Gerardo Ramirez-Rodriguez

Summary

Country: Germany

Publications

  1. ncbi request reprint Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98101 1304, USA
    J Neurosci 28:3707-17. 2008
  2. ncbi request reprint Proliferative response of distinct hippocampal progenitor cell populations after cortical infarcts in the adult brain
    Albrecht Kunze
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Neurobiol Dis 21:324-32. 2006
  3. doi request reprint Seven principles in the regulation of adult neurogenesis
    Gerd Kempermann
    CRTD Center for Regenerative Therapies Dresden, and DZNE, German Center for Neurodegenerative Diseases, Dresden, Germany
    Eur J Neurosci 33:1018-24. 2011
  4. pmc Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    Alexander Garthe
    CRTD, Center for Regenerative Therapies Dresden, Dresden, Germany
    PLoS ONE 4:e5464. 2009
  5. pmc The mammalian adult neurogenesis gene ontology (MANGO) provides a structural framework for published information on genes regulating adult hippocampal neurogenesis
    Rupert W Overall
    CRTD Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e48527. 2012
  6. pmc Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
    Rupert W Overall
    Genomics of Regeneration, DFG Research Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Germany
    Front Neurosci 3:55. 2009
  7. pmc Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice
    Klaus Fabel
    CRTD DFG Research Center for Regenerative Therapies Dresden, Germany
    Front Neurosci 3:50. 2009
  8. pmc Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling
    Harish Babu
    Max Delbrück Center for Molecular Medicine Berlin Buch Berlin, Germany
    Front Neurosci 3:49. 2009
  9. pmc A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus
    Harish Babu
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Stanford, CA, USA
    Front Neurosci 5:89. 2011
  10. pmc Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
    Rolf Knoth
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e8809. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output
    Rebecca D Hodge
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98101 1304, USA
    J Neurosci 28:3707-17. 2008
    ..These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex...
  2. ncbi request reprint Proliferative response of distinct hippocampal progenitor cell populations after cortical infarcts in the adult brain
    Albrecht Kunze
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Neurobiol Dis 21:324-32. 2006
    ..The present study indicates that the proliferative response of precursor cell subpopulations in the subgranular zone might differ under physiological and pathophysiological conditions...
  3. doi request reprint Seven principles in the regulation of adult neurogenesis
    Gerd Kempermann
    CRTD Center for Regenerative Therapies Dresden, and DZNE, German Center for Neurodegenerative Diseases, Dresden, Germany
    Eur J Neurosci 33:1018-24. 2011
    ....
  4. pmc Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    Alexander Garthe
    CRTD, Center for Regenerative Therapies Dresden, Dresden, Germany
    PLoS ONE 4:e5464. 2009
    ..The discovery of highly specific behavioral deficits as consequence of a suppression of adult hippocampal neurogenesis thus allows to link cellular hippocampal plasticity to well-defined hypotheses from theoretical models...
  5. pmc The mammalian adult neurogenesis gene ontology (MANGO) provides a structural framework for published information on genes regulating adult hippocampal neurogenesis
    Rupert W Overall
    CRTD Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e48527. 2012
    ..Formal structure, such as provided by ontologies, is essential in any field for comprehensive interpretation of existing knowledge but, until now, such a structure has been lacking for adult neurogenesis...
  6. pmc Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
    Rupert W Overall
    Genomics of Regeneration, DFG Research Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Germany
    Front Neurosci 3:55. 2009
    ....
  7. pmc Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice
    Klaus Fabel
    CRTD DFG Research Center for Regenerative Therapies Dresden, Germany
    Front Neurosci 3:50. 2009
    ..We thus propose that physical activity can "prime" the neurogenic region of the dentate gyrus for increased neurogenesis in the case the animal is exposed to an additional cognitive stimulus, here represented by the enrichment paradigm...
  8. pmc Synaptic Network Activity Induces Neuronal Differentiation of Adult Hippocampal Precursor Cells through BDNF Signaling
    Harish Babu
    Max Delbrück Center for Molecular Medicine Berlin Buch Berlin, Germany
    Front Neurosci 3:49. 2009
    ..This suggests that activity-dependent stem cell differentiation within the hippocampal network is mediated via synaptically evoked BDNF signaling...
