Claus Vogelmeier

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi request reprint Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA
    J Heitmann
    Philipps University Marburg, Marburg, Germany
    Curr Med Res Opin 26:1925-32. 2010
  2. doi request reprint Effect of tiotropium vs. salmeterol on exacerbations: GOLD II and maintenance therapy naïve patients
    Claus Vogelmeier
    Department of Internal Medicine, Division for Pulmonary Diseases, Hospital of the University of Marburg, Philipps Universtät Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Respir Med 107:75-83. 2013
  3. pmc Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations
    Kai Michael Beeh
    insaf Respiratory Research Institute, Wiesbaden, Germany
    Int J Chron Obstruct Pulmon Dis 4:119-25. 2009
  4. pmc Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial
    Kai M Beeh
    University Medical Center Giessen and Marburg, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Respir Res 14:116. 2013
  5. ncbi request reprint Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study
    Claus F Vogelmeier
    Universitätsklinikum Gießen und Marburg, Marburg, Germany Electronic address
    Lancet Respir Med 1:51-60. 2013
  6. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
  7. doi request reprint Budesonide/formoterol maintenance and reliever therapy in Asian patients (aged ≥16 years) with asthma: a sub-analysis of the COSMOS study
    C Vogelmeier
    Marburg University Hospital, Germany
    Clin Drug Investig 32:439-49. 2012
  8. doi request reprint A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium
    Claus Vogelmeier
    Universitätsklinikum Giessen und Marburg, Marburg, Germany
    COPD 9:111-20. 2012
  9. pmc Regional differences in prediction models of lung function in Germany
    Eva Schnabel
    Helmholtz Zentrum Munchen, Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Respir Res 11:40. 2010
  10. pmc Indacaterol provides 24-hour bronchodilation in COPD: a placebo-controlled blinded comparison with tiotropium
    Claus Vogelmeier
    Novartis Pharmaceuticals Inc, One Health Plaza, East Hanover, NJ 07936 1080, USA
    Respir Res 11:135. 2010

Detail Information

Publications98

  1. doi request reprint Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA
    J Heitmann
    Philipps University Marburg, Marburg, Germany
    Curr Med Res Opin 26:1925-32. 2010
    ..To investigate the effect of nebivolol, a third generation beta-blocker, on blood pressure (BP) reduction and polysomnographic parameters in hypertensive patients with mild-to-moderate obstructive sleep apnoea (OSA)...
  2. doi request reprint Effect of tiotropium vs. salmeterol on exacerbations: GOLD II and maintenance therapy naïve patients
    Claus Vogelmeier
    Department of Internal Medicine, Division for Pulmonary Diseases, Hospital of the University of Marburg, Philipps Universtät Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Respir Med 107:75-83. 2013
    ..66; 95% CI, 0.48-0.91; p = 0.012). In conclusion, results from this prespecified subgroup analysis support the selection of tiotropium as first-choice maintenance therapy for patients with GOLD stage II COPD...
  3. pmc Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations
    Kai Michael Beeh
    insaf Respiratory Research Institute, Wiesbaden, Germany
    Int J Chron Obstruct Pulmon Dis 4:119-25. 2009
    ..Other challenges in designing exacerbation trials such as differential discontinuation and follow-up of discontinued patients are discussed...
  4. pmc Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial
    Kai M Beeh
    University Medical Center Giessen and Marburg, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Respir Res 14:116. 2013
    ..Data examining the characteristics of patients with frequent exacerbations of chronic obstructive pulmonary disease (COPD) and associated hospitalisations and mortality are scarce...
  5. ncbi request reprint Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study
    Claus F Vogelmeier
    Universitätsklinikum Gießen und Marburg, Marburg, Germany Electronic address
    Lancet Respir Med 1:51-60. 2013
    ..We aimed to compare the efficacy, safety, and tolerability of QVA149 versus salmeterol-fluticasone (SFC) over 26 weeks in patients with moderate-to-severe COPD...
  6. pmc Krüppel-like zinc finger proteins in end-stage COPD lungs with and without severe alpha1-antitrypsin deficiency
    A Rembert Koczulla
    Institute of Pathology, Hannover Medical School, Hanover, Germany
    Orphanet J Rare Dis 7:29. 2012
    ..A study was undertaken to investigate gene expression patterns in end-stage COPD lungs from patients with and without AATD...
  7. doi request reprint Budesonide/formoterol maintenance and reliever therapy in Asian patients (aged ≥16 years) with asthma: a sub-analysis of the COSMOS study
    C Vogelmeier
    Marburg University Hospital, Germany
    Clin Drug Investig 32:439-49. 2012
    ....
