Research Topics
Species | Karin Stiasny-KolsterSummaryAffiliation: Philipps University Country: Germany Publications
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Publications
CSF hypocretin-1 levels in restless legs syndromeK Stiasny-Kolster
Department of Neurology, Philipps University Marburg, Germany
Neurology 61:1426-9. 2003..Hypocretin-1 levels did not correlate with RLS severity or polysomnographic measures. These results contrast with previous findings reporting significantly increased CSF hypocretin-1 in the late evening and mostly in early onset RLS...- Restless legs syndrome--new insights into clinical characteristics, pathophysiology, and treatment optionsK Stiasny-Kolster
Department of Neurology, Philipps University Marburg, Rudolf Bultmann Strasse 8, 35033 Marburg, Germany
J Neurol 251:VI/39-43. 2004..Placebo-controlled large-scale phase II and III treatment trials have shown that dopamine agonists are safe and efficacious agents for the treatment of this disorder... - Effective cabergoline treatment in idiopathic restless legs syndromeK Stiasny-Kolster
Department of Neurology, Philipps University, Marburg, Germany
Neurology 63:2272-9. 2004..To assess the efficacy and safety of the dopamine agonist cabergoline (CAB) in patients with restless legs syndrome (RLS)... - Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECTK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Germany
Brain 128:126-37. 2005..Since narcoleptic patients are not known to have an increased risk of developing parkinsonism, the pathophysiology and clinical relevance of hyposmia in RBD/narcolepsy patients requires further research... - Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot studyKarin Stiasny-Kolster
Department of Neurology, Philipps University, Marburg, Germany
Mov Disord 19:1432-8. 2004..This pilot study suggests that continuous delivery of rotigotine by means of a patch may provide an effective and well-tolerated treatment of RLS symptoms both during night and day... - Low-dose pramipexole in the management of restless legs syndrome. An open label trialKarin Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
Neuropsychobiology 50:65-70. 2004..Pramipexole has proven a suitable alternative in patients with moderate to severe RLS, particularly when their therapy has to be switched to a dopamine agonist... - Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndromeK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
Brain 127:773-82. 2004.... - Normal dopaminergic and serotonergic metabolites in cerebrospinal fluid and blood of restless legs syndrome patientsKarin Stiasny-Kolster
Department of Neurology, Philipps University Marburg, Germany
Mov Disord 19:192-6. 2004..In addition, serotonin in whole blood and plasma activity of aromatic amino acid decarboxylase were all normal. Our results suggest that dopaminergic and serotonergic release is not substantially affected in RLS... - Daytime sleep latency in medication-matched Parkinsonian patients with and without sudden onset of sleepJ Carsten Moller
Department of Neurology, Philipps University Marburg, Marburg, Germany
Mov Disord 20:1620-2. 2005..The mean sleep latency on the multiple sleep latency test was in the normal range and not significantly different between the groups. These data suggest that sleep attacks can occur against a background of normal alertness... 
Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic studyWolfgang H Oertel
Department of Neurology, Philipps Universitat, Rudolf Bultmann Str 8, Marburg, Germany
Sleep Med 11:848-56. 2010....- One year open-label safety and efficacy trial with rotigotine transdermal patch in moderate to severe idiopathic restless legs syndromeWolfgang H Oertel
Department of Neurology, Philipps Universitat, Marburg, Germany
Sleep Med 9:865-73. 2008..Long-term efficacy and tolerability data are not yet available for patch formulations of dopamine agonists in restless legs syndrome... - Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in EuropeWolfgang H Oertel
Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, D 35039 Marburg, Germany
Sleep Med 9:228-39. 2008..In a pilot placebo-controlled study, low dosages of 0.5-2mg/24h rotigotine showed a dose-dependent beneficial effect in restless legs syndrome (RLS) patients... - Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension studyWolfgang Oertel
Philipps Universitat, Marburg, Germany
Lancet Neurol 10:710-20. 2011..We did a prospective open-label extension of a 6-week, double-blind randomised trial to assess the safety, tolerability, and efficacy of rotigotine transdermal patch for up to 5 years in patients with restless legs syndrome... - Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath testMarcus M Unger
Department of Neurology, Philipps University Marburg, Marburg, Germany
Mov Disord 26:2559-63. 2011..Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated... - Preprohypocretin polymorphisms in Parkinson disease patients reporting "sleep attacks"Ida Rissling
Department of Neurology, Philipps University Marburg, Germany
Sleep 28:871-5. 2005..Here we evaluated the association between the preprohypocretin (-909T/C), (-22C/T), and (-20C/A) polymorphisms and sudden onset of sleep in the same population of patients with Parkinson disease... - Validation of the "L-DOPA test" for diagnosis of restless legs syndromeKarin Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
Mov Disord 21:1333-9. 2006..We recommend the L-DOPA test for diagnostic decision making in all patients with an unclear RLS diagnosis according to the essential diagnostic criteria of the International RLS Study Group... - Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECTMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Germany
Mov Disord 23:596-9. 2008..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD... - Postprandial ghrelin response is reduced in patients with Parkinson's disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson's disease?Marcus M Unger
Department of Neurology, Philipps Universitat Marburg, Rudolf Bultmann Strasse 8, 35033, Marburg, Germany
J Neurol 258:982-90. 2011..The impaired ghrelin excretion might qualify as a peripheral biomarker and be of diagnostic or therapeutic value... - Sudden onset of sleep and dopaminergic therapy in patients with restless legs syndromeJens Carsten Moller
Department of Neurology, Philipps University, 35033 Marburg, Germany
Sleep Med 7:333-9. 2006..Here, we investigated as to what extent SOS is found in patients with restless legs syndrome (RLS), who are frequently treated with dopaminergic drugs, and controls... 
Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regionsMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Marburg, Germany
Sleep 33:767-73. 2010....- The REM sleep behavior disorder screening questionnaire--a new diagnostic instrumentKarin Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
Mov Disord 22:2386-93. 2007..02 +/- 1.78) was significantly lower than in the RBD group (P < 0.0005), revealing a specificity of 0.92. Due to its high sensitivity, the RBDSQ appears to be particularly useful as a screening tool... - Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-RLS study)Wolfgang H Oertel
Philipps University Marburg, Marburg, Germany
Mov Disord 22:213-9. 2007..35 mg/day; P < 0.0001). CGI-I responder rates were 32.5% (placebo) and 62.9% (pramipexole) (P < 0.0001). For all secondary endpoints, pramipexole showed superior results. Pramipexole was well tolerated throughout the study... - Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson diseaseIda Rissling
Department of Neurology, Philipps University Marburg, Germany
Sleep 29:108-11. 2006..We sought to confirm this association in a large group of patients with PD... - Restless Legs Syndrome (RLS) and Parkinson's disease (PD)-related disorders or different entities?Jens Carsten Moller
Department of Neurology, Philipps University, Marburg, Germany
J Neurol Sci 289:135-7. 2010..This review provides an overview of the current pertinent literature and discusses the possible association between RLS and PD... - Transcranial midbrain sonography in narcoleptic subjects with and without concomitant REM sleep behaviour disorderMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Rudolf Bultmann Str 8, 35039, Marburg, Germany
J Neurol 256:874-7. 2009..Reduced echogenicity of the brainstem raphe might indicate an involvement of the serotonergic system in narcoleptic subjects with RBD... - Quantification of tonic and phasic muscle activity in REM sleep behavior disorderGeert Mayer
Department of Neurology, Hephata Klinik, Schwalmstadt Treysa, Germany
J Clin Neurophysiol 25:48-55. 2008.... - Cortical silent period is shortened in restless legs syndrome independently from circadian rhythmK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps-University of Marburg, Rudolf-Bultmann-Strasse 8, D-35033 Marburg, Germany
Suppl Clin Neurophysiol 56:381-9. 2003 - Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorderK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Schwalmstadt Treysa, Germany
Brain 130:442-9. 2007..In contrast to patients with idiopathic RBD, hyposmia in patients with RBD associated with narcolepsy is unlikely to be a predictor for developing parkinsonism... - Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR)W H Oertel
Department of Neurology, Center of Nervous Diseases, Philipps University Marburg, Rudolf Bultmann Str 8, D 35033 Marburg, Germany
Neurology 67:1040-6. 2006..To assess the efficacy and safety of the dopamine agonist cabergoline in the treatment of patients with idiopathic restless legs syndrome (CATOR study)... - Pharmacotherapy of Parkinson's disease in GermanyJ C Moller
Dept of Neurology, Philipps Universitat Marburg, Rudolf Bultmann Str 8, 35039 Marburg, Germany
J Neurol 252:926-35. 2005..In addition our data suggest that non-motor symptoms in PD are not adequately treated and that concomitant sedative medication contributes to the occurrence of SOS... - Health economic burden of patients with restless legs syndrome in a German ambulatory settingRichard Dodel
Department of Neurology, Philipps University Marburg, Marburg, Germany
Pharmacoeconomics 28:381-93. 2010..RLS places a notable financial burden on society as well as on patients and their families. More detailed studies are needed to evaluate the health economic impact of this disorder... - Continuous sleep EEG monitoring in PD patients with and without sleep attacksJens Carsten Moller
Department of Neurology, Philipps University Marburg, Rudolf Bultmann Strasse 8, 35039 Marburg, Germany
Parkinsonism Relat Disord 15:238-41. 2009..Future studies should systematically address the awareness of short sleep episodes in patients with PD and other disorders with increased daytime sleepiness... - Differential diagnosis of unpleasant sensations in the legs: prevalence of restless legs syndrome in a primary care populationCaroline Möller
Department of Neurology, J W Goethe University, Frankfurt am Main, Germany Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
Sleep Med 11:161-6. 2010..Restless legs syndrome (RLS) is a common neurological condition. We investigated the prevalence of RLS in patients suffering from unpleasant sensations in the legs... - State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndromeWolfgang H Oertel
Department of Neurology, Philipps University, Marburg, Germany
