Research Topics
| Heinz RuppSummaryAffiliation: Philipps University Country: Germany Publications
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Detail Information
Publications
Treatment of inflammatory dilated cardiomyopathy and (peri)myocarditis with immunosuppression and i.v. immunoglobulinsBernhard Maisch
Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
Herz 29:624-36. 2004..In Parvo B19 associated DCMi therefore dose finding studies and randomized trials are needed...- Activated nuclear transcription factor kappaB in patients with myocarditis and dilated cardiomyopathy--relation to inflammation and cardiac functionPeter Alter
Philipps University of Marburg, Department of Internal Medicine Cardiology, Germany
Biochem Biophys Res Commun 339:180-7. 2006..The latter also applies to the course of autoimmune myocarditis. One principal candidate for an adverse remodeling is nuclear factor-kappaB (NFkappaB)... 
Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency"Heinz Rupp
Experimental Cardiology Laboratory, Department of Internal Medicine Cardiology, Philipps University Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
Can J Physiol Pharmacol 90:55-73. 2012..Based on administration of omega-3 HUFA (OMACOR), dilatation is identified as a target for 1-2 g omega-3 HUFA·day(-1). Interventions for reduced arachidonic acid remain to be explored...- Risk reduction by preventing stroke: need for blockade of angiotensin II and catecholamines?Heinz Rupp
Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
Curr Med Res Opin 23:S25-9. 2007..Eprosartan, by blocking AT II receptors, reducing noradrenaline release and blocking catecholamine actions, may, therefore, provide greater protection against vascular events than CCBs or other ARBs... - Separation of large mammalian ventricular myosin differing in ATPase activityHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Karl von Frisch Strasse 1, 35033 Marburg, Germany
Can J Physiol Pharmacol 85:326-31. 2007..The data demonstrate a heterogeneity of large mammalian ventricular myosin, whereby an increased cardiac load appeared to be associated with a higher myosin VA proportion that exhibited a reduced ATPase activity... - Acute heart failure--basic pathomechanism and new drug targetsHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043, Marburg, Germany
Herz 31:727-35. 2006..four capsules daily)... - Omacor (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemiaHeinz Rupp
Experimental Cardiology Laboratory, Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043 Marburg, Germany
Adv Ther 26:675-90. 2009..At higher dosages (daily, 3-4 g) Omacor exhibits more pronounced cardiovascular benefits and, as a licensed indication, improves hypertriglyceridemia and related lipid parameters... - Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heartH Rupp
Philipps University, Department of Internal Medicine Cardiology, Experimental Cardiology Laboratory, Karl von Frisch Strasse 1, Marburg, Germany
Heart 96:595-8. 2010..Cardiac dilatation is associated with impaired pump function, progression of heart failure and electrical instability. Risk of sudden death is associated with a low blood level of n-3 polyunsaturated fatty acids... - [Metabolism and the hypertrophied heart of the elderly]H Rupp
Molekular kardiologisches Labor, Klinik für Innere Medizin und Kardiologie, Philipps Universitat Marburg, Marburg
Dtsch Med Wochenschr 130:726-30. 2005.... - Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acidsHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Marburg, Germany
Herz 29:673-85. 2004..With documented coronary heart disease, it was advised to consume approximately 1 g/day of EPA+DHA... - Intrapericardial procedures for cardiac regeneration by stem cells: need for minimal invasive access (AttachLifter) to the normal pericardial cavityH Rupp
Department of Internal Medicine Cardiology, Experimental Cardiology Laboratory, Philipps University of Marburg, Marburg, Deutschland
Herz 35:458-65. 2010..A fiberscope can be used to inspect the pericardium prior to puncture. Based on these procedures, the role of the pericardial space and the presence of pericardial effusion in cardiac regeneration can be assessed... - Abdominal fat and sympathetic overactivity. From calorie intake to postmenopausal hypertensionHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
Herz 28:668-73. 2003..It is proposed to further assess the potential of transthoracic echocardiography as routine imaging method for the prediction of visceral fat accumulation and its adverse health consequences... - The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failureHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, University of Marburg, Germany
Herz 27:621-36. 2002..Further progress in elucidating novel compounds which upregulate SERCA2 expression is closely linked to the characterization of regulatory sequences of the SERCA2 promoter... - Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level"Heinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
Herz 31:30-49. 2006..The pharmacological effects of ethyl esters are compared with the naturally occurring EPA and DHA triacylglycerols present in fish or fish oils which are of interest in primary prevention of cardiovascular disorders... - Association of hyperhomocysteinemia with left ventricular dilatation and mass in human heartPeter Alter