  8. doi request reprint A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium
    Claus Vogelmeier
    Universitätsklinikum Giessen und Marburg, Marburg, Germany
    COPD 9:111-20. 2012
    ..These results raise important questions for future investigation of anti-inflammatory and disease-modifying agents in patients with COPD...
  9. pmc Regional differences in prediction models of lung function in Germany
    Eva Schnabel
    Helmholtz Zentrum Munchen, Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Respir Res 11:40. 2010
    ..The aim of this analysis was to determine whether lung function determinants differ between subpopulations within Germany and whether prediction equations developed for one subpopulation are also adequate for another subpopulation...
  10. pmc Indacaterol provides 24-hour bronchodilation in COPD: a placebo-controlled blinded comparison with tiotropium
    Claus Vogelmeier
    Novartis Pharmaceuticals Inc, One Health Plaza, East Hanover, NJ 07936 1080, USA
    Respir Res 11:135. 2010
    ..This randomized, double-blind study compared the bronchodilator efficacy of indacaterol with that of placebo and tiotropium in patients with moderate-to-severe COPD...
  11. pmc Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
    Thomas Glaab
    Pulmonary Department, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Respir Res 11:79. 2010
    ....
  12. pmc Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
    Rembert Koczulla
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Respir Res 10:78. 2009
    ..Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases...
  13. pmc Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology, Uppsala University, Sweden
    Respir Res 10:11. 2009
    ....
  14. doi request reprint Profiling the bronchodilator effects of the novel ultra-long-acting β2-agonist indacaterol against established treatments in chronic obstructive pulmonary disease
    Claus Vogelmeier
    University Hospital Giessen und Marburg, Standort Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ther Adv Respir Dis 5:345-57. 2011
    ..To conclude, indacaterol is a highly effective bronchodilator that is superior to or at least as effective as other available long-acting bronchodilators for COPD...
  15. ncbi request reprint [Pathogenesis of chronic obstructive pulmonary disease]
    C Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg Standort Marburg
    Internist (Berl) 47:885-6, 888-90, 892-4. 2006
    ..Finally, several studies have indicated that a systemic inflammation is induced by COPD that may be of relevance to the development of systemic components that are observed in COPD patients...
  16. ncbi request reprint [Chronic obstructive lung disease]
    C Vogelmeier
    Klinik fur Innere Medizin, Klinikum der Philipps Universität Marburg
    Internist (Berl) 44:S16-22, S24-7. 2003
    ..Strategies for primary prevention and smoking cessation programs are extremely important. To get to the diagnosis of COPD as early as possible, all smokers with cough and phlegm should undergo spirometry...
  17. doi request reprint Safety and tolerability of NVA237, a once-daily long-acting muscarinic antagonist, in COPD patients
    C Vogelmeier
    Universitätsklinikum Giessen und Marburg, Marburg, Germany
    Pulm Pharmacol Ther 23:438-44. 2010
    ..Overall, the present study provides further evidence of the safety, tolerability and bronchodilator efficacy of once-daily treatment with NVA237 100 and 200 microg in patients with moderate-to-severe COPD...
  18. ncbi request reprint [Bronchodilators--effective also in negative broncholysis test. Decreased dyspnea decreased in any case]
    C Vogelmeier
    Klinik fur Innere Medizin, Schwerpunkt Pneumologie, Klinikum der Philipps Univ, Marburg
    MMW Fortschr Med 144:34-6, 38. 2002
    ..The sole life-prolonging treatment for COPD continues to be the long-term administration of oxygen; the only measure capable of stopping progressive deterioration of lung function is cessation of smoking...
  19. doi request reprint Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study
    Claus Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg Baldingerstrasse, D 35043 Marburg, Germany
    Respir Med 102:1511-20. 2008
    ..Combined bronchodilator therapy may be a valuable treatment option for patients with COPD...
  20. ncbi request reprint Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option?
    C Vogelmeier
    Klinikum der Philipps Universität Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Eur Respir J 26:819-28. 2005
    ..day(-1)). The simplified strategy using budesonide/formoterol for maintenance and reliever therapy is feasible, safe and at least as effective as salmeterol/fluticasone plus salbutamol...
  21. ncbi request reprint [Pneumology -- current developments]
    C Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt, Pneumologie, Universitätskliniken Giessen und Marburg, Standort Marburg, 35043 Marburg
    Dtsch Med Wochenschr 131:1431-4. 2006
  22. ncbi request reprint Treating the systemic effects of chronic obstructive pulmonary disease
    Claus F Vogelmeier
    Department of Respiratory Medicine, University of Marburg, Baldingerstrasse, Germany
    Proc Am Thorac Soc 8:376-9. 2011
    ..Physical inactivity may be a major cause for systemic inflammation. In turn, exercise training may be an effective form of therapy. Although smoking cessation is very effective, it is not successful in the majority of cases...
