Harald Renz

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi request reprint Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 121:910-916.e5. 2008
  2. pmc Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
    Melanie L Conrad
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35043 Marburg, Germany
    J Exp Med 206:2869-77. 2009
  3. doi request reprint Advances in in vitro diagnostics in allergy, asthma, and immunology in 2012
    Harald Renz
    Institute of Laboratory Medicine, Philipps Universitat Marburg, Marburg, Germany Electronic address
    J Allergy Clin Immunol 132:1287-92. 2013
  4. doi request reprint The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
    Harald Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Medical Faculty, Baldingerstrasse, 35043 Marburg, Germany
    Nat Rev Immunol 12:9-23. 2012
  5. ncbi request reprint The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital of the Philipps University, Baldingerstr, D 35033 Marburg, Germany
    Prog Brain Res 146:325-33. 2004
  6. ncbi request reprint The immunological basis of the hygiene hypothesis
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Germany
    Chem Immunol Allergy 91:30-48. 2006
  7. ncbi request reprint The biology of T-cells in allergy and asthma: beyond the TH1/TH2 concept
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Pediatr Pulmonol Suppl 26:40-1. 2004
  8. ncbi request reprint Prenatal influences on the development of allergy and asthma TH1/TH2 balance
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Pediatr Pulmonol Suppl 26:206-7. 2004
  9. ncbi request reprint Development and regulation of immune responses to food antigens in pre- and postnatal life
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Faculty of Medicine, Philipps University, Marburg, Germany
    Nestle Nutr Workshop Ser Pediatr Program 64:139-51; discussion 151-5, 251-7. 2009
  10. doi request reprint Gene-environment interaction in chronic disease: a European Science Foundation Forward Look
    Harald Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
    J Allergy Clin Immunol 128:S27-49. 2011

Detail Information

Publications99

  1. doi request reprint Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 121:910-916.e5. 2008
    ..DNAzymes represent a new class of antisense molecules that combines the specificity of DNA base pairing with an inherent RNA-cleaving enzymatic activity...
  2. pmc Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
    Melanie L Conrad
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35043 Marburg, Germany
    J Exp Med 206:2869-77. 2009
    ..lwoffii F78-exposed mothers. These data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny...
  3. doi request reprint Advances in in vitro diagnostics in allergy, asthma, and immunology in 2012
    Harald Renz
    Institute of Laboratory Medicine, Philipps Universitat Marburg, Marburg, Germany Electronic address
    J Allergy Clin Immunol 132:1287-92. 2013
    ..The latter area has implications for the diagnostics of food allergy, pollen-induced allergies, asthma, and insect allergies...
  4. doi request reprint The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
    Harald Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Medical Faculty, Baldingerstrasse, 35043 Marburg, Germany
    Nat Rev Immunol 12:9-23. 2012
    ..These complex microbial-host interactions operate in a delicate temporal and spatial manner and have an important role in the induction of homeostatic mechanisms...
  5. ncbi request reprint The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital of the Philipps University, Baldingerstr, D 35033 Marburg, Germany
    Prog Brain Res 146:325-33. 2004
    ..These effects are defined as neuronal plasticity. The consequences are the development of neurogenic inflammation...
  6. ncbi request reprint The immunological basis of the hygiene hypothesis
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Germany
    Chem Immunol Allergy 91:30-48. 2006
    ..These novel immunoregulatory events may explain the hygiene hypothesis by an interaction of environmental factors with innate immune mechanisms and various subtypes of T-cell responses...
  7. ncbi request reprint The biology of T-cells in allergy and asthma: beyond the TH1/TH2 concept
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Pediatr Pulmonol Suppl 26:40-1. 2004
  8. ncbi request reprint Prenatal influences on the development of allergy and asthma TH1/TH2 balance
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, Hospital University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Pediatr Pulmonol Suppl 26:206-7. 2004
  9. ncbi request reprint Development and regulation of immune responses to food antigens in pre- and postnatal life
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Faculty of Medicine, Philipps University, Marburg, Germany
    Nestle Nutr Workshop Ser Pediatr Program 64:139-51; discussion 151-5, 251-7. 2009
    ..Epigenetic regulation represents an important novel mechanism in this regard. This concept opens new avenues for the development of preventive strategies to avoid inappropriate immune responses against food antigens...
