H Remschmidt

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Management of schizophrenia in children and adolescents. The role of clozapine
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    Paediatr Drugs 2:253-62. 2000
  2. ncbi request reprint Global consensus on ADHD/HKD
    Helmut Remschmidt
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitat Marburg, Hans Sachs Str 4 6, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 14:127-37. 2005
  3. ncbi request reprint Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Federal Republic of Germany
    J Neural Transm 109:101-17. 2002
  4. ncbi request reprint Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    J Clin Pharm Ther 35:207-11. 2010
  5. ncbi request reprint Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
    J Neural Transm 114:513-21. 2007
  6. ncbi request reprint Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    J Psychiatr Res 35:339-45. 2001
  7. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
  8. ncbi request reprint Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    J Neural Transm 114:1091-5. 2007
  9. ncbi request reprint A prospective study of serum ghrelin levels in patients treated with clozapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 112:1411-6. 2005
  10. ncbi request reprint Forty-two-years later: the outcome of childhood-onset schizophrenia
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Marburg, Germany
    J Neural Transm 114:505-12. 2007

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Management of schizophrenia in children and adolescents. The role of clozapine
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    Paediatr Drugs 2:253-62. 2000
    ..Careful monitoring of haematological parameters and other adverse effects are preconditions for a successful treatment programme...
  2. ncbi request reprint Global consensus on ADHD/HKD
    Helmut Remschmidt
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitat Marburg, Hans Sachs Str 4 6, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 14:127-37. 2005
    ..The evidence supporting medication-based interventions (such as methylphenidate) is strong and consensus treatment algorithms to guide the multimodal treatment of ADHD, alone and in combination with common comorbidities, are suggested...
  3. ncbi request reprint Early-onset schizophrenia as a progressive-deteriorating developmental disorder: evidence from child psychiatry
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Federal Republic of Germany
    J Neural Transm 109:101-17. 2002
    ..Brain morphological studies and intelligence testing as well as investigations of the course provide evidence of deterioration. Therefore, early-onset schizophrenia can be understood as a progressive-deteriorating developmental disorder...
  4. ncbi request reprint Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    J Clin Pharm Ther 35:207-11. 2010
    ..We aim to study this further by including patients treated with the atypical antipsychotics olanzapine or risperidone as well as opposite-sex sib pairs...
  5. ncbi request reprint Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
    J Neural Transm 114:513-21. 2007
    ..We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD...
  6. ncbi request reprint Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    J Psychiatr Res 35:339-45. 2001
    ..Together with other published findings in adults, these results suggest an increased prevalence of obesity among young patients with schizophrenia and especially among patients chronically treated with atypical antipsychotics...
  7. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  8. ncbi request reprint Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    J Neural Transm 114:1091-5. 2007
    ..To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs)...
  9. ncbi request reprint A prospective study of serum ghrelin levels in patients treated with clozapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 112:1411-6. 2005
    ..Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain...
  10. ncbi request reprint Forty-two-years later: the outcome of childhood-onset schizophrenia
    H Remschmidt
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Marburg, Germany
    J Neural Transm 114:505-12. 2007
    ....
  11. ncbi request reprint Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Mol Psychiatry 2:330-4. 1997
    ..Peak leptin levels reached after weight gain are possibly the cause of increased energy expenditure during this stage of the disorder...
  12. ncbi request reprint Prediction of low body weight at long-term follow-up in acute anorexia nervosa by low body weight at referral
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Am J Psychiatry 154:566-9. 1997
    ..The authors investigated the hypothesis that in acute anorexia nervosa a low body weight predicts a poor weight prognosis for the future...
  13. ncbi request reprint Prospective 10-year follow-up in adolescent anorexia nervosa--course, outcome, psychiatric comorbidity, and psychosocial adaptation
    B Herpertz-Dahlmann
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Germany
    J Child Psychol Psychiatry 42:603-12. 2001
    ..Those who achieve complete recovery from the eating disorder have a good chance of overcoming other psychiatric disorders and to adapt to social requirements...
  14. ncbi request reprint Molecular genetic aspects of attention-deficit/hyperactivity disorder
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Neurosci Biobehav Rev 28:625-41. 2004
    ..The molecular results mentioned above are presented and discussed in detail, thus providing both clinicians and geneticists with an overview of the current research status of this important child and adolescent psychiatric disorder...
  15. ncbi request reprint A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 11:196-205. 2006
    ..Despite differences in ethnicity, ascertainment and phenotyping schemes, linkage results in ADHD appear remarkably consistent...
  16. ncbi request reprint No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Pharmacogenomics J 7:275-81. 2007
    ..In conclusion, we have not identified a novel binding site of the two investigated atypical AP that could contribute to the induced weight gain...
  17. ncbi request reprint Efficacy of inpatient and home treatment in psychiatrically disturbed children and adolescents. Follow-up assessment of the results of a controlled treatment study
    F Mattejat
    Dept of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    Eur Child Adolesc Psychiatry 10:I71-9. 2001
    ..Thus, in terms of psychiatric care and clinical practice, our results provide empirical support to the idea that home treatment should be used more frequently and much more broadly in the future...
  18. ncbi request reprint Body image distortion in Anorexia Nervosa--is there really a perceptual deficit?
    K Hennighausen
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 8:200-6. 1999
    ..Profile analyses of the body part estimation procedure revealed significant differences between groups in the ideal body shape at the body regions thigh, hip, waist and chest with control patients again showing a lower BPI...
  19. ncbi request reprint Long-term outcome and prognosis of obsessive-compulsive disorder with onset in childhood or adolescence
    C Wewetzer
    Department of Child and Adolescent Psychiatry, , , , Germany
    Eur Child Adolesc Psychiatry 10:37-46. 2001
    ..5%), avoidant (21.8%), and paranoid (12.7%) personality disorders. In-patient treatment, terminating treatment against advice and tics in childhood or adolescence significantly correlated with more severe OC symptoms in adulthood...
  20. ncbi request reprint The List of Individual Symptoms for Therapy Evaluation (LISTE)--an efficient method for individualized outcome assessment
    F Mattejat
    Dept. of Child and Adolescent Psychiatry, Philipps-University, Marburg, Germany
    Eur Child Adolesc Psychiatry 10:I46-58. 2001
    ..It can be used for face-to-face interviews or telephone interviews, and can also be applied as a paper-and-pencil test. Issues of application and the need for further studies are discussed...
  21. ncbi request reprint Symptom control in children and adolescents with attention-deficit/hyperactivity disorder on switching from immediate-release MPH to OROS MPH Results of a 3-week open-label study
    H Remschmidt
    Klinik für Kinder und Jugendpsychiatrie, Hans Sachs Strasse 6, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 14:297-304. 2005
    ....
  22. ncbi request reprint Candidate gene polymorphisms in eating disorders
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Str 6, D 35033, Marburg, Germany
    Eur J Pharmacol 410:147-159. 2000
    ..This kind of approach has already been initiated for anorexia nervosa. Genetic research on eating disorders will hopefully lead to new pharmacological treatment strategies...
  23. ncbi request reprint [Neuropsychology of autistic disorders]
    H Remschmidt
    Klinik für Kinder und Jugendpsychiatrie und psychotherapie der Philipps Universität Marburg
    Fortschr Neurol Psychiatr 73:654-63. 2005
    ..Autistic disorders can be understood as an integration deficit of these different functions...
  24. ncbi request reprint [Diagnosis of reading and spelling disorder]
    G Schulte-Körne
    Klinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters der Philipps Universität Marburg
    Z Kinder Jugendpsychiatr Psychother 29:113-6. 2001
    ..In addition, a table is presented that contains the data required to make diagnostic decisions based on the regression model. Furthermore, an expected prevalence rate was calculated using randomized computer data...
  25. ncbi request reprint Neurophysiological correlates of word recognition in dyslexia
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philips University, Marburg, Germany
    J Neural Transm 111:971-84. 2004
    ..This result strengthens the view that dyslexic children are not generally impaired in recognition memory but specific for linguistic material like words...
  26. ncbi request reprint Spatial-frequency- and contrast-dependent visible persistence and reading disorder: no evidence for a basic perceptual deficit
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philips University Marburg, Germany
    J Neural Transm 111:941-50. 2004
    ..Additionally, correlation analysis revealed no evidence for a significance of VP for spelling, phoneme awareness and speech discrimination. This study does not encourage either a magnocellular nor parvocellular deficit in dyslexia...
  27. ncbi request reprint Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations
    J Hebebrand
    Department of Child and Adolescent Psychiatry of the Philipps University of Marburg, Germany
    Mol Psychiatry 9:796-800. 2004
    ..In particular, we found no evidence for an increased rate of binge-eating behavior in obese carriers of MC4R variants. Our findings do not support the strong association between BED and MC4R carrier status...
  28. ncbi request reprint [Quality of life of children and adolescents with psychiatric disorders. Results of the 1st multicenter study with an inventory to assess the quality of life in children and adolescents]
    F Mattejat
    Klinik für Kinder und Jugendpsychiatrie und Psychotherapie des Kindes und Jugendalters der Philipps Universität Marburg Hans Sachs Strasse 4 6 D 35033 Marburg
    Z Kinder Jugendpsychiatr Psychother 31:293-303. 2003
    ..1998) was tested with regard to its ability to differentiate between psychiatric in- and outpatient samples...
  29. ncbi request reprint No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 109:402-5. 2001
    ..35; underweight: 0.32). Similarly, genotype frequencies did not differ between the groups. We concluded that the 825-T allele of the GNB3 does not play a major role in weight regulation in German children, adolescents and young adults...
  30. ncbi request reprint White blood cells and cortisol after sleep deprivation and recovery sleep in humans
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Germany
    Eur Arch Psychiatry Clin Neurosci 250:16-23. 2000
    ..The cortisol rhythm was affected neither by SD nor recovery sleep...
  31. ncbi request reprint Epidemic obesity: are genetic factors involved via increased rates of assortative mating?
    J Hebebrand
    Department of Child and Adolescent Psychiatry of the Philips University of Marburg, Germany
    Int J Obes Relat Metab Disord 24:345-53. 2000
    ..We speculate that the recent upsurge in social stigmatization of obese individuals underlies the hypothesized increase in assortative mating...
  32. ncbi request reprint [Is topiramate effective for weight loss in neuroleptic-induced obesity? 2 case reports]
    M Schüler-Springorum
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Philipps Universitat Marburg
    Z Kinder Jugendpsychiatr Psychother 30:51-8. 2002
    ..This finding raises the interesting question of whether both mood and body weight can be stabilized in patients who have gained weight while being treated with neuroleptics for one of the disorders mentioned above...
  33. ncbi request reprint [The Marburg Parent-Child Spelling Trainer--follow up studies after 2 years]
    G Schulte-Körne
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Philipps Universitat Marburg
    Z Kinder Jugendpsychiatr Psychother 26:167-73. 1998
    ..Supervised tutoring by the parents was shown to be effective for improving childrens' spelling ability...
  34. ncbi request reprint Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents
    H Roth
    Clinical Research Group, Institute of Human Genetics, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 105:341-4. 1997
    ..015 for the 214 bp allele of D7S1875 (corrected p-value = 0.03) and 0.215 for the 145 bp allele of D7S504 (corrected p-value = 0.43). These findings substantiate the evidence for linkage of extreme obesity to OB...
  35. ncbi request reprint Pre-attentive processing of auditory patterns in dyslexic human subjects
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Germany
    Neurosci Lett 276:41-4. 1999
    ..MMN scalp topographies were similar for both groups, showing a maximum over fronto-central leads...
  36. ncbi request reprint Role of auditory temporal processing for reading and spelling disability
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    Percept Mot Skills 86:1043-7. 1998
    ..The results were discussed regarding the relevance for the popular hypothesis of an auditory temporal processing deficit underlying dyslexia...
  37. ncbi request reprint Genetic predisposition to obesity in bulimia nervosa: a mutation screen of the melanocortin-4 receptor gene
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Germany
    Mol Psychiatry 7:647-51. 2002
    ..Our findings suggest that overweight is a risk factor for BN in clinically ascertained patients. For the first time a genotype predisposing to obesity has been detected in an extremely obese patient with BN...
  38. ncbi request reprint Objective measurement of hyperactivity, impulsivity, and inattention in children with hyperkinetic disorders before and after treatment with methylphenidate
    P Heiser
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Strasse 6, 35037 Marburg, Germany
    Eur Child Adolesc Psychiatry 13:100-4. 2004
    ....
  39. ncbi request reprint The component model of treatment in child and adolescent psychiatry: theoretical concept and empirical results
    H Remschmidt
    Dept. of Child and Adolescent Psychiatry, Philipps-University, Marburg, Germany
    Eur Child Adolesc Psychiatry 10:I26-45. 2001
    ..84 for non-beginners vs. drop-outs. In spite of some methodological restrictions, the results of this naturalistic study can be used to improve empirically based treatment procedures under realistic clinical conditions...
  40. ncbi request reprint Myocarditis, pericarditis and cardiomyopathy in patients treated with clozapine
    P M Wehmeier
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Clin Pharm Ther 30:91-6. 2005
    ..This is the first comprehensive review of the literature on this topic...
  41. ncbi request reprint Body image assessment using body size estimation in recent studies on anorexia nervosa. A brief review
    S Skrzypek
    Department of Child and Adolescent Psychiatry, Philipps-University, Marburg, Germany
    Eur Child Adolesc Psychiatry 10:215-21. 2001
    ..Thus, body size estimation remains a worthwhile approach to assessing body image disturbance in eating disorders. The identification of sensory and non-sensory factors in body image is considered a promising issue for further research...
  42. ncbi request reprint Alterations of host defence system after sleep deprivation are followed by impaired mood and psychosocial functioning
    P Heiser
    Department of Neurochemistry, Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Hans Sachs Str 6, 35037 Marburg, Germany
    World J Biol Psychiatry 2:89-94. 2001
    ..e., already in the morning following SD. Our findings therefore suggest an SD-induced alteration of these psychoimmune response patterns in healthy humans preceding deterioration of mood and psychosocial functioning...
  43. ncbi request reprint Speech perception deficit in dyslexic adults as measured by mismatch negativity (MMN)
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans Sachs Strasse 6, 35039, Marburg, Germany
    Int J Psychophysiol 40:77-87. 2001
    ..This suggests that speech perception as measured on an early, pre-attentive level plays a major role in dyslexia not only in children (as shown in our previous study) but also in adults...
  44. ncbi request reprint Visual information processing in dyslexic children
    P Scheuerpflug
    Department of Child and Adolescent Psychiatry, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Clin Neurophysiol 115:90-6. 2004
    ..We investigated two well-known paradigms (motion-onset and random-dot-kinematogram) with regard to global electrophysiological parameters...
  45. ncbi request reprint Interrelationship and familiality of dyslexia related quantitative measures
    G Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Ann Hum Genet 71:160-75. 2007
    ..25 and 0.63. Instead of analyzing single dyslexia-related components, multivariate analyses including factor analytic approaches may help in the identification of susceptibility genes...
  46. ncbi request reprint No evidence for involvement of the promoter polymorphism -866 G/A of the UCP2 gene in childhood-onset obesity in humans
    N Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Marburg, Germany
    Exp Clin Endocrinol Diabetes 111:73-6. 2003
    ..Allele and genotype frequencies did not differ between the extremely obese and never-obese subjects. In conclusion, we cannot confirm the results of ) in our young sample...
  47. ncbi request reprint [Schizophrenia in children and adolescents. An investigation of 305 consecutive inpatient treatment cases]
    H Remschmidt
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Philipps Universitat, Marburg
    Nervenarzt 75:663-74. 2004
    ....
  48. ncbi request reprint Spectrum of binge eating symptomatology in patients treated with clozapine and olanzapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Federal Republic of Germany
    J Neural Transm 110:111-21. 2003
    ..For future research in this field we suggest a novel DSM-IV research classification "Medication-induced eating disorders"...
  49. ncbi request reprint Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia
    J Hebebrand
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Hans Sachs Strasse 6, 35033 Marburg, Germany
    Physiol Behav 79:25-37. 2003
    ..In the first and second parts of our review, we will summarize the relevant findings pertaining to hyperactivity in AN patients and in the rat model, respectively. We conclude with a synopsis and implications for future research...
  50. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 7:1054-7. 2002
    ..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD...
  51. ncbi request reprint Serum levels of olanzapine and its N-desmethyl and 2-hydroxymethyl metabolites in child and adolescent psychiatric disorders: effects of dose, diagnosis, age, sex, smoking, and comedication
    Frank M Theisen
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Ther Drug Monit 28:750-9. 2006
    ..The data are compared with the literature, and the relevance of therapeutic antipsychotic drug monitoring in previously sparsely investigated subgroups, such as children and adolescents or patients with AN, is emphasized...
  52. ncbi request reprint Prevalence of movement disorders in adolescent patients with schizophrenia and in relationship to predominantly atypical antipsychotic treatment
    Stefan Gebhardt
    Dept of Psychiatry and Psychotherapy, Philipps University of Marburg, Rudolf Bultmann Strasse 8, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 15:371-82. 2006
    ..To examine prevalence of movement disorders (MDs) such as tardive dyskinesia (TD), parkinsonism or akathisia in an adolescent population with schizophrenia and in relationship to predominantly atypical antipsychotic treatment...
  53. ncbi request reprint Twin study on heritability of activity, attention, and impulsivity as assessed by objective measures
    Philip Heiser
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    J Atten Disord 9:575-81. 2006
    ..The purpose of this study was to assess heritability of activity, attention, and impulsivity by comparing young monozygotic (MZ) twins with dizygotic (DZ) twins using objective measures...
  54. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
    ....
  55. ncbi request reprint Clozapine-induced weight gain: a study in monozygotic twins and same-sex sib pairs
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, D 35039 Marburg, Germany
    Psychiatr Genet 15:285-9. 2005
    ..An important caveat is that, owing to the sample size, the heritability estimates have a large standard error and thus have to be interpreted with caution...
  56. ncbi request reprint Large intraindividual variability of olanzapine serum concentrations in adolescent patients
    Christian J Bachmann
    Department of Child and Adolescent Psychiatry, University Hospital Marburg and Giessen, Campus Marburg, Germany
    Ther Drug Monit 30:108-12. 2008
    ..It is recommended that repeated serum concentration measurements are made in individuals treated with OLZ, in order to obtain a more precise estimate of the intraindividual variability of serum concentrations...
  57. ncbi request reprint [Depressive disorders in childhood and adolescence]
    Maike Preiss
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitätsklinikum Giessen Marburg
    Z Kinder Jugendpsychiatr Psychother 35:385-96; quiz 396-7. 2007
    ..It is especially essential to establish adequate pharmaco- and psychotherapeutic treatments to ameliorate prognosis, progression and persistence of depressive disorders in children...
  58. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 115:1071-8. 2008
    ..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group...
  59. ncbi request reprint A prospective study of body weight and serum leptin levels in patients treated with topiramate
    Frank M Theisen
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Clin Neuropharmacol 31:226-30. 2008
    ..We prospectively studied 26 (10 women) patients (age, 37.4 +/- 10.3 years) with different types of refractory focal epilepsy who received topiramate as adjunctive treatment...
  60. doi request reprint No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level
    Anne Kathrin Wermter
    Clinical Research Group, Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:535-7. 2008
    ..We conclude that there is no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level in our study group...
  61. ncbi request reprint Effectiveness and tolerability of olanzapine in the treatment of adolescents with schizophrenia and related psychotic disorders: results from a large, prospective, open-label study
    Ralf W Dittmann
    Medical Department, Child and Adolescent Psychiatry, Lilly Deutschland GmbH, Saalburgstrasse 153, Bad Homburg, Germany
    J Child Adolesc Psychopharmacol 18:54-69. 2008
    ..The aim of this study was to assess effectiveness and tolerability of oral olanzapine treatment of adolescents with schizophrenic disorders...