  23. ncbi request reprint [Guidelines for the diagnosis and therapy of COPD issued by Deutsche Atemwegsliga and Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin]
    C Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Marburg, Germany
    Pneumologie 61:e1-40. 2007
  24. doi request reprint NVA237, a long-acting muscarinic antagonist, as an emerging therapy for chronic obstructive pulmonary disease
    Claus Vogelmeier
    Department for Respiratory Diseases, University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Ther Adv Respir Dis 5:163-73. 2011
    ..Phase III studies are ongoing that will assess the long-term safety and efficacy of NVA237...
  25. doi request reprint Tiotropium versus salmeterol for the prevention of exacerbations of COPD
    Claus Vogelmeier
    Hospital of the Universities of Giessen and Marburg, Marburg, Germany
    N Engl J Med 364:1093-1103. 2011
    ..We investigated whether the anticholinergic drug tiotropium is superior to the β(2)-agonist salmeterol in preventing exacerbations of COPD...
  26. doi request reprint Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers
    A Rembert Koczulla
    Department of Internal Medicine, Division of Pulmonary Diseases, University Hospital Giessen and Marburg, Marburg, Germany koczulla med uni marburg de
    Respiration 79:61-7. 2010
    ..Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of inflammation...
  27. doi request reprint Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients
    A Rembert Koczulla
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Hospital of the University of Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Respir Med 106:120-6. 2012
    ..Deficiency of AAT may result in early-onset respiratory symptoms. Measurement of exhaled breath condensate (EBC) is a noninvasive method to investigate biomarkers present in the epithelial lining fluid, such as AAT...
  28. pmc The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils
    Sadek M Alalwani
    Department of Internal Medicine, Division of Pulmonary Diseases, Philipps University Marburg, Marburg, Germany
    Eur J Immunol 40:1118-26. 2010
    ..In conclusion, LL-37 modulates the response of neutrophils to bacterial activation. Cathelicidin controls the release of inflammatory mediators while increasing antimicrobial activity of neutrophils...
  29. pmc Comparison of two devices and two breathing patterns for exhaled breath condensate sampling
    Eva Maria Hüttmann
    Division for Pulmonary Diseases, Department of Internal Medicine, Philipps University Marburg, Marburg, Germany
    PLoS ONE 6:e27467. 2011
    ..In addition, we assessed different breathing patterns in healthy controls with protein markers to analyze the source of the EBC...
  30. ncbi request reprint Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program
    Robert Bals
    Department of Internal Medicine, Division for Pulmonary Diseases, Hospital of the University of Marburg, Philipps Universtät Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Respir Med 101:1708-14. 2007
    ..It was the aim of the study to determine whether the combination of an awareness program with the offer of a cost-free diagnostic test results in the identification of a significant number of individuals with severe AATD...
  31. doi request reprint Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose
    Akira D M Hattesohl
    Department for Internal Medicine, Division for Pulmonary Diseases, Philipps University Marburg, Marburg, Germany
    Respirology 16:1258-64. 2011
    ..To compare the volatile organic compound patterns of patients with COPD with and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology...
  32. pmc TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer
    Carola Seifart
    Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Germany
    Dis Markers 21:157-65. 2005
    ..The functional IL-10-1082 polymorphism correlates with altered IL-10 levels and might influence lung cancer susceptibility by altered inflammatory responses in the airways...
  33. ncbi request reprint Microbial DNA induces a host defense reaction of human respiratory epithelial cells
    Juliane Platz
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps University Marburg, Marburg, Germany
    J Immunol 173:1219-23. 2004
    ..The respiratory epithelium has an important function in triggering innate immune responses and therefore represents an interesting target for anti-inflammatory therapy...
  34. ncbi request reprint Emerging drugs in chronic obstructive pulmonary disease
    Carola Seifart
    University Hospital Giessen and Marburg GmbH, Division of Respiratory Medicine, Department of Internal Medicine, Marburg GmbH, Marburg, Germany
    Expert Opin Emerg Drugs 14:181-94. 2009
    ..Novel anti-inflammatory concepts that go beyond corticosteroids are in early phases of development and it remains to be seen how effective they are and what side effects they may carry...
  35. ncbi request reprint Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial
    Timm Greulich
    Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University, Member of the German Center for Lung Research DZL, Marburg 35043, Germany
    BMC Pulm Med 14:60. 2014
    ..We aimed to evaluate whether this modality added to conventional physiotherapy in exacerbated hospitalised COPD patients would be safe and would improve exercise capacity and quality of life...
  36. doi request reprint Ambient temperature impacts on pH of exhaled breath condensate
    Andreas R Koczulla
    Department of Internal Medicine, Pulmonology, Philipps University Marburg, Germany
    Respirology 15:155-9. 2010
    ..Low pH is correlated with inflammatory diseases like asthma and COPD. The aim of this study was to assess the influence of measurement temperature on pH values of EBC...
  37. doi request reprint The discovery of α1-antitrypsin and its role in health and disease
    Sabina M Janciauskiene
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Respir Med 105:1129-39. 2011
    ..In this review co-occurrence of several diseases with AAT deficiency is discussed...
  38. ncbi request reprint Allergic airway inflammation inhibits pulmonary antibacterial host defense
    Christoph Beisswenger
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Germany
    J Immunol 177:1833-7. 2006
    ..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
  39. ncbi request reprint Exposure of differentiated airway epithelial cells to volatile smoke in vitro
    Christoph Beisswenger
    Department of Internal Medicine, Division of Pulmonary Diseases, Philipps University of Marburg, Marburg, Germany
    Respiration 71:402-9. 2004
    ..The knowledge about the cellular and molecular mechanisms underlying the smoke-induced inflammation in epithelial cells is limited...
  40. ncbi request reprint C-Flex technology: effects on breathing parameters and inspiratory flow limitation
    Sebastian Canisius
    Faculty of Medicine, Sleep Disorders Center, Philipps University, DE 35043 Marburg, Germany
    Respiration 78:168-76. 2009
    ..However, the effects of C-Flex on ventilation during sleep have not been studied yet...
  41. ncbi request reprint Dynamics of heart rate and sleep stages in normals and patients with sleep apnea
    Thomas Penzel
    Division of Pulmonary Diseases, Department of Internal Medicine, Hospital of Philipps University, Baldingerstrasse 1, D 35033 Marburg, Germany
    Neuropsychopharmacology 28:S48-53. 2003
    ..Heart-rate regulation is part of the autonomous nervous system and sympathetic tone is strongly influenced by the sleep stages...
  42. ncbi request reprint [Differential diagnoses of dyspnoea]
    A R Koczulla
    Abteilung für Pulmonologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Baldingerstrasse 1, Marburg, Germany
    Internist (Berl) 48:1389-99; quiz 1400. 2007
    ..The aim of this article is to give an overview of basic pathophysiological mechanisms, diagnostic procedures and considerations with regard to possible differential diagnoses...
  43. doi request reprint [Chronic obstructive pulmonary disease: from pathogenesis to treatment]
    A R Koczulla
    Abteilung für Pulmonologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Baldingerstrasse 1, 35042 Marburg
    Dtsch Med Wochenschr 133:471-5. 2008
    ..New therapy concepts based on these findings will hopefully result in improvements of morbidity, disease control and quality of life...
  44. doi request reprint [The German registry of individuals with alpha-1-antitrypsin deficiency--a source for research on patient care]
    R Koczulla
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Philipps Universitat Marburg, Universitätsklinikum Giessen und Marburg, Marburg
    Pneumologie 62:655-8. 2008
    ..The low prevalence of AATD suggested the establishment of a registry with the aim to learn more details about the natural history and the quality of care for these patients...
  45. ncbi request reprint [Parapneumonic effusion and pleural empyema--diagnosis and conservative therapy]
    U Wagner
    Klinik fur Innere Medizin, Schwerpunkt Pneumologie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 130:525-9. 2005
  46. ncbi request reprint [Acute dyspnoea]
    U Wagner
    Klinik fur Innere Medizin, Schwerpunkt Pneumologie, Philipps Universitat Marburg
    Internist (Berl) 46:965-73. 2005
    ..Therefore, it is of utmost importance to identify the cause of dyspnoea immediately. Once found, the disorder is treated according to the guidelines for the underlying disease...
  47. ncbi request reprint Peripheral arterial tonometry for the diagnosis of obstructive sleep apnea
    T Penzel
    Klinik für Innere Medizin Pneumologie, Klinikum, Philipps Universitat, Marburg, Deutschland
    Biomed Tech (Berl) 47:315-7. 2002
    ..01) were significant. The PAT signal cannot substitute blood pressure but allows a good recognition of apneas and subcortical arousal and gives additional information on changes of sympathetic and parasympathetic tone during sleep...
