Lisa Polzien

Summary

Country: Germany

Publications

  1. doi Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part
    Lisa Polzien
    Theodor Boveri Institute, Department of Microbiology, University of Wuerzburg, 97074 Wuerzburg, Germany
    Biochim Biophys Acta 1810:162-9. 2011
  2. pmc BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling
    Lisa Polzien
    Department of Microbiology, Biocenter, University of Wurzburg, 97074 Wurzburg, Germany
    J Biol Chem 286:17934-44. 2011
  3. pmc Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
    Lisa Polzien
    Institute for Medical Radiation and Cell Research, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 284:28004-20. 2009
  4. pmc Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase
    Angela Baljuls
    Theodor Boveri Institute of Bioscience, Department of Microbiology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 286:16491-503. 2011

Detail Information

Publications4

  1. doi Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part
    Lisa Polzien
    Theodor Boveri Institute, Department of Microbiology, University of Wuerzburg, 97074 Wuerzburg, Germany
    Biochim Biophys Acta 1810:162-9. 2011
    ..Since the functional role of the BAD C-terminal part has not been considered so far, we have investigated here the interplay of the structure and function of this region...
  2. pmc BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling
    Lisa Polzien
    Department of Microbiology, Biocenter, University of Wurzburg, 97074 Wurzburg, Germany
    J Biol Chem 286:17934-44. 2011
    ..Collectively, our findings provide new insights into the regulation of BAD function by phosphorylation and its role in cancer signaling...
  3. pmc Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation
    Lisa Polzien
    Institute for Medical Radiation and Cell Research, University of Wuerzburg, 97078 Wuerzburg, Germany
    J Biol Chem 284:28004-20. 2009
    ..This pore-forming capacity was dependent on phosphorylation status and interaction with 14-3-3 proteins. Collectively, our findings provide new insights into the regulation of BAD function by phosphorylation...
  4. pmc Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase
    Angela Baljuls
    Theodor Boveri Institute of Bioscience, Department of Microbiology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 286:16491-503. 2011
    ..In summary, we provide evidence that each of the basic residues within the RKTR motif is indispensable for correct RAF function...