Internal Medicine Cardiology, Philipps University, Marburg, Germany
Clin Chem Lab Med 48:555-60. 2010..We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopathy... - Increased enddiastolic wall stress precedes left ventricular hypertrophy in dilative heart failure-Use of the volume-based wall stress indexPeter Alter
Internal Medicine Cardiology, Philipps University, Marburg, Germany
Int J Cardiol 157:233-8. 2012.... - [Physical activity and sports in heart failure due to myocarditis and dilated cardiomyopathy]Peter Alter
Department of Internal Medicine Cardiology, Philipps University of Marburg, Germany
Herz 29:391-400. 2004..This raises the question to what extent physical activity in patients with myocarditis, dilated cardiomyopathy or heart failure in general is tolerable... - Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non-ischaemic dilated cardiomyopathyPeter Alter
Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
Eur J Heart Fail 13:937-44. 2011..Occurrence of late gadolinium enhancement (LGE) as assessed by cardiac magnetic resonance (CMR) imaging has been attributed to various myocardial injuries. We hypothesized that LGE is associated with left ventricular (LV) wall stress... - [Myocardial fibrosis: a cardiopathophysiologic Janus head]Bernhard Maisch
, Angiologie, , , Baldingerstrasse, 35043, Marburg, Germany
Herz 31:260-8. 2006 - Effects of ACE inhibition versus non-ACE inhibitor antihypertensive treatment on myocardial fibrosis in patients with arterial hypertension. Retrospective analysis of 120 patients with left ventricular endomyocardial biopsiesChristian G Brilla
Division of Cardiology, Center of Internal Medicine, Philipps University of Marburg, Germany
Herz 28:744-53. 2003.... - Indications for angiography subsequent to coronary artery bypass graftingPeter Alter
Department of Internal Medicine Cardiology, Philipps University of Marburg Lahn, Marburg, Germany
Am Heart J 149:1082-90. 2005..Early markers for coronary bypass graft failure or native vessel occlusion are required, because immediate intervention could prevent major myocardial damage... - [Functional genomics of pressure-loaded cardiomyocytes: etomoxir in heart failure?]Heinz Rupp
Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg
Herz 27:166-73. 2002..Since viral or inflammatory injury of the heart can also induce a fetal phenotype, metabolic modulators such as etomoxir represent a promising therapeutic approach also for cardiomyopathies with inadequate SERCA2 expression... - Characterization of sucrose-induced changes in cardiac phenotypeHeinz Rupp
Department of Internal Medicine and Cardiology, Karl von Frisch Strasse 1, 35033 Marburg, Germany
Pflugers Arch 445:32-9. 2002..The data show that adrenergic activity and metabolic signals are important for an increase in myosin V1 in sucrose-fed rats, which can be associated with an unaltered SR Ca(2+) uptake rate... - Depression of heart rate variability in patients with increased ventricular wall stressPeter Alter
Department of Internal Medicine Cardiology, Philipps University, Marburg, Gremany
Pacing Clin Electrophysiol 32:S26-31. 2009..Depression of HRV is related to several hemodynamic parameters. We hypothesized that an increased left ventricular (LV) wall stress is related to a depressed HRV in patients with LV dilatation or dysfunction... - Drug development based on functional genomics of overloaded cardiomyocytes: a novel approach for preventing progression of heart failureHeinz Rupp
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
J Muscle Res Cell Motil 25:608-9. 2004 - Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure?Heinz Rupp
Cardiovasc Res 66:423-6. 2005 
Tedisamil attenuates foetal transformation of myosin in the hypertrophied rat myocardiumMarian Turcani
Department of Physiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
Br J Pharmacol 143:561-72. 2004..Postulated mechanism of this effect is the phenotype modification of myosin filaments in hypertrophied myocardium...- Re: Heusser et al: elevation of sympathetic activity by eprosartan in young male subjectsHeinz Rupp
Am J Hypertens 17:281; author reply 281-3. 2004 - Modification of myosin gene expression by imidapril in failing heart due to myocardial infarctionJingwei Wang
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
J Mol Cell Cardiol 34:847-57. 2002.... - Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a targetAngel Zarain-Herzberg
Laboratorio de Biologia Molecular, Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 159, Mexico D F 04510
Expert Opin Investig Drugs 11:345-56. 2002..In particular, signals need to be identified which are altered in overloaded hearts and can selectively be re-activated by etomoxir... - Assessment and relevance of ventricular wall stress in heart failurePeter Alter
Eur Heart J 29:2316. 2008 - Differential effects of etomoxir treatment on cardiac Na+-K+ ATPase subunits in diabetic ratsKiminori Kato
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Mol Cell Biochem 232:57-62. 2002..However, no increase in alpha1-subunit mRNA abundance was seen in the etomoxir treated rats, which suggests that possibly post-transcriptional mechanisms are occurring in these hearts...