  9. pmc A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus
    Harish Babu
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University Stanford, CA, USA
    Front Neurosci 5:89. 2011
    ..We also highlight potential modifications to the protocol...
  10. pmc Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
    Rolf Knoth
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e8809. 2010
    ....
  11. pmc Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice
    Friederike Klempin
    ISCRM, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e25760. 2011
    ..DCX is thus, per se, no marker of neurogenesis but might be associated more broadly with plasticity...
  12. doi request reprint New neurons for 'survival of the fittest'
    Gerd Kempermann
    Center for Regenerative Therapies Dresden and the German Center for Neurodegenerative Diseases, Fetscherstraße 105, 01307 Dresden, Germany
    Nat Rev Neurosci 13:727-36. 2012
    ..Moving actively in a changing world and dealing with novelty and complexity regulate adult neurogenesis. New neurons might thus provide the cognitive adaptability to conquer ecological niches rich with challenging stimuli...
  13. doi request reprint [Physical activity and brain function]
    G Kempermann
    CRTD DFG Forschungszentrum für Regenerative Therapien Dresden, und Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Fetscherstrasse 105, Dresden, Germany
    Internist (Berl) 53:698-704. 2012
    ....
  14. pmc Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice
    Dan Ehninger
    DZNE German Center for Neurodegenerative Diseases, Bonn, Germany
    Cell Tissue Res 345:69-86. 2011
    ..The adult amygdala thus shows signs of mixed activity-dependent plasticity: reduced numbers of microglia and, presumably, an altered fate of NG2 cells...
  15. pmc Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, and Volkswagenstiftung Research Group, Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    Cell Commun Signal 8:12. 2010
    ..In addition we used cannabinoid receptor 1 (CB1) deficient mice and treatment with CB1 antagonist AM251 in Nestin-GFP-reporter mice to investigate the role of the CB1 receptor in adult neurogenesis in detail...
  16. doi request reprint The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
    Gerd Kempermann
    Genomics of Regeneration, CRTD Center for Regenerative Therapies Dresden, Tatzberg 47 49, 01307 Dresden, Germany
    Trends Neurosci 31:163-9. 2008
    ....
  17. ncbi request reprint The pessimist's and optimist's views of adult neurogenesis
    Gerd Kempermann
    CRTD, DFG Center for Regenerative Therapies Dresden, Tatzberg 47 49, 01307 Dresden, Germany
    Cell 145:1009-11. 2011
    ..in Cell Stem Cell) come to differing conclusions about whether and how the proliferation of radial glia-like stem cells of the adult hippocampus impacts their long-term potential for neurogenesis...
  18. doi request reprint The contribution of failing adult hippocampal neurogenesis to psychiatric disorders
    Gerd Kempermann
    Center for Regenerative Therapies Dresden, Technical University of Dresden, Dresden, Germany
    Curr Opin Psychiatry 21:290-5. 2008
    ..The level of evidence in favor of such hypotheses varies, but disturbed cellular plasticity in the hippocampus may be a common aspect of several neuropsychiatric diseases...
  19. pmc Tis21 expression marks not only populations of neurogenic precursor cells but also new postmitotic neurons in adult hippocampal neurogenesis
    Alessio Attardo
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cereb Cortex 20:304-14. 2010
    ..We hypothesize that this function is related to the final functional integration of the newborn neurons. Tis21 can thus serve as new marker for key stages of adult neurogenesis...
  20. pmc Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity
    Benedikt Römer
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:107. 2011
    ..In a second part of this study, published separately (Krebs et al., 2011) we have addressed the question of whether there is a shared genetics underlying both traits...
  21. doi request reprint Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease
    Sebastian Mirochnic
    Genomics of Regeneration in CNS, Center for Regenerative Therapies Dresden CRTD, Dresden, Germany
    Hippocampus 19:1008-18. 2009
    ..We thus propose that in this model, ENR even more than RUN might contribute to a "neurogenic reserve" despite a stable plaque load and that age affects the outcome of an interaction based on "activity."..
