Zhihai Qin

Summary

Country: Germany

Publications

  1. ncbi request reprint Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors
    Zhihai Qin
    Institute of Immunology, Universitaetsklinikum Benjamin Franklin, Haus IA, Hindenburgdamm 30, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 62:2856-60. 2002
  2. ncbi request reprint A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells
    Zhihai Qin
    Institute of Immunology, University Clinic Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 63:4095-100. 2003
  3. pmc Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction
    Zhihai Qin
    Institute of Immunology, Free University Berlin, 12200 Berlin, Germany
    J Exp Med 195:1479-90. 2002
  4. ncbi request reprint Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells
    Hye Jung Kim
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Immunol 172:4037-47. 2004
  5. doi request reprint IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis
    Michael Rothe
    Institute of Immunology, Charite Campus Buch, 13125, Berlin, Germany
    Cancer Med 2:815-25. 2013
  6. ncbi request reprint The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Curr Opin Immunol 15:148-54. 2003
  7. ncbi request reprint Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells
    Jun Guo
    Institute of Immunology, Second Military Medical University, Shanghai, PR China
    Int J Cancer 103:212-20. 2003
  8. ncbi request reprint Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1
    Jun Guo
    Institute of Immunology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China
    Immunol Lett 89:1-7. 2003
  9. ncbi request reprint Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection
    Zhiguang Li
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    J Immunol 179:1568-76. 2007
  10. ncbi request reprint Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance
    Thomas Blankenstein
    Max Delbrück Centrum for Molecular Medicine, 13092 Berlin, Germany
    Adv Cancer Res 90:179-207. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumors
    Zhihai Qin
    Institute of Immunology, Universitaetsklinikum Benjamin Franklin, Haus IA, Hindenburgdamm 30, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 62:2856-60. 2002
    ..Thus, the lack of TAP1 expression did not change the immunogenicity of tumor cells. It may enable tumor cells to escape T-cell recognition during the effector phase of an antitumor immune response...
  2. ncbi request reprint A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells
    Zhihai Qin
    Institute of Immunology, University Clinic Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany
    Cancer Res 63:4095-100. 2003
    ..Taken together with our previous findings, we conclude that IFN-gamma-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4(+) and CD8(+) T-cell effectors...
  3. pmc Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction
    Zhihai Qin
    Institute of Immunology, Free University Berlin, 12200 Berlin, Germany
    J Exp Med 195:1479-90. 2002
    ..This mechanism is more efficient in the presence of IFN-gammaR. Our results indicates that inflammation and scarring, both suspected to contribute to malignancy, prevent cancer in certain situations...
  4. ncbi request reprint Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cells
    Hye Jung Kim
    Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
    J Immunol 172:4037-47. 2004
    ....
  5. doi request reprint IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis
    Michael Rothe
    Institute of Immunology, Charite Campus Buch, 13125, Berlin, Germany
    Cancer Med 2:815-25. 2013
    ..Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. ..
  6. ncbi request reprint The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis
    Thomas Blankenstein
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Curr Opin Immunol 15:148-54. 2003
    ..During MCA-induced tumorigenesis IFN-gamma is involved in the inhibition of MCA diffusion by encapsulation and reduction of DNA damage. This mechanism may primarily protect tissue from damage and simultaneously inhibit tumor development...
  7. ncbi request reprint Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells
    Jun Guo
    Institute of Immunology, Second Military Medical University, Shanghai, PR China
    Int J Cancer 103:212-20. 2003
    ..Our data suggested that FK gene transfer to tumor cells could induce T-cell-dependent antitumor immunity through chemoattraction and activation of DC...
  8. ncbi request reprint Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1
    Jun Guo
    Institute of Immunology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China
    Immunol Lett 89:1-7. 2003
    ....
  9. ncbi request reprint Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejection
    Zhiguang Li
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    J Immunol 179:1568-76. 2007
    ..Together, our results clearly illustrate how T cells cooperate with innate immune cells for IFN-gamma-mediated tumor rejection and this may have important indications for clinical trials of tumor immunotherapy...
  10. ncbi request reprint Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance
    Thomas Blankenstein
    Max Delbrück Centrum for Molecular Medicine, 13092 Berlin, Germany
    Adv Cancer Res 90:179-207. 2003
    ....
  11. ncbi request reprint Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18
    Terry H Wu
    Department of Pathology, Committee on Cancer Biology, Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    J Immunol 172:3243-51. 2004
    ..These results strongly suggest a novel function for the endogenous IFN-gamma pathway that without measurable IFN-gamma production or activity affects the ability of TNF to suppress tumor development...
  12. ncbi request reprint Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis
    Xueqiang Zhao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Cancer Res 67:4443-50. 2007
    ..Our results show for the first time that TNFR2 expressed on host innate immune cells is sufficient to mediate the antitumor effect of TNF, and NO is necessary for this process, possibly by inhibition of angiogenesis in the tumor...
  13. doi request reprint Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice
    Dmitry V Kuprash
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
    Cancer Lett 268:70-5. 2008
    ....
  14. ncbi request reprint A cancer immunosurveillance controversy
    Zhihai Qin
    Nat Immunol 5:3-4; author reply 4-5. 2004
  15. pmc Involvement of tumour necrosis factor-alpha-related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharide-stimulated dendritic cells to activated T cells
    Yizhi Yu
    Institute of Immunology, Second Military Medical University, Shanghai People s Republic of China
    Immunology 106:308-15. 2002
    ..Therefore, our results show that activation-induced cell death of T hybridoma cells can be influenced by DC, suggesting that DC may be involved in elimination of activated T cells at the end of primary immune responses...
  16. pmc Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
    Huazhang An
    Institute of Immunology, Second Military Medical University, Shanghai, China
    Immunology 106:38-45. 2002
    ..Up-regulation of TLR2, TLR4 and TLR9 expression by LPS might promote the overall responses of DC to bacteria and help to explain the synergy between LPS and other bacterial products in the induction of cytokine production...