  10. doi request reprint Gene-environment interaction in chronic disease: a European Science Foundation Forward Look
    Harald Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
    J Allergy Clin Immunol 128:S27-49. 2011
    ....
  11. doi request reprint Allergic diseases, gene-environment interactions
    H Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital Giessen and Marburg Faculty of Medicine, Philipps University Marburg, Germany
    Allergy 66:10-2. 2011
    ..This dysregulation is the result of complex interactions between genes and environment. These interactions occur both pre- and postnatally, providing opportunities for early interventions in immunological programming...
  12. ncbi request reprint Suppression of IL-2 and IFN-gamma production in women with spontaneous preterm labor
    Cathrin Wilke
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, University Hospital Giessen and Marburg, Baldingerstrasse, 35033 Marburg, Germany
    J Perinat Med 34:20-7. 2006
    ....
  13. ncbi request reprint [In vitro allergy diagnosis. Guideline of the German Society of Asthma and Immunology in conjunction with the German Society of Dermatology]
    Harald Renz
    Abt Klinische Chemie und MolekulareDiagnostik, Universitat Marburg, D 35033 Marburg
    J Dtsch Dermatol Ges 4:72-85. 2006
  14. ncbi request reprint Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma
    Sebastian Kerzel
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
    Am J Respir Cell Mol Biol 28:170-8. 2003
    ..Furthermore, neuronal hyperreactivity depends entirely on this receptor. Based on these data, a novel molecular pathway in the neuroimmune pathogenesis of bronchial asthma could be defined...
  15. ncbi request reprint Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Hans Meerwein Strasse, 35033 Marburg, Germany
    J Immunol 178:7805-13. 2007
    ..These data indicate that TLR-3 or TLR-7 activation by viral TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10...
  16. ncbi request reprint Allergic airway inflammation inhibits pulmonary antibacterial host defense
    Christoph Beisswenger
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Germany
    J Immunol 177:1833-7. 2006
    ..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
  17. ncbi request reprint Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation
    Christian Hahn
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the University, Philipps University Marburg, Germany
    J Allergy Clin Immunol 117:787-94. 2006
    ..Neurotrophin levels are increased in bronchoalveolar lavage fluid during allergic asthma...
  18. ncbi request reprint Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma
    Michael Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Am J Respir Cell Mol Biol 36:61-7. 2007
    ..Therefore, antagonizing CCR-3 represents a new approach toward a promising asthma therapy...
  19. doi request reprint Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymes
    Tanja Dicke
    Sterna Biologicals GmbH and Co KG, Marburg, Germany
    Nucleic Acid Ther 22:117-26. 2012
    ..Consequently, use of GATA-3-specific DNAzymes may represent a novel and highly specific approach for the treatment of allergic diseases...
  20. doi request reprint Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study
    Petra Ina Pfefferle
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35033 Marburg, Germany
    J Allergy Clin Immunol 125:108-15.e1-3. 2010
    ..Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection...
  21. ncbi request reprint Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates
    Heiko Uthoff
    Clinical Chemistry and Molecular Diagnostics, Department of Internal Medicine Cardiology, Hospital of Philipps University, Marburg, Germany
    J Immunol 171:3485-92. 2003
    ..These data indicate a critical role for maternal T and B cell response in shaping pre- and postnatal maturation of specific immunity to allergens...
  22. doi request reprint Neurotrophins in chronic allergic airway inflammation and remodeling
    Harald Renz
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany marburg de
    Chem Immunol Allergy 98:100-17. 2012
    ..These and other data open the opportunity to therapeutically interfere also on this level of regulation as a novel approach...
  23. doi request reprint Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation
    Melanie Abram
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
    J Immunol 182:4705-12. 2009
    ..We conclude that the neurotrophins NGF and NT3 act as survival factors for pulmonary plasma cells and thus are important regulators of the local Ab production in the allergic airway disease...
  24. ncbi request reprint Monitoring of functional plasminogen in the blood of patients on fibrinolytics
    Thomas W Stief
    Department of Laboratory Medicine, Hospital of Philipps University, Marburg, Germany
    Clin Appl Thromb Hemost 15:297-308. 2009
    ..The present findings support the profibrinolytic action of chloramines...
  25. ncbi request reprint Alpha-melanocyte-stimulating hormone inhibits allergic airway inflammation
    Ulrike Raap
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Germany
    J Immunol 171:353-9. 2003
    ..This study provides evidence for a novel function of alpha-MSH linking neuroimmune functions in allergic airway inflammation...
  26. doi request reprint Nerve growth factor induces type III collagen production in chronic allergic airway inflammation
    Ayse Kilic
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Medical Faculty Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 128:1058-66.e1-4. 2011
    ..The molecular mechanism leading to aberrant collagen deposition is not fully understood...
  27. ncbi request reprint DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma
    Stephanie Brand
    Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 129:1602-10.e6. 2012
    ..However, the contribution to the development of a chronic inflammatory phenotype remains still unclear...
  28. ncbi request reprint Augmentation of allergic early-phase reaction by nerve growth factor
    Gunter Path
    Department of Clinical Chemistry and Molecular Diagnostic, University Hospital of Marburg, Marburg, Germany
    Am J Respir Crit Care Med 166:818-26. 2002
    ..These data provide evidence for the functional role of NGF in the development of allergic early phase responses in the airways and the lung...
  29. ncbi request reprint Nerve growth factor: the central hub in the development of allergic asthma?
    Christina Nassenstein
    Fraunhofer Institute of Toxicology and Experimental Medicine, 30625 Hannover, and Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
    Eur J Pharmacol 533:195-206. 2006
    ..We hypothesize that NGF overexpression in certain vulnerable time windows during infancy could be a major risk factor for the development of asthma symptoms...
  30. ncbi request reprint Epidemiological and immunological evidence for the hygiene hypothesis
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str 2, 35043 Marburg, Germany
    Immunobiology 212:441-52. 2007
    ..These processes start already in utero and prenatal as well as early postnatal developmental stages seem to represent a certain "window of opportunity" for allergy-preventing environmental influences...
  31. ncbi request reprint Induction of autoallergy with an environmental allergen mimicking a self protein in a murine model of experimental allergic asthma
    Robert Bünder
    Department of Clinical Chemistry and Molecular Diagnostics, University of Marburg, Germany
    J Allergy Clin Immunol 114:422-8. 2004
    ..Allergy and autoimmunity are traditionally considered as 2 exclusive entities related to the development of either TH2-dominated or TH1-dominated immune responses...
  32. doi request reprint Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes
    Stephanie Brand
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 128:618-25.e1-7. 2011
    ..Epigenetic regulation is an important mechanism by which environmental factors might interact with genes involved in allergy and asthma development...
  33. doi request reprint Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs
    Agnieszka Turowska
    Sterna Biologicals GmbH and Co KG, Marburg, Germany
    Toxicol Appl Pharmacol 272:365-72. 2013
    ..Repeated administration did not lead to drug accumulation in plasma of dogs and rats. These pharmacokinetic of hgd40 provide guidance for clinical development, and support an infrequent and convenient dose administration regimen...
  34. ncbi request reprint Neurotrophin effects on eosinophils in allergic inflammation
    Christina Nassenstein
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Baldingerstrasse, 35043 Marburg, Germany
    Curr Allergy Asthma Rep 5:204-11. 2005
    ..The aim of this review is to elucidate the direct and indirect mechanisms of neurotrophins contributing to eosinophilia in allergic diseases...
  35. doi request reprint Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study
    Petra Ina Pfefferle
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 122:711-6. 2008
    ..It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants...
  36. ncbi request reprint Development of mucosal immune function in the intrauterine and early postnatal environment
    Nicole Blümer
    Department of Clinical Chemistry and Molecular Diagnostics, University of Marburg, Marburg, Germany
    Curr Opin Gastroenterol 23:655-60. 2007
    ..This review summarizes recent progress in the field of early gut immunology with special attention to factors contributing to the intrauterine and early postnatal development of mucosal immune responses in the gut...