  22. pmc Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene
    Julia Krebs
    Genomics of Regeneration, Center for Regenerative Therapies Dresden Dresden, Germany
    Front Neurosci 5:106. 2011
    ..Despite explaining on its own very little of the variance in the highly multigenic traits studied, our results suggest Nos1 may play a part in the complex genetic control of adult neurogenesis and IMF morphology...
  23. ncbi request reprint Physical activity and the regulation of neurogenesis in the adult and aging brain
    Klaus Fabel
    Center for Regenerative Therapies Dresden, DFG Forschungszentrum und Exzellenzcluster, Tatzberg 47 49, 01307 Dresden, Germany
    Neuromolecular Med 10:59-66. 2008
    ..This would also explain why few new neurons could be beneficial for successful aging. We here review the current stage of the knowledge how this exercise-induced regulation of neurogenesis might work...
  24. doi request reprint Physical exercise increases Notch activity, proliferation and cell cycle exit of type-3 progenitor cells in adult hippocampal neurogenesis
    Moritz D Brandt
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    Eur J Neurosci 32:1256-64. 2010
    ..These pro-proliferative effects are independent of Notch1, whereas the running-induced survival and cell cycle exit of type-3 progenitor cells might by mediated by Notch1 activity...
  25. pmc Why and how physical activity promotes experience-induced brain plasticity
    Gerd Kempermann
    Center for Regenerative Therapies Dresden, German Research Foundation Dresden, Germany
    Front Neurosci 4:189. 2010
    ....
  26. ncbi request reprint Adult hippocampal neurogenesis and aging
    Friederike Klempin
    Volkswagen Research Group at the Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstr 21 22, 10117 Berlin, Germany
    Eur Arch Psychiatry Clin Neurosci 257:271-80. 2007
    ..e. the maintained potential for structural plasticity that allows compensation in situations of functional losses with aging. As such we propose that adult neurogenesis might contribute to the structural correlates of successful aging...
  27. ncbi request reprint Two genetic rat models of arterial hypertension show different mechanisms by which adult hippocampal neurogenesis is increased
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    Dev Neurosci 29:124-33. 2007
    ..However, in both SHR and SHRSP, cell proliferation showed an association with blood pressure recordings...
  28. ncbi request reprint Adult neurogenesis and neurodegenerative disease
    Barbara Steiner
    VolkswagenStiftung Research Group, Dept of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Regen Med 1:15-28. 2006
    ....
  29. ncbi request reprint Selective targeting of adenoviral vectors to neural precursor cells in the hippocampus of adult mice: new prospects for in situ gene therapy
    Anke Schmidt
    Department of Vector Technology and Experimental Gene Therapy, Biomedical Research Center, Schillingallee 69, D 18057 Rostock, Germany
    Stem Cells 25:2910-8. 2007
    ..Our approach represents a novel method for specific manipulation of NPC in the adult brain and may have major implications for the use of precursor cells as therapeutic delivery vehicles in the central nervous system...
  30. ncbi request reprint Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1
    Golo Kronenberg
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Brain Struct Funct 212:19-35. 2007
    ..We conclude that astrogenesis in CA1 is influenced by environmental conditions. However, SVZ precursor cells do not contribute to physiological cellular plasticity in CA1...
  31. pmc Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase
    Golo Kronenberg
    Klinik und Poliklinik fur Neurologie, Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Campus Mitte, D 10117 Berlin, Germany
    J Neurosci 28:7219-30. 2008
    ..These results indicate that impaired uracil repair is involved in neurodegeneration and neuropsychiatric dysfunction induced by experimental folate deficiency...
  32. pmc Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
    Tobias Plümpe
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Germany
    BMC Neurosci 7:77. 2006
    ..Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events...
  33. ncbi request reprint Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis
    Barbara Steiner
    Max Delbrück Center for Molecular Medicine Berlin Buch, 13125 Berlin Buch, Germany
    Glia 54:805-14. 2006
    ..Our data further support the existence of proliferative precursor cells that mark the transition between glia-like states and neuronal differentiation...
