Tassula Proikas-Cezanne

Summary

Country: Germany

Publications

  1. pmc Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition
    Anja Gaugel
    From the Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tuebingen, Auf der Morgenstelle 15, 72076, Tuebingen, Germany
    J Mol Signal 7:16. 2012
  2. ncbi request reprint WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
    Tassula Proikas-Cezanne
    Department of Molecular Biology, Institute for Cell Biology, University of Tuebingen, Auf der Morgenstelle 15, Tuebingen, Germany
    Oncogene 23:9314-25. 2004
  3. doi request reprint Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tuebingen, Tubingen, Germany
    J Cell Mol Med 15:2007-10. 2011
  4. doi request reprint Assessing mammalian autophagy by WIPI-1/Atg18 puncta formation
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Methods Enzymol 452:247-60. 2009
  5. ncbi request reprint Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
    FEBS Lett 581:3396-404. 2007
  6. ncbi request reprint Rab14 is part of the early endosomal clathrin-coated TGN microdomain
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, Institute for Cell Biology, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
    FEBS Lett 580:5241-6. 2006
  7. pmc Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation
    Mario Mauthe
    Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany
    Autophagy 7:1448-61. 2011
  8. doi request reprint Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy
    Simon G Pfisterer
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tuebingen, Tuebingen, Germany
    Mol Pharmacol 80:1066-75. 2011
  9. pmc WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation
    Mario Mauthe
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Int J Cell Biol 2012:179207. 2012
  10. doi request reprint WIPI β-propellers in autophagy-related diseases and longevity
    Daniela Bakula
    Autophagy Laboratory, Interfaculty Institute of Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, D 72076 Tübingen, Germany
    Biochem Soc Trans 41:962-7. 2013

Collaborators

  • Horst Robenek
  • Patrice Codogno
  • York Dieter Stierhof
  • Claus Garbe
  • Birgit Schittek
  • Dirk Schadendorf
  • Mario Mauthe
  • Daniela Bakula
  • Anja Gaugel
  • Simon G Pfisterer
  • Heike Niessner
  • Zsuzsanna Takacs
  • Friedrich Götz
  • Anneliese Hoffmann
  • Wenqi Yu
  • Oleg Krut
  • Martin Kronke
  • Dagmar Kulms
  • Tobias Sinnberg
  • Jeannette Gogel
  • Alexander Berger
  • Sandra Freiberger
  • Konstantinos Lasithiotakis
  • Mahmoud Toulany
  • Anke Jacob
  • Evelyn Maczey
  • Keith Flaherty
  • Sascha Venturelli
  • Katharina Hentschel
  • Martin Schaller
  • Friedegund Meier
  • Daniela Beck

Detail Information

Publications11

  1. pmc Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition
    Anja Gaugel
    From the Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute of Cell Biology, Eberhard Karls University Tuebingen, Auf der Morgenstelle 15, 72076, Tuebingen, Germany
    J Mol Signal 7:16. 2012
    ..abstract:..
  2. ncbi request reprint WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
    Tassula Proikas-Cezanne
    Department of Molecular Biology, Institute for Cell Biology, University of Tuebingen, Auf der Morgenstelle 15, Tuebingen, Germany
    Oncogene 23:9314-25. 2004
    ..Our data suggest that WIPI proteins share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers...
  3. doi request reprint Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tuebingen, Tubingen, Germany
    J Cell Mol Med 15:2007-10. 2011
    ..Hence therapeutic modulation of autophagy could involve approaches that functionally target human WIPI proteins...
  4. doi request reprint Assessing mammalian autophagy by WIPI-1/Atg18 puncta formation
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tubingen, Tubingen, Germany
    Methods Enzymol 452:247-60. 2009
    ..Here we present an experimental step-to-step guide for assaying WIPI-1 puncta formation in human cells by confocal microscopy, live-cell imaging, and phosphoinositide binding...
  5. ncbi request reprint Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
    FEBS Lett 581:3396-404. 2007
    ..WIPI-1 puncta-formation is inhibited by wortmannin and LY294002, and PI(3)P-binding-deficient WIPI-1 is puncta-formation-incompetent. Quantification of WIPI-1 puncta should be suitable to assay mammalian autophagy...
  6. ncbi request reprint Rab14 is part of the early endosomal clathrin-coated TGN microdomain
    Tassula Proikas-Cezanne
    Autophagy Laboratory, Department of Molecular Biology, Institute for Cell Biology, University of Tuebingen, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
    FEBS Lett 580:5241-6. 2006
    ..We suggest that the AP-1 microdomain represents the interconnecting compartment in which Rab14 vesicles cycle between early endosomes and the Golgi cisternae...
  7. pmc Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation
    Mario Mauthe
    Autophagy Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Tuebingen, Germany
    Autophagy 7:1448-61. 2011
    ....
  8. doi request reprint Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy
    Simon G Pfisterer
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tuebingen, Tuebingen, Germany
    Mol Pharmacol 80:1066-75. 2011
    ..Our data also suggest that AMPKα(1)/α(2) might differentially contribute to the regulation of WIPI-1 at the onset of autophagy...
  9. pmc WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation
    Mario Mauthe
    Autophagy Laboratory, Interfaculty Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Int J Cell Biol 2012:179207. 2012
    ..We suggest that invading S. aureus cells become entrapped in autophagosome-like WIPI-1 positive vesicles targeted for lysosomal degradation in nonprofessional host cells...
  10. doi request reprint WIPI β-propellers in autophagy-related diseases and longevity
    Daniela Bakula
    Autophagy Laboratory, Interfaculty Institute of Cell Biology, Eberhard Karls University Tübingen, Auf der Morgenstelle 15, D 72076 Tübingen, Germany
    Biochem Soc Trans 41:962-7. 2013
    ..We also discuss the PtdIns(3)P effector function of WIPIs in the context of longevity and autophagy-related human diseases, such as cancer and neurodegeneration. ..
  11. doi request reprint The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells
    Heike Niessner
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    J Invest Dermatol 131:468-79. 2011
    ..Together, these findings suggest that the FTI lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells and may therefore represent an effective alternative for melanoma treatment...