Mov Disord 22:S466-75. 2007..Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L)... - Health-related quality of life and economic burden in patients with restless legs syndromeJens P Reese
Philipps University Marburg, Department of Neurology, Rudolf Bultmannstr 8, 35039 Marburg, Germany
Expert Rev Pharmacoecon Outcomes Res 7:503-21. 2007..Very few of the RLS treatment options, however, have been evaluated for their cost-effectiveness, and further research is needed on both quality-of-life issues and the economic impact of RLS... - Genome-wide association study of restless legs syndrome identifies common variants in three genomic regionsJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center of Environment and Health, D 85764 Neuherberg, Munich, Germany
Nat Genet 39:1000-6. 2007..MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder... - Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndromeClaudia Trenkwalder
Paracelsus Elena Klinik, Kassel, Germany
Mov Disord 21:1404-10. 2006..The great majority of adverse events (AEs) were mild or moderate, and of expected types. Augmentation was considered an AE, but in this population of responders it did not occur... - Predictors of freezing in Parkinson's disease: a survey of 6,620 patientsMichael Macht
Department of Psychology, University of Wurzburg, Wurzburg, Germany
Mov Disord 22:953-6. 2007.... - Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndromeDiego Garcia-Borreguero
Fundacion Jimenez Diaz, Madrid, Spain
Sleep Med 8:455-63. 2007..The changes in each dimension are summed to give an ASRS total score... - PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndromeBarbara Schormair
Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg 85764, Germany
Nat Genet 40:946-8. 2008..91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS... - Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndromeJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 23:350-8. 2008..Potential usage of NO modulating agents as new treatment options for RLS have become a challenging aspect for future research of this disorder... - Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trialClaudia Trenkwalder
Paracelsus Elena Hospital, Kassel, Germany
Lancet Neurol 7:595-604. 2008..Continuous administration of a dopamine agonist could be used to treat patients with restless legs syndrome. Our aim was to investigate the efficacy of transdermal rotigotine in the treatment of idiopathic restless legs syndrome... - Driving in Parkinson's disease: mobility, accidents, and sudden onset of sleep at the wheelCharlotte Meindorfner
Center for Traffic Sciences, Department of Psychology, , , Germany
Mov Disord 20:832-42. 2005..The results suggest that real sleep attacks without any prior sleepiness are rare. However, our data underline the importance of mobility for patients and the need for further studies addressing the ability to drive in PD... - Predictors of sudden onset of sleep in Parkinson's diseaseYvonne Körner
Center for Traffic Sciences, Department of Psychology, University of Wuerzburg, Wuerzburg, Germany
Mov Disord 19:1298-305. 2004..We recommend the development of a standardised question to recognise SOS and to facilitate the comparison of prevalence estimates... - Update of the pathophysiology of the restless-legs-syndromeWalter Paulus
Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
Mov Disord 22:S431-9. 2007..Furthermore, this may create a framework to help understand why dopamine, opioid, and some anticonvulsant therapies are effective in RLS patients... - Pathophysiological concepts of restless legs syndromeWalter Paulus
Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
Mov Disord 22:1451-6. 2007..Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing... - Family-based association study of the restless legs syndrome loci 2 and 3 in a European populationDavid Kemlink
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:207-12. 2007..0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS... - Magnesium not likely to play a major role in the pathogenesis of Restless Legs Syndrome: serum and cerebrospinal fluid studiesArthur S Walters
Sleep Med 8:186-7. 2007 - Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)Claudia Trenkwalder
Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
Mov Disord 22:S495-504. 2007..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols... - Assessment of restless legs syndrome--methodological approaches for use in practice and clinical trialsRalf Kohnen
IMEREM Institute for Medical Research Management, Biometrics Ltd, University of Erlangen Nuremberg, Nuremberg, Germany
Mov Disord 22:S485-94. 2007.... - Genetics of restless legs syndrome (RLS): State-of-the-art and future directionsJuliane Winkelmann
Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
Mov Disord 22:S449-58. 2007..One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies...