B J Pichler

Summary

Country: Germany

Publications

  1. pmc Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [¹⁸F]-fluoro-azomycinarabino-furanoside ([¹⁸F]FAZA)
    Florian C Maier
    Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Germany
    Radiat Oncol 6:165. 2011
  2. doi request reprint PET/MRI: paving the way for the next generation of clinical multimodality imaging applications
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, University of Tubingen, Tubingen, Germany
    J Nucl Med 51:333-6. 2010
  3. ncbi request reprint Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
  4. doi request reprint Latest advances in molecular imaging instrumentation
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Nucl Med 49:5S-23S. 2008
  5. ncbi request reprint Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI
    Bernd J Pichler
    Department of Biomedical Engineering, University of California, Davis, USA
    J Nucl Med 47:639-47. 2006
  6. pmc Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging?
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, University of Tubingen, Tubingen, Germany
    Semin Nucl Med 38:199-208. 2008
  7. doi request reprint PET/MRI hybrid imaging: devices and initial results
    Bernd J Pichler
    Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Eur Radiol 18:1077-86. 2008
  8. ncbi request reprint Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET
    B J Pichler
    Department of Biomedical Engineering, University of California, Davis, CA, USA
    Phys Med Biol 49:4305-19. 2004
  9. ncbi request reprint A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals
    S I Ziegler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    Eur J Nucl Med 28:136-43. 2001
  10. ncbi request reprint PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology, Clinic of Radiology, University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Radiology 244:807-14. 2007

Research Grants

  1. Non-Invasive Imaging of T Cell Trafficking
    Bernd Pichler; Fiscal Year: 2006
  2. An Integrated PET-MRI System for Molecular Imaging
    Bernd Pichler; Fiscal Year: 2005

