Claudia E Rübe
Rübe C, Fricke A, Wendorf J, Stützel A, Kühne M, Ong M, et al
. Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation. Int J Radiat Oncol Biol Phys. 2010;76:1206-13 pubmed publisher
..Moreover, our data indicate that even minor impairments in DSB repair lead to exceeding DNA damage accumulation during fractionated irradiation and thus may have a significant impact on normal tissue responses in clinical radiotherapy. ..
Lorat Y, Brunner C, Schanz S, Jakob B, Taucher Scholz G, RÃ¼be C. Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy--the heavy burden to repair. DNA Repair (Amst). 2015;28:93-106 pubmed publisher
..Hence, the spacing and quantity of DSBs in clustered lesions influence DNA repair efficiency, and may determine the radiobiological outcome. ..
Grewenig A, Schuler N, RÃ¼be C. Persistent DNA Damage in Spermatogonial Stem Cells After Fractionated Low-Dose Irradiation of Testicular Tissue. Int J Radiat Oncol Biol Phys. 2015;92:1123-1131 pubmed publisher
..SSCs revealed elevated levels of DSBs for weeks after radiation, and if these DSBs persist through differentiation to spermatozoa, this may have severe consequences for the genomic integrity of the fertilizing sperm. ..
Timm S, Lorat Y, Jakob B, Taucher Scholz G, Rübe C. Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. Radiother Oncol. 2018;: pubmed publisher
..Clustered damage concentrated in particle trajectories causes persistent rearrangements in chromatin architecture, which may affect structural and functional organization of cell nuclei. ..
Lorat Y, Schanz S, Rübe C. Ultrastructural Insights into the Biological Significance of Persisting DNA Damage Foci after Low Doses of Ionizing Radiation. Clin Cancer Res. 2016;22:5300-5311 pubmed
..Multiple unrepaired DSBs account for large-sized foci in repair-deficient neurons, thus quantifying foci alone may underestimate extent and complexity of persistent DNA damage. Clin Cancer Res; 22(21); 5300-11. ©2016 AACR. ..
Lorat Y, Timm S, Jakob B, Taucher Scholz G, Rübe C. Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation. Radiother Oncol. 2016;121:154-161 pubmed publisher
..The clustering of DSBs in heterochromatin following high-LET irradiation perturbs efficient DNA repair, leading to greater biological effectiveness of high-LET irradiation versus that of low-LET irradiation. ..
Rübe C, Fricke A, Schneider R, Simon K, Kühne M, Fleckenstein J, et al
. DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities. Int J Radiat Oncol Biol Phys. 2010;78:359-69 pubmed publisher
..Phosphorylated H2AX analysis of blood samples allows one to detect DSB repair deficiencies and thus enables identification of children at risk for high-grade toxicities. ..