Magdalena Huber

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi request reprint c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells
    Alexander Visekruna
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 40:671-6. 2010
  2. ncbi request reprint IL-27 inhibits the development of regulatory T cells via STAT3
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
    Int Immunol 20:223-34. 2008
  3. pmc IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 105:20846-51. 2008
  4. doi request reprint A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity
    Magdalena Huber
    Institute for Medical Microbiology and Hygiene, University of Marburg, Germany
    Eur J Immunol 39:1716-25. 2009
  5. ncbi request reprint The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    Anne Brüstle
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany
    Nat Immunol 8:958-66. 2007
  6. pmc Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    Nadine Bollig
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 109:8664-9. 2012
  7. doi request reprint Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation
    Alexander Visekruna
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 43:606-18. 2013
  8. pmc IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
    Magdalena Huber
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    J Clin Invest 123:247-60. 2013
  9. doi request reprint c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection
    Katharina Reinhard
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 41:1388-98. 2011
  10. doi request reprint The role of NF-κB activation during protection against Leishmania infection
    Katharina Reinhard
    Institute for Medical Microbiology and Hygiene, University of Marburg, Hans Meerwein Straße 2, 35032 Marburg, Germany
    Int J Med Microbiol 302:230-5. 2012

Collaborators

Detail Information

Publications13

  1. doi request reprint c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells
    Alexander Visekruna
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 40:671-6. 2010
    ..The addition of exogenous IL-2 was sufficient to rescue the development of c-Rel-deficient iTreg. Thus, c-Rel is essential for the development of Foxp3(+) Treg but not for T(H)17 cells via regulating the production of IL-2...
  2. ncbi request reprint IL-27 inhibits the development of regulatory T cells via STAT3
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, Hans Meerwein Strasse 2, 35043 Marburg, Germany
    Int Immunol 20:223-34. 2008
    ..Thus, IL-27 and TGFbeta mutually control their effects on CD4+ T-cell differentiation, whereby IL-27 favours inflammatory conditions through a STAT3-dependent inhibition of Treg generation...
  3. pmc IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 105:20846-51. 2008
    ..These data highlight IRF4 as a decisive factor during the IL-21-mediated steps of Th17 development by influencing the balance of Foxp3, RORalpha, and RORgammat...
  4. doi request reprint A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity
    Magdalena Huber
    Institute for Medical Microbiology and Hygiene, University of Marburg, Germany
    Eur J Immunol 39:1716-25. 2009
    ..Furthermore, Tc17 cells producing IL-17 but not granzyme B are also detectable in EAE, a mouse model for multiple sclerosis. Our data point to the existence of mutually exclusive CTL and Tc17 developmental pathways in vitro and in vivo...
  5. ncbi request reprint The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    Anne Brüstle
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany
    Nat Immunol 8:958-66. 2007
    ..Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also T(H)-17 differentiation...
  6. pmc Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
    Nadine Bollig
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 109:8664-9. 2012
    ..Together with its known B lineage-specific roles during plasma cell maturation and class switch, our study places IRF4 in the center of antibody production toward T-cell-dependent antigens...
  7. doi request reprint Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation
    Alexander Visekruna
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 43:606-18. 2013
    ..Thus, our data point to the existence of Tc9 cells and to their supportive function in Th2-dependent airway inflammation, suggesting that these cells might be a therapeutic target in allergic disorders...
  8. pmc IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
    Magdalena Huber
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    J Clin Invest 123:247-60. 2013
    ..Our results reveal that Tc17 cells contribute to the initiation of CNS autoimmunity in mice and humans by supporting Th17 cell pathogenicity...
  9. doi request reprint c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection
    Katharina Reinhard
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 41:1388-98. 2011
    ..In conclusion, our data suggest that the expression of c-Rel in myeloid cells is essential for clearance of L. major and that this c-Rel-mediated effect is dominant over the lack of Tregs...
  10. doi request reprint The role of NF-κB activation during protection against Leishmania infection
    Katharina Reinhard
    Institute for Medical Microbiology and Hygiene, University of Marburg, Hans Meerwein Straße 2, 35032 Marburg, Germany
    Int J Med Microbiol 302:230-5. 2012
    ....
  11. ncbi request reprint Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation
    Peter Kleemann
    Institut fuer Medizinische Mikrobiologie und Krankenhaushygiene, University of Marburg, BMFZ, Hans Meerweinstrasse, 35043 Marburg, Germany
    Int Immunol 18:1603-6. 2006
    ....
  12. ncbi request reprint IRF4 at the crossroads of effector T-cell fate decision
    Magdalena Huber
    Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 44:1886-95. 2014
    ..In this review, we focus on recent findings on the role of IRF4 during the development of CD4(+) and CD8(+) T-cell subsets and the impact of IRF4 on T-cell-mediated immune responses in vivo. ..
  13. doi request reprint IRF4 provides rations for cytotoxic CD8(+) T cell soldiers
    Magdalena Huber
    Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, 35043 Marburg, Germany
    Immunity 39:797-9. 2013
    ..In this issue, Yao et al. (2013) identify IRF4 as a regulator of checkpoints in the final steps and maintenance of CD8(+) T cell effector differentiation. ..