- Treatment of major depression with bilateral theta burst stimulation: A randomized controlled pilot trialChristian Plewnia
Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tubingen, Calwerstrasse 14, Tubingen D 72076, Germany Electronic address
J Affect Disord 156:219-23. 2014..Here, we investigated the efficacy of bilateral TBS to the dorsolateral prefrontal cortex (dlPFC) in patients with MD in additon to ongoing medication and psychotherapy...
- Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphismChristian Plewnia
Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tubingen, Germany
Cortex 49:1801-7. 2013..In this study, we hypothesized that the COMT Met allele homozygosity, associated with higher levels of prefrontal dopamine, would influence the effect of tDCS on higher-level executive functions...
- [Transcranial and invasive brain stimulation for depression]C Plewnia
Universitatsklinik fur Psychiatrie und Psychotherapie, Abteilung für Allgemeine Psychiatrie und Psychotherapie mit Poliklinik, Eberhard Karls Universitat Tubingen, Calwerstr 14, 72076 Tubingen, Deutschland
Nervenarzt 83:1006-12. 2012..However, the field yields a promising rapid development which may substantially enrich the armamentarium of antidepressant interventions in the near future...
- Treatment of chronic tinnitus with θ burst stimulation: a randomized controlled trialC Plewnia
Departments of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tubingen, Germany
Neurology 78:1628-34. 2012..To test whether 4 weeks of bilateral repetitive transcranial magnetic stimulation (rTMS) to the temporal or temporoparietal cortex is effective and safe in the treatment of chronic tinnitus...
- Brain stimulation: new vistas for the exploration and treatment of tinnitusChristian Plewnia
Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Psychiatry, University of Tubingen Medical School, Tubingen, Germany
CNS Neurosci Ther 17:449-61. 2011..In this review, a comprehensive overview on the use of brain-stimulation techniques in the exploration and experimental treatment of tinnitus is provided...
- Enhancement of long-range EEG coherence by synchronous bifocal transcranial magnetic stimulationChristian Plewnia
Department of Psychiatry and Psychotherapy, University of Tubingen, Osianderstrasse 24, D 72076 Tubingen, Germany
Eur J Neurosci 27:1577-83. 2008..Furthermore, they raise the hypothesis that interventional enhancement of long-range coherence may effectively modulate interregional integration with behavioral consequences...
- Suppression of verbal hallucinations and changes in regional cerebral blood flow after intravenous lidocaine: a case reportChristian Plewnia
Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D 72076 Tuebingen, Germany
Prog Neuropsychopharmacol Biol Psychiatry 31:301-3. 2007....
- Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot studyC Plewnia
Brain Stimulation Laboratory, Department of Psychiatry, University of Tuebingen, Tuebingen, Germany
J Neurol Neurosurg Psychiatry 78:152-6. 2007..Tinnitus has been shown to respond to modulations of cortical activity by high-frequency and low-frequency repetitive transcranial magnetic stimulation (rTMS)...
- No effects of enhanced central norepinephrine on finger-sequence learning and attentionChristian Plewnia
Department of Psychiatry and Psychotherapy, Eberhard Karls University Medical School, Osianderstrasse 24, Tuebingen 72076, Germany
Psychopharmacology (Berl) 187:260-5. 2006..When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions...
- Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trialDaniel Weiss
German Centre for Neurodegenerative Diseases DZNE, Tubingen, Germany
Brain 136:2098-108. 2013....
- Improved motor skill acquisition after selective stimulation of central norepinephrineChristian Plewnia
Cortical Physiology Research Group, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
Neurology 62:2124-6. 2004..Therefore, alpha-adrenergic mechanisms could possibly be manipulated to magnify training effects in neurorehabilitation...
- To act or not to act. Neural correlates of executive control of learned motor behaviorFriedhelm Hummel
Cortical Physiology Research Group, Department of Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tubingen, 72076 Tubingen, Germany
Neuroimage 23:1391-401. 2004....
- Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordingsDaniel Weiss
Center of Neurology and Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases, University of Tubingen, Germany
Mov Disord 26:323-7. 2011..Corticomuscular coherence at tremor frequency was completely suppressed by Vim-DBS. Our case study demonstrates central oscillators underlying neuropathic tremor and implies a strong pathophysiological rationale for Vim-DBS...
- Alpha coherence predicts accuracy during a visuomotor tracking taskAlbrecht J Rilk
Department of Psychiatry and Psychotherapy, Neurophysiology and Interventional Neuropsychiatry, University of Tubingen, Tubingen, Germany
Neuropsychologia 49:3704-9. 2011..These results provide further evidence that coherent brain oscillations in alpha and beta bands significantly contribute to effective functional integration of visual and motor areas...
- Event-related desynchronization and excitability of the ipsilateral motor cortex during simple self-paced finger movementsCornelia Rau
Department of Neurology, Cortical Physiology Research Group, University of Tuebingen, Hoppe Seyler Strasse 3, D 72076, Tuebingen, Germany
Clin Neurophysiol 114:1819-26. 2003..To study the time course of oscillatory EEG activity and corticospinal excitability of the ipsilateral primary motor cortex (iM1) during self-paced phasic extension movements of fingers II-V...
