Heinz Rupp

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Treatment of inflammatory dilated cardiomyopathy and (peri)myocarditis with immunosuppression and i.v. immunoglobulins
    Bernhard Maisch
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Herz 29:624-36. 2004
  2. ncbi request reprint Activated nuclear transcription factor kappaB in patients with myocarditis and dilated cardiomyopathy--relation to inflammation and cardiac function
    Peter Alter
    Philipps University of Marburg, Department of Internal Medicine Cardiology, Germany
    Biochem Biophys Res Commun 339:180-7. 2006
  3. doi request reprint Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency"
    Heinz Rupp
    Experimental Cardiology Laboratory, Department of Internal Medicine Cardiology, Philipps University Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Can J Physiol Pharmacol 90:55-73. 2012
  4. ncbi request reprint Acute heart failure--basic pathomechanism and new drug targets
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043, Marburg, Germany
    Herz 31:727-35. 2006
  5. ncbi request reprint Separation of large mammalian ventricular myosin differing in ATPase activity
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Karl von Frisch Strasse 1, 35033 Marburg, Germany
    Can J Physiol Pharmacol 85:326-31. 2007
  6. doi request reprint Risk reduction by preventing stroke: need for blockade of angiotensin II and catecholamines?
    Heinz Rupp
    Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
    Curr Med Res Opin 23:S25-9. 2007
  7. ncbi request reprint [Metabolism and the hypertrophied heart of the elderly]
    H Rupp
    Molekular kardiologisches Labor, Klinik für Innere Medizin und Kardiologie, Philipps Universitat Marburg, Marburg
    Dtsch Med Wochenschr 130:726-30. 2005
  8. ncbi request reprint Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Marburg, Germany
    Herz 29:673-85. 2004
  9. doi request reprint Omacor (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia
    Heinz Rupp
    Experimental Cardiology Laboratory, Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043 Marburg, Germany
    Adv Ther 26:675-90. 2009
  10. doi request reprint Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heart
    H Rupp
    Philipps University, Department of Internal Medicine Cardiology, Experimental Cardiology Laboratory, Karl von Frisch Strasse 1, Marburg, Germany
    Heart 96:595-8. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Treatment of inflammatory dilated cardiomyopathy and (peri)myocarditis with immunosuppression and i.v. immunoglobulins
    Bernhard Maisch
    Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Herz 29:624-36. 2004
    ....
  2. ncbi request reprint Activated nuclear transcription factor kappaB in patients with myocarditis and dilated cardiomyopathy--relation to inflammation and cardiac function
    Peter Alter
    Philipps University of Marburg, Department of Internal Medicine Cardiology, Germany
    Biochem Biophys Res Commun 339:180-7. 2006
    ..The latter also applies to the course of autoimmune myocarditis. One principal candidate for an adverse remodeling is nuclear factor-kappaB (NFkappaB)...
  3. doi request reprint Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency"
    Heinz Rupp
    Experimental Cardiology Laboratory, Department of Internal Medicine Cardiology, Philipps University Marburg, Baldingerstrasse 1, 35043 Marburg, Germany
    Can J Physiol Pharmacol 90:55-73. 2012
    ..Based on administration of omega-3 HUFA (OMACOR), dilatation is identified as a target for 1-2 g omega-3 HUFA·day(-1). Interventions for reduced arachidonic acid remain to be explored...
  4. ncbi request reprint Acute heart failure--basic pathomechanism and new drug targets
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043, Marburg, Germany
    Herz 31:727-35. 2006
    ..four capsules daily)...
  5. ncbi request reprint Separation of large mammalian ventricular myosin differing in ATPase activity
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Karl von Frisch Strasse 1, 35033 Marburg, Germany
    Can J Physiol Pharmacol 85:326-31. 2007
    ..The data demonstrate a heterogeneity of large mammalian ventricular myosin, whereby an increased cardiac load appeared to be associated with a higher myosin VA proportion that exhibited a reduced ATPase activity...
  6. doi request reprint Risk reduction by preventing stroke: need for blockade of angiotensin II and catecholamines?
    Heinz Rupp
    Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
    Curr Med Res Opin 23:S25-9. 2007
    ..Eprosartan, by blocking AT II receptors, reducing noradrenaline release and blocking catecholamine actions, may, therefore, provide greater protection against vascular events than CCBs or other ARBs...
  7. ncbi request reprint [Metabolism and the hypertrophied heart of the elderly]
    H Rupp
    Molekular kardiologisches Labor, Klinik für Innere Medizin und Kardiologie, Philipps Universitat Marburg, Marburg
    Dtsch Med Wochenschr 130:726-30. 2005
    ....
