A Zielke

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Influence of ultrasound on clinical decision making in acute appendicitis: a prospective study
    A Zielke
    Department of Surgery, Phillips University of Marburg, Germany
    Eur J Surg 164:201-9. 1998
  2. ncbi request reprint A unique allogenic model of metastatic pheochromocytoma: PC12 rat pheochromocytoma xenografts to nude mice and establishment of metastases-derived PC12 variants
    A Zielke
    Department of Surgery, Philipps University of Marburg, Germany
    Clin Exp Metastasis 16:341-52. 1998
  3. ncbi request reprint [Can diagnostic scoring systems help decision making in primary care of patients with suspected acute appendicitis?]
    A Zielke
    Klinik für Ailgemeinchirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 124:545-50. 1999
  4. ncbi request reprint [Validation of a diagnostic scoring system (Ohmann score) in acute appendicitis]
    A Zielke
    Klinik für Allgemeinchirurgie, Philipps Universitat Marburg
    Chirurg 70:777-83; discussion 784. 1999
  5. ncbi request reprint Pleiotropic effects of thyroid stimulating hormone in a differentiated thyroid cancer cell line. Studies on proliferation, thyroglobulin secretion, adhesion, migration and invasion
    A Zielke
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 107:361-9. 1999
  6. ncbi request reprint [Appendicitis. Present-day diagnosis]
    A Zielke
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg, Baldinger Strasse, Postfach 100, 35043 Marburg
    Chirurg 73:782-90. 2002
  7. ncbi request reprint Functional thyrotropin receptor attenuates malignant phenotype of follicular thyroid cancer cells
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, 35043 Marburg, Germany
    Endocrine 30:129-38. 2006
  8. ncbi request reprint Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, Marburg, 35043, Germany
    Endocrine 31:105-13. 2007
  9. ncbi request reprint Spatial perception predicts laparoscopic skills on virtual reality laparoscopy simulator
    I Hassan
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University of Marburg, Baldinger Strasse, 35043, Marburg, Germany
    Childs Nerv Syst 23:685-9. 2007
  10. ncbi request reprint [Operative management and long-term survival in patients with neuroendocrine tumors of the pancreas--experience with 144 patients]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 132:195-200. 2007

Detail Information

Publications40

  1. ncbi request reprint Influence of ultrasound on clinical decision making in acute appendicitis: a prospective study
    A Zielke
    Department of Surgery, Phillips University of Marburg, Germany
    Eur J Surg 164:201-9. 1998
    ..To assess the efficacy of ultrasound (US) as part of an algorithm to establish the indication for laparotomy in patients with suspected acute appendicitis...
  2. ncbi request reprint A unique allogenic model of metastatic pheochromocytoma: PC12 rat pheochromocytoma xenografts to nude mice and establishment of metastases-derived PC12 variants
    A Zielke
    Department of Surgery, Philipps University of Marburg, Germany
    Clin Exp Metastasis 16:341-52. 1998
    ..This unique model system should be useful for further studies relating to the invasion and metastases of pheochromocytoma and may prove valuable for investigations of novel antineoplastic therapies in vitro and in vivo...
  3. ncbi request reprint [Can diagnostic scoring systems help decision making in primary care of patients with suspected acute appendicitis?]
    A Zielke
    Klinik für Ailgemeinchirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 124:545-50. 1999
    ..To assess two recently developed scoring systems with respect to making or excluding the diagnosis of acute appendicitis...
  4. ncbi request reprint [Validation of a diagnostic scoring system (Ohmann score) in acute appendicitis]
    A Zielke
    Klinik für Allgemeinchirurgie, Philipps Universitat Marburg
    Chirurg 70:777-83; discussion 784. 1999
    ..It may therefore be of value in the preclinical evaluation of patients with suspected acute appendicitis and may be instrumental as a quality control tool and in clinical guidelines...
  5. ncbi request reprint Pleiotropic effects of thyroid stimulating hormone in a differentiated thyroid cancer cell line. Studies on proliferation, thyroglobulin secretion, adhesion, migration and invasion
    A Zielke
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 107:361-9. 1999
    ....
  6. ncbi request reprint [Appendicitis. Present-day diagnosis]
    A Zielke
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg, Baldinger Strasse, Postfach 100, 35043 Marburg
    Chirurg 73:782-90. 2002
    ..It is apparent that in everyday practice, none of the technical modalities can replace the skill and precision of surgical exploration...