Collaborators

Detail Information

Publications35

  1. pmc Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [¹⁸F]-fluoro-azomycinarabino-furanoside ([¹⁸F]FAZA)
    Florian C Maier
    Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Germany
    Radiat Oncol 6:165. 2011
    ....
  2. doi request reprint PET/MRI: paving the way for the next generation of clinical multimodality imaging applications
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, University of Tubingen, Tubingen, Germany
    J Nucl Med 51:333-6. 2010
    ..It requires not only significant modifications of the PET detector to make it compact and insensitive to magnetic fields but also a major redesign of the MRI hardware...
  3. ncbi request reprint Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
    ..We studied a hapten-induced delayed-type hypersensitivity reaction (DTHR) as a model for inflammatory processes, since DTHRs are involved in many human autoimmune disorders...
  4. doi request reprint Latest advances in molecular imaging instrumentation
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Nucl Med 49:5S-23S. 2008
    ..Hyperpolarized imaging, functional MRI, and MR spectroscopy provide molecular information in vivo. A special focus of this review article is multimodality imaging and, in particular, the emerging field of combined PET/MRI...
  5. ncbi request reprint Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI
    Bernd J Pichler
    Department of Biomedical Engineering, University of California, Davis, USA
    J Nucl Med 47:639-47. 2006
    ..Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation...
  6. pmc Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging?
    Bernd J Pichler
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, University of Tubingen, Tubingen, Germany
    Semin Nucl Med 38:199-208. 2008
    ..The combination of PET and MRI is a promising tool in preclinical research and will certainly progress to clinical application...
  7. doi request reprint PET/MRI hybrid imaging: devices and initial results
    Bernd J Pichler
    Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Eur Radiol 18:1077-86. 2008
    ..Initial pilot studies with prototype animal PET/MRI systems have shown promising results by combining high resolution morphology with multifunctional information isochronously...
  8. ncbi request reprint Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET
    B J Pichler
    Department of Biomedical Engineering, University of California, Davis, CA, USA
    Phys Med Biol 49:4305-19. 2004
    ..These results demonstrate the ability to decode densely packed LSO scintillation blocks with compact APD arrays. The good timing and energy resolution makes these detectors suitable for high resolution PET...
  9. ncbi request reprint A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals
    S I Ziegler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Germany
    Eur J Nucl Med 28:136-43. 2001
    ..APD arrays in combination with LSO crystals offer new design possibilities for positron tomographs with finely granulated detector channels...
  10. ncbi request reprint PET/MR images acquired with a compact MR-compatible PET detector in a 7-T magnet
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology, Clinic of Radiology, University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Radiology 244:807-14. 2007
    ..To prospectively use compact avalanche photodiodes instead of photomultiplier tubes to integrate a positron emission tomographic (PET) detector and a 7-T magnetic resonance (MR) imager...
  11. doi request reprint Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancer - detected in a tumor mouse model using positron emission tomography/magnetic resonance imaging
    Derek Zieker
    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 26:147-54. 2010
    ....
  12. doi request reprint Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT
    Andreas Boss
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany
    J Nucl Med 51:1198-205. 2010
    ....
  13. doi request reprint Diffusion tensor imaging in a human PET/MR hybrid system
    Andreas Boss
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    Invest Radiol 45:270-4. 2010
    ....
  14. doi request reprint Measurement of T1, T2, and magnetization transfer properties during embryonic development at 7 Tesla using the chicken model
    Andreas Boss
    Section of Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 28:1510-4. 2008
    ..To evaluate whether techniques of high field magnetic resonance imaging may be used to characterize embryonic tissue during proliferation and differentiation...
  15. pmc An integrated MR/PET system: prospective applications
    Heinz Peter Schlemmer
    Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Abdom Imaging 34:668-74. 2009
    ....
  16. doi request reprint Simultaneous MR/PET imaging of the human brain: feasibility study
    Heinz Peter W Schlemmer
    Department of Diagnostic Radiology, University Hospital Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Radiology 248:1028-35. 2008
    ..MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging...
  17. ncbi request reprint Single and dual energy attenuation correction in PET/CT in the presence of iodine based contrast agents
    Niklas S Rehfeld
    Laboratory for Preclinical Imaging and Imaging Technology, Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, D 72076 Tubingen, Germany
    Med Phys 35:1959-69. 2008
    ..Atomic number/density scaling and hybrid DECTAC could be generalized to reduce these problems...
  18. doi request reprint The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice
    Tanja Schonberger
    DVM, Medizinische Klinik III, Abt Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Cardiovasc Res 80:131-7. 2008
    ..In this study, we examined binding of soluble platelet collagen receptor GPVI-Fc to atherosclerotic lesions and its effect on platelet-triggered athero-progression and neointima formation after wire-induced carotid injury...
  19. ncbi request reprint Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph
    M Rafecas
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22 81675 München, Germany