  8. ncbi request reprint Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Marburg, Germany
    Herz 29:673-85. 2004
    ..With documented coronary heart disease, it was advised to consume approximately 1 g/day of EPA+DHA...
  9. doi request reprint Omacor (prescription omega-3-acid ethyl esters 90): From severe rhythm disorders to hypertriglyceridemia
    Heinz Rupp
    Experimental Cardiology Laboratory, Heart Center, Department of Internal Medicine and Cardiology, Philipps University of Marburg, 35043 Marburg, Germany
    Adv Ther 26:675-90. 2009
    ..At higher dosages (daily, 3-4 g) Omacor exhibits more pronounced cardiovascular benefits and, as a licensed indication, improves hypertriglyceridemia and related lipid parameters...
  10. doi request reprint Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heart
    H Rupp
    Philipps University, Department of Internal Medicine Cardiology, Experimental Cardiology Laboratory, Karl von Frisch Strasse 1, Marburg, Germany
    Heart 96:595-8. 2010
    ..Cardiac dilatation is associated with impaired pump function, progression of heart failure and electrical instability. Risk of sudden death is associated with a low blood level of n-3 polyunsaturated fatty acids...
  11. ncbi request reprint Abdominal fat and sympathetic overactivity. From calorie intake to postmenopausal hypertension
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany
    Herz 28:668-73. 2003
    ..Calorie-dependent parameters reflecting sympathetic overactivity are an increased body fat mass and body mass index...
  12. doi request reprint Intrapericardial procedures for cardiac regeneration by stem cells: need for minimal invasive access (AttachLifter) to the normal pericardial cavity
    H Rupp
    Department of Internal Medicine Cardiology, Experimental Cardiology Laboratory, Philipps University of Marburg, Marburg, Deutschland
    Herz 35:458-65. 2010
    ..A fiberscope can be used to inspect the pericardium prior to puncture. Based on these procedures, the role of the pericardial space and the presence of pericardial effusion in cardiac regeneration can be assessed...
  13. ncbi request reprint The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, University of Marburg, Germany
    Herz 27:621-36. 2002
    ..Further progress in elucidating novel compounds which upregulate SERCA2 expression is closely linked to the characterization of regulatory sequences of the SERCA2 promoter...
  14. ncbi request reprint Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level"
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
    Herz 31:30-49. 2006
    ..The pharmacological effects of ethyl esters are compared with the naturally occurring EPA and DHA triacylglycerols present in fish or fish oils which are of interest in primary prevention of cardiovascular disorders...
  15. doi request reprint Replacement of reduced highly unsaturated fatty acids (HUFA deficiency) in dilative heart failure: dosage of EPA/DHA and variability of adverse peroxides and aldehydes in dietary supplement fish oils
    Thomas P Rupp
    Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Cardiology 125:223-31. 2013
    ..To judge the usefulness of various EPA/DHA preparations, their content of peroxides and aldehydes was determined...
  16. doi request reprint Increased end diastolic wall stress precedes left ventricular hypertrophy in dilative heart failure--use of the volume-based wall stress index
    Peter Alter
    Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Int J Cardiol 157:233-8. 2012
    ....
  17. doi request reprint Association of hyperhomocysteinemia with left ventricular dilatation and mass in human heart
    Peter Alter
    Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Clin Chem Lab Med 48:555-60. 2010
    ..We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopathy...
  18. ncbi request reprint [Physical activity and sports in heart failure due to myocarditis and dilated cardiomyopathy]
    Peter Alter
    Department of Internal Medicine Cardiology, Philipps University of Marburg, Germany
    Herz 29:391-400. 2004
    ..This raises the question to what extent physical activity in patients with myocarditis, dilated cardiomyopathy or heart failure in general is tolerable...
  19. doi request reprint Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non-ischaemic dilated cardiomyopathy
    Peter Alter
    Department of Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Eur J Heart Fail 13:937-44. 2011
    ..Occurrence of late gadolinium enhancement (LGE) as assessed by cardiac magnetic resonance (CMR) imaging has been attributed to various myocardial injuries. We hypothesized that LGE is associated with left ventricular (LV) wall stress...