  7. ncbi request reprint Functional thyrotropin receptor attenuates malignant phenotype of follicular thyroid cancer cells
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, 35043 Marburg, Germany
    Endocrine 30:129-38. 2006
    ..The present data highlight the pivotal role of TSHR to affect transformed thyrocytes in vitro and in vivo. They also suggest a role for EGF as a modulator of angiogenesis in thyrocytes devoid of TSHR...
  8. ncbi request reprint Differential effects of cetuximab and AEE 788 on epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) in thyroid cancer cell lines
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, Marburg, 35043, Germany
    Endocrine 31:105-13. 2007
    ..g., by AEE 788 induces reduced proliferation and apoptosis in vitro. This suggests a particular rationale for the use of tyrosine kinase inhibitors with dual modes of action such as AEE 788 in thyroid cancer...
  9. ncbi request reprint Spatial perception predicts laparoscopic skills on virtual reality laparoscopy simulator
    I Hassan
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University of Marburg, Baldinger Strasse, 35043, Marburg, Germany
    Childs Nerv Syst 23:685-9. 2007
    ..This study evaluates the influence of visual-spatial perception on laparoscopic performance of novices with a virtual reality simulator (LapSim(R))...
  10. ncbi request reprint [Operative management and long-term survival in patients with neuroendocrine tumors of the pancreas--experience with 144 patients]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 132:195-200. 2007
    ..To evaluate the outcome of patients with pancreatic endocrine tumors (PETs) in a tertiary referral centre...
  11. ncbi request reprint How asymptomatic is asymptomatic primary hyperparathyroidism?
    C Hasse
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 108:265-74. 2000
    ..quot;Asymptomatic" patients with pHPT may share the same objective and subjective benefits from PTX as symptomatic patients. They should be operated as soon as the diagnosis is established...
  12. ncbi request reprint An authentic malignant epithelioid hemangioendothelioma of the thyroid: a case report and review of the literature
    I Hassan
    Department of Surgery, Philipps University of Marburg, 35033 Marburg, Germany
    Thyroid 15:1377-81. 2005
    ..An improvement of the very poor prognosis of this rare tumor may depend on early tumor diagnosis and surgery combined with a multimodal treatment...
  13. ncbi request reprint Targeting the EGF/VEGF-R system by tyrosine-kinase inhibitors--a novel antiproliferative/antiangiogenic strategy in thyroid cancer
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Langenbecks Arch Surg 391:589-96. 2006
    ..The aim of this study, therefore, was to evaluate two tyrosine-kinase inhibitors (TKI, ZD 1839 gefitinib and ZD 6474 vandetanib), directed against the EGF/VEGF receptor for possible antitumor therapy in thyroid cancer...
  14. ncbi request reprint Differential pattern of integrin receptor expression in differentiated and anaplastic thyroid cancer cell lines
    S Hoffmann
    Department of Surgery, Philipps University of Marburg, Germany
    Thyroid 15:1011-20. 2005
    ..In vitro adhesion to ECM proteins and IRM expression concur. Finally, TSH-stimulated adhesion of thyroid tumor cell lines to ECM may not be associated with altered IRM expression...
  15. ncbi request reprint Negative stress-coping strategies among novices in surgery correlate with poor virtual laparoscopic performance
    I Hassan
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University of Marburg, Marburg, Germany
    Br J Surg 93:1554-9. 2006
    ..This study explored the impact of habitual stress-coping strategies on the laparoscopic performance of novices in surgery using a virtual reality simulator...
  16. ncbi request reprint [Reoperation for primary hyperparathyroidism]
    E Karakas
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 76:207-16. 2005
    ..The best option to avoid reoperations and associated complications is a successful initial intervention by an experienced surgeon. However, reoperations should always be performed by an experienced surgeon...
  17. ncbi request reprint [Zollinger-Ellison syndrome]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 76:217-26. 2005
    ..If the source of gastrin secretion can be regionalized to the pancreatic head by a preoperative SASI angiography, a pylorus-preserving partial pancreaticoduodenectomy might be the treatment of choice...
  18. ncbi request reprint First successful xenotransplantation of microencapsulated human parathyroid tissue in experimental hypoparathyroidism: long-term function without immunosuppression
    C Hasse
    Department of Surgery, Philipps University of Marburg, Germany
    J Microencapsul 14:617-26. 1997
    ..This may be a crucial step towards the first clinical application of this method...