  34. ncbi request reprint Age-dependent expression of glucocorticoid- and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus
    Ana Garcia
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Aging Cell 3:363-71. 2004
    ..This course and variability of receptor expression in aging might help to explain differential vulnerability of adult neural precursor cells to corticoid-mediated influences...
  35. ncbi request reprint Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004
    ..The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development...
  36. ncbi request reprint Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Berlin, Germany
    Glia 46:41-52. 2004
    ....
  37. ncbi request reprint Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice
    Moritz D Brandt
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 24:603-13. 2003
    ..In these models the induction of cell proliferation was paralleled by an increase of CR-positive cells, indicating the stimulus-dependent progression from cell division to a postmitotic stage...
  38. ncbi request reprint A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input
    Li Ping Wang
    Cellular Neuroscience, Max Delbrueck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin, Germany
    Mol Cell Neurosci 29:181-9. 2005
    ..This early establishment of GABAergic innervation in adult neurogenesis thus mimics the pattern described for brain development...
  39. ncbi request reprint Neuroscience. Microglia: the enemy within?
    Gerd Kempermann
    Neuronal Stem Cells Research Group, Max Delbrück Centrum für Molekulare Medizin Berlin Buch, 13125 Berlin, Germany
    Science 302:1689-90. 2003
  40. ncbi request reprint Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Medicine, Berlin, Germany
    Exp Neurol 196:342-51. 2005
    ..Thus, seizure-generated neurons might contribute to the disease process of epilepsy...
  41. ncbi request reprint Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Neurobiol Aging 27:1505-13. 2006
    ..We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells...
  42. ncbi request reprint A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus
    Laurenz Wiskott
    Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    Hippocampus 16:329-43. 2006
    ..A simple network simulation demonstrates that adding new plastic neurons is indeed a successful strategy for adaptation without catastrophic interference...
  43. ncbi request reprint Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression
    Gerd Kempermann
    Max Delbrück Center for Molecular Medicine Berlin Buch, and Department of Experimental Neurology, Charite University Hospital, Humboldt University, Berlin, Germany
    Biol Psychiatry 54:499-503. 2003
    ..We therefore propose that consideration of the neurogenesis hypothesis of depression be the most prominent aspect of a more general cellular plasticity hypothesis...
  44. ncbi request reprint Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis
    Gerd Kempermann
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA
    Brain Res Dev Brain Res 134:1-12. 2002
    ..At the present time it cannot be determined whether this regulation occurs by influencing cell fate decisions or by promoting selective survival...
  45. ncbi request reprint Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression
    Gerd Kempermann
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, and Department of Neurology, Charite University Hospital, Humboldt University Berlin, Berlin, Germany
    Bipolar Disord 4:17-33. 2002
    ..While the 'neurogenic theory' of depression remains highly speculative today, it might stimulate the generation of sophisticated working hypotheses, useful animal experiments and the first step towards new therapeutic approaches...
  46. ncbi request reprint Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..Activity exerts not only an acute but also a sustained effect on brain plasticity...
  47. ncbi request reprint Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Development 130:391-9. 2003
    ..These new data suggest that new neurons are recruited early from the pool of proliferating progenitor cells and lead to a lasting effect of adult neurogenesis...
  48. ncbi request reprint Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, 13125 Berlin, Germany
    J Comp Neurol 467:455-63. 2003
    ..These findings allow us to break down what was broadly perceived as "proliferation" in earlier experiments into the relative contribution of several cell types, representing the earliest steps of neuronal development...
  49. ncbi request reprint Adult-born hippocampal neurons mature into activity-dependent responsiveness
    Sebastian Jessberger
    VolkswagenStiftung Research Group at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, Robert Rossle Str 10, D 13125 Berlin, Berlin Buch, Germany
    Eur J Neurosci 18:2707-12. 2003
    ..Thus, new neurons appear quantitatively integrated into hippocampal circuits, suggestive of a relevant contribution to hippocampal function...
