Stefan K Plontke

Summary

Country: Germany

Publications

  1. pmc Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Audiol Neurootol 12:37-48. 2007
  2. pmc Dexamethasone concentration gradients along scala tympani after application to the round window membrane
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Otol Neurotol 29:401-6. 2008
  3. ncbi request reprint [Recovery of normal auditory threshold after hearing damage from fireworks and signalling pistols]
    S Plontke
    Klinik fur Hals, Nasen und Ohrenheilkunde am Universitätsklinikum Tübingen
    HNO 51:245-50. 2003
  4. doi request reprint Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic the
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    Laryngoscope 119:359-69. 2009
  5. ncbi request reprint Comparison of pure-tone audiometry analysis in sudden hearing loss studies: lack of agreement for different outcome measures
    Stefan K Plontke
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Otol Neurotol 28:753-63. 2007
  6. ncbi request reprint [Recent aspects in Menière's disease]
    S Plontke
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Tubingen, 72076, Tubingen
    HNO 55:12-4. 2007
  7. pmc Simulation of application strategies for local drug delivery to the inner ear
    Stefan K Plontke
    Tubingen Hearing Research Center and Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    ORL J Otorhinolaryngol Relat Spec 68:386-92. 2006
  8. ncbi request reprint Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Germany
    Otol Neurotol 27:912-7. 2006
  9. ncbi request reprint [Inquiries into local application of drugs on the inner ear. Innovation prize of the Working Group for German Speaking Audiologists and Neuro-otologists 2005]
    S Plontke
    Universitätsklinik für Hals, Nasen, Ohrenheilkunde, Kopf und Halschirurgie Tübingen
    HNO 53:837-44. 2005
  10. doi request reprint [Intratympanic glucocorticoid therapy of sudden hearing loss]
    S K Plontke
    Klinik fur Hals, Nasen, Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Tubingen, Elfriede Aulhorn Str 5, 72076 Tubingen
    HNO 58:1025-30. 2010

Collaborators

Detail Information

Publications32

  1. pmc Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Audiol Neurootol 12:37-48. 2007
    ..Cochlear fluid pharmacokinetics can be better represented by three-dimensional (3D) finite-element simulations of drug dispersal...
  2. pmc Dexamethasone concentration gradients along scala tympani after application to the round window membrane
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Otol Neurotol 29:401-6. 2008
    ..Local application of dexamethasone-21-dihydrogen-phosphate (Dex-P) to the round window (RW) membrane of guinea pigs produces a substantial basal-apical concentration gradient in scala tympani (ST) perilymph...
  3. ncbi request reprint [Recovery of normal auditory threshold after hearing damage from fireworks and signalling pistols]
    S Plontke
    Klinik fur Hals, Nasen und Ohrenheilkunde am Universitätsklinikum Tübingen
    HNO 51:245-50. 2003
  4. doi request reprint Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic the
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    Laryngoscope 119:359-69. 2009
    ..To study the safety and efficacy of continuous intratympanic dexamethasone-phosphate (Dex-P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or sudden idiopathic anacusis after failure of systemic therapy...
  5. ncbi request reprint Comparison of pure-tone audiometry analysis in sudden hearing loss studies: lack of agreement for different outcome measures
    Stefan K Plontke
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Otol Neurotol 28:753-63. 2007
    ..Different methods of pure-tone audiometry analysis in sudden hearing loss studies show a lack of agreement with respect to outcome, and the choice of outcome measure influences sample size calculation...
  6. ncbi request reprint [Recent aspects in Menière's disease]
    S Plontke
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Tubingen, 72076, Tubingen
    HNO 55:12-4. 2007
  7. pmc Simulation of application strategies for local drug delivery to the inner ear
    Stefan K Plontke
    Tubingen Hearing Research Center and Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Tubingen, Germany
    ORL J Otorhinolaryngol Relat Spec 68:386-92. 2006
    ..For a brief (30 min) application, the basal to apical drug gradient was higher than for longer delivery times. These findings show that controlling middle ear drug clearance is of critical importance...
  8. ncbi request reprint Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Germany
    Otol Neurotol 27:912-7. 2006
    ..Despite its invasiveness, the temporary implantation of a microcatheter into the middle ear cavity is an appropriately safe method for providing continuous drug delivery to the inner ear...
  9. ncbi request reprint [Inquiries into local application of drugs on the inner ear. Innovation prize of the Working Group for German Speaking Audiologists and Neuro-otologists 2005]
    S Plontke
    Universitätsklinik für Hals, Nasen, Ohrenheilkunde, Kopf und Halschirurgie Tübingen
    HNO 53:837-44. 2005
  10. doi request reprint [Intratympanic glucocorticoid therapy of sudden hearing loss]
    S K Plontke
    Klinik fur Hals, Nasen, Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Tubingen, Elfriede Aulhorn Str 5, 72076 Tubingen
    HNO 58:1025-30. 2010
    ....
  11. ncbi request reprint [1D-and 3D- computer simulation for experimental planning and interpretation of pharmacokinetic studies in the inner ear after local drug delivery]
    Stefan Plontke
    Klinik fur Hals, Nasen und Ohrenheilkunde am Universitätsklinikum Tübingen und Hörforschungszentrum D Tübingen THRC, Tuebingen
    ALTEX 21:77-85. 2004
    ....
  12. ncbi request reprint Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials
    Stefan Plontke
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Acta Otolaryngol 125:830-9. 2005
    ..Comparison of different application protocols and drug delivery systems will allow assessment of the value of continuous versus intermittent intratympanic glucocorticoid drug delivery...
  13. ncbi request reprint [Hearing disorder. Conservative management]
    S Plontke
    Universitätsklinik für Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie Tübingen, Elfriede Aulhorn Strasse 4, 72076 Tubingen
    Laryngorhinootologie 84:S1-36. 2005
  14. ncbi request reprint [Current viewpoints on hearing loss caused by occupational and leisure noise]
    S Plontke
    Universitätsklinik für Hals, Nasen und Ohrenheilkunde Tübingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen
    Laryngorhinootologie 83:S122-64. 2004
  15. pmc Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration
    Hartmut Hahn
    Department of Otorhinolaryngology Head and Neck Surgery, Tübingen Hearing Research Center, University of Tubingen, Elfriede Aulhorn Str 5, D 72076 Tubingen, Germany
    Hear Res 212:236-44. 2006
    ..The observed interanimal variation, e.g., in RWM permeability, is likely to be clinically relevant to the local application of drugs in patients...
  16. doi request reprint Hearing loss in Muckle-Wells syndrome
    Jasmin B Kuemmerle-Deschner
    University Hospital Tuebingen, Tuebingen, Germany
    Arthritis Rheum 65:824-31. 2013
    ..The aims of this study were to determine the otologic characteristics of MWS, define trajectories of hearing loss, and explore the association with distinct NLRP3 genotypes...
  17. pmc Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig
    Hartmut Hahn
    Department of Otorhinolaryngology Head and Neck Surgery and Tübingen Hearing Research Center, University of Tubingen, Tubingen, Germany
    Otol Neurotol 33:660-5. 2012
    ....
  18. pmc Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane
    Stefan K Plontke
    Department of Otorhinolaryngology, Head and Neck Surgery and Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Laryngoscope 117:1191-8. 2007
    ..In the present study, gradients of gentamicin along the cochlea were measured...
  19. doi request reprint Fine structure of distortion product otoacoustic emissions: its dependence on age and hearing threshold and clinical implications
    Wolfgang Wagner
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, Elfriede Aulhorn Str 5, 72076 Tubingen, Germany
    Eur Arch Otorhinolaryngol 265:1165-72. 2008
    ..g. during exposure to ototoxic substances or noise...
  20. doi request reprint Hearing safety of long-term treatment with theta burst stimulation
    Sebastian P Schraven
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen Medical School, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
    Brain Stimul 6:563-8. 2013
    ..Possible interference with physiological brain function and the noise emitted by the rTMS device might induce relevant unwanted impairment of hearing and speech perception...
  21. doi request reprint Standardized tinnitus-specific individual cognitive-behavioral therapy: a controlled outcome study with 286 tinnitus patients
    Hans Peter Zenner
    Department of Otolaryngology, Head and Neck Surgery, Tübingen University Medical Center, Elfriede Aulhorn Str 5, 72076 Tubingen, Germany
    Hear Res 298:117-25. 2013
    ..Pharmacological treatment of tinnitus cannot be considered well established. Thus, reducing tinnitus severity through behavioral therapy is emerging as a key goal...
  22. ncbi request reprint Acute effect of rheopheresis on peripheral endothelial dysfunction in patients suffering from sudden hearing loss
    Bernd M Balletshofer
    Department of Endocrinology, Metabolism and Vascular Medicine, Eberhard Karls University, Tubingen, Germany
    Ther Apher Dial 9:385-90. 2005
    ..01). Based on this case series we conclude that single Rheopheresis treatment might have an acute beneficial effect on endothelial dysfunction in patients suffering from SSHL...
  23. ncbi request reprint Noise in magnetic resonance imaging: no risk for sensorineural function but increased amplitude variability of otoacoustic emissions
    Wolfgang Wagner
    Department of Otorhinolaryngology, University of Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Germany
    Laryngoscope 113:1216-23. 2003
    ....
  24. pmc Efficacy and safety of bilateral continuous theta burst stimulation (cTBS) for the treatment of chronic tinnitus: design of a three-armed randomized controlled trial
    Carola Arfeller
    University Hospital of Tubingen, Department of Psychiatry and Psychotherapy, Tubingen, Germany
    Trials 10:74. 2009
    ..Recently, continuous theta burst stimulation (cTBS) has been put forward as an effective rTMS protocol for the reduction of pathologically enhanced cortical excitability...
  25. doi request reprint Progressive familial hearing loss in Muckle-Wells syndrome
    Assen Koitschev
    Department of Otorhinolaryngology, Klinikum Stuttgart, University Hospital Tubingen, Germany
    Acta Otolaryngol 132:756-62. 2012
    ..The design of further clinical trials should focus on hearing in order to document the long-term effect of anti-interleukin (IL)-1 drugs on hearing preservation...
  26. ncbi request reprint Theta burst stimulation in the treatment of incapacitating tinnitus accompanied by severe depression
    Surjo R Soekadar
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    CNS Spectr 14:208-11. 2009
    ..Hamilton Rating Scale for Depression score dropped from 44 to 23 points. TBS showed to be efficient, well-tolerated, and practical in the management of distressing tinnitus accompanied by symptoms of severe depression...
  27. doi request reprint Gentamicin concentration gradients in scala tympani perilymph following systemic applications
    Hartmut Hahn
    Department of Otorhinolaryngology, Head and Neck Surgery and Tübingen Hearing Research Center THRC, University of Tubingen, Tubingen, Germany
    Audiol Neurootol 18:383-91. 2013
    ..In this case the faster kinetics in apical turns could be due to the smaller cross-sectional area of ST relative to endolymph in the apical turns...
  28. ncbi request reprint Speech-in-noise intelligibility does not correlate with efferent olivocochlear reflex in humans with normal hearing
    Wolfgang Wagner
    Tübingen Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Tubingen, Germany
    Acta Otolaryngol 128:53-60. 2008
    ....
  29. ncbi request reprint Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation
    Christian Plewnia
    Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Tuebingen, Germany
    Hum Brain Mapp 28:238-46. 2007
    ..Of note, these effects were related to stimulation of cortical association areas, not primary auditory cortex, emphasizing the crucial role of higher-order sensory processing in the pathophysiology of chronic tinnitus...
  30. pmc Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols
    Alec N Salt
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Laryngoscope 118:1793-800. 2008
    ..To establish safe dosing protocols for the treatment of patients with Meniere's disease with intratympanic gentamicin...
  31. pmc Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex
    Robert Mynatt
    Department of Otolaryngology, St Louis University School of Medicine, St Louis, MO 63110, USA
    J Assoc Res Otolaryngol 7:182-93. 2006
    ..The method can be used for any substance for which a sensitive assay is available and is therefore of high relevance for the development of preclinical and clinical strategies for local drug delivery to the inner ear...
  32. pmc Marker retention in the cochlea following injections through the round window membrane
    Alec N Salt
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 232:78-86. 2007
    ..The findings demonstrate that in order to perform quantitative drug injections into perilymph, even small rates of fluid leakage at the injection site must be controlled...