determination of sMICA and sMICB levels may be implemented as a prognostic parameter in patients with hematopoietic malignancies...
  30. doi request reprint Essential differences in ligand presentation and T cell epitope recognition among HLA molecules of the HLA-B44 supertype
    Nina Hillen
    Department of Immunology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 38:2993-3003. 2008
    ..Taken together, these results challenge the common paradigm of broadly presented epitopes within this supertype...
  31. doi request reprint Primary blood neutrophils express a functional cell surface Toll-like receptor 9
    Dennis Lindau
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 43:2101-13. 2013
    ..This pathway may be triggered when pathogen-derived TLR9 ligands cannot reach the endosome, offering a rescue mechanism for neutrophil activation. ..
  32. ncbi request reprint High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors
    Steffen Walter
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 35:2876-85. 2005
    ..Thus, cytokeratin 18-specific cells constitute a frequently encountered, new CD8+ T lymphocyte subpopulation without classical effector status and with so far unknown function...
  33. ncbi request reprint TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus
    Viktoria M Rönnefarth
    Department of Immunology, Interfaculty Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    J Immunol 177:7740-9. 2006
    ..Importantly, neutrophils have been suggested to link innate and adaptive immunity. Thus, nucleosomes trigger a previously unknown pathway of innate immunity, which may partially explain why peripheral tolerance is broken in SLE patients...
  34. ncbi request reprint Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
    Katrin Wiemann
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Immunol 175:720-9. 2005
    ....
  35. doi request reprint Novel multi-peptide vaccination in Hla-A2+ hormone sensitive patients with biochemical relapse of prostate cancer
    Susan Feyerabend
    Department of Urology, University of Tubingen, Germany
    Prostate 69:917-27. 2009
    ..A phase I/II trial was conducted to assess feasibility and tolerability of tumor associated antigen peptide vaccination in hormone sensitive prostate carcinoma (PC) patients with biochemical recurrence after primary surgical treatment...
  36. ncbi request reprint The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions
    Markus P Radsak
    University Medical Hospital, Department Hematology Oncology, University of Tubingen, Tubingen, Germany
    Blood 101:2810-5. 2003
    ..In conclusion, we demonstrate that Gp96 specifically binds to and activates PMNs and monocytes, extending the function of Gp96 as a danger signal to additional members of the innate immune system...
  37. ncbi request reprint Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation
    Patrice Decker
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    J Immunol 174:3326-34. 2005
    ..Altogether, these results strengthen the key role of nucleosomes in systemic lupus erythematosus and might explain how peripheral tolerance is broken in patients...
  38. ncbi request reprint SNEP: SNP-derived epitope prediction program for minor H antigens
    Mathias M Schuler
    Abteilung Immunologie, Interfakultäres Institut für Zellbiologie, Universitat Tubingen, Germany
    Immunogenetics 57:816-20. 2005
    ..The predictions are available for several human leucocyte antigen class I and class II allelic products, which allow for a rapid and precise evaluation of potential miHAgs within polymorphic antigens...
  39. ncbi request reprint Human platelets express heat shock protein receptors and regulate dendritic cell maturation
    Norbert Hilf
    Department of Immunology, University of Tubingen, Germany
    Blood 99:3676-82. 2002
    ..This effect might be of significance in wounds in which chronic inflammation and immune responses against autoantigens have to be prevented...
  40. ncbi request reprint Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA
    Birgit Scheel
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 36:2807-16. 2006
    ..In conclusion, RNA molecules are potent and safe danger signals that are relevant for active immunotherapy strategies aimed at the eradication of solid tumors...
  41. ncbi request reprint CD8+ T cells specific for a potential HLA-A*0201 epitope from Chlamydophila pneumoniae are present in the PBMCs from infected patients
    Jean Philippe Carralot
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Int Immunol 17:591-7. 2005
    ..Our studies pave the way to the immunomonitoring of the anti-Cpn CTL immune response present in patients suffering from different diseases potentially linked to Cpn or anti-Cpn immunity...
