Guido Posern

Summary

Country: Germany

Publications

  1. pmc Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor
    Guido Posern
    Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, Transcription Laboratory, London WC2A 3PX, United Kingdom
    Mol Biol Cell 13:4167-78. 2002
  2. ncbi request reprint Actin' together: serum response factor, its cofactors and the link to signal transduction
    Guido Posern
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Trends Cell Biol 16:588-96. 2006
  3. pmc Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
    Kristin Katsch
    Institut fur Klinische und Molekulare Virologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Cell Commun Signal 10:5. 2012
  4. doi request reprint MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins
    Laura Leitner
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Sci 124:4318-31. 2011
  5. pmc Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
    Laura Leitner
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Mol Cancer 9:60. 2010
  6. doi request reprint E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells
    Stephan Busche
    Department of Molecular Biology, AG Regulation of Gene Expression, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Sci 123:2803-9. 2010
  7. doi request reprint Myocardin-related transcription factor A regulates expression of Bok and Noxa and is involved in apoptotic signalling
    Dmitry Shaposhnikov
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell Cycle 11:141-50. 2012
  8. doi request reprint Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction
    Arnaud Descot
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Cell 35:291-304. 2009
  9. pmc OTT-MAL is a deregulated activator of serum response factor-dependent gene expression
    Arnaud Descot
    Max Planck Institute of Biochemistry, Department of Molecular Biology, Martinsried, Germany
    Mol Cell Biol 28:6171-81. 2008
  10. doi request reprint A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription
    Sina Stern
    Neuronal Gene Expression Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, Tubingen, Germany
    J Neurosci 29:4512-8. 2009

Collaborators

  • Reinhard Hoffmann
  • Laura Leitner
  • Richard Treisman
  • Sina Stern
  • Bernd Knöll
  • Axel Ullrich
  • Harald Genth
  • Arnaud Descot
  • Stephan Busche
  • Dmitry Shaposhnikov
  • Kristin Katsch
  • Susanne Muehlich
  • Francesc Miralles
  • Brigitte Biesinger
  • Sarah Jill de Jong
  • Julia Steger
  • Johannes Schilling
  • Jens Christian Albrecht
  • Elisabeth Kremmer
  • Markus Reschke
  • Antje Menssen
  • Monika Rex-Haffner
  • Geneviève Courtois
  • Sylvia Julien
  • Olivier A Bernard
  • Thomas Mercher
  • Dominique Bluteau
  • Margarete Goppelt-Struebe
  • Bettina Krueger
  • Christoph D Garlichs
  • Iwona Cicha
  • Alexia Ileana Zaromytidou

Detail Information

Publications14

  1. pmc Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor
    Guido Posern
    Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, Transcription Laboratory, London WC2A 3PX, United Kingdom
    Mol Biol Cell 13:4167-78. 2002
    ..Taken together, these results provide strong evidence that G-actin, or a subpopulation of it, plays a direct role in signal transduction to SRF...
  2. ncbi request reprint Actin' together: serum response factor, its cofactors and the link to signal transduction
    Guido Posern
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Trends Cell Biol 16:588-96. 2006
    ..Here we discuss how the competition among cofactors might integrate these distinct signalling pathways into a specific transcriptional response and biological function...
  3. pmc Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
    Kristin Katsch
    Institut fur Klinische und Molekulare Virologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Cell Commun Signal 10:5. 2012
    ..Independent of Tip, T-cell stimulation orchestrates Src-family kinase, MAPK and actin pathways to induce SRF. These findings establish actin-regulated transcription in human T cells and suggest its role in viral oncogenesis...
  4. doi request reprint MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins
    Laura Leitner
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Sci 124:4318-31. 2011
    ..We conclude that the actin-MAL pathway promotes adhesive gene expression, including integrin α5, Pkp2 and FHL1, and that this is anti-motile for non-invasive cells harbouring high basal activity...
  5. pmc Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators
    Laura Leitner
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Mol Cancer 9:60. 2010
    ..The tumor suppressor Eplin-alpha is thus a novel cytoskeletal target gene transcriptionally regulated by the actin-MAL-SRF pathway, which supports a role in cancer biology...
  6. doi request reprint E-cadherin regulates MAL-SRF-mediated transcription in epithelial cells
    Stephan Busche
    Department of Molecular Biology, AG Regulation of Gene Expression, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Sci 123:2803-9. 2010
    ....
  7. doi request reprint Myocardin-related transcription factor A regulates expression of Bok and Noxa and is involved in apoptotic signalling
    Dmitry Shaposhnikov
    AG Regulation of Gene Expression, Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell Cycle 11:141-50. 2012
    ..This is accompanied by nuclear accumulation of MRTFs. The results suggest a role for MAL in TNF signaling and implicate the MAL-SRF transcription module in regulating the proapoptotic Bcl-2 family network...
  8. doi request reprint Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction
    Arnaud Descot
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Cell 35:291-304. 2009
    ..Our results show the existence of negatively acting transcriptional networks between pro- and antiproliferative signaling pathways toward SRF...
  9. pmc OTT-MAL is a deregulated activator of serum response factor-dependent gene expression
    Arnaud Descot
    Max Planck Institute of Biochemistry, Department of Molecular Biology, Martinsried, Germany
    Mol Cell Biol 28:6171-81. 2008
    ..Our data suggest that the deregulated activation of MAL-dependent and -independent promoters results in tissue-specific functions of OTT-MAL...
  10. doi request reprint A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription
    Sina Stern
    Neuronal Gene Expression Laboratory, Department of Molecular Biology, Interfaculty Institute for Cell Biology, Eberhard Karls University Tubingen, Auf der Morgenstelle 15, Tubingen, Germany
    J Neurosci 29:4512-8. 2009
    ..Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription...
  11. doi request reprint Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling
    Stephan Busche
    Department of Molecular Biology, AG Regulation of Gene Expression, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    J Cell Sci 121:1025-35. 2008
    ..We conclude that E-cadherin-dependent cell-cell junctions facilitate transcriptional activation via Rac, G-actin, MAL and SRF upon epithelial disintegration...
  12. ncbi request reprint Actin-dependent regulation of connective tissue growth factor
    Susanne Muehlich
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Loschgestrasse 8, D 91054 Erlangen, Germany
    Am J Physiol Cell Physiol 292:C1732-8. 2007
    ..These findings provide novel evidence that monomeric actin is the connecting link between alterations in the cytoskeleton and CTGF gene expression and demonstrate the importance of SRF in regulating CTGF transcription...
  13. pmc Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL
    Guido Posern
    Transcription Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
    EMBO J 23:3973-83. 2004
    ..We propose a model in which actin G15S acts directly to promote MAL nuclear entry...
  14. ncbi request reprint Actin dynamics control SRF activity by regulation of its coactivator MAL
    Francesc Miralles
    Transcription Laboratory, Room 401, Cancer Research UK London Research Institute, Lincolns Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cell 113:329-42. 2003
    ..Constitutively cytoplasmic MAL derivatives interfere with MAL redistribution and Rho-actin signaling to SRF. MAL associates with several SRF target promoters regulated via the Rho-actin pathway...