M Schoppet

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Alcohol and the heart
    M Schoppet
    Department of Internal Medicine, Cardiology and Angiology, Philipps University Marburg, Germany
    Herz 26:345-52. 2001
  2. ncbi request reprint Expression of bone-regulating factors osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) in heterotopic vascular ossification
    Nadia Al-Fakhri
    Department of Clinical Chemistry, Philipps University, Marburg, Germany
    Thromb Haemost 94:1335-7. 2005
  3. ncbi request reprint Images in cardiovascular medicine. Phenotype of infiltrating T lymphocytes in cardiac sarcoidosis
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Baldingerstrasse, Marburg, Germany
    Circulation 105:e67-8. 2002
  4. doi request reprint Crystallizing nanoparticles derived from vascular smooth muscle cells contain the calcification inhibitor osteoprotegerin
    Michael Schoppet
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biochem Biophys Res Commun 407:103-7. 2011
  5. doi request reprint Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
    M Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    Kidney Int 73:989-91. 2008
  6. ncbi request reprint Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependent
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    J Cell Biochem 100:1430-9. 2007
  7. ncbi request reprint TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, D 35033 Marburg, Germany
    Biochem Biophys Res Commun 338:1745-50. 2005
  8. ncbi request reprint CD83+ dendritic cells in inflammatory infiltrates of Churg-Strauss myocarditis
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Arch Pathol Lab Med 127:98-101. 2003
  9. ncbi request reprint Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis
    Michael Schoppet
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Clin Endocrinol Metab 89:4104-12. 2004
  10. ncbi request reprint Severe abdominal aortic calcification in older men is negatively associated with DKK1 serum levels: the STRAMBO study
    P Szulc
    Inserm Unité Mixte de Recherche 1033 P S, R C, University of Lyon, Hospices Civils de Lyon, F 69437 Lyon, France Department of Internal Medicine and Cardiology M S, Philipps University, D 35043 Marburg, Germany Division of Endocrinology, Diabetes, and Bone Diseases T D R, L C H, Dresden University Medical Center, Dresden, Germany and Center for Regenerative Therapies L C H, D 01307 Dresden, Germany
    J Clin Endocrinol Metab 99:617-24. 2014

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Alcohol and the heart
    M Schoppet
    Department of Internal Medicine, Cardiology and Angiology, Philipps University Marburg, Germany
    Herz 26:345-52. 2001
    ..Alcohol interferes with other medications, and drinking can exacerbate a variety of medical illnesses...
  2. ncbi request reprint Expression of bone-regulating factors osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) in heterotopic vascular ossification
    Nadia Al-Fakhri
    Department of Clinical Chemistry, Philipps University, Marburg, Germany
    Thromb Haemost 94:1335-7. 2005
  3. ncbi request reprint Images in cardiovascular medicine. Phenotype of infiltrating T lymphocytes in cardiac sarcoidosis
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Baldingerstrasse, Marburg, Germany
    Circulation 105:e67-8. 2002
  4. doi request reprint Crystallizing nanoparticles derived from vascular smooth muscle cells contain the calcification inhibitor osteoprotegerin
    Michael Schoppet
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biochem Biophys Res Commun 407:103-7. 2011
    ..Like other calcification inhibitors, OPG may be specifically loaded into these nanoparticles to be deposited at remote sites, where it acts to inhibit calcification...
  5. doi request reprint Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
    M Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    Kidney Int 73:989-91. 2008
    ..Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels...
  6. ncbi request reprint Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependent
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    J Cell Biochem 100:1430-9. 2007
    ..In summary, we describe that the expression of OPG by DC increases with maturation and is NF-kappaB-dependent, possibly regulating immune responses in lymphoid tissues...
  7. ncbi request reprint TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, D 35033 Marburg, Germany
    Biochem Biophys Res Commun 338:1745-50. 2005
    ..001 vs. controls). In conclusion, myocardial overexpression of antiapoptotic OPG in DCM patients may represent a compensatory mechanism to limit systemic activation of TRAIL in patients with congestive heart disease...
  8. ncbi request reprint CD83+ dendritic cells in inflammatory infiltrates of Churg-Strauss myocarditis
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Arch Pathol Lab Med 127:98-101. 2003
    ....
  9. ncbi request reprint Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis
    Michael Schoppet
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Clin Endocrinol Metab 89:4104-12. 2004
    ....
  10. ncbi request reprint Severe abdominal aortic calcification in older men is negatively associated with DKK1 serum levels: the STRAMBO study
    P Szulc
    Inserm Unité Mixte de Recherche 1033 P S, R C, University of Lyon, Hospices Civils de Lyon, F 69437 Lyon, France Department of Internal Medicine and Cardiology M S, Philipps University, D 35043 Marburg, Germany Division of Endocrinology, Diabetes, and Bone Diseases T D R, L C H, Dresden University Medical Center, Dresden, Germany and Center for Regenerative Therapies L C H, D 01307 Dresden, Germany
    J Clin Endocrinol Metab 99:617-24. 2014
    ..Experimental data show that dickkopf-1 (DKK1) may be involved in the regulation of arterial calcification. However, clinical data on the association between serum DKK1 levels and severity of abdominal aortic calcification (AAC) are scarce...
  11. ncbi request reprint Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease
    A M Sattler
    Division of Cardiology, Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Calcif Tissue Int 74:103-6. 2004
    ..In summary, there is increasing evidence that RANKL and OPG may link the skeletal with the vascular system...
  12. ncbi request reprint Vascular calcification and osteoporosis--from clinical observation towards molecular understanding
    L C Hofbauer
    Department of Internal Medicine LCH, CCB, MS, Philipps University, Marburg, Germany
    Osteoporos Int 18:251-9. 2007
    ..We propose a unifying hypothesis of vascular calcification that combines both active and passive mechanisms of vascular mineralization with aspects of bone resorption and age-related changes...
  13. ncbi request reprint Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death
    J Schrader
    Division of Gastroenterology and Endocrinology, Department of Medicine, Philipps University, Baldingerstrasse, 35033 Marburg, Germany
    Diabetologia 50:1243-7. 2007
    ..The aim of the present study was to characterise the functional role and signalling pathways of OPG that are involved in cytokine-induced beta cell death...
  14. ncbi request reprint Exploring the biology of vascular calcification in chronic kidney disease: what's circulating?
    M Schoppet
    Division of Cardiovascular Medicine, Addenbrooke s Hospital, Cambridge, UK
    Kidney Int 73:384-90. 2008
    ..A greater understanding of the origins and roles of potential circulating inhibitors may result in novel strategies aimed at the prevention or reversal of the life-limiting calcifying vasculopathies seen in CKD patients...
  15. doi request reprint Serum level of the phosphaturic factor FGF23 is associated with abdominal aortic calcification in men: the STRAMBO study
    M Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg D 35043, Germany
    J Clin Endocrinol Metab 97:E575-83. 2012
    ..Fibroblast growth factor-23 (FGF23) is a key molecule regulating mineral homeostasis...
  16. ncbi request reprint Tumour necrosis factor-related apoptosis-inducing ligand and osteoprotegerin serum levels in psoriatic arthritis
    L C Hofbauer
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Rheumatology (Oxford) 45:1218-22. 2006
    ....
  17. doi request reprint TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor
    Mary M Kavurma
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 283:7754-62. 2008
    ..Thus, TRAIL may play an important role in atherosclerosis by regulating IGF1R expression in VSMC in an NF-kappaB-dependent manner...
  18. doi request reprint Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway
    Nicola C Stein
    Department of Medicine, Philipps University, Marburg, Germany
    J Bone Miner Res 23:750-8. 2008
    ..RANKL is the essential factor for differentiation, activation, and survival of osteoclasts, whereas osteoprotegerin (OPG) is a soluble decoy receptor and inhibitor for RANKL...
  19. ncbi request reprint Detection and characterization of RANK ligand and osteoprotegerin in the thyroid gland
    Lorenz C Hofbauer
    Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
    J Cell Biochem 86:642-50. 2002
    ..Thus, these cytokines may represent important local immunoregulatory factors involved in the pathogenesis of autoimmune thyroid diseases...
  20. ncbi request reprint Osteoprotegerin gene polymorphism and the risk of osteoporosis and vascular disease
    Lorenz C Hofbauer
    J Clin Endocrinol Metab 87:4078-9. 2002
  21. ncbi request reprint RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function
    Michael Schoppet
    Divisions of Cardiology, Department of Medicine, Philipps University, Marburg, Germany
    Arterioscler Thromb Vasc Biol 22:549-53. 2002
    ....
  22. ncbi request reprint Interleukin-4 differentially regulates osteoprotegerin expression and induces calcification in vascular smooth muscle cells
    Lorenz C Hofbauer
    Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Thromb Haemost 95:708-14. 2006
    ....
  23. ncbi request reprint Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University, Goettingen, Germany
    J Cell Biochem 96:1244-53. 2005
    ..In summary, our data suggest that atorvastatin enhances osteoblastic differentiation and production of OPG. This may contribute to the bone-sparing effects of statins...
  24. ncbi request reprint Osteoprotegerin (OPG) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels in atherosclerosis
    Michael Schoppet
    Atherosclerosis 184:446-7. 2006
  25. ncbi request reprint Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women
    Lorenz C Hofbauer
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    Clin Endocrinol (Oxf) 60:214-9. 2004
    ..To define the effects of oestrogens on the RANKL/OPG system in vivo, we evaluated OPG and both free and total soluble RANKL (sRANKL) serum levels in healthy young women with or without oral contraceptives...
  26. ncbi request reprint Parvovirus B19 genome in endomyocardial biopsy specimen
    Sabine Pankuweit
    Circulation 109:e179. 2004
  27. ncbi request reprint Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    Lorenz C Hofbauer
    Department of Gastroenterology, Philipps University, Marburg, Germany
    JAMA 292:490-5. 2004
    ..This review summarizes the clinical implications of the OPG/RANKL/RANK system for bone and vascular diseases...
  28. ncbi request reprint Osteoprotegerin gene polymorphisms in men with coronary artery disease
    Muhidien Soufi
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    J Clin Endocrinol Metab 89:3764-8. 2004
    ..02). In summary, linkage of genetic variations of the OPG gene at positions 950 and 1181 may confer an increased risk of CAD in Caucasian men...
  29. ncbi request reprint Low serum levels of soluble RANK ligand are associated with the presence of coronary artery disease in men
    Michael Schoppet
    Circulation 107:e76; author reply e76. 2003
  30. ncbi request reprint Increased osteoprotegerin serum levels in men with coronary artery disease
    Michael Schoppet
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Clin Endocrinol Metab 88:1024-8. 2003
    ..We conclude that increased OPG serum levels may reflect advanced cardiovascular disease in men...
  31. ncbi request reprint Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Gottingen, Gottingen, Germany
    J Bone Miner Res 20:2036-43. 2005
    ..The iCR effect, abrogated by the pure estrogen receptor antagonist ICI 182,780, also enhanced ALP activity (4-fold) and osteocalcin expression (3-fold), possibly contributing to the skeletal effects of black cohosh...
  32. ncbi request reprint Osteoprotegerin deficiency and juvenile Paget's disease
    Lorenz C Hofbauer
    N Engl J Med 347:1622-3; author reply 1622-3. 2002
  33. ncbi request reprint Estrogen therapy and coronary-artery calcification
    Lorenz C Hofbauer
    N Engl J Med 357:1253-4; author reply 1254. 2007
  34. ncbi request reprint Cardiac sarcoidosis: cytokine patterns in the course of the disease
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    Arch Pathol Lab Med 127:1207-10. 2003
    ..These changes may point to a role of T(H)1 and T(H)2 cytokines in the pathogenesis and the healing process of cardiac sarcoidosis...
  35. doi request reprint Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization
    Melinda J Duer
    Department of Chemistry, University of Cambridge, Cambridge, UK
    Arterioscler Thromb Vasc Biol 28:2030-4. 2008
    ..This study was undertaken to compare the poorly understood interface in mineralized plaque with that of bone, which is considerably better characterized...
  36. ncbi request reprint DKK1 in multiple myeloma
    Lorenz C Hofbauer
    N Engl J Med 350:1464-6; author reply 1464-6. 2004
  37. doi request reprint 17beta-Estradiol inhibits osteoprotegerin production by the estrogen receptor-alpha-positive human breast cancer cell line MCF-7
    Tilman D Rachner
    Division of Gastroenterology and Endocrinology, Department of Medicine, Philipps University, Marburg, Germany
    Biochem Biophys Res Commun 368:736-41. 2008
    ..In conclusion, 17beta-estradiol suppressed OPG production by human breast cancer cell lines in a dose-dependent and specific manner, indicating that the RANKL/OPG cytokine system is an estrogen-responsive target in breast cancer...
  38. ncbi request reprint Matrix metalloproteinases and their inhibitors in malignant and autoreactive pericardial effusion
    Steffen Lamparter
    Diakonie Krankenhaus Wehrda, Department of Internal Medicine, Marburg, Germany
    Am J Cardiol 95:1065-9. 2005
    ..The involvement of MMP-2 in the pathogenesis of malignant PE may indicate a potential role of MMP inhibitors in the control of malignant PE...
  39. ncbi request reprint Acute parvovirus B19 infection associated with myocarditis in an immunocompetent adult
    Steffen Lamparter
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    Hum Pathol 34:725-8. 2003
    ..Because PVB19 myocarditis may progress to chronic dilated cardiomyopathy, early diagnosis by endomyocardial biopsy is important to initiate anti-inflammatory treatment...