  42. ncbi request reprint Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry
    Jörn Dengjel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 34:3644-51. 2004
    ..This method will help in identifying peptide candidates for vaccination studies for tumor immunotherapy...
  43. ncbi request reprint Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells
    Despina Rudolf
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Cancer Immunol Immunother 57:175-83. 2008
    ..We present a highly defined APC platform using off-the-shelf reagents for the convenient generation of large numbers of antigen-specific CTLs...
  44. ncbi request reprint Moderate degradation does not preclude microarray analysis of small amounts of RNA
    Oliver Schoor
    University of Tubingen, Tubingen, Germany
    Biotechniques 35:1192-6, 1198-201. 2003
    ....
  45. pmc Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
    Jörn Dengjel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 102:7922-7. 2005
    ..Our study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4(+) T cell-mediated processes...
  46. ncbi request reprint Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling
    Verena S Meyer
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    J Immunol 181:6371-83. 2008
    ....
  47. ncbi request reprint Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
    Karin Schilbach
    University Children s Hospital Tubingen, Hoppe Seyler Str 1, D 72076 Tubingen, Germany
    Blood 106:144-9. 2005
    ..These findings indicate that aAPCs are attractive tools for the ex vivo generation of HA-1H-specific CTLs suitable for immunotherapy of relapsed leukemia...
  48. ncbi request reprint Immunotherapy of renal cell carcinoma
    Cecile Gouttefangeas
    Institute for Cell Biology, Department of Immunology, Eberhard Karls University, Auf der Morgenstelle 15, 72076, Tubingen, Germany
    Cancer Immunol Immunother 56:117-28. 2007
    ..Hopefully these will very soon contribute to an improvement in renal cell carcinoma specific immunotherapy and its evaluation...
  49. ncbi request reprint A CTL epitope from human cytomegalovirus IE1 defined by combining prediction of HLA binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation
    Holger Hebart
    Medizinische Klinik II, Institut fur Zellbiologie, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Exp Hematol 31:966-73. 2003
    ..In an attempt to define HCMV IE1-derived, HLA-A(*)0201-restricted epitopes, an advanced computer-based epitope prediction combining HLA binding and proteasomal cleavages in silico was performed...
  50. ncbi request reprint Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Blood 111:2152-4. 2008
    ..Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study...
  51. ncbi request reprint Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding
    Helmut R Salih
    Department of Internal Medicine II, University Hospital, Eberhard Karls University, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Immunol 169:4098-102. 2002
    ..Shedding of MICA by tumor cells may modulate NKG2D-mediated tumor immune surveillance. In addition, determination of soluble MICA levels may be implemented as an immunological diagnostic marker in patients with epithelial malignancies...
  52. doi request reprint Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells
    Yuko Yokoyama
    Department of Oncology, Hematology, Immunology, Rheumatology And Pulmology, University of Tubingen, Tubingen, Germany
    Clin Cancer Res 14:5503-11. 2008
    ..MMP-7 can promote cancer invasion and angiogenesis by proteolytic cleavage of extracellular matrix and basement membrane proteins, thus making it a promising target in the context of immunotherapies...
  53. pmc Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4-/CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis
    Andreas Oliver Weinzierl
    Department of Molecular Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    J Virol 82:8149-60. 2008
    ..We conclude that MHC-independent genetic factors involving DC-related IP-10 secretion and TLR3 expression are beneficial in the prevention of chronic coxsackievirus myocarditis...
  54. ncbi request reprint Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy
    Hermann Einsele
    Medizinische Klinik und Poliklinik, Abteilung II, Tubingen, Germany
    Blood 99:3916-22. 2002
    ..Hence, anti-CMV cellular therapy was successful in 5 of 7 patients, whereas in 2 of 7 patients, who received an intensified immune suppression at the time of or after T-cell therapy, only transient reductions in virus load were obtained...