  19. ncbi request reprint Clinical decision-making, ultrasonography, and scores for evaluation of suspected acute appendicitis
    A Zielke
    Department of Surgery, Philipps-University of Marburg, Baldingerstrasse, PO Box 100, 35033 Marburg, Germany
    World J Surg 25:578-84. 2001
    ..The joint evaluation of score results and clinical evaluation may deliver information of similar accuracy...
  20. ncbi request reprint Clinical background is required for optimum performance with a VR laparoscopy simulator
    I Hassan
    Department of Surgery, Philipps University Marburg, Germany
    Comput Aided Surg 11:103-6. 2006
    ..To determine the role of clinical background when assessing the learning effect using a virtual-reality (VR) laparoscopy simulator (LapSim)...
  21. ncbi request reprint Antisense p53 oligonucleotides inhibit proliferation and induce chemosensitivity in follicular thyroid cancer cells
    I Hassan
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University of Marburg, Germany
    Anticancer Res 26:1171-6. 2006
    ..The potential of MTp53 knockout by oligodesoxyribonucleotide phosphothioates (ODNs) to affect proliferation, apoptosis and chemosensitivity in undifferentiated thyroid cancer (UTC) cells with a recessive MTp53 mutation was evaluated...
  22. ncbi request reprint Successful treatment of solid-pseudopapillary tumor of the pancreas with multiple liver metastases
    I Hassan
    Department of Surgery, Institute of Theoretical Surgery, Philipps University of Marburg, Marburg, Germany
    Pancreatology 5:289-94. 2005
    ..The patient is disease free after a follow-up of 18 months after resection of the primary tumor, suggesting that an aggressive surgical treatment might also be justified for metastasized SPT...
  23. ncbi request reprint Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors
    E P Slater
    Department of Surgery, Philipps University Marburg, Germany
    Eur J Endocrinol 154:587-98. 2006
    ..The comparative analysis by cDNA microarrays of gene-expression patterns of benign and malignant adrenocortical tumors allows us to identify new tumor-suppressor genes and proto-oncogenes underlying adrenocortical tumorigenesis...
  24. ncbi request reprint Feasibility of MRI in the diagnosis of acute diverticulitis: initial results
    J T Heverhagen
    Department of Diagnostic Radiology, University Hospital, Philipps University, Baldingerstr, 35033 Marburg, Germany
    MAGMA 12:4-9. 2001
    ..The purpose of this study was to evaluate MRI as a diagnostic tool in patients with suspected acute sigmoid diverticulitis. Furthermore, we sought to develop an optimal imaging protocol in these patients...
  25. doi request reprint Severe Graves' ophthalmopathy may be a risk factor for the development of postthyroidectomy hypocalcaemia
    I Hassan
    Department of Visceral, Thoracic and Vascular Surgery, University of Giessen and Marburg, Germany
    Exp Clin Endocrinol Diabetes 116:614-8. 2008
    ..The aim of this study was to compare the rate of hypocalcaemia after thyroid resection in patients with versus patients without Graves' Ophthalmopathy (GO)...
  26. ncbi request reprint [An integrated concept of management for service-oriented hospitals--the "Balanced Scorecard"]
    B Dick
    Klinik fur Psychiatrie und Psychotherapie, Klinikum der Phillips Universität Marburg
    Dtsch Med Wochenschr 127:1656-9. 2002
  27. ncbi request reprint Antisense p53 decreases production of VEGF in follicular thyroid cancer cells
    I Hassan
    Department of Visceral, Thoracic, and Vascular Surgery Philipps University of Marburg, Germany
    Endocrine 29:409-12. 2006
    ..03). These results suggest that transient MTp53 knockout with ODNs complementary to p53 nucleotide sequences impair secretion of VEGF in the undifferentiated thyroid cancer cell line FTC-133...
  28. ncbi request reprint Medical and surgical treatment for secondary and tertiary hyperparathyroidism
    K Schlosser
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Marburg, Germany
    Scand J Surg 93:288-97. 2004
    ..Indication and results of medical and surgical therapy for SHPT and THPT have remained under discussion during the last decades. This review resumes the current medical and surgical strategies for patients with SHPT and THPT...
  29. ncbi request reprint Acute colonic diverticulitis: visualization in magnetic resonance imaging
    J T Heverhagen
    Department of Diagnostic Radiology, University Hospital, Philipps University, Marburg, Germany
    Magn Reson Imaging 19:1275-7. 2001
    ..MRI was diagnostic in all but one patient. It is concluded that MRI has considerable diagnostic potential in ACD and should be formally evaluated...
