J Hebebrand

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Mol Psychiatry 2:330-4. 1997
  2. ncbi request reprint The genetics of obesity: practical implications
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Int J Obes Relat Metab Disord 25:S10-8. 2001
  3. ncbi request reprint Prediction of low body weight at long-term follow-up in acute anorexia nervosa by low body weight at referral
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Am J Psychiatry 154:566-9. 1997
  4. ncbi request reprint Epidemic obesity: are genetic factors involved via increased rates of assortative mating?
    J Hebebrand
    Department of Child and Adolescent Psychiatry of the Philips University of Marburg, Germany
    Int J Obes Relat Metab Disord 24:345-53. 2000
  5. ncbi request reprint No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 109:402-5. 2001
  6. doi request reprint Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    J Clin Pharm Ther 35:207-11. 2010
  7. ncbi request reprint No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity
    A Hinney
    Department of Child and Adolescent Psychiatry, Clinical Research Group, University of Marburg, Germany e
    Am J Med Genet 88:594-7. 1999
  8. ncbi request reprint Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    J Psychiatr Res 35:339-45. 2001
  9. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
  10. ncbi request reprint Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents
    H Roth
    Clinical Research Group, Institute of Human Genetics, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 105:341-4. 1997

Detail Information

Publications83

  1. ncbi request reprint Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Mol Psychiatry 2:330-4. 1997
    ..Peak leptin levels reached after weight gain are possibly the cause of increased energy expenditure during this stage of the disorder...
  2. ncbi request reprint The genetics of obesity: practical implications
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Int J Obes Relat Metab Disord 25:S10-8. 2001
    ..We conclude by discussing the implications of the recent molecular findings in humans for phenotypical assessment in ongoing family studies...
  3. ncbi request reprint Prediction of low body weight at long-term follow-up in acute anorexia nervosa by low body weight at referral
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Am J Psychiatry 154:566-9. 1997
    ..The authors investigated the hypothesis that in acute anorexia nervosa a low body weight predicts a poor weight prognosis for