- Deep-brain-stimulation does not impair deglutition in Parkinson's diseaseSabrina Lengerer
Department for Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Straße 3, 72076 Tubingen, Germany
Parkinsonism Relat Disord 18:847-53. 2012..e., aspirational pneumonia. So far, little is known on how deep-brain-stimulation of the subthalamic nucleus influences deglutition in PD...
- Theta burst stimulation in the treatment of incapacitating tinnitus accompanied by severe depressionSurjo R Soekadar
Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
CNS Spectr 14:208-11. 2009..Hamilton Rating Scale for Depression score dropped from 44 to 23 points. TBS showed to be efficient, well-tolerated, and practical in the management of distressing tinnitus accompanied by symptoms of severe depression...
- Combined STN/SNr-DBS for the treatment of refractory gait disturbances in Parkinson's disease: study protocol for a randomized controlled trialDaniel Weiss
German Centre of Neurodegenerative Diseases, Tubingen, Germany
Trials 12:222. 2011..High-frequent stimulation of the substantia nigra pars reticulata preferentially modulated axial symptoms and therefore is suggested as a novel therapeutic candidate target for neuromodulation of refractory gait disturbances in PD...
- Enhancement of planning ability by transcranial direct current stimulationColleen A Dockery
Max Planck Graduate School of Neural and Behavioral Sciences, University of Tuebingen, D 72074 Tuebingen, Germany
J Neurosci 29:7271-7. 2009..In conclusion, the specific coupling of stimulation and training phase interventions may support the treatment of cognitive disorders involving frontal lobe functions...
- The role of multiple contralesional motor areas for complex hand movements after internal capsular lesionMartin Lotze
Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
J Neurosci 26:6096-102. 2006..The present results argue for a persistent beneficial role of the dPMC, M1, and SPL of the CON-H on some aspects of effectively recovered complex motor behavior after subcortical stroke...
- Transient suppression of tinnitus by transcranial magnetic stimulationChristian Plewnia
Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Germany
Ann Neurol 53:263-6. 2003..05; compared with control), indicating that secondary auditory areas can be critical for tinnitus perception, perhaps as a consequence of maladaptive cortical reorganization...
- Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulationChristian Plewnia
Department of Psychiatry, Neurophysiology Section, University of Tuebingen, Tuebingen, Germany
Hum Brain Mapp 28:238-46. 2007..Of note, these effects were related to stimulation of cortical association areas, not primary auditory cortex, emphasizing the crucial role of higher-order sensory processing in the pathophysiology of chronic tinnitus...
- Efficacy and safety of bilateral continuous theta burst stimulation (cTBS) for the treatment of chronic tinnitus: design of a three-armed randomized controlled trialCarola Arfeller
University Hospital of Tubingen, Department of Psychiatry and Psychotherapy, Tubingen, Germany
Trials 10:74. 2009..Recently, continuous theta burst stimulation (cTBS) has been put forward as an effective rTMS protocol for the reduction of pathologically enhanced cortical excitability...
- Disinhibition of the contralateral motor cortex by low-frequency rTMSChristian Plewnia
Cortical Physiology Research Group, Department of Neurology, Eberhard Karls University Medical School, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
Neuroreport 14:609-12. 2003....
- Enhancement of human cortico-motoneuronal excitability by the selective norepinephrine reuptake inhibitor reboxetineChristian Plewnia
Neurophysiology Section, Department of Psychiatry, University of Tuebingen, Osianderstrasse 22, 72076 Tuebingen, Germany
Neurosci Lett 330:231-4. 2002....
- Hearing safety of long-term treatment with theta burst stimulationSebastian P Schraven
Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen Medical School, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
Brain Stimul 6:563-8. 2013..Possible interference with physiological brain function and the noise emitted by the rTMS device might induce relevant unwanted impairment of hearing and speech perception...
- Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entitiesDaniel Weiss
Center of Neurology, Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases DZNE, University of Tubingen, Tubingen, Germany
J Neurol Neurosurg Psychiatry 81:1002-7. 2010..To gain insight into the hitherto undefined pathophysiology of IEC after STN-DBS, we performed a comprehensive clinical and electrophysiological characterisation of lid function in a total of six PD patients...
- Clinical efficacy and cognitive side effects of bifrontal versus right unilateral electroconvulsive therapy (ECT): a short-term randomised controlled trial in pharmaco-resistant major depressionGerhard W Eschweiler
Department of Psychiatry and Psychotherapy, Eberhard Karls University Tuebingen, Germany
J Affect Disord 101:149-57. 2007..In most studies right unilateral electroconvulsive therapy (ECT) has been shown to cause fewer cognitive side effects but less antidepressant efficacy compared with bi(fronto)temporal ECT at certain intensities...
- Controversy: Does repetitive transcranial magnetic stimulation/ transcranial direct current stimulation show efficacy in treating tinnitus patients?Berthold Langguth
Department of Psychiatry, University of Regensburg, Germany
Brain Stimul 1:192-205. 2008..Therefore, targeted modulation of auditory cortex has been proposed as a new therapeutic approach for chronic tinnitus...
- Comment on "Neuronavigated repetitive transcranial magnetic stimulation in patients with tinnitus: a short case series"Christian Plewnia
Biol Psychiatry 55:1117; author reply 1117-8. 2004