  37. ncbi request reprint Autosensitization as a pathomechanism in asthma
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Strasse 2, D 35043, Marburg, Germany
    Ann N Y Acad Sci 1107:417-25. 2007
    ....
  38. doi request reprint The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis
    Salima Mrabet-Dahbi
    Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 121:1013-9. 2008
    ..More than 10% of patients with AD are heterozygous for the Toll-like receptor 2 (TLR-2) R753Q single nucleotide polymorphism (SNP) and exhibit severe eczema...
  39. doi request reprint Immunological approaches for tolerance induction in allergy
    Melanie L Conrad
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Centre, Philipps University of Marburg, Hans Meerwein Str 2, 35043 Marburg, Germany
    Curr Top Microbiol Immunol 352:1-26. 2011
    ..Investigation of allergenicity versus immunogenicity, native versus modified allergens, and the use of adjuvant and modality of dosing are all current strategies for immunotherapy advancement that will be reviewed in this article...
  40. ncbi request reprint Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules
    Wolfgang Andreas Nockher
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat Marburg, Germany
    J Allergy Clin Immunol 117:583-9. 2006
    ..We discuss recent findings in human and animal studies such as the regulation of neurotrophin expression during allergic inflammation and the effect of neurotrophins on the development and magnitude of allergic reactions...
  41. ncbi request reprint Animal models of type I allergy using recombinant allergens
    Udo Herz
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
    Methods 32:271-80. 2004
    ....
  42. ncbi request reprint NO2-induced airway inflammation is associated with progressive airflow limitation and development of emphysema-like lesions in C57bl/6 mice
    Michael Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Exp Toxicol Pathol 56:341-50. 2005
    ..Thus, NO2-exposed mice may serve as a model to investigate pathophysiological mechanisms that contribute to the development of human COPD...
  43. ncbi request reprint Treatment of allergic asthma by targeting transcription factors using nucleic-acid based technologies
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Curr Pharm Des 12:3293-304. 2006
    ....
  44. ncbi request reprint Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation
    Christian Böcking
    Institute for Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
    Int Arch Allergy Immunol 163:234-42. 2014
    ..We aim to prove this hypothesis in a murine model of allergic airway inflammation...
  45. ncbi request reprint Amphiphilic biodegradable PEG-PCL-PEI triblock copolymers for FRET-capable in vitro and in vivo delivery of siRNA and quantum dots
    Thomas Endres
    Department of Pharmaceutics and Biopharmacy, Philipps Universitat Marburg, Ketzerbach 63, 35037 Marburg, Germany
    Mol Pharm 11:1273-81. 2014
    ....
  46. ncbi request reprint Neurotrophins in inflammatory lung diseases: modulators of cell differentiation and neuroimmune interactions
    Wolfgang Andreas Nockher
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat Marburg, Marburg 35033, Germany
    Cytokine Growth Factor Rev 14:559-78. 2003
    ..This article will review the most recent data of neurotrophin signaling in the normal and inflamed lung and as yet unexplored, roles of neurotrophins in the complex communication within the neuroimmune network...
  47. ncbi request reprint Neurotrophins and asthma: novel insight into neuroimmune interaction
    Wolfgang Andreas Nockher
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat Marburg, Marburg, Germany
    J Allergy Clin Immunol 117:67-71. 2006
    ..In this review we will provide an overview of how neurotrophins connect the pathobiology of airway inflammation and hyperresponsiveness, which are the hallmarks of allergic asthma...
  48. doi request reprint Maternal signals for progeny prevention against allergy and asthma
    Leigh Matthew Marsh
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg 35043, Germany
    Cell Mol Life Sci 68:1851-62. 2011
    ..Furthermore, the role of environmental microbes provides another and maybe even more important group of exogenous exposures which operates in this critical time frame...
  49. ncbi request reprint A role for brain-derived neurotrophic factor in B cell development
    Berit Schuhmann
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat, Baldingerstrasse, 35033 Marburg, Germany
    J Neuroimmunol 163:15-23. 2005
    ..In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow...
  50. doi request reprint Development and validation of a combined method for the biomonitoring of omega-3/-6 fatty acids and conjugated linoleic acids in different matrices from human and nutritional sources
    Christian Böcking
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Germany
    Clin Chem Lab Med 48:1757-63. 2010
    ..In order to investigate the etiology of these diseases, rapid, combined and comparable methods are invaluable for monitoring both the intake and the incorporation of these fatty acids (FA)...
  51. pmc Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma
    Sanchaita Sriwal Sonar
    Department of Clinical Chemistry and Molecular Diagnostics, University of Marburg, Marburg, Germany
    J Clin Invest 120:2767-81. 2010
    ....
  52. doi request reprint Contribution of microRNA 24-3p and Erk1/2 to interleukin-6-mediated plasma cell survival
    Jessica Gabler
    Department of Pediatrics, Philipps University Marburg, Marburg, Germany Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany
    Eur J Immunol 43:3028-37. 2013
    ..miR-24-3p could therefore be a promising target for new therapeutic strategies for autoimmune and allergic diseases and for multiple myeloma. ..
  53. pmc Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model
    Mohammed Alrifai
    Institute of Laboratory Medicine and Pathobiochemistry Molecular Diagnostics, Medical Faculty, Philipps University Marburg, Universities of Giessen and Marburg Lung Center UGMLC, Member of the German Center for Lung Research, Marburg, Germany
    PLoS ONE 9:e85839. 2014
    ..We have therefore investigated the dynamics of airway remodelling and repair in an experimental asthma model and studied how pharmacological intervention affects these processes...
  54. ncbi request reprint Effect of barrier microbes on organ-based inflammation
    Holger Garn
    Institute of Laboratory Medicine, Philipps Universitat Marburg, Marburg, Germany
    J Allergy Clin Immunol 131:1465-78. 2013
    ..In this article the recent epidemiologic, clinical, and experimental evidence for this interaction is discussed...
  55. ncbi request reprint Consumption of omega3-fatty acids during perinatal life: role in immuno-modulation and allergy prevention
    Nicole Blümer
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Germany
    J Perinat Med 35:S12-8. 2007
    ..In these studies perinatal supplementation had some positive effects on distinct clinical phenotypes of the atopic syndrome. However, more studies are needed to fully explore the opportunity of perinatal immuno-modulation...
  56. doi request reprint Fetal epigenetic mechanisms and innate immunity in asthma
    Petra Ina Pfefferle
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Germany
    Curr Allergy Asthma Rep 10:434-43. 2010
    ..A better understanding of fetal immuno-maturation conditions will provide the basis for the development of novel allergo-protective clinical strategies...
  57. ncbi request reprint Diagnostic and analytical performance of a screening panel for allergy
    Ileana Herzum
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35033 Marburg, Germany
    Clin Chem Lab Med 43:963-6. 2005
    ..2 IU/mL IgE. In conclusion, the Allergy Screen panel yields reliable results in the detection of allergic sensitisation to common allergens...
  58. ncbi request reprint Influence of coagulation factors on intrinsic thrombin generation
    Thomas W Stief
    Department of Clinical Chemistry, University Hospital Marburg, Germany
    Blood Coagul Fibrinolysis 18:67-71. 2007
    ..The INCA allows one to diagnose defects in the intrinsic coagulation system and might be a useful test to support development and characterization of new drugs targeted at the intrinsic generation of thrombin...
  59. ncbi request reprint Influence of coagulation factors on extrinsic thrombin generation
    Thomas W Stief
    Department of Clinical Chemistry, University Hospital Marburg, Germany
    Blood Coagul Fibrinolysis 18:105-12. 2007
    ..Fibrinogen seems to act as antithrombin I; thrombin might be entrapped in the nascent fibrin. The EXCA is suitable to diagnose the level of extrinsic factors in patient plasma...
  60. ncbi request reprint The intrinsic coagulation activity assay
    Thomas W Stief
    Department of Clinical Chemistry Central Laboratory, University Hospital Giessen and Marburg, Germany
    Blood Coagul Fibrinolysis 17:369-78. 2006
    ....
  61. ncbi request reprint Elimination of the cardiac natriuretic peptides B-type natriuretic peptide (BNP) and N-terminal proBNP by hemodialysis
    Hans Günther Wahl
    Klinikum der Philipps Universität Marburg, Department of Clinical Chemistry and Molecular Diagnostics, 35033 Marburg, Germany
    Clin Chem 50:1071-4. 2004
  62. ncbi request reprint Immunochemical quantification of free light chains in urine
    Ileana Herzum
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
    Clin Chem 51:1033-5. 2005
  63. doi request reprint Analytical performance of a multiplexed, bead-based cytokine detection system in small volume samples
    Martin Bomert
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University, Marburg, Germany
    Clin Chem Lab Med 49:1691-3. 2011
    ..In the present study we set out to define the reliability and consistency of a suspension multiplexed protein array, the cytometric bead array (CBA), in large-scale, longitudinal studies...
  64. doi request reprint The extrinsic coagulation activity assay
    Thomas W Stief
    Department of Clinical Chemistry, Central Laboratory, University Hospital, Marburg, Germany
    Clin Appl Thromb Hemost 14:303-18. 2008
    ....
  65. doi request reprint Intrinsic hemostasis activation by freezing and thawing of plasma
    Thomas W Stief
    Department of Clinical Chemistry, University Hospital Giessen and Marburg, Germany
    Clin Appl Thromb Hemost 15:59-64. 2009
    ..The intrinsic coagulation activity assay allows the measurement of low-grade contact activation of frozen/thawed plasma...
  66. ncbi request reprint Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation
    Wolfgang Andreas Nockher
    Department of Clinical Chemistry and Molecular Diagnostics, University Hospital, Philipps Universitat, 35033 Marburg, Baldingerstrasse, Germany
    Clin Chim Acta 352:49-74. 2005
    ..Furthermore, new aspects of neurotrophin actions in maintenance of body energy balance and in reproductive endocrinology will be presented...
  67. doi request reprint Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
    Mengyao Zheng
    Department of Pharmaceutics and Biopharmacy, Philipps Universitat Marburg, Marburg, Germany
    Biomaterials 33:6551-8. 2012
    ....
  68. pmc Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str, 35043 Marburg, Germany
    Respir Res 7:4. 2006
    ..So far it is unclear, whether a functional shift in the already present AM population or the occurrence of a new, phenotypically different AM population is responsible for these observations...
  69. ncbi request reprint Determination of the global fibrinolytic state
    Thomas W Stief
    Department of Clinical Chemistry, University Hospital, Marburg, Germany
    Blood Coagul Fibrinolysis 18:479-87. 2007
    ..Chloramine (1.5 mmol/l) oxidation of the microclots favours their fibrinolytic breakdown, especially if lysis-resistant microclots are oxidized. The FIPA and CLA-PMN are new economical tests for the fibrinolytic state in patient blood...
  70. ncbi request reprint Analysis of cytokine levels in human lymphangiomas
    Susanne Wiegand
    Department of Otolaryngology, Philipps University of Marburg, Marburg, Germany
    In Vivo 22:253-6. 2008
    ..Different theories concerning the origin of lymphangiomas have been formulated but their precise pathogenesis is still unknown. This study aimed to analyze the levels of different cytokines in lymphangioma cyst fluids...
  71. doi request reprint Development and clinical application of a LC-MS/MS method for simultaneous determination of various tyrosine kinase inhibitors in human plasma
    Lutz Götze
    Institute of Laboratory Medicine and Pathobiochemistry, Philipps University Marburg, Marburg, Germany
    Clin Chim Acta 413:143-9. 2012
    ..The aim of this study was to develop and validate a specific, simple and rapid quantification method for various TKIs in human plasma...
  72. ncbi request reprint Analysis of hemostasis alterations in sepsis
    Thomas W Stief
    Department of Clinical Chemistry, University Hospital Giessen and Marburg, Marburg, Germany
    Blood Coagul Fibrinolysis 18:179-86. 2007
    ..Whether the observed alterations are of clinical significance has to be determined in well defined patient groups...
  73. doi request reprint Association of hyperhomocysteinemia with left ventricular dilatation and mass in human heart
    Peter Alter
    Internal Medicine Cardiology, Philipps University, Marburg, Germany
    Clin Chem Lab Med 48:555-60. 2010
    ..We hypothesized that hyperhomocysteinemia is associated with left ventricular (LV) dilatation and hypertrophy in dilative cardiomyopathy...
  74. ncbi request reprint Reliability of IFCC method for lactate dehydrogenase measurement in lithium-heparin plasma samples
    Ileana Herzum
    Klinikum der Philipps Universität Marburg, Department of Clinical Chemistry, 35033 Marburg, Germany
    Clin Chem 49:2094-6. 2003
  75. ncbi request reprint Animal models of T-cell-mediated skin diseases
    Thomas M Zollner
    CRBA Dermatology, Schering AG, Berlin, Germany
    Bioessays 26:693-6. 2004
  76. pmc Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation
    Armin Braun
    Department of Immunology and Allergology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, Hannover D 30625, Germany
    Br J Pharmacol 141:431-40. 2004
    ..Our data indicate that development of allergen-induced neuronal hyper-reactivity in mice is partially mediated by BDNF. British Journal of Pharmacology (2004) 141, 431-440. doi:10.1038/sj.bjp.0705638..
  77. ncbi request reprint T(H)1/T(H)2 immune response profiles differ between atopic children in eastern and western Germany
    Harald Renz
    Clinical Chemistry and Molecular Diagnostics, University Hospital Marburg, Germany
    J Allergy Clin Immunol 109:338-42. 2002
    ..Lower prevalence rates for childhood respiratory allergies have been reported in eastern Germany than in western Germany...
  78. ncbi request reprint Environmental exposure to endotoxin and its relation to asthma in school-age children
    Charlotte Braun-Fahrlander
    Institute of Social and Preventive Medicine, Basel, Switzerland
    N Engl J Med 347:869-77. 2002
    ..Immune activation may direct the immune response, thus conferring tolerance to allergens such as animal dander or tree and grass pollen...
  79. pmc Levels of antibodies specific to tetanus toxoid, Haemophilus influenzae type b, and pneumococcal capsular polysaccharide in healthy children and adults
    Uwe Schauer
    Klinik für Kinder und Jugendmedizin der Ruhr Universität, Bochum, Germany
    Clin Diagn Lab Immunol 10:202-7. 2003
    ..Thereafter, IgG anti-PCP antibody titers increased steadily to adult levels (59.5 mg/liter). The data are intended to provide reference ranges to aid in the interpretation of specific antibody determinations in the clinical setting...
  80. ncbi request reprint Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia
    Gisela Wohlleben
    Center for Infectious Diseases and Department of Pathology, University of Wurzburg, Wurzburg, Germany
    J Immunol 170:4601-11. 2003
    ..Flu virus infection also directly induced AHR and goblet cell metaplasia. Taken together, our results show that flu virus infections can induce, exacerbate, and suppress features of asthmatic disease in mice...
  81. ncbi request reprint Stress enhances airway reactivity and airway inflammation in an animal model of allergic bronchial asthma
    Ricarda A Joachim
    Department of Internal Medicine, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Psychosom Med 65:811-5. 2003
    ..To explore potential mechanisms linking stress to asthma exacerbation we developed an animal model that combines allergic airway inflammation and exposure to stress...
  82. ncbi request reprint Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma
    Christian Hahn
    Klinik und Poliklinik für Haut und Geschlechtskrankheiten, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Allergy Clin Immunol 111:1361-9. 2003
    ..IL-4 and IL-13 are considered as key regulators for the development of atopic disease...
  83. pmc The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma
    Christina Nassenstein
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    J Exp Med 198:455-67. 2003
    ..Our findings suggest that neurotrophin-mediated activation of bronchial eosinophils might play a role in the regulation of eosinophilic inflammation in allergic asthma...
  84. ncbi request reprint Neurotrophins in allergic airway dysfunction: what the mouse model is teaching us
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18055 Rostock, Germany marek lommatzschmed uni rostock de
    Ann N Y Acad Sci 992:241-9. 2003
    ..Thus, our experiments suggest that NGF and BDNF have a profound, but differential impact on allergic airway dysfunction...