  48. ncbi request reprint TNF-alpha-, TNF-beta-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease
    C Seifart
    Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Marburg, Germany
    Tissue Antigens 65:93-100. 2005
    ..Therefore, it might be associated with altered or abnormal inflammatory response, a mechanism that could be postulated to be important in both chronic bronchitis and coronary heart disease...
  49. ncbi request reprint [Obstructive sleep apnea, autonomic dysfunction and cardiovascular risk]
    U Koehler
    Klinik fur Innere Medizin, Schwerpunkt Pneumologie, Intensiv und Schlafmedizin, Philipps Universitat Marburg
    Dtsch Med Wochenschr 128:1124-8. 2003
  50. ncbi request reprint [Acoustic follow-up of nocturnal bronchial obstruction therapy]
    U Koehler
    Klinik fur Innere Medizin, SP Pneumologie, Intensiv und Schlafmedizin, Philipps Universitat Marburg
    Pneumologie 57:198-201. 2003
    ..Acoustic long term monitoring confirms the reduction of nocturnal bronchial obstructions under therapy with beta 2-agonists. A better sleep quality may be expected from the improvement of the respiratory situation during sleep...
  51. ncbi request reprint [Alpha-1-antitrypsin-laboratory and German alpha-1-antitrypsin-registry]
    R Bals
    Klinikum der Philipps Universität Marburg
    Pneumologie 58:637-8. 2004
  52. ncbi request reprint [Effect of subcutaneous fatty tissue on normal respiratory sounds]
    V Gross
    Klinik fur Innere Medizin, SP Pneumologie, Philipps Universitat Marburg
    Biomed Tech (Berl) 48:182-5. 2003
    ..The results of this study show that the influence of subcutaneous fat layer is negligible and can be ignored in the automatic detection of lung sounds...
  53. ncbi request reprint [Nocturnal long-term recording of breath sounds in patients with bronchial asthma -- a reasonable diagnostic option?]
    U Koehler
    Klinik fur Innere Medizin, SP Pneumologie, Intensiv und Schlafmedizin, Philipps Universitat, Marburg
    Pneumologie 59:872-8. 2005
    ..A mobile recording system provides a non-invasive monitoring at home which is independent of vigilance. Furthermore it can be used for follow-up examinations of medical interventions...
  54. ncbi request reprint [Acute exacerbation of COPD]
    R Bals
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Marburg
    Pneumologie 60:11-23; quiz 24-5. 2006
  55. ncbi request reprint [Why is obstructive sleep apnea (OSA) a cardiovascular risk factor?]
    U Koehler
    Klinik für Innere Medizin SP Pneumologie, Intensiv und Schlafmedizin, Philipps Universitat Marburg, Baldingerstrasse 1, 35033 Marburg, Germany
    Z Kardiol 92:977-84. 2003
    ..The extent and need for therapy should be assessed by three criteria: 1) daytime symptoms, 2) the extent of breathing disorder and 3) cardiovascular comorbidity...
  56. ncbi request reprint Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients
    J Heitmann
    Sleep Laboratory, Division of Pulmonary Diseases, Dept of Internal Medicine, Marburg University, Germany
    Eur Respir J 23:255-62. 2004
    ..This may explain, at least in part, some of the discrepant results in previous treatment studies...
  57. ncbi request reprint Detection of bronchial breathing caused by pneumonia
    V Gross
    Dept of Respir and Crit Care Med, Philipps University of Marburg
    Biomed Tech (Berl) 47:146-50. 2002
    ..0 +/- 0.1, p = 0.005 Wilcoxon-test). The computer based detection of bronchial breathing can be considered useful as part of a quantitative monitoring of patients at risk to develop pneumonia...
  58. ncbi request reprint A randomized clinical trial to assess the influence of a three months training program (Gym-based individualized vs. Calisthenics-based non-invidualized) in COPD-patients
    Timm Greulich
    Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University Marburg, Member of the German Center for Lung Research DZL, Marburg, Germany
    Respir Res 15:36. 2014
    ..Current guidelines recommend exercise training in patients with mild to very severe disease. However, there is insufficient data comparing the efficacy of different training approaches and intensities...
  59. ncbi request reprint Cell-specific modulation of surfactant proteins by ambroxol treatment
    Carola Seifart
    Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Toxicol Appl Pharmacol 203:27-35. 2005
    ..The results indicate that ambroxol may exert its positive effects, observed in the treatment of diseases related to surfactant deficiency, via modulation of surfactant protein expression...
  60. ncbi request reprint Inhibition of NF-kappaB mediated inflammation by siRNA expressed by recombinant adeno-associated virus
    Olaf Pinkenburg
    Department of Internal Medicine, Division of Pulmonary Diseases, Hospital of the University of Marburg, Philipps Universtät Marburg, Baldingerstrasse 1, D 35043 Marburg, Germany
    J Virol Methods 120:119-22. 2004
    ..In conclusion, rAAV vectors coding for siRNA are an useful tool for efficient gene silencing in mammalian cells and can be used to modify NF-kappaB mediated inflammation...
  61. ncbi request reprint Nonrandom variability of respiration during sleep in healthy humans
    Sven Rostig
    SP Pneumologie, Philipps Universitat Marburg, Schlafmedizinisches Labor, Marburg, Germany
    Sleep 28:411-7. 2005
    ....
  62. ncbi request reprint The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands
    Kerstin Kandler
    Department of Internal Medicine, Division for Pulmonary Diseases, Baldingerstrasse 1, 35043 Marburg, Germany
    Int Immunol 18:1729-36. 2006
    ..In conclusion, we demonstrate that the anti-microbial peptide LL-37 inhibits the activation of DCs by TLR ligands. We propose that LL-37 is a regulator of host defense responses at the intersection of innate and adaptive immune systems...
  63. doi request reprint [Chronic obstructive pulmonary disease (COPD) as a systemic disease]
    T Greulich
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Philipps Universitat Marburg, Baldingerstrasse, Marburg
    Dtsch Med Wochenschr 134:1231-5. 2009
    ..In addition, the part of the disease that is treatable with physiotherapy and rehabilitation must be fully taken into account. Such multimodal treatment regimens have so far not been implemented into clinical guidelines...
  64. doi request reprint Alpha1-antitrypsin deficiency - diagnostic testing and disease awareness in Germany and Italy
    Timm Greulich
    Division for Pulmonary Diseases, Department of Internal Medicine, Philipps University Marburg, 35043 Marburg, Germany
    Respir Med 107:1400-8. 2013
    ..Lack of awareness leads to long delays in diagnostic testing. Subsequently, lifestyle and treatment choices with potentially positive effects on prognosis may be postponed...
  65. ncbi request reprint [Intermediate care units and noninvasive ventilation]
    Heinrich F Becker
    Klinik fur Innere Medizin, SP Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Marburg
    Med Klin (Munich) 101:334-9. 2006
    ..The high prevalence of pulmonary diseases and NIV emphasizes the importance of pneumologists as directors of both ICU and IMC...
  66. ncbi request reprint Recombinant Sendai virus for efficient gene transfer to human airway epithelium
    Olaf Pinkenburg
    Hospital of the University of Marburg, Department of Internal Medicine, Division of Pulmonology, Philipps UniverstätMarburg, Marburg, Germany
    Exp Lung Res 30:83-96. 2004
    ..In conclusion, rSeV infects differentiated human airway epithelial cells with high efficiency. Transgene expression is transient and accompanied by the secretion of an inflammatory cytokine...
  67. ncbi request reprint Association of right ventricular dysfunction and Cheyne-Stokes respiration in patients with chronic heart failure
    Michael Christ
    Klinik fur Innere Medizin, Kardiologie, Philipps Universitat Marburg, Marburg, Germany
    J Sleep Res 12:161-7. 2003
    ..In conclusion, CSR is associated with depressed systolic RV function and increased RV dimensions in CHF patients. Future studies will show whether optimized treatment of CSR will improve RV function...
  68. ncbi request reprint Peripheral arterial tonometry, oximetry and actigraphy for ambulatory recording of sleep apnea
    Thomas Penzel
    Division for Pulmonary Diseases, Department of Internal Medicine, Hospital of Philipps University, Baldingerstr 1, D 35033 Marburg, Germany
    Physiol Meas 25:1025-36. 2004
    ..Arousals are not unique to apnea events and therefore the specifity of the Watch-PAT is limited. In conclusion, the Watch-PAT is well suited to perform therapy control studies in patients suffering from sleep apnea and being treated...
  69. doi request reprint Suppression of pulmonary innate host defence in smokers
    C Herr
    Department of Internal Medicine, Division of Pulmonology, Hospital of the University of Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Thorax 64:144-9. 2009
    ..It is postulated that cigarette smoke suppresses the activation of the innate immune system in response to bacterial infection...