  62. ncbi request reprint [Phenomenology and co-morbidity of childhood onset obsessive compulsive disorder]
    Thomas Jans
    Klinik und Poliklinik für Kinder und Jugendpsychiatrie und Psychotherapie der Julius Maximilians Universität Würzburg, Germany
    Z Kinder Jugendpsychiatr Psychother 35:41-50. 2007
    ..The goal of the study was to investigate the contents and comorbidity features of obsessive-compulsive disorder in children and adolescents...
  63. ncbi request reprint [Switching from a short-acting to a long-acting methylphenidate preparation: a multicentre, open study in children with ADHD]
    Steffen Heger
    Praxis für Psychosomatische Medizin und Psychotherapie, Koln
    Z Kinder Jugendpsychiatr Psychother 34:257-65. 2006
    ..The objective was to evaluate the safety and efficacy of a switch in medication to a single daily dose of OROS-Methylphenidate (OROS-MPH, Concerta) in clinically stable children and adolescents with ADHD...
  64. pmc Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents
    Zina M Manjaly
    Institute of Neuroscience and Biophysics, Department of Medicine, Research Centre Julich, 52425 Julich, Germany
    Neuroimage 35:283-91. 2007
    ..These results suggest that enhanced local processing in early visual areas, as opposed to impaired processing of global context, is characteristic for performance of the EFT by autistic patients...
  65. ncbi request reprint Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder
    Andreas Lazar
    Department of Pharmacology, University of Cologne, Cologne, Germany
    Int J Neuropsychopharmacol 11:35-48. 2008
    ..Heterologous expression of mutant cDNA revealed a 40% decline of transport capacity for norepinephrine. Rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of OCD...
  66. ncbi request reprint [Genetics of dyslexia]
    Gerd Schulte-Körne
    1 Klinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, DE 80336 München
    Z Kinder Jugendpsychiatr Psychother 34:435-44. 2006
    ..The goal of this project is to investigate the biological basis of dyslexia in order to improve the basis for the development of successful diagnostics and therapies...
  67. ncbi request reprint Relations between movement disorders and psychopathology under predominantly atypical antipsychotic treatment in adolescent patients with schizophrenia
    Stefan Gebhardt
    Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Rudolf Bultmann Str 8, 35033 Marburg, Germany
    Eur Child Adolesc Psychiatry 17:44-53. 2008
    ..To examine relations between movement disorders (MD) and psychopathological symptoms in an adolescent population with schizophrenia under treatment with predominantly atypical antipsychotics...
  68. ncbi request reprint Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder
    Sarah Brieber
    Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, University Hospital Aachen, Germany
    J Child Psychol Psychiatry 48:1251-8. 2007
    ..For the identification of endophenotypes across diagnostic categories, further investigations of phenotypic overlap between ADHD and autism at the behavioural, neurocognitive, and brain levels are needed...
  69. ncbi request reprint [Memorandum on application and expert assessment procedures of the DFG (German Research Society)]
    Helmut Remschmidt
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitätsklinikum Giessen und Marburg GmbH
    Z Kinder Jugendpsychiatr Psychother 34:177-9. 2006
  70. ncbi request reprint [Memorandum for improving research performance and for supporting the future medical generation in child and adolescent psychiatry, psychosomatic medicine and psychotherapy]
    Johannes Hebebrand
    Klinik für Kinder und Jugendpsychiatrie und psychotherapie der Rheinischen Kliniken der Universität Duisburg Essen
    Z Kinder Jugendpsychiatr Psychother 34:169-76. 2006
  71. ncbi request reprint Clinical drug monitoring in child and adolescent psychiatry: side effects of atypical neuroleptics
    Christian Fleischhaker
    Department of Child and Adolescent Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Hauptstrasse 8, 79104 Freiburg, Germany
    J Child Adolesc Psychopharmacol 16:308-16. 2006
    ..The aim of this study was to improve and evaluate the practibility of a method for the assessment of drug-associated side effects, and we implemented a clinical drug monitoring for atypical neuroleptics...
  72. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  73. ncbi request reprint Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Hum Mol Genet 13:1205-12. 2004
    ..These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors...
  74. ncbi request reprint Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, D 35039 Marburg, Germany
    J Clin Endocrinol Metab 88:4258-67. 2003
    ..8% (P = 0.033; exact one-sided McNemar test). These results support the hypothesis that these MC4R mutations represent major gene effects for obesity...
  75. ncbi request reprint Motion-onset VEPs in dyslexia. Evidence for visual perceptual deficit
    Gerd Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans Sachs Strasse 6, 35039 Marburg, Germany
    Neuroreport 15:1075-8. 2004
    ..These results support the hypothesis of an impairment of a specific magnocellular function in dyslexia...
  76. ncbi request reprint Visual evoked potential elicited by coherenty moving dots in dyslexic children
    Gerd Schulte-Körne
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans Sachs Strasse 6, 35039 Marburg, Germany
    Neurosci Lett 357:207-10. 2004
    ..The area of this component becomes larger at a higher level of coherence. This study supports the hypothesis of an impairment of a specific magnocellular function in dyslexia...
  77. ncbi request reprint Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro
    Philip Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Hans Sachs Str 6, Marburg 35037, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:297-302. 2004
    ....
  78. ncbi request reprint Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
    Hai Jun Wang
    Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
    J Clin Endocrinol Metab 89:157-62. 2004
    ..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups...
  79. ncbi request reprint Serotonergic effects of clozapine and its metabolites in hippocampal HT22 cells
    Philip Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Hans Sachs Str 6, Philipps University of Marburg, Marburg, Germany
    Psychiatry Res 112:221-9. 2002
    ....
  80. ncbi request reprint Pharmacokinetics of clozapine and its metabolites in hippocampal HT22 cells
    Philip Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, Hans Sachs Str 6, 35037 Marburg, Germany
    Eur J Pharmacol 476:167-72. 2003
    ..Moreover, CYP1A2 mRNA levels were significantly changed by incubation with clozapine 200...
  81. ncbi request reprint Lower serum leptin levels in female students of the nutritional sciences with eating disorders
    Joachim Frey
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Eur J Nutr 42:142-8. 2003
    ..It is unknown if these lower leptin levels represent a state or trait marker...
  82. ncbi request reprint Induced delusional disorder. a review of the concept and an unusual case of folie à famille
    Peter M Wehmeier
    Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    Psychopathology 36:37-45. 2003
    ..The boy was admitted to our child and adolescent psychiatric unit for in-patient treatment. Treatment success was moderate in terms of improving the features of folie à famille in the three individuals involved...
  83. ncbi request reprint Genome scan for childhood and adolescent obesity in German families
    Kathrin Saar
    Molecular Genetics and Gene Mapping Center, Max Delbruck Center, Berlin, Germany
    Pediatrics 111:321-7. 2003
    ....
  84. ncbi request reprint No evidence for involvement of the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity
    Anke Hinney
    Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Clinical Research Group, Schützenstr 49, Germany
    Mol Genet Metab 76:152-6. 2002
    ..4). All subsequent exploratory analyses were negative. Our analysis of the relationship between the NIDDM 'high-risk' haplotype combination and extreme early onset obesity revealed no evidence for linkage and association...
  85. ncbi request reprint [The Marburg Rating Scale for Asperger's Syndrome (MBAS)--a screening instrument for high-functioning autistic disorders]
    Inge Kamp-Becker
    Klinik für Kinder und Jugendpsychiatrie und psychotherapie der Philipps Universität Marburg
    Z Kinder Jugendpsychiatr Psychother 33:15-26. 2005
    ..Even today these disorders are unfortunately diagnosed very late, often in the wake of earlier, different diagnoses. The purpose of this study is to present a screening instrument (MBAS), which is sensitive to these disorders...
  86. ncbi request reprint Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation
    Peter M Wehmeier
    Department of Child and Adolescent Psychiatry, Philipps University, Hans Sachs Str 4 8, 35033 Marburg, Germany
    Psychiatry Res 133:273-6. 2005
    ..2 kg and finally had a weight of 100.4 kg (BMI=33.8 kg/m2). Because both patients experienced considerable weight gain during treatment, our observation suggests that the antipsychotic-induced weight gain is under strong genetic control...
  87. ncbi request reprint Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Eur J Hum Genet 13:428-34. 2005
    ..These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI...
  88. ncbi request reprint Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder
    Rainald Mossner
    Int J Neuropsychopharmacol 8:133-6. 2005
  89. ncbi request reprint [Diagnosis and etiology of Asperger syndrome in children and adolescents]
    Inge Kamp-Becker
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Marburg
    Prax Kinderpsychol Kinderpsychiatr 53:371-94. 2004
    ..In terms of causes of Asperger-Syndrom the following factors are discussed: genetic reasons, neurobiological disturbances and neuropsychological deficits...
  90. ncbi request reprint Chart review for potential features of myocarditis, pericarditis, and cardiomyopathy in children and adolescents treated with clozapine
    Peter M Wehmeier
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Strasse 4 8, 35033 Marburg, Germany
    J Child Adolesc Psychopharmacol 14:267-71. 2004
    ..With the exception of the case which prompted our study, none of the patients were found to have developed any such disorder in the course of further treatment with clozapine...
  91. ncbi request reprint Developmental dyslexia--recurrence risk estimates from a german bi-center study using the single proband sib pair design
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Lubeck, Germany
    Hum Hered 59:136-43. 2005
    ..The aims of this paper therefore are to demonstrate the practicability of the SPSP design and the estimation of recurrence risks for reading and writing...
  92. ncbi request reprint Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Psychiatr Genet 14:139-42. 2004
    ..Further pharmacogenetic studies pertaining to antipsychotic-induced weight gain are warranted...
  93. ncbi request reprint Mutation analysis of the MCHR1 gene in human obesity
    Anne Kathrin Wermter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, 45147 Essen, Germany
    Eur J Endocrinol 152:851-62. 2005
    ..The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity...
  94. ncbi request reprint Long-term course of adolescent schizophrenia
    Christian Fleischhaker
    Department of Child and Adolescent Psychiatry, Albert Ludwigs University Freiburg, Hauptstr 8, D 79104 Freiburg, Germany
    Schizophr Bull 31:769-80. 2005
    ..Premorbid adjustment was the best predictor of outcome in our schizophrenia sample. A poor prognosis was found in patients with premorbid developmental delays and those who were introverted and withdrawn before their psychotic state...
  95. ncbi request reprint Genetic risk factors in eating disorders
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Clinical Research Group, Philipps University of Marburg, Marburg, Germany
    Am J Pharmacogenomics 4:209-23. 2004
    ..Fine mapping of one of these regions led to the identification of genes where an association with anorexia nervosa was detected. Currently treatment of patients with eating disorders can not rely on results of molecular genetic studies...
  96. ncbi request reprint HLA-DRB genotyping in Gilles de la Tourette patients and their parents
    Sarah Schoenian
    Department of Neurology, Philipps University Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 119:60-4. 2003
    ..741, Monte Carlo P = 0.4998). Our results imply that the HLA-DRB locus does not confer genetic susceptibility to GTS...
  97. ncbi request reprint Olanzapine overdose in children and adolescents: two case reports and a review of the literature
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, and District General Hospital Frankenburg, Germany
    J Child Adolesc Psychopharmacol 15:986-95. 2005
    ....
  98. ncbi request reprint Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, D 52074 Aachen, Germany
    J Clin Endocrinol Metab 88:5169-74. 2003
    ..003). Our results suggest that, similar to semistarvation-induced hyperactivity in rats, hypoleptinemia in patients with AN may be one important factor underlying the excessive physical activity...
  99. ncbi request reprint Pancreatitis followed by pericardial effusion in an adolescent treated with clozapine
    Peter M Wehmeier
    J Clin Psychopharmacol 23:102-3. 2003
  100. ncbi request reprint Repeated creatine kinase elevation under treatment with quetiapine, clozapine, and aripiprazole in an adolescent
    Christian J Bachmann
    J Clin Psychopharmacol 27:710-1. 2007
  101. ncbi request reprint [The development of the personality in childhood epilepsy with complex-partial seizures]
    Wilfried Pott
    DRK Kinderklinik Siegen
    Prax Kinderpsychol Kinderpsychiatr 56:604-24. 2007
    ..Patients who continued to show seizures reported less life satisfaction, a more passive attitude and higher emotional instability at follow-up in comparison to patients with a complete remission of epilepsy...