Research Topics
| Zhihai QinSummaryCountry: Germany Publications
| Collaborators
|
Detail Information
Publications
Increased tumorigenicity, but unchanged immunogenicity, of transporter for antigen presentation 1-deficient tumorsZhihai Qin
Institute of Immunology, Universitaetsklinikum Benjamin Franklin, Haus IA, Hindenburgdamm 30, Free University of Berlin, 12200 Berlin, Germany
Cancer Res 62:2856-60. 2002..Thus, the lack of TAP1 expression did not change the immunogenicity of tumor cells. It may enable tumor cells to escape T-cell recognition during the effector phase of an antitumor immune response...
Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reactionZhihai Qin
Institute of Immunology, Free University Berlin, 12200 Berlin, Germany
J Exp Med 195:1479-90. 2002..This mechanism is more efficient in the presence of IFN-gammaR. Our results indicates that inflammation and scarring, both suspected to contribute to malignancy, prevent cancer in certain situations...- A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cellsZhihai Qin
Institute of Immunology, University Clinic Benjamin Franklin, Free University of Berlin, 12200 Berlin, Germany
Cancer Res 63:4095-100. 2003..Taken together with our previous findings, we conclude that IFN-gamma-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4(+) and CD8(+) T-cell effectors... - Establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin alpha and in the combined absence of functional B and T cellsHye Jung Kim
Institute of Immunology, Charite Campus Benjamin Franklin, Berlin, Germany
J Immunol 172:4037-47. 2004.... - Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1Jun Guo
Institute of Immunology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China
Immunol Lett 89:1-7. 2003.... - Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillanceThomas Blankenstein
, 13092 Berlin, Germany
Adv Cancer Res 90:179-207. 2003.... - Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasisXueqiang Zhao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Cancer Res 67:4443-50. 2007..Our results show for the first time that TNFR2 expressed on host innate immune cells is sufficient to mediate the antitumor effect of TNF, and NO is necessary for this process, possibly by inhibition of angiogenesis in the tumor... - The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesisThomas Blankenstein
Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
Curr Opin Immunol 15:148-54. 2003..During MCA-induced tumorigenesis IFN-gamma is involved in the inhibition of MCA diffusion by encapsulation and reduction of DNA damage. This mechanism may primarily protect tissue from damage and simultaneously inhibit tumor development... - Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cellsJun Guo
Institute of Immunology, Second Military Medical University, Shanghai, PR China
Int J Cancer 103:212-20. 2003..Our data suggested that FK gene transfer to tumor cells could induce T-cell-dependent antitumor immunity through chemoattraction and activation of DC... - Cross-talk between T cells and innate immune cells is crucial for IFN-gamma-dependent tumor rejectionZhiguang Li
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
J Immunol 179:1568-76. 2007..Together, our results clearly illustrate how T cells cooperate with innate immune cells for IFN-gamma-mediated tumor rejection and this may have important indications for clinical trials of tumor immunotherapy... - Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18Terry H Wu
Department of Pathology, Committee on Cancer Biology, Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
J Immunol 172:3243-51. 2004..These results strongly suggest a novel function for the endogenous IFN-gamma pathway that without measurable IFN-gamma production or activity affects the ability of TNF to suppress tumor development... - A cancer immunosurveillance controversyZhihai Qin
Nat Immunol 5:3-4; author reply 4-5. 2004 - Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cellsHuazhang An
Institute of Immunology, Second Military Medical University, Shanghai, China
Immunology 106:38-45. 2002..Up-regulation of TLR2, TLR4 and TLR9 expression by LPS might promote the overall responses of DC to bacteria and help to explain the synergy between LPS and other bacterial products in the induction of cytokine production... - Involvement of tumour necrosis factor-alpha-related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharide-stimulated dendritic cells to activated T cellsYizhi Yu
Institute of Immunology, Second Military Medical University, Shanghai People's Republic of China
Immunology 106:308-15. 2002..Therefore, our results show that activation-induced cell death of T hybridoma cells can be influenced by DC, suggesting that DC may be involved in elimination of activated T cells at the end of primary immune responses... 
Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient miceDmitry V Kuprash
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia
Cancer Lett 268:70-5. 2008....