  70. pmc Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules
    R Bals
    Medizinische Klinik und Poliklinik I, Hospital of the University of Munich, Campus Grosshadern, Schwerpunkt Pneumologie, Ludwig Maximilians Universitat, Marchioninstr 15, 81377 Munich, Germany
    Clin Diagn Lab Immunol 8:370-5. 2001
    ..The present study demonstrates that beta-defensins and cathelicidins of rhesus monkeys are close homologues to the human molecules and indicate that nonhuman primates represent valid model organisms to study innate immune functions...
  71. pmc An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
    Rembert Koczulla
    Hospital of the University of Marburg, Department of Internal Medicine, Philipps Universtät Marburg, Marburg, Germany
    J Clin Invest 111:1665-72. 2003
    ..Taken together, these findings demonstrate that LL-37/hCAP-18 is a multifunctional antimicrobial peptide with a central role in innate immunity by linking host defense and inflammation with angiogenesis and arteriogenesis...
  72. doi request reprint [Update: Alpha-1-antitrypsin deficiency. Summary of a scientific symposium at the conference of the Swiss Pneumologic Society on April 16th, 2009]
    C Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Deutschland
    Pneumologie 63:718-25. 2009
    ..Alpha-1 centres provide particular expertise, and it is recommended that every patient should be seen in one of these specialised outpatient clinics...
  73. ncbi request reprint [Therapy of lung diseases with antiproteases]
    C Vogelmeier
    Pneumologische Abteilung Klimikum Grosshadern,
    Pneumologie 48:57-62. 1994
    ..abstract truncated at 250 words)..
  74. ncbi request reprint [Management of acute exacerbation of chronic obstructive pulmonary disease (COPD)]
    A Gillissen
    Robert Koch Klinik, Klinikum St Georg, Leipzig
    Dtsch Med Wochenschr 128:1721-7. 2003
  75. ncbi request reprint [Reflux-associated respiratory tract diseases: asthma, chronic cough, sleep apnea. Epidemiology, diagnosis and therapy]
    D Jaspersen
    Medizinische Klinik II, Klinikum Fulda
    Internist (Berl) 44:58-62. 2003
  76. ncbi request reprint [Difficult to manage asthma: clinical phenotypes and principles of therapy]
    G Menz
    Hochgebirgsklinik Davos Wolfgang, CH
    Pneumologie 56:132-7. 2002
  77. ncbi request reprint Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  78. ncbi request reprint [Guidelines for diagnosis and treatment of asthma patients]
    R Buhl
    Schwerpunkt Pneumologie, III Medizinische Klinik, Mainz
    Pneumologie 60:139-77. 2006
  79. ncbi request reprint [Inhalation therapy with Respimat soft inhaler in patients with COPD and asthma]
    T Voshaar
    Krankenhaus Bethanien, Moers
    Pneumologie 59:25-32. 2005
    ..The Respimat SI meets the requirements for an ideal inhaler better than any other previous device and must therefore be regarded as a significant new development...
  80. ncbi request reprint [beta(2)-Sympathomimetics: risks for asthma therapy? Lessons from the SMART1 Study. A statement from the German Respiratory Tract League]
    A Gillissen
    Robert Koch Klinik, Thoraxzentrum des Klinikums St Georg, Leipzig
    Dtsch Med Wochenschr 132:33-9. 2007
  81. ncbi request reprint The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing
    R Buhl
    Mainz University Hospital, Germany
    Curr Med Res Opin 20:1209-20. 2004
    ..Budesonide/formoterol in a single inhaler is an effective therapy for asthma. We investigated whether adjustable maintenance dosing with budesonide/formoterol could maintain health-related quality of life (HRQL) and asthma control...
  82. ncbi request reprint Automatic CPAP titration with different self-setting devices in patients with obstructive sleep apnoea
    A Stammnitz
    Dept of Respiratory Medicine and Sleep Unit, Philipps University Marburg, Marburg an der Lahn, Germany
    Eur Respir J 24:273-8. 2004
    ..It is concluded that automatic continuous positive airway pressure devices produce a significant reduction in apnoea/hypopnoea index; however, there is considerable difference in the efficacy of the various devices...
  83. ncbi request reprint Exacerbations of COPD: quantifying the patient's perspective using discrete choice modelling
    J Haughney
    Dept of General Practice and Primary Care, University of Aberdeen, Westburn Road, Aberdeen, AB25 2AY, UK, and Marburg University Hospital, Germany
    Eur Respir J 26:623-9. 2005
    ..Strategies for the clinical management of chronic obstructive pulmonary disease should clearly address patients' concerns and focus on preventing and treating exacerbations to avoid these feared outcomes...
  84. ncbi request reprint [Guideline of the German respiratory society for diagnosis and treatment of patients suffering from acute or chronic cough]
    P Kardos
    Gemeinschaftspraxis und Pneumologisches Allergologisches Zentrum Maingau Krankenhaus Frankfurt am Main
    Pneumologie 58:570-602. 2004
  85. ncbi request reprint Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma
    P Kuna
    Division of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Respir Med 100:2151-9. 2006
    ..Budesonide/formoterol administered once daily in the evening is a convenient treatment regimen that is as effective in improving asthma control as twice-daily dosing in patients with mild to moderate persistent asthma...
  86. ncbi request reprint [Clinical significance of gastrooesophageal reflux in asthma]
    T Rothe
    Luzerner Höhenklinik Montana, Switzerland
    Pneumologie 60:672-8. 2006
    ..An algorithm to guide the diagnostic and therapeutic steps in such cases is presented...
  87. ncbi request reprint [Guidelines for diagnosing extrinsic allergic alveolitis (hypersensitivity pneumonitis) (German Extrinsic Allergic Alveolitis Study Group)]
    J Sennekamp
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Pneumologie 61:52-6. 2007
  88. ncbi request reprint [Therapy of lung diseases with anti-oxidants]
    R Buhl
    ,
    Pneumologie 48:50-6. 1994
    ....
  89. ncbi request reprint [COPD or how much do we spend for what]
    C Vogelmeier
    Pneumologie 58:833-4. 2004
  90. ncbi request reprint The role of neutrophils in the pathogenesis of obliterative bronchiolitis after lung transplantation
    A Elssner
    Department of Internal Medicine, Division of Pulmonary and Critical Care, The Heart and Lung Institute, Ohio State University, Columbus, Ohio, USA
    Transpl Infect Dis 3:168-76. 2001
    ..These mechanisms may provide possible targets to develop new therapeutic strategies that either prevent neutrophil sequestration and activation, or inhibit neutrophil products in order to prevent or attenuate airway damage...
  91. ncbi request reprint Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction
    J R Garcia
    IPF PharmaCeuticals GmbH, Feodor Lynen Strasse 31, 30625 Hanover, Germany
    Cell Tissue Res 306:257-64. 2001
    ..Human beta-defensins represent a family of antimicrobial peptides differentially expressed in most tissues, regulated by specific mechanisms, and exerting physiological functions not only related to direct host defense...
  92. pmc Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele
    D T Curiel
    Pulmonary Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892
    Mol Cell Biol 10:47-56. 1990
    ..e., the alpha 1AT Mmineral springs allele predisposes to emphysema on the basis of serum apha 1AT deficiency coupled with alpha AT dysfunction...
  93. ncbi request reprint Bronchial epithelial cell B7-1 and B7-2 mRNA expression after lung transplantation: a role in allograft rejection?
    A Elssner
    Section for Pulmonary Diseases, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Germany
    Eur Respir J 20:165-9. 2002
    ..In summary, B7 messenger ribonucleic acid expression by bronchial epithelial cells may play a role in (chronic) lung allograft rejection...
  94. ncbi request reprint [The 10-minute consultation: hemoptysis]
    A R Koczulla
    Philipps Univ Marburg, Innere Medizin Pneumologie
    MMW Fortschr Med 149:46-7. 2007
  95. doi request reprint [Care of patients under mechanical ventilation at home and in nursing home conditions. Position paper of the German Medical Associations of Pneumology and Ventilatory Support ("Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin e. V." and "Arbeits
    W Randerath
    Institut für Pneumologie an der Universität Witten Herdecke, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf und Beatmungsmedizin, Krankenhaus Bethanien, Aufderhöher Strasse 169 175, 42699 Solingen
    Pneumologie 62:305-8. 2008
    ..V." and the "Arbeitsgemeinschaft für Heimbeatmung und Respiratorentwöhnung e. V.", wish to present this actual position paper. However, scientific guidelines are in preparation...
  96. ncbi request reprint [The pneumologist as detective]
    C Vogelmeier
    Pneumologie 58:639-40. 2004
  97. ncbi request reprint IPF or NSIP? That is the question
    C Vogelmeier
    Eur Respir J 22:191-2. 2003
  98. ncbi request reprint ESPEN Guidelines on Enteral Nutrition: Cardiology and pulmonology
    S D Anker
    Division of Applied Cachexia Research, Department of Cardiology, Charite Universitatsmedizin Berlin, CVK, Berlin, Germany
    Clin Nutr 25:311-8. 2006
    ..Frequent small amounts of ONS are preferred in order to avoid postprandial dyspnoea and satiety as well as to improve compliance...