  20. ncbi request reprint [Myocardial fibrosis: a cardiopathophysiologic Janus head]
    Bernhard Maisch
    Direktor der Klinik für Innere Medizin Kardiologie, Angiologie, Intensivmedizin und Kardioprävention, Philipps Universitat, Baldingerstrasse, 35043, Marburg, Germany
    Herz 31:260-8. 2006
  21. ncbi request reprint Effects of ACE inhibition versus non-ACE inhibitor antihypertensive treatment on myocardial fibrosis in patients with arterial hypertension. Retrospective analysis of 120 patients with left ventricular endomyocardial biopsies
    Christian G Brilla
    Division of Cardiology, Center of Internal Medicine, Philipps University of Marburg, Germany
    Herz 28:744-53. 2003
    ....
  22. ncbi request reprint Indications for angiography subsequent to coronary artery bypass grafting
    Peter Alter
    Department of Internal Medicine Cardiology, Philipps University of Marburg Lahn, Marburg, Germany
    Am Heart J 149:1082-90. 2005
    ..Early markers for coronary bypass graft failure or native vessel occlusion are required, because immediate intervention could prevent major myocardial damage...
  23. ncbi request reprint [Functional genomics of pressure-loaded cardiomyocytes: etomoxir in heart failure?]
    Heinz Rupp
    Klinik für Innere Medizin Kardiologie, Philipps Universitat Marburg
    Herz 27:166-73. 2002
    ..Promising are drugs targeted at ventricular diastolic dysfunction which is a marker of early progression of heart failure...
  24. doi request reprint Pericardioscopy and epi- and pericardial biopsy - a new window to the heart improving etiological diagnoses and permitting targeted intrapericardial therapy
    Bernhard Maisch
    Department of Internal Medicine and Cardiology, UKGM and Faculty of Medicine, Philipps University Marburg, Baldingerstr 1, 35033, Marburg, Germany
    Heart Fail Rev 18:317-28. 2013
    ....
  25. doi request reprint Depression of heart rate variability in patients with increased ventricular wall stress
    Peter Alter
    Department of Internal Medicine Cardiology, Philipps University, Marburg, Gremany
    Pacing Clin Electrophysiol 32:S26-31. 2009
    ..Depression of HRV is related to several hemodynamic parameters. We hypothesized that an increased left ventricular (LV) wall stress is related to a depressed HRV in patients with LV dilatation or dysfunction...
  26. ncbi request reprint Characterization of sucrose-induced changes in cardiac phenotype
    Heinz Rupp
    Department of Internal Medicine and Cardiology, Karl von Frisch Strasse 1, 35033 Marburg, Germany
    Pflugers Arch 445:32-9. 2002
    ..The data show that adrenergic activity and metabolic signals are important for an increase in myosin V1 in sucrose-fed rats, which can be associated with an unaltered SR Ca(2+) uptake rate...
  27. ncbi request reprint Drug development based on functional genomics of overloaded cardiomyocytes: a novel approach for preventing progression of heart failure
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
    J Muscle Res Cell Motil 25:608-9. 2004
  28. ncbi request reprint Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction
    Jingwei Wang
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Mol Cell Cardiol 34:847-57. 2002
    ....
  29. ncbi request reprint Re: Heusser et al: elevation of sympathetic activity by eprosartan in young male subjects
    Heinz Rupp
    Am J Hypertens 17:281; author reply 281-3. 2004
  30. pmc Tedisamil attenuates foetal transformation of myosin in the hypertrophied rat myocardium
    Marian Turcani
    Department of Physiology, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    Br J Pharmacol 143:561-72. 2004
    ..Postulated mechanism of this effect is the phenotype modification of myosin filaments in hypertrophied myocardium...
  31. ncbi request reprint Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure?
    Heinz Rupp
    Cardiovasc Res 66:423-6. 2005
  32. ncbi request reprint Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target
    Angel Zarain-Herzberg
    Laboratorio de Biologia Molecular, Departamento de Bioquimica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 159, Mexico D F 04510
    Expert Opin Investig Drugs 11:345-56. 2002
    ..In particular, signals need to be identified which are altered in overloaded hearts and can selectively be re-activated by etomoxir...
  33. ncbi request reprint Differential effects of etomoxir treatment on cardiac Na+-K+ ATPase subunits in diabetic rats
    Kiminori Kato
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Mol Cell Biochem 232:57-62. 2002
    ..However, no increase in alpha1-subunit mRNA abundance was seen in the etomoxir treated rats, which suggests that possibly post-transcriptional mechanisms are occurring in these hearts...
  34. doi request reprint Assessment and relevance of ventricular wall stress in heart failure
    Peter Alter
    Eur Heart J 29:2316. 2008