Volker Ruppert

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Molecular signatures and the study of gene expression profiles in inflammatory heart diseases
    V Ruppert
    Department of Internal Medicine Cardiology, Biomedical Research Center, University Hospital Giessen and Marburg and Philipps University Marburg, Hans Meerwein Str, 35043, Marburg, Germany
    Herz 37:619-26. 2012
  2. ncbi request reprint Genetics of human hypertension
    Volker Ruppert
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Herz 28:655-62. 2003
  3. ncbi request reprint Novel point mutations in the mitochondrial DNA detected in patients with dilated cardiomyopathy by screening the whole mitochondrial genome
    Volker Ruppert
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Marburg, Germany
    Biochem Biophys Res Commun 318:535-43. 2004
  4. ncbi request reprint Gene symbol: MYBPC3. Disease: Cardiomyopathy, hypertrophic
    Volker Ruppert
    Philipps Universitat Marburg, Innere Medizin, Kardiologie, Hans Meerwein Strasse, 1, 35043 Marburg, Germany
    Hum Genet 124:314. 2008
  5. doi request reprint Gene expression profiling from endomyocardial biopsy tissue allows distinction between subentities of dilated cardiomyopathy
    Volker Ruppert
    Department of Cardiology, University of Marburg, Baldingerstrasse, Marburg, Germany
    J Thorac Cardiovasc Surg 136:360-369.e1. 2008
  6. ncbi request reprint Isolated cardiac sarcoidosis associated with the expression of a splice variant coding for a truncated BTNL2 protein
    Thomas Meyer
    Department of Internal Medicine Cardiology, Philipps University of Marburg, Marburg, Germany
    Cardiology 109:117-21. 2008
  7. ncbi request reprint Ischemic preconditioning results in an ATP-dependent inhibition of cytochrome C oxidase
    Sebastian Vogt
    Cardiovascular Research Lab, Biomedical Research Center of the Philipps University Marburg, Marburg, Germany
    Shock 40:407-13. 2013
  8. ncbi request reprint Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependent
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    J Cell Biochem 100:1430-9. 2007
  9. doi request reprint Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis
    Volker Ruppert
    Department of Cardiology, University of Marburg, Marburg, Germany
    Cardiovasc Pathol 17:81-92. 2008
  10. doi request reprint Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro
    Philipp Stahl
    Laboratory of Parasitology, Institute for Virology, Philipps University, 35043 Marburg, Germany
    Apoptosis 18:653-63. 2013

Detail Information

Publications29

  1. ncbi request reprint Molecular signatures and the study of gene expression profiles in inflammatory heart diseases
    V Ruppert
    Department of Internal Medicine Cardiology, Biomedical Research Center, University Hospital Giessen and Marburg and Philipps University Marburg, Hans Meerwein Str, 35043, Marburg, Germany
    Herz 37:619-26. 2012
    ..Expression profiling may be particularly helpful to improve the differential diagnosis of heart failure and enable novel insight into selected molecular pathways...
  2. ncbi request reprint Genetics of human hypertension
    Volker Ruppert
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Herz 28:655-62. 2003
    ..Causative genes and chromosomal fragments harboring disease susceptibility genes have been identified, e. g., for glucocorticoid-remediable aldosteronism, Liddle's syndrome, mineralocorticoid excess...
  3. ncbi request reprint Novel point mutations in the mitochondrial DNA detected in patients with dilated cardiomyopathy by screening the whole mitochondrial genome
    Volker Ruppert
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Marburg, Germany
    Biochem Biophys Res Commun 318:535-43. 2004
    ..6% of patients as well as in 9.7% of controls. Thus, mutations altering the function of the enzyme subunits of the respiratory chain can be relevant for the pathogenesis of dilated cardiomyopathy...
  4. ncbi request reprint Gene symbol: MYBPC3. Disease: Cardiomyopathy, hypertrophic
    Volker Ruppert
    Philipps Universitat Marburg, Innere Medizin, Kardiologie, Hans Meerwein Strasse, 1, 35043 Marburg, Germany
    Hum Genet 124:314. 2008
  5. doi request reprint Gene expression profiling from endomyocardial biopsy tissue allows distinction between subentities of dilated cardiomyopathy
    Volker Ruppert
    Department of Cardiology, University of Marburg, Baldingerstrasse, Marburg, Germany
    J Thorac Cardiovasc Surg 136:360-369.e1. 2008
    ..Expression profile analysis using endomyocardial biopsy specimens from patients with cardiomyopathies promises to improve the differential diagnosis of heart failure...