    Phys Med Biol 48:821-48. 2003
    ....
  20. ncbi request reprint Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner
    Ciprian Catana
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    J Nucl Med 47:1968-76. 2006
    ..We have designed and built a MR-compatible PET scanner based on avalanche photodiode technology that allows simultaneous acquisition of PET and MR images in small animals...
  21. doi request reprint Simultaneous PET-MRI: a new approach for functional and morphological imaging
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Nat Med 14:459-65. 2008
    ..Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging...
  22. doi request reprint Evaluation of Geiger-mode APDs for PET block detector designs
    Armin Kolb
    Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Phys Med Biol 55:1815-32. 2010
    ..G-APDs with a low number of cells provide a good timing and (DeltaEpsilon/Epsilon) and linear signals in block detector designs, where the scintillation light is shared over many G-APDs...
  23. ncbi request reprint Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors
    Martin S Judenhofer
    Department of Biomedical Engineering, University of California, Davis, 95616, USA
    Phys Med Biol 50:29-44. 2005
    ..The crystals (1.2 x 1.2 x 12 mm3) within a 9 x 9 LSO block detector could be clearly separated in an acquired position profile. Thus, these boards are well suited for data acquisition with novel detectors developed for nuclear imaging...
  24. pmc Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation
    Manfred Kneilling
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Blood 114:1696-706. 2009
    ..As substitution of TNF(-/-) mice with TNF-producing mast cells fully restored DTHR in these mice, signaling of mast cell-derived TNF through TNFR1-expressing ECs is essential for the recruitment of leukocytes into sites of inflammation...
  25. doi request reprint Pre-clinical PET/MR: technological advances and new perspectives in biomedical research
    Hans F Wehrl
    Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, 72076, Tubingen, Germany
    Eur J Nucl Med Mol Imaging 36:S56-68. 2009
    ..Especially in small-animal research, where high soft tissue contrast is required, and the scan time as well as radiation dose are critical factors, the combination of PET and MRI would be beneficial compared with PET/CT...
  26. ncbi request reprint A hyperspectral fluorescence system for 3D in vivo optical imaging
    Guido Zavattini
    Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Phys Med Biol 51:2029-43. 2006
    ..We also characterize the basic performance of the imaging system...
  27. doi request reprint Akt2/PKBbeta-sensitive regulation of renal phosphate transport
    D S Kempe
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Acta Physiol (Oxf) 200:75-85. 2010
    ..The kinase is expressed in proximal renal tubules. The present study explored the influence of Akt/PKB on renal tubular phosphate transport...
  28. ncbi request reprint Combined PET/MR imaging--technology and applications
    H F Wehrl
    University of Tuebingen, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Roentgenweg 13, 72076 Tuebingen, Germany
    Technol Cancer Res Treat 9:5-20. 2010
    ..Simultaneous multifunctional and anatomical imaging using PET/MR has a great potential to impact biomedical imaging in research and clinic...
  29. doi request reprint MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration
    Matthias Hofmann
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University, Tuebingen, Germany
    J Nucl Med 49:1875-83. 2008
    ..This task is challenging because MR intensities correlate with proton densities and tissue-relaxation properties, rather than with attenuation-related mass density...
  30. ncbi request reprint Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice
    Manfred Kneilling
    Eberhard Karls University, Tubingen, Germany
    Arthritis Rheum 56:1806-16. 2007
    ....
  31. pmc Radionuclide imaging: a molecular key to the atherosclerotic plaque
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Am Coll Cardiol 52:1-12. 2008
    ..This review gives an update on the relevant noninvasive plaque imaging approaches using nuclear imaging techniques to detect atherosclerotic vascular lesions...
  32. doi request reprint Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
    Silke Nuber
    Department of Medical Genetics, University of Tubingen, Calwerstr 7, 72076 Tubingen, Germany
    Neurogenetics 11:107-20. 2010
    ..These findings suggest a pathological role of overexpressed synphilin-1 in vivo and will help to further elucidate the mechanisms of protein aggregation and neuronal cell death...
  33. doi request reprint Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite
    Cora Hübner
    Institute for Tropical Medicine, University Clinics of Tübingen, Wilhelmstrasse 27, 72074, Tubingen, Germany
    Parasitol Res 107:459-63. 2010
    ..Magnetic resonance imaging appears suitable to monitor in vivo the effects of drugs on growth progression and regression only of larger Em-metacestode tissues...
  34. pmc Simultaneous in vivo positron emission tomography and magnetic resonance imaging
    Ciprian Catana
    Department of Biomedical Engineering, University of California, Genome and Biomedical Sciences Facility, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:3705-10. 2008
    ..In vivo simultaneous PET and MRI studies were performed in mice. Proof-of-principle in vivo MR spectroscopy and functional MRI experiments were also demonstrated with the combined scanner...
  35. doi request reprint Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
    Silke Nuber
    Department of Medical Genetics, University of Tuebingen, D 72076 Tuebingen, Germany
    J Neurosci 28:2471-84. 2008
    ..Furthermore, alpha-syn-associated cytotoxicity is independent of filamentous inclusion body formation in our conditional mouse model...

Research Grants2

  1. Non-Invasive Imaging of T Cell Trafficking
    Bernd Pichler; Fiscal Year: 2006
    ..abstract_text> ..
  2. An Integrated PET-MRI System for Molecular Imaging
    Bernd Pichler; Fiscal Year: 2005
    ..abstract_text> ..