  55. ncbi request reprint The non-classical HLA class I molecule HFE does not influence the NK-like activity contained in fresh human PBMCs and does not interact with NK cells
    Steve Pascolo
    Department of Immunology, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Int Immunol 17:117-22. 2005
    ..Moreover, using fluorescent HFE tetramers, we could confirm that blood NK cells as well as blood gammadelta T cells do not bind HFE. Altogether, our data indicate that HFE does not affect the NK activity contained in the PBMCs...
  56. ncbi request reprint The Tübingen approach: identification, selection, and validation of tumor-associated HLA peptides for cancer therapy
    Harpreet Singh-Jasuja
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076, Tubingen, Germany
    Cancer Immunol Immunother 53:187-95. 2004
    ..The aim is to develop effective immunotherapeutics consisting of multiple tumor-associated epitopes in order to induce a broad and specific immune response against cancer cells...
  57. pmc EpiToolKit--a web server for computational immunomics
    Magdalena Feldhahn
    Simulation of Biological Systems, Center for Bioinformatics, Institute for Cell Biology, Eberhard Karls University Tubingen, Germany
    Nucleic Acids Res 36:W519-22. 2008
    ..We illustrate the value of the approach with a set of novel tumor-associated peptides. EpiToolKit is available online at www.epitoolkit.org...
  58. ncbi request reprint The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway
    Ramunas M Vabulas
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    J Biol Chem 277:20847-53. 2002
    ..This feature explains the remarkable ability of Gp96 to induce specific immune responses against tumors and pathogens...
  59. doi request reprint miHA-Match: computational detection of tissue-specific minor histocompatibility antigens
    Magdalena Feldhahn
    University of Tubingen, Center for Bioinformatics, Applied Bioinformatics, Sand 14, 72076 Tubingen, Germany
    J Immunol Methods 386:94-100. 2012
    ..A comparison of our computational pipeline and experimentally derived datasets shows excellent agreement and coverage of the computationally predicted miHAs...
  60. doi request reprint Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction
    Maya Caroline André
    Department of Pediatric Hematology and Oncology, University Children s Hospital, Eberhard Karls University, Tubingen, Germany
    Int J Cancer 131:1601-10. 2012
    ....
  61. pmc Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation
    Sebastian P Haen
    Interfakultaeres Institut fuer Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, 72076, Tuebingen, Germany
    Cell Stress Chaperones 16:495-504. 2011
    ..Elevated heat shock protein 70 serum levels may constitute a biomarker for favorable clinical outcome...
  62. ncbi request reprint An impedance-based cytotoxicity assay for real-time and label-free assessment of T-cell-mediated killing of adherent cells
    Janet Kerstin Peper
    Department of Immunology, Institute of Cell Biology, University of Tubingen, and German Cancer Consortium, DKFZ Partner site Tübingen, Tubingen, Germany Electronic address
    J Immunol Methods 405:192-8. 2014
    ..05:1. The impedance-based assay represents a valuable and highly sensitive tool for label-free real-time high throughput analysis of T-cell-mediated cytotoxicity. ..
  63. doi request reprint Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    Steffen Walter
    Immatics Biotechnologies GmbH, Tubingen, Germany
    Nat Med 18:1254-61. 2012
    ..A randomized phase 3 study to determine the clinical benefit of treatment with IMA901 is ongoing. ..
  64. ncbi request reprint IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
    Cancer Immunol Immunother 58:153-7. 2009
    ..The levo-isoform (L-1MT) blocks IDO1, whereas dextro-1MT (D-1MT), which is used in clinical trials, inhibits IDO2. Here we analyze IDO2 expression in human cancer cells and the impact of both 1-MT isoforms on IDO activity...
  65. ncbi request reprint Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival
    Markus P Radsak
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tuebingen, Germany
    J Immunol 172:4956-63. 2004
    ..These results give a new perspective for the regulation of neutrophil inflammatory responses emphasizing the importance of TREM-1 in innate immunity...
