Florian Schubert

Summary

Affiliation: Physikalisch-Technische Bundesanstalt
Country: Germany

Publications

  1. ncbi request reprint Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations
    Florian Schubert
    Department of Medical Physics and Metrological Information Technology, Physikalisch Technische Bundesanstalt, Abbestrasse 2 12, D 10587, Berlin, Germany
    MAGMA 14:213-22. 2002
  2. ncbi request reprint Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla
    Florian Schubert
    Laboratory of Biomedical Optics and NMR Measuring Techniques, Division of Medical Physics and Metrological Information Technology, D 10587 Berlin, Germany
    Neuroimage 21:1762-71. 2004
  3. doi request reprint Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
  4. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
  5. doi request reprint Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
  6. ncbi request reprint Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 62:530-5. 2007
  7. doi request reprint Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study
    Andreas Arthur Klär
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 53:51-7. 2010
  8. ncbi request reprint Quantitative magnetic resonance spectroscopy: semi-parametric modeling and determination of uncertainties
    Clemens Elster
    Physikalisch Technische Bundesanstalt, 105857 Berlin, Germany
    Magn Reson Med 53:1288-96. 2005
  9. doi request reprint Region-specific glutamate changes in patients with unipolar depression
    Simone Grimm
    Affective Neuroscience and Emotion Modulation, Department of Psychiatry, Campus Benjamin Franklin, Charite, Germany
    J Psychiatr Res 46:1059-65. 2012
  10. ncbi request reprint Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Neuroimage 26:123-31. 2005

Detail Information

Publications17

  1. ncbi request reprint Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations
    Florian Schubert
    Department of Medical Physics and Metrological Information Technology, Physikalisch Technische Bundesanstalt, Abbestrasse 2 12, D 10587, Berlin, Germany
    MAGMA 14:213-22. 2002
    ..The biochemical abnormalities found in NAWM emphasize the importance of analyzing both lesion and NAWM...
  2. ncbi request reprint Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla
    Florian Schubert
    Laboratory of Biomedical Optics and NMR Measuring Techniques, Division of Medical Physics and Metrological Information Technology, D 10587 Berlin, Germany
    Neuroimage 21:1762-71. 2004
    ..9 mmol/l in hc, P = 0.023) and decrease with age (P < 0.04). These concentrations agreed well with those determined using the quantum coherence filter method although the uncertainty of the latter limits reliable analysis...
  3. doi request reprint Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
    ..We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder...
  4. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
    ..In this study, proton magnetic resonance spectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC)...
  5. doi request reprint Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
    ....
  6. ncbi request reprint Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity
    Undine E Lang
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 62:530-5. 2007
    ..In the present study we hypothesized that serum BDNF concentration is associated with in vivo level of cerebral N-acetylaspartate (NAA), a well established marker of neuronal integrity...
  7. doi request reprint Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study
    Andreas Arthur Klär
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 53:51-7. 2010
    ..However, the possible interaction between regional NAA reduction and volume deficits has been targeted only marginally in previous investigations...
  8. ncbi request reprint Quantitative magnetic resonance spectroscopy: semi-parametric modeling and determination of uncertainties
    Clemens Elster
    Physikalisch Technische Bundesanstalt, 105857 Berlin, Germany
    Magn Reson Med 53:1288-96. 2005
    ..In particular, for high SNR and strong baseline contributions the proposed procedure yields a more appropriate characterization of the accuracy of parameter estimates than Crémer-Rao lower bounds, which tend to overestimate accuracy...
  9. doi request reprint Region-specific glutamate changes in patients with unipolar depression
    Simone Grimm
    Affective Neuroscience and Emotion Modulation, Department of Psychiatry, Campus Benjamin Franklin, Charite, Germany
    J Psychiatr Res 46:1059-65. 2012
    ..These findings might serve as a starting point for future studies in which the value of this metabolite pattern for treatment response prediction should be investigated...
  10. ncbi request reprint Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany
    Neuroimage 26:123-31. 2005
    ....
  11. doi request reprint Reduction of cerebellar grey matter in Crus I and II in schizophrenia
    Simone Kühn
    Clinic for Psychiatry and Psychotherapy, St Hedwig Krankenhaus, Charite University Medicine, Campus Mitte, Berlin, Germany
    Brain Struct Funct 217:523-9. 2012
    ..The failure of conventional VBM to detect such effects suggests that previous studies might have underestimated the importance of cerebellar structural deficits in schizophrenia...
  12. pmc Prefrontal cortex glutamate correlates with mental perspective-taking
    Christiane Montag
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    PLoS ONE 3:e3890. 2008
    ..However, the role of the glutamate system for different dimensions of empathy has not been investigated so far...
  13. ncbi request reprint Plasticity of hippocampal subfield volume cornu ammonis 2+3 over the course of withdrawal in patients with alcohol dependence
    Simone Kühn
    Max Planck Institute for Human Development, Center for Lifespan Psychology, Berlin, Germany
    JAMA Psychiatry 71:806-11. 2014
    ..Chronic alcoholism is associated with decreased plasticity and reduced whole hippocampal volume that could contribute to neuropsychiatric characteristics and outcome of the disease...
  14. doi request reprint Effects of age and sex on the concentrations of glutamate and glutamine in the human brain
    Sven Hädel
    Department of Psychiatry and Psychotherapy, Psychiatric University Hospital St Hedwig, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    J Magn Reson Imaging 38:1480-7. 2013
    ..Exploratory examinations of other brain metabolites were also conducted...
  15. pmc Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis
    Caspar F Pfueller
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18019. 2011
    ....
  16. ncbi request reprint Smoking and structural brain deficits: a volumetric MR investigation
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Eur J Neurosci 24:1744-50. 2006
    ..The present findings may explain in part the frequently reported cognitive dysfunctions in chronic cigarette consumers...
  17. ncbi request reprint Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression
    Alexander Luborzewski
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Eschenallee 3, D 14050 Berlin, Germany
    J Psychiatr Res 41:606-15. 2007
    ..Our results indicate that metabolic, state-dependent changes within the left DLPFC in major depressive disorder involve the glutamate system and can be reversed in a dose-dependent manner by rTMS...