Research Topics
| Andrea MaisnerSummaryAffiliation: Philipps University Country: Germany Publications
| Collaborators
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Detail Information
Publications
Organ- and endotheliotropism of Nipah virus infections in vivo and in vitroAndrea Maisner
Institute of Virology, Philipps University, Marburg, Germany
Thromb Haemost 102:1014-23. 2009....
Activation of the Nipah virus fusion protein in MDCK cells is mediated by cathepsin B within the endosome-recycling compartmentSandra Diederich
Institute of Virology, Philipps University of Marburg, Marburg, Germanya Faculty of Chemistry, University of Bielefeld, Bielefeld, Germany
J Virol 86:3736-45. 2012..In summary, this study shows for the first time that endosomal cathepsin B can play a functional role in the activation of highly pathogenic NiV...- Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytesNicole Runkler
Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, D 35043 Marburg, Germany
J Gen Virol 89:687-96. 2008.... - Tyrosine residues in the cytoplasmic domains affect sorting and fusion activity of the Nipah virus glycoproteins in polarized epithelial cellsCarolin Weise
Institute of Virology, Philipps University of Marburg, Marburg, Germany
J Virol 84:7634-41. 2010.... - Endocytosis of the Nipah virus glycoproteinsCarola Vogt
Institut fur Virologie, Philipps University of Marburg, Germany
J Virol 79:3865-72. 2005..F endocytosis clearly depended on a membrane-proximal YXXPhi motif and was found to be of functional importance for the biological activity of the protein... - Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tailLena Thiel
Institute of Virology, Philipps University of Marburg, Marburg, Germany
Virol J 5:163. 2008.... 
The nipah virus fusion protein is cleaved within the endosomal compartmentSandra Diederich
Institute of Virology, Philipps University of Marburg, Germany
J Biol Chem 280:29899-903. 2005..To our knowledge, this is the first example of a viral class I fusion protein whose activation depends on clathrin-mediated constitutive endocytosis...- Nipah virus infection and glycoprotein targeting in endothelial cellsStephanie Erbar
Institute of Virology, Philipps University of Marburg, Germany
Virol J 7:305. 2010..Since endothelial cells share many characteristics with epithelial cells in terms of polarization and protein sorting, we wanted to elucidate the role of the NiV glycoprotein targeting signals in endothelial cells... - Measles virus nucleocapsid transport to the plasma membrane requires stable expression and surface accumulation of the viral matrix proteinNicole Runkler
Institute of Virology, Philipps University Marburg, Hans Meerwein Strasse 2, D 35043 Marburg, Germany
Cell Microbiol 9:1203-14. 2007..Thus, we show for the first time that M stability and accumulation at intracellular membranes is a prerequisite for M and nucleocapsid co-transport to the plasma membrane and for subsequent virus assembly and budding processes... - Sorting signals in the measles virus wild-type glycoproteins differently influence virus spread in polarized epithelia and lymphocytesNicole Runkler
Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, D 35043 Marburg, Germany
J Gen Virol 90:2474-82. 2009.... - Role of endocytosis and cathepsin-mediated activation in Nipah virus entrySandra Diederich
Institute of Virology, Philipps University of Marburg, Germany
Virology 375:391-400. 2008..Our data clearly demonstrate that proteolytic activation of the NiV F protein is required before incorporation into budding virions but not after virus entry... - Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivoMarkus Moll
Institute of Virology, Philipps University Marburg, Robert-Koch-Str 17, 35037 Marburg, Germany
J Gen Virol 85:1019-27. 2004..These data strongly suggest that basolateral targeting of MV glycoproteins helps to overcome the epithelial barrier and thereby facilitates the systemic spread of MV infection in vivo... - Molecular characteristics of the Nipah virus glycoproteinsSandra Diederich
Philipps Universitat Marburg, Institut fur Virologie, Hans Meerwein Str 2, Marburg, Germany
Ann N Y Acad Sci 1102:39-50. 2007..Since viral glycoproteins are major determinants for cell tropism and virus spread, a detailed knowledge of these proteins can help to understand the molecular basis of viral pathogenicity... - Selective receptor expression restricts Nipah virus infection of endothelial cellsStephanie Erbar
Institute of Virology, Philipps University of Marburg, Marburg, Germany
Virol J 5:142. 2008..This strongly suggests that limitations in receptor expression restrict virus entry in certain EC subsets in vivo, and are thus responsible for the differences in EC tropism observed in human and animal NiV infections... - Nipah virus entry and egress from polarized epithelial cellsBoris Lamp
Institute of Virology, Philipps University of Marburg, Marburg, Germany
J Virol 87:3143-54. 2013..Studies with stably M-expressing and with monensin-treated cells furthermore demonstrated that M protein transport is independent from the glycoproteins, implying that the M protein possesses an intrinsic apical targeting signal... - Influence of N-glycans on processing and biological activity of the nipah virus fusion proteinMarkus Moll
Institut fur Virologie, Philipps University of Marburg, Germany
J Virol 78:7274-8. 2004..This finding indicates that in the absence of g4, the amino acid sequence around position 414 is important for folding and transport... - Importance of the cytoplasmic tails of the measles virus glycoproteins for fusogenic activity and the generation of recombinant measles virusesMarkus Moll
Institute of Virology, Philipps University of Marburg, Marburg, Germany
J Virol 76:7174-86. 2002..Thus, glycoprotein truncation does not interfere with the successful generation of recombinant MV if fusion competence is maintained... - Canine distemper virus matrix protein influences particle infectivity, particle composition, and envelope distribution in polarized epithelial cells and modulates virulenceErik Dietzel
Institute of Virology, Philipps University Marburg, Marburg, Germany
J Virol 85:7162-8. 2011.... - The microtubule motor protein KIF13A is involved in intracellular trafficking of the Lassa virus matrix protein ZSarah Katharina Fehling
Institute of Virology, Philipps University Marburg, Hans Meerwein Str 2, 35043 Marburg, Germany
Cell Microbiol 15:315-34. 2013..In summary, our studies identify for the first time a molecular motor protein as a critical mediator for intracellular microtubule-dependent transport of arenavirus matrix proteins... - Bats host major mammalian paramyxovirusesJan Felix Drexler
Institute of Virology, University of Bonn Medical Centre, Bonn 53127, Germany
Nat Commun 3:796. 2012..Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data... - Measles virus matrix protein is not cotransported with the viral glycoproteins but requires virus infection for efficient surface targetingPetra Riedl
Institute of Virology, Philipps University of Marburg, Robert-Koch-Strasse 17, 35037 Marburg, Germany
Virus Res 83:1-12. 2002..Although cotransport with the viral glycoproteins was not needed, M transport to the plasma membrane required a component only provided in MV-infected cells...