  6. ncbi request reprint Isolated cardiac sarcoidosis associated with the expression of a splice variant coding for a truncated BTNL2 protein
    Thomas Meyer
    Department of Internal Medicine Cardiology, Philipps University of Marburg, Marburg, Germany
    Cardiology 109:117-21. 2008
    ..Thus, detection of the disease-associated btln2 allele may help to identify patients with sarcoidosis as the underlying cause of heart failure...
  7. ncbi request reprint Ischemic preconditioning results in an ATP-dependent inhibition of cytochrome C oxidase
    Sebastian Vogt
    Cardiovascular Research Lab, Biomedical Research Center of the Philipps University Marburg, Marburg, Germany
    Shock 40:407-13. 2013
    ..This report addresses the possible involvement of this mechanism in case of myocardial preconditioning...
  8. ncbi request reprint Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependent
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany
    J Cell Biochem 100:1430-9. 2007
    ..In summary, we describe that the expression of OPG by DC increases with maturation and is NF-kappaB-dependent, possibly regulating immune responses in lymphoid tissues...
  9. doi request reprint Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus-adenovirus receptor during viral myocarditis
    Volker Ruppert
    Department of Cardiology, University of Marburg, Marburg, Germany
    Cardiovasc Pathol 17:81-92. 2008
    ....
  10. doi request reprint Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro
    Philipp Stahl
    Laboratory of Parasitology, Institute for Virology, Philipps University, 35043 Marburg, Germany
    Apoptosis 18:653-63. 2013
    ..In conclusion, cardiomyopathy observed in Chagas' disease might be in part due to apoptosis of cardiomyocytes induced directly by the parasite...
  11. doi request reprint Viral genomes in the pericardial fluid and in peri- and epicardial biopsies from a German cohort of patients with large to moderate pericardial effusions
    Sabine Pankuweit
    Department of Internal Medicine Cardiology, Angiology, Intensive Care and Prevention, UKGM GmbH, Marburg, Germany
    Heart Fail Rev 18:329-36. 2013
    ..The identification of specific viral signatures will help to understand pathogenetic mechanisms in pericarditis and allow to tailor an adequate therapy beyond antiphlogistic treatment...
  12. ncbi request reprint TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy
    Michael Schoppet
    Department of Internal Medicine and Cardiology, Philipps University, D 35033 Marburg, Germany
    Biochem Biophys Res Commun 338:1745-50. 2005
    ..001 vs. controls). In conclusion, myocardial overexpression of antiapoptotic OPG in DCM patients may represent a compensatory mechanism to limit systemic activation of TRAIL in patients with congestive heart disease...
  13. doi request reprint [Classification of cardiomyopathies and indication for endomyocardial biopsy revisited]
    Sabine Pankuweit
    Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg, Baldingerstrasse, 35043, Marburg
    Herz 34:55-62. 2009
    ....
  14. doi request reprint Cardiomyopathies: classification, diagnosis, and treatment
    Bernhard Maisch
    Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Philipps University, UKGM GmbH, Baldinger Street, 35043 Marburg, Germany
    Heart Fail Clin 8:53-78. 2012
    ..In this overview, a special emphasis is also placed on the management of inflammatory and viral cardiomyopathies...
  15. doi request reprint Genotype-specific effects on left ventricular function in parvovirus B19-positive patients with dilated cardiomyopathy
    Volker Ruppert
    Department of Cardiology, University Hospital Gießen and Marburg, Marburg, Germany
    J Med Virol 83:1818-25. 2011
    ..Future studies with larger sample sizes and longer follow-up periods will be required to confirm this observation...
  16. doi request reprint [Familial predisposition and microbial etiology in dilated cardiomyopathy]
    Sabine Pankuweit
    Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Herz 34:110-6. 2009
    ..A possible family history including a pedigree should be ascertained and with regard to a possible inflammatory or viral heart disease, endomyocardial biopsies should be investigated by polymerase chain reaction and immunohistochemistry...
  17. doi request reprint The HLA class II allele DQB1 0309 is associated with dilated cardiomyopathy
    Sabine Pankuweit
    Klinik fur Kardiologie, Philipps Universitat Marburg, Marburg, Germany
    Gene 531:180-3. 2013
    ....