  50. ncbi request reprint Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
    Jason Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Eur J Neurosci 17:2042-6. 2003
    ..The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus...
  51. ncbi request reprint Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes
    Vitali Filippov
    Max Delbrück Center for Molecular Medicine MDS Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Mol Cell Neurosci 23:373-82. 2003
    ....
  52. ncbi request reprint Adult hippocampal neurogenesis and voluntary running activity: circadian and dose-dependent effects
    Melissa M Holmes
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci Res 76:216-22. 2004
    ....
  53. ncbi request reprint Functional significance of adult neurogenesis
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch and Volkswagenstiftung Research Group at the Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Curr Opin Neurobiol 14:186-91. 2004
    ..Nevertheless, the information that has been obtained and published so far provides ample evidence that neurons generated in the adult can function and even suggests how they might contribute to cognitive processes...
  54. ncbi request reprint Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease
    Susanne A Wolf
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Charite University Medicine, Berlin, Germany
    Biol Psychiatry 60:1314-23. 2006
    ..Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD)...
  55. ncbi request reprint They are not too excited: the possible role of adult-born neurons in epilepsy
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Neuron 52:935-7. 2006
    ..Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe...
  56. ncbi request reprint Temporal and spatial dynamics of brain structure changes during extensive learning
    Bogdan Draganski
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Neurosci 26:6314-7. 2006
    ..These results indicate that the acquisition of a great amount of highly abstract information may be related to a particular pattern of structural gray matter changes in particular brain areas...
  57. pmc Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring
    Anika Bick-Sander
    Volkswagen Stiftung Research Group, Department of Experimental Neurology, Charite University Medicine, and Max Delbruck Center for Molecular Medicine, Berlin Buch, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:3852-7. 2006
    ..Our data indicate that maternal behavior and physical activity affects infantile growth-factor expression and can transiently stimulate postnatal hippocampal development in the offspring...
  58. pmc Natural variation and genetic covariance in adult hippocampal neurogenesis
    Gerd Kempermann
    Max Delbröck Center for Molecular Medicine, Berlin Buch, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:780-5. 2006
    ..The use of genetic reference panels coupled with phenotyping and global transcriptome profiling thus allowed insight into the complexity of the genetic control of adult neurogenesis...
  59. ncbi request reprint New neurons in the adult mammalian brain: synaptogenesis and functional integration
    Hongjun Song
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:10366-8. 2005
  60. ncbi request reprint Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease
    Barbara Steiner
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Exp Neurol 199:291-300. 2006
    ..Thus, physiological neurogenic and gliogenic stimuli induce significant microenvironmental changes in the adult SN and improve motor behavior in the 6-OHDA lesion model of PD...
  61. doi request reprint Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
    Michael Rohe
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    J Biol Chem 283:14826-34. 2008
    ..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients...
  62. ncbi request reprint Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia
    Golo Kronenberg
    Klinik und Poliklinik fur Neurologie, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    J Cereb Blood Flow Metab 25:1613-24. 2005
    ..We hypothesize that the change in physiologic properties induced by the ischemic insult is directed toward a specific function of nestin-expressing cells...
  63. ncbi request reprint Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells
    Jason G Emsley
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Edwards 410 EDR 410, 50 Blossom Street, Boston MA 02114, USA
    Prog Neurobiol 75:321-41. 2005
    ....
  64. ncbi request reprint Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival
    Rainer Glass
    Cellular Neuroscience Group, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Neurosci 25:2637-46. 2005
    ..Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging...
  65. ncbi request reprint Why new neurons? Possible functions for adult hippocampal neurogenesis
    Gerd Kempermann
    Research Group VolkswagenStiftung at the Department of Experimental Neurology, Charite University Hospital, Humboldt University Berlin, 10117 Berlin, Germany
    J Neurosci 22:635-8. 2002
  66. ncbi request reprint Role of endogenous neural stem cells in neurological disease and brain repair
    Jörg Dietrich
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Adv Exp Med Biol 557:191-220. 2006
    ..The following years will have to show how we can influence andmodulate endogenous repair nisms by increasing the cellular plasticity in the young and aged CNS...