  30. ncbi request reprint [The new role for endoscopic ultrasound in endocrinology: imaging of the adrenals and the endocrine pancreas]
    P H Kann
    Bereich Endokrinologie und Diabetologie, 35033 Marburg
    Dtsch Med Wochenschr 131:567-72. 2006
    ..Endoscopic ultrasound imaging is especially relevant in the diagnosis of insulinomas and primary hyperaldosteronism, because it has direct consequences in planning a diagnostic and therapeutic strategy...
  31. ncbi request reprint Endoscopic ultrasound imaging of insulinomas: limitations and clinical relevance
    P H Kann
    Division of Endocrinology and Diabetology, Philipp s University Hospital, Marburg, Germany
    Exp Clin Endocrinol Diabetes 113:471-4. 2005
    ..As illustrated by three cases, endoscopic ultrasound imaging enables to identify patients that qualify for laparoscopic, minimal invasive surgery...
  32. ncbi request reprint Diagnostic score in appendicitis. Validation of a diagnostic score (Eskelinen score) in patients in whom acute appendicitis is suspected
    H Sitter
    Institute of Theoretical Surgery, Philipps University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Langenbecks Arch Surg 389:213-8. 2004
    ..However, for minimum morbidity to be obtained, early and accurate diagnosis is essential. This study aimed to validate a scoring system proposed by Eskelinen et al. as an aid in making the diagnosis of appendicitis...
  33. ncbi request reprint [Diagnosis and surgical treatment of insulinoma--experiences in 40 cases]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 129:941-6. 2004
    ..It was the aim of this study to analyse and evaluate our group of patients with regard to preoperative tumor localization and overall surgical results...
  34. ncbi request reprint Conventional bilateral cervical exploration versus open minimally invasive parathyroidectomy under local anaesthesia for primary hyperparathyroidism
    A Bergenfelz
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Br J Surg 92:190-7. 2005
    ..Thus far, only one randomized trial has compared video-assisted MIP with conventional bilateral cervical exploration (BCE). The value of open MIP is therefore not known...
  35. ncbi request reprint Long-term results of surgical treatment in Graves' disease orbitopathy. Is there a correlation between the extent of thyroidectomy and the course of orbithopathy?
    Elisabeth Maurer
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University of Marburg, Germany
    Chirurgia (Bucur) 103:291-5. 2008
    ..The place of thyroidectomy in the management of the Graves' disease patients with endocrine orbitopathy (EO) is still controversial. The aim of this study was to evaluate the course of EO according to the extent of thyroid resection...
  36. ncbi request reprint In vitro and in vivo angiogenesis in PC12 pheochromocytoma cells is mediated by vascular endothelial growth factor
    M Middeke
    Departments of Surgery and Internal Medicine LCH, Philipps University of Marburg, 35039 Marburg, Germany
    Exp Clin Endocrinol Diabetes 110:386-92. 2002
    ..Our data further suggest that NGF may contribute to angiogenesis in experimental pheochromocytoma...
  37. ncbi request reprint [Minimal-invasive operative treatment of organic hyperinsulinism]
    P Langer
    Klinik für Visceral, Thorax und Gefasschirurgie, Klinikum der Philipps Universität, 35043 Marburg
    Dtsch Med Wochenschr 130:514-8. 2005
    ..On the occasion of two cases, this report describes the laparoscopic treatment of these rare tumors...
  38. ncbi request reprint [A virtual reality simulator for objective assessment of surgeons' laparoscopic skill]
    I Hassan
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 76:151-6. 2005
    ..The aim of this study was to validate computed virtual reality simulation as a tool to assess laparoscopic skills and to establish whether the simulator allows differentiating between surgeons with different laparoscopic experience...
  39. ncbi request reprint [Premedication visits. Economizing at the cost of the patient?]
    C D Kratz
    Klinik für Anästhesie und Intensivmedizin, Klinikum der Philipps Universität Marburg
    Anaesthesist 53:862-70. 2004
    ..A working group from the university hospital in Marburg has developed a strategy for risk classification and further diagnostic and therapeutic measures as outlined in this article...
  40. ncbi request reprint The impact of parathyroid gland autotransplantation during bilateral thyroid surgery for Graves' disease on postoperative hypocalcaemia
    E Karakas
    Departement of Visceral, Thoracic and Vascular Surgery, University of Giessen and Marburg, Germany
    Endocr Regul 42:39-44. 2008
    ..The aim of this study was to compare the rate of hypocalcaemia after bilateral thyroid resection for Graves' Disease in patients with and without parathyroid gland autotransplantation (PTAT)...