  18. ncbi request reprint Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria
    Kathrin Wennicke
    Department of Internal Medicine Cardiology, Philipps University of Marburg, University Hospital, Baldingerstrasse 1, 35043 Marburg Lahn, Germany
    Apoptosis 13:857-66. 2008
    ..Previous studies demonstrated cardiac involvement in patients suffering from severe malaria due to P. falciparum. Therefore, we tested the hypothesis that GPI induces apoptosis in cardiomyocytes...
  19. ncbi request reprint Hereditary long QT syndrome due to autoimmune hypoparathyroidism in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome
    Thomas Meyer
    Abteilung Innere Medizin Kardiologie, Philipps Universitat Marburg, Baldingerstrasse, 35033 Marburg, Germany
    J Electrocardiol 40:504-9. 2007
    ..This finding defines a congenital autoimmune disease as a hereditary long QT syndrome...
  20. ncbi request reprint Inflammation in dilated cardiomyopathy
    Sabine Pankuweit
    Department of Internal Medicine Cardiology, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Herz 29:788-93. 2004
    ..This may change the management of the disease in the future. One of the hopes is to discern the underlying dominant mechanism in a given patient to make a decision for the most promising therapy...
  21. ncbi request reprint Familial inflammatory dilated cardiomyopathy
    Irene Portig
    Philipps University Hospital, Department of Internal Medicine and Cardiology, Baldingerstrasse, 35033 Marburg, Germany
    Eur J Heart Fail 8:816-25. 2006
    ..Mutations in genes encoding proteins responsible for myocardial architecture have been identified, but additional pathophysiological mechanisms including inflammatory reactions have been proposed...
  22. ncbi request reprint Management of fulminant myocarditis: a diagnosis in search of its etiology but with therapeutic options
    Bernhard Maisch
    Medical Faculty of Philipps University Marburg and Cardiovascular Center Marburg, Erlenring 19, 35037, Marburg, Germany
    Curr Heart Fail Rep 11:166-77. 2014
    ..ECMO, IABP, ventricular assist devices, LifeVest, or ICD implantation can bridge to recovery or to heart transplantation. ..
  23. pmc Two glutamic acid residues in the DNA-binding domain are engaged in the release of STAT1 dimers from DNA
    Verena Koch
    Klinik fur Kardiologie, Philipps Universitat Marburg, Marburg, Germany
    BMC Cell Biol 13:22. 2012
    ..However, the molecular steps that facilitate GAS binding and the subsequent liberation of STAT1 homodimers from these promoter elements are not well understood...
  24. doi request reprint Activated STAT1 and STAT5 transcription factors in extramedullary hematopoietic tissue in a polycythemia vera patient carrying the JAK2 V617F mutation
    Thomas Meyer
    Department of Cardiology, University of Marburg, Baldingerstrasse 1, 35033, Marburg, Germany
    Int J Hematol 91:117-20. 2010
    ..Our data suggest that dysregulated STAT signal pathways are engaged in extramedullary hematopoiesis in polycythemia vera...
  25. doi request reprint Heat shock protein expression and change of cytochrome c oxidase activity: presence of two phylogenic old systems to protect tissues in ischemia and reperfusion
    Sebastian Vogt
    Biomedical Research Center, Philipps University Marburg, Marburg, Germany
    J Bioenerg Biomembr 43:425-35. 2011
    ..Special focus is laid on function of the enzyme's subunits and importance of cellular energy availability and maintenance...
  26. ncbi request reprint Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy
    Maximilian G Posch
    Mol Genet Metab 91:207-8. 2007
  27. doi request reprint A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy
    Maximilian G Posch
    Experimental and Clinical Research Center ECRC, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Genet Metab 95:74-80. 2008
    ..Thus, our study identified the DSG2-V55M polymorphism as a novel risk variant for DCM associated with shortened desmosomes of the cardiac intercalated disc...
  28. ncbi request reprint JAK-STAT signaling circuits in myocarditis and dilated cardiomyopathy
    Volker Ruppert
    University Hospital of Internal Medicine and Cardiology, UKGM GmbH, Philipps University of Marburg, Germany
    Herz 32:474-81. 2007
    ..This review summarizes the mechanistic design of the Janus kinase-STAT signaling circuit and discusses its pathophysiological implications in myocarditis and dilated cardiomyopathy...
  29. ncbi request reprint Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue
    Dominic Wichmann
    Bernhard Nocht Institute for Tropical Medicine, Clinical Research Unit, Bernhard Nocht Str 74, 20359 Hamburg, Germany
    Apoptosis 12:1037-41. 2007
    ..However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFalpha and nitric oxide production...