  66. ncbi request reprint Plasmid DNA- and messenger RNA-based anti-cancer vaccination
    Benjamin Weide
    Department of Dermatology, University of Tubingen, Liebermeisterstrasse 25, Tubingen, Germany
    Immunol Lett 115:33-42. 2008
    ..Combining optimized MNAV formulations and parallel adjuvant treatments could allow to turn MNAV-based vaccines into efficient anti-tumor immunotherapies in humans...
  67. ncbi request reprint Glycan side chains on naturally presented MHC class II ligands
    Jörn Dengjel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, 72076 Tubingen, Germany
    J Mass Spectrom 40:100-4. 2005
    ....
  68. doi request reprint Identification of HLA-A*01- and HLA-A*02-restricted CD8+ T-cell epitopes shared among group B enteroviruses
    Andreas O Weinzierl
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Gen Virol 89:2090-7. 2008
    ..All four epitopes were homologous in 36-92% of group B enteroviruses, providing a strong basis for monitoring the divergence of T-cell-based immune responses in enterovirus-induced acute and chronic diseases...
  69. doi request reprint Ex vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein show a contracted specificity of T(HELPER) cells following stem cell transplantation
    Celine Serangeli
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karls University, Hoppe Seyler Strabetae 1, D 72076 Tubingen, Germany
    Virology 397:277-84. 2010
    ..The ex vivo detection of Hexon-specific CD4(+) T-cells, without any long-term culture in vitro, enables the detection and generation of HAdV-specific CD4(+) T cells for adoptive T-cell transfer against HAdV-infection post SCT...
  70. doi request reprint Tumor-associated MICA is shed by ADAM proteases
    Inja Waldhauer
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Cancer Res 68:6368-76. 2008
    ..Hence, therapeutic blockade of ADAM10 and ADAM17 seems promising for cancer treatment by targeting both growth and immune escape of tumors...
  71. pmc Glycoprotein 96-activated dendritic cells induce a CD8-biased T cell response
    Sabina Rayo Ramirez
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Cell Stress Chaperones 10:221-9. 2005
    ....
  72. doi request reprint Natural HLA class I ligands from glioblastoma: extending the options for immunotherapy
    Marian Christoph Neidert
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    J Neurooncol 111:285-94. 2013
    ....
  73. doi request reprint The mouse dendritic cell marker CD11c is down-regulated upon cell activation through Toll-like receptor triggering
    Harpreet Singh-Jasuja
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    Immunobiology 218:28-39. 2013
    ..Thus, activated mouse DC may be transiently CD11c-negative in vivo, hampering the identification of those cells. On the other hand, cell surface CD11c down-regulation may serve as a new activation marker for mouse DC...
  74. pmc Quantification of HLA class I molecules on renal cell carcinoma using Edman degradation
    Juliane S Stickel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Germany
    BMC Urol 11:1. 2011
    ..HLA loss or down-regulation have often been reported and might interfere with immunotherapeutic approaches aimed at the recognition of HLA-presented peptides...
  75. pmc Immune evasion by Yersinia enterocolitica: differential targeting of dendritic cell subpopulations in vivo
    Stella E Autenrieth
    Interfakultäres Institut für Zellbiologie, Universitat Tubingen, Tubingen, Germany
    PLoS Pathog 6:e1001212. 2010
    ..These events may contribute to reduced T-cell proliferation and immune evasion of Ye...
  76. ncbi request reprint Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma
    Jörg Wischhusen
    Laboratories of Molecular Neuro Oncology, Institute for Cell Biology, University of Tubingen, 72076 Tubingen, Germany
    Cancer Res 62:2592-9. 2002
    ..Thus, induction of B-cell and T-cell apoptosis via interactions of CD70 expressed on glioma cells and CD27 expressed on B and T cells may be a novel way for the immune escape of malignant gliomas...
  77. ncbi request reprint HLA ligand profiles of primary renal cell carcinoma maintained in metastases
    Juliane Sarah Stickel
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Cancer Immunol Immunother 58:1407-17. 2009
    ..Furthermore we were able to identify several peptides derived from tumor-associated antigens that are suitable for vaccination of metastatic RCC...
  78. ncbi request reprint Comparative analysis of volatile constituents from mice and their urine
    Frank Röck
    Institut fur Physikalische Chemie, Interfakultäres Institut für Zellbiologie, Universitat Tubingen, Germany
    J Chem Ecol 32:1333-46. 2006
    ..Because receptors for these aldehydes have been extensively characterized in the main olfactory organ, these components may be important for mice in recognizing their conspecifics...
  79. ncbi request reprint Nucleosomes induce lymphocyte necrosis
    Patrice Decker
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Eur J Immunol 33:1978-87. 2003
    ..Taken together, this is the first report indicating that nucleosomes are able to induce necrosis,which in turn could result in an amplification loop of the disease causing the inflammation observed in lupus patients...
  80. doi request reprint Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients
    Benjamin Weide
    Department of Dermatology, Division of Dermatooncology, University of Tubingen, Tubingen, Germany
    J Immunother 32:498-507. 2009
    ....
  81. doi request reprint Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus
    Dennis Lindau
    University of Tubingen, Institute for Cell Biology, Department of Immunology, Tubingen, Germany
    Eur J Immunol 41:669-81. 2011
    ..TLR9 may thus be differently required in the triggering of nucleosome-induced innate immunity and anti-nucleosome B-cell autoimmunity...
  82. ncbi request reprint Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus
    Patrice Decker
    Institute for Cell Biology, Department of Immunology, Auf der Morgenstelle 15, D 72076, Tubingen, Germany
    Rheumatology (Oxford) 45:1087-95. 2006
    ..As a consequence, we compared the activation state of human monocyte-derived DCs (MDDCs) obtained from lupus patients and normal individuals...
  83. doi request reprint Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons
    Theo Sturm
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Nat Commun 4:1616. 2013
    ..Hence, urinary peptides represent a real-time sampling of the expressed genome available for chemosensory assessment by other individuals...
  84. ncbi request reprint Peptide analysis, stability studies, and structural modeling explain contradictory peptide motifs and unique properties of the NOD mouse MHC class II molecule H2-A(g7)
    CHRISTIAN MUNZ
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 32:2105-16. 2002
    ..These results allow a better understanding of the role of this molecule in the development of autoimmunity and the identification of epitopes relevant to diabetes...
  85. doi request reprint NKp80 defines and stimulates a reactive subset of CD8 T cells
    Sabrina Kuttruff
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University Tubingen, Germany
    Blood 113:358-69. 2009
    ..Hence, NKp80 may enable effector memory CD8 T cells to interact functionally with cells of myeloid origin at sites of inflammation...
  86. doi request reprint Phagocytosis of dying tumor cells by human peritoneal mesothelial cells
    Britta Janina Wagner
    Department of Immunology, University of Tubingen, Tubingen 72076, Germany
    J Cell Sci 124:1644-54. 2011
    ..Our data strongly suggest that HMCs contribute to dying cell removal in the peritoneum, and future studies will elucidate in what manner this influences tumor cell dissemination and the antitumor immune response...
  87. doi request reprint Construction of optimized bispecific antibodies for selective activation of the death receptor CD95
    Tanja Herrmann
    Department of Immunology, University of Tubingen, Tubingen, Germany
    Cancer Res 68:1221-7. 2008
    ..We believe that these results may point the way to a successful application of bispecific CD95 antibodies in experimental tumor therapy...
  88. ncbi request reprint Peptides made to order
    Hans Georg Rammensee
    Department of Immunology, University of Tubingen, D 72076 Tubingen, Germany
    Immunity 25:693-5. 2006
    ..2006) in this issue of Immunity: The individual MHC molecule serves as a template for its own ligand...
  89. ncbi request reprint A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing
    Ludger Grosse-Hovest
    Institute for Cell Biology, Department of Immunology, University of Tubingen, Tubingen, Germany
    Eur J Immunol 33:1334-40. 2003
    ....
  90. doi request reprint Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
    Stefan Lob
    Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    Nat Rev Cancer 9:445-52. 2009
    ..A better understanding of IDO biology is needed to comprehend the effect of IDO inhibitors and to provide a rationale for their therapeutic application in cancer...
  91. pmc Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences
    Frank Röck
    Institut fur Physikalische Chemie, Interfakultäres Institut für Zellbiologie, Universitat Tubingen, Tubingen, Germany
    PLoS ONE 2:e429. 2007
    ....
  92. doi request reprint Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation
    Melanie Widenmeyer
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
    Int J Cancer 128:2653-62. 2011
    ..These findings suggest that in addition to the local control of tumor growth, RF ablation can provide the appropriate conditions for activating tumor-antigen specific immune responses...
  93. ncbi request reprint Identification of natural MHC class II presented phosphopeptides and tumor-derived MHC class I phospholigands
    Verena S Meyer
    Department of Immunology, Institute for Cell Biology, University of Tubingen, D 72076 Tubingen, Germany
    J Proteome Res 8:3666-74. 2009
    ..We further discovered the first natural phosphorylated MHC class II ligands. They revealed several novel phosphorylation sites of significant transmembrane receptors, such as Frizzled 6, CXCR4 and CD20...
  94. ncbi request reprint Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences and protection from rheumatoid arthritis
    Jan T Maier
    Department of Hematology and Oncology, Children s Hospital, University of Tubingen, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    Immunogenetics 54:67-73. 2002
    ..Thus, our results suggest a possible association of non-binding of HSP70 to HLA-DR molecules or its 70-74 fragments and protection from RA...
  95. ncbi request reprint CD8+ T-cell response against MUC1-derived peptides in gastrointestinal cancer survivors
    Jasmin Dittmann
    Department of Surgery, University Hospital, Tubingen, Germany
    Cancer Immunol Immunother 54:750-8. 2005
    ..Interestingly, the majority of these patients reacts to the two MUC1-derived HLA-A*0201 epitopes tested (14 from 16), demonstrating that this protein represents one dominant target for CD8+ T cells in gastrointestinal cancer...
  96. ncbi request reprint Immunoinformatics: bioinformatic strategies for better understanding of immune function. Introduction
    Hans Georg Rammensee
    Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Universitat Tubingen, Germany
    Novartis Found Symp 254:1-2. 2003
  97. ncbi request reprint Precursor frequency can compensate for lower TCR expression in T cell competition during priming in vivo
    Gerd Rechtsteiner
    Institute for Immunology, Johannes Gutenberg University, Mainz, Germany
    Eur J Immunol 36:2613-23. 2006
    ..A new model in which TCR density and precursor frequency define the outcome of a CTL response is discussed...
  98. ncbi request reprint Induction of HA-1-specific cytotoxic T-cell clones parallels the therapeutic effect of donor lymphocyte infusion
    Brigitte Kircher
    Laboratory for Tumour and Immunobiology, Bone Marrow Transplant Unit, Division of Haematology and Oncology, Department of Internal Medicine, Innsbruck University Hospital, Anichstrasse 35, 6020 Innsbruck, Austria
    Br J Haematol 117:935-9. 2002
    ..Our finding provides evidence of HA-1-associated GvL effects after DLI that paralleled the eradication of full-blown, chemotherapy-refractory ALL relapse after allogeneic SCT...
  99. ncbi request reprint Proteasome-assisted identification of a SSX-2-derived epitope recognized by tumor-reactive CTL infiltrating metastatic melanoma
    Maha Ayyoub
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital, Lausanne, Switzerland
    J Immunol 168:1717-22. 2002
    ....
  100. ncbi request reprint Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment
    Carmen Scheibenbogen
    Medizinische Klinik III, Hematology, Oncology and Transfusion Medicine, Universitaetsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Int J Cancer 98:409-14. 2002
    ....
  101. ncbi request reprint Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses
    Tobias Warger
    Institute of Immunology, University of Mainz, Obere Zahlbacherstrasse 67, 55131 Mainz, Germany
    J Biol Chem 281:22545-53. 2006
    ....