  85. ncbi request reprint Autoimmunity and atopic dermatitis
    Irene Mittermann
    Department of Pathophysiology, Division of Immunopathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
    Curr Opin Allergy Clin Immunol 4:367-71. 2004
    ..This review summarizes evidence for autoimmune mechanisms in atopic dermatitis and suggests novel pathomechanisms that may be involved in this disease...
  86. ncbi request reprint Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties
    Jennifer Debarry
    Division of Innate Immunity, Research Center Borstel, Leibniz Center for Medicine, and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 119:1514-21. 2007
    ....
  87. doi request reprint Anti-acids lead to immunological and morphological changes in the intestine of BALB/c mice similar to human food allergy
    Isabella Pali-Schöll
    Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Exp Toxicol Pathol 60:337-45. 2008
    ..Therefore, this medication leads to sensitization against food with changes typical for food allergy also in the intestine...
  88. ncbi request reprint Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
    Kay Vogel
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008
    ..Because of their small size and thereby their potential for deposition in lower airways of small children, bacterial spores may be candidates for such allergy-protective effects...
  89. ncbi request reprint Prenatal exposure to a farm environment modifies atopic sensitization at birth
    Markus Johannes Ege
    University Children s Hospital, Munich, Germany
    J Allergy Clin Immunol 122:407-12, 412.e1-4. 2008
    ..Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age...
  90. doi request reprint Early identification of atopy in the prediction of persistent asthma in children
    Peter D Sly
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Lancet 372:1100-6. 2008
    ..Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies...
  91. ncbi request reprint The course of allergen-induced leukocyte infiltration in human and experimental asthma
    Marek Lommatzsch
    Department of Pneumology, Clinic of Internal Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    J Allergy Clin Immunol 118:91-7. 2006
    ....
  92. ncbi request reprint Intranasal tolerance induction with polypeptides derived from 3 noncross-reactive major aeroallergens prevents allergic polysensitization in mice
    Karin Hufnagl
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    J Allergy Clin Immunol 116:370-6. 2005
    ..Specific immunotherapy is less effective in patients with multiple allergic sensitizations compared with monosensitized patients...
  93. ncbi request reprint Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, 18057 Rostock, Germany
    Int J Dev Neurosci 23:495-500. 2005
    ..In conclusion, we show that neurotrophins display a very differential and dynamic profile in internal organs after birth...
  94. ncbi request reprint Brain-derived neurotrophic factor is increased in atopic dermatitis and modulates eosinophil functions compared with that seen in nonatopic subjects
    Ulrike Raap
    Department of Dermatology and Allergology, Hannover Medical University, Ricklingerstrasse 5, 30449 Hannover, Germany
    J Allergy Clin Immunol 115:1268-75. 2005
    ..Recently, the pivotal role of brain-derived neurotrophic factor (BDNF) has been described in allergic asthma. However, the role of this neurotrophin in atopic dermatitis (AD) still remains unknown...
  95. ncbi request reprint Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo
    Rene Rückert
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 174:5507-15. 2005
    ..This phenomenon is not mediated by enhanced numbers of CD4(+)/CD25(+) T cells. These results show that IL-15 is important for the induction of allergen-specific, Th2-differentiated T cells and induction of allergic inflammation in vivo...
  96. ncbi request reprint Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes
    Olaf Schulte-Herbrüggen
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    J Neuroimmunol 160:204-9. 2005
    ..None of the cytokines induced BDNF secretion in T- or B-cells. Thus, our data provide evidence that IL-6 and TNF-alpha represent a specific link between monocyte infiltration and neuronal changes in inflammatory diseases...
  97. pmc The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
    Aysefa Doganci
    Laboratory of Cellular and Molecular Immunology of the Lung, First Medical Clinic, University of Mainz, Mainz, Germany
    J Clin Invest 115:313-25. 2005
    ..Furthermore, inhibition of IL-6 signaling emerges as a novel molecular approach for the treatment of allergic asthma...
  98. ncbi request reprint Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
    ..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma...