Research Topics
Species | R MollSummaryAffiliation: Philipps University Country: Germany Publications
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Detail Information
Publications
The cardiac isoform of alpha-actin in regenerating and atrophic skeletal muscle, myopathies and rhabdomyomatous tumors: an immunohistochemical study using monoclonal antibodiesRoland Moll
Institute of Pathology, Philipp University of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
Virchows Arch 449:175-91. 2006....
[The initial CUP situation and CUP syndrome: pathological diagnostics]R Moll
Institut fur Pathologie, Philipps Universität Marburg und Universitätsklinikum Giessen und Marburg GmbH, Standort Marburg, Baldingerstr, 35033 Marburg
Pathologe 30:161-7. 2009..Future basic and clinical research is required to unravel the still enigmatic tumor biology of the CUP syndrome and to improve the hitherto very unfavorable prognosis by developing new efficient therapy regimens...
The human keratins: biology and pathologyRoland Moll
Institute of Pathology, Philipps University, 35033, Marburg, Germany
Histochem Cell Biol 129:705-33. 2008..Future research might open further fields of clinical application for this remarkable protein family...- Endothelial and virgultar cell formations in the mammalian lymph node sinus: endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens)Roland Moll
Institute of Pathology, Philipps University of Marburg, 35033 Marburg, Germany
Cell Tissue Res 335:109-41. 2009..Finally, physiological and pathological alterations of the SEVC system will be presented, and the possible value of the molecular markers described in histological diagnoses of autochthonous lymph node tumors will be discussed... - Value of sentinel lymphonodectomy in head and neck cancer patients without evidence of lymphogenic metastatic diseaseA A Dünne
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Deutschhausstr 3, 35037, Marburg, Germany
Auris Nasus Larynx 28:339-44. 2001..Based on the results of 38 investigated patients with clinically N0-neck the feasibility of SN biopsy in HNSCC is critically discussed... - Analysis of beta-catenin gene mutations in pancreatic tumorsB Gerdes
Department of General Surgery, Philipps University, Marburg, Germany
Digestion 60:544-8. 1999..The aim of this study was to determine the role of the beta-catenin gene in the genesis of exocrine and endocrine tumors of the pancreas... - Chromophilic renal cell carcinoma: cytomorphological and cytogenetic characterisation of four permanent cell linesC D Gerharz
Institute of Pathology, Heinrich Heine University, , Germany
Br J Cancer 74:1605-14. 1996..Karyological aberrations were least pronounced in chromphi-2 and most complex in chromphi-1. Chromosomal aberrations typically affecting the short arm of chromosome 3 in clear cell RCCs were not observed in any of our cell lines... - [The sentinel node concept in head and neck squamous cell carcinoma--a critical analysis in 100 patients]J A Werner
Klinik fur Hals, Nasen und Ohrenheilkunde, Germany
Laryngorhinootologie 81:31-9. 2002..Few investigations deal with SN biopsy in head and neck squamous cell carcinomas (HNSCC). For this reason the SN concept was investigated based on the results of the so far largest group of 100 patients... - Number and location of radiolabeled, intraoperatively identified sentinel nodes in 48 head and neck cancer patients with clinically staged N0 and N1 neckJ A Werner
Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany
Eur Arch Otorhinolaryngol 259:91-6. 2002..The value of the SN concept, however, currently remains unclear for patients suffering from HNSCC... - Meta-analysis of the prognostic significance of perinodal spread in head and neck squamous cell carcinomas (HNSCC) patientsA A Dünne
Department of Otolaryngology, Head and Neck Surgery, Philipps University Marburg, Deutschhausstrasse 3, 35037 Marburg, Germany
Eur J Cancer 42:1863-8. 2006..These results support the conclusion that perinodal spread is a significant adverse risk factor for survival in patients with HNSCC... - Experiences with a generator tool for building clinical application modulesK A Kuhn
Institute of Medical Informatics, Philipps University Marburg, Germany
Methods Inf Med 42:37-44. 2003..To elaborate main system characteristics and relevant deployment experiences for the health information system (HIS) Orbis/OpenMed, which is in widespread use in Germany, Austria, and Switzerland... - Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell culturesH Stoppler
Department of Pharmacology and Toxicology, Philipps University Marburg, Germany
Arch Dermatol Res 293:397-406. 2001..These results show that despite their pronounced neuroendocrine differentiation and their occurrence in patients of advanced age, Merkel cell carcinomas possess telomerase activity similar to that of common carcinoma types... - Differentiation between thyroidal and ectopic calcitonin secretion in patients with coincidental thyroid nodules and pancreatic tumors - a report of two casesR Schneider
Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
Exp Clin Endocrinol Diabetes 118:520-3. 2010..On the basis of these case reports, the diagnostic work flow and management in case of clearly elevated calcitonin levels are described and discussed... - [Fulminant course of falciparum malaria]S Lamparter
Klinik für Innere Medizin SP Kardiologie, Philipps Universitat Marburg
Dtsch Med Wochenschr 126:76-8. 2001..Autopsy revealed prominent congestion of liver, spleen and cerebral vessels as well as subdural and subarachnoidal hemorrhage... - Differential diagnosis of pericardial effusion after stem cell transplantation in acute myeloic leukemiaB Maisch
Department of Internal Medicine and Cardiology, University Hospital Gießen and Marburg UKGM GmbH and Philipps University Marburg, Deutschland
Herz 36:352-4. 2011..An intrapericardial instillation of 1000 mg triamcinolone acetate at day 1 and 50 mg/m(2) cisplatin at day 3 effectively prevented the recurrence of tamponade, but could not prevent a lethal outcome 3 weeks later... - Arrhythmias in acute pericarditis. An endomyocardial biopsy studyA D Ristic
University Institute for Cardiovascular Diseases, Medical Centre of Serbia, Belgrade, Yugoslavia
Herz 25:729-33. 2000..On the contrary, incidence of transitory atrial fibrillation was higher in acute pericarditis, than in myocarditis... - [Studies on significance of sentinel lymphadenectomy in pharyngeal and laryngeal carcinoma]J A Werner
Klinik und Poliklinik Fur Hals, Nasen und Ohrenheilkunde, Philipps Universitat Marburg
Laryngorhinootologie 78:663-70. 1999..The question arises whether the sentinel node (SN) concept as it is performed in different areas of clinical oncology is applicable to ear, nose, and throat medicine... - Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breastPeter J Barth
Institute of Pathology, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
Virchows Arch 446:532-6. 2005..carcinoma: CD34-alpha-SMA+SPARC+) as a tool in distinguishing benign from malignant breast lesion one has to keep in mind that the phenotype of granulation tissue in areas of antecedent biopsy resembles that of tumor stroma... - Effectiveness of radiochemotherapy on lymph node metastases in patients with stage IV oropharyngeal cancerNikolay R Sapundzhiev
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Deutschhausstr. 3, Marburg 35037, Germany
Oral Oncol 40:1007-16. 2004..The observed high incidence of vital LN metastases, which abide the radiochemotherapy, advocates further studies, concerning the value of planed ND after radiochemotherapy... - CD34+ fibrocytes, alpha-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynxPeter J Barth
Institute of Pathology, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
Virchows Arch 444:231-4. 2004..The diagnostic impact of this finding is, however, limited by the fact that chronic inflammation may also be accompanied by a focal loss of CD34+ fibrocytes... - Genetic pathways and new progression markers for prostate cancer suggested by microsatellite allelotypingRolf von Knobloch
Department of Urology, Philipps University Marburg Medical School, Baldingerstrasse, D 35043 Marburg Lahn, Germany
Clin Cancer Res 10:1064-73. 2004..Performing microsatellite allelotyping on a large series of consecutive prostate cancers procured during radical prostatectomy at our institution, we sought to identify molecular markers associated with disease progression... - Value of sentinel lymphadenectomy in head and neck cancerJochen A Werner
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Germany
Ann Surg Oncol 11:267S-70S. 2004..Sentinel lymphadenectomy for head and neck cancer may prove helpful if the indications for its use are clearly defined... - p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an RbBerthold Gerdes
Department of Visceral, Thoracic, and Vascular Surgery, Philipps University of Marburg, Marburg, Germany
Ann Surg 235:51-9. 2002..To identify the prognostic relevance of the G1/S cell cycle regulator genes p16INK4a, p53, MDM2, and Rb in patients with resected ductal pancreatic cancer (PC)... - Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trialRudolf Arnold
Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps University, Marburg, Germany
Clin Gastroenterol Hepatol 3:761-71. 2005.... - CD34(+) fibrocytes in normal cervical stroma, cervical intraepithelial neoplasia III, and invasive squamous cell carcinoma of the cervix uteriPeter J Barth
Institute of Pathology, Philipps University Marburg, Baldingerstrasse, Germany
Virchows Arch 441:564-8. 2002..Moreover, the present study shows that CD34(+) fibrocytes and myofibroblasts play an important role in stromal remodeling associated with invasive squamous cell carcinoma of the cervix... - Genetic pathways and new progression markers for prostate cancer defined by microsatellite allelotypingRolf von Knobloch
Department of Urology, Philipps University Marburg Medical School, Marburg Lahn, Germany
Urologe A 43:S149-52. 2004.... - CD34+ fibrocytes in neoplastic and inflammatory pancreatic lesionsPeter J Barth
Institute of Pathology, Philipps University Marburg, Germany
Virchows Arch 440:128-33. 2002..Moreover, CD34+ fibrocytes and myofibroblasts appear to be involved in stromal remodeling associated with chronic pancreatitis and ductal adenocarcinoma... - Images in cardiovascular medicine. Phenotype of infiltrating T lymphocytes in cardiac sarcoidosisMichael Schoppet
Department of Internal Medicine and Cardiology, Philipps-University, Baldingerstrasse, Marburg, Germany
Circulation 105:e67-8. 2002 - CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesionsPeter J Barth
Institute of Pathology, Philipps University, 35033 Marburg, Germany
Virchows Arch 440:298-303. 2002..These findings may be helpful tools in distinguishing benign breast lesions (e.g., sclerosing adenosis) from invasive breast cancer and in characterizing stromal remodeling associated with invasive cancer... - The sentinel node concept in head and neck cancer: solution for the controversies in the N0 neck?Jochen A Werner
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Germany
Head Neck 26:603-11. 2004..With this background, our investigation critically analyzes the value of sentinel lymphadenectomy... - Prognostic value of E-cadherin expression in 413 gastric carcinomasH E Gabbert
Institute of Pathology, University of Dusseldorf, Germany
Int J Cancer 69:184-9. 1996..This prognostic impact remained present in a multivariate Cox regression analysis, including the prognostic parameters pT category, pN category and vascular invasion... - Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomasR Moll
Institut fur Pathologie, Medical School, University of Mainz, Germany
Am J Pathol 143:1731-42. 1993..The generation of dedifferentiated IDCs can only in part be correlated with reduced expression of the intercellular adhesion molecule E-cadherin. Other factors are obviously also involved during invasion of this carcinoma type... - CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladderWilhelm Nimphius
Institute of Pathology, University Hospital Giessen and Marburg GmbH, Location Marburg, Medical Faculty of Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
Virchows Arch 450:179-85. 2007..Stromal remodeling associated with invasive carcinomas in the urinary bladder is characterized by a loss of CD34+ fibrocytes paralleled by a gain of alpha-SMA-positive myofibroblasts and increased expression of SPARC... - CD34+ fibrocytes in tubular carcinomas and radial scars of the breastAnnette Ramaswamy
Institute of Pathology, Philipps-University Marburg, Baldingerstrasse, 35033 Marburg, Germany
Virchows Arch 443:536-40. 2003.... - Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological conceptWerner Bocker
Institute of Pathology, University of Munster, Munster, Germany
Lab Invest 82:737-46. 2002..The significance of this new cell biological model is that it might serve as a tool to unravel the regulatory mechanisms that govern regeneration and abnormal proliferation of breast epithelium at the cellular level... - Successful selective internal radiotherapy (SIRT) in a patient with a malignant solid pseudopapillary pancreatic neoplasm (SPN)S Krug
Department of Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany
Pancreatology 12:423-7. 2012..The selective internal radiotherapy is a suitable approach for inducing long-term remissions of the strongly vascularized liver metastases... - Proliferation and number of Clara cell 10-kDa protein (CC10)-reactive epithelial cells and basal cells in normal, hyperplastic and metaplastic bronchial mucosaP J Barth
Department of Pathology, Philipps University, Marburg, Germany
Virchows Arch 437:648-55. 2000..However, because the proliferative activity is inversely related to the number of CC10-reactive cells, the CC10 protein may play a role in the regulation of epithelial repair. Squamous metaplasia most likely originates from basal cells... - Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbitR Mandic
Department of Otorhinolaryngology, Philipps University, Deutschhausstr. 3, 35037 Marburg, Germany
Anticancer Res 22:3281-4. 2002..These observations further underline the significance of the VX2 carcinoma as a model tumor of human HNSCC... - Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder?Ina Riedel
Institute of Pathology, Philipp University, D 35033 Marburg, Germany
Eur J Cell Biol 84:393-405. 2005..Additional studies are needed to distinguish these two possibilities and to elucidate the physiological and pathological significance of the observed urothelial and uroplakin heterogeneity... - Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakinsI Riedel
Department of Pathology, Philipp University, University Hospital, Marburg, Germany
Virchows Arch 438:181-91. 2001..These results may explain the controversies as expressed in the recent literature concerning TCC of the ovary and establish its place among the ovarian adenocarcinomas of müllerian type... - Successful treatment of solid-pseudopapillary tumor of the pancreas with multiple liver metastasesI Hassan
Department of Surgery, Institute of Theoretical Surgery, Philipps University of Marburg, Marburg, Germany
Pancreatology 5:289-94. 2005..The patient is disease free after a follow-up of 18 months after resection of the primary tumor, suggesting that an aggressive surgical treatment might also be justified for metastasized SPT... - Neoplastic pericardial effusion. Efficacy and safety of intrapericardial treatment with cisplatinB Maisch
Department of Internal Medicine-Cardiology, Philipps University, Marburg, Germany
Eur Heart J 23:1625-31. 2002..CONCLUSION: Intrapericardial treatment with cisplatin appeared to successfully prevent recurrences of neoplastic pericardial effusion. The treatment was more successful in lung than in breast cancer patients... - [Unusual presentation of autoimmune pancreatitis type 1]T Linhart
Klinik fur Innere Medizin, Schwerpunkt Gastroenterologie, Endokrinologie und Stoffwechsel, Universitätsklinikum Giessen und Marburg, Standort Marburg, Marburg
Dtsch Med Wochenschr 135:1662-6. 2010..Laboratory findings on admission revealed liver function tests that were moderately (AST, ALT) or markedly elevated (GGT and AP)... - Growth inhibition in clonal subpopulations of a human epithelioid sarcoma cell line by retinoic acid and tumour necrosis factor alphaR Engers
Institute of Pathology, Heinrich Heine University, Dusseldorf, Germany
Br J Cancer 73:491-8. 1996..Whereas the TNF-alpha response seems to depend on the expression of TNF-R1, no simple correlation could be found between RA sensitivity and the expression pattern of RARs... - Sentinel node detection in N0 cancer of the pharynx and larynxJ A Werner
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Deutschhausstr 3, 35037 Marburg, Germany
Br J Cancer 87:711-5. 2002..Future studies must show, if sentinel node detection is suitable to limit the extent of lymph node dissection in clinically N0 necks of patients suffering from pharyngeal and laryngeal squamous cell carcinoma... - CD44: survival and metastasis in chondrosarcomaT J Heyse
Department of Orthopedics and Rheumatology, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany
Osteoarthritis Cartilage 18:849-56. 2010..In this study the expression of CD44s and two variant isoforms was evaluated. It was assumed that abnormalities in these receptor proteins may be associated with clinical outcome of the patients... - Prevalence of the parvovirus B19 genome in endomyocardial biopsy specimensSabine Pankuweit
Department of Internal Medicine'Cardiology and Patholody, Philipps'University Marburg, Marburg, Germany
Hum Pathol 34:497-503. 2003..PVB19 should therefore be recognized as a potential cardiotropic pathogen in patients of all ages... - Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta geneSabine Müller-Brüsselbach
Institute of Molecular Biology and Tumor Research IMT, Philipps University, Marburg, Germany
Int J Oncol 31:607-11. 2007..These results are relevant with respect to the clinical application of drugs modulating the activity of PPARbeta or PPARgamma... - The ubiquitin-specific protease USP28 is required for MYC stabilityNikita Popov
Institute of Molecular Biology and Tumor Research, Emil Mannkopff Str 2, 35033 Marburg, Germany
Nat Cell Biol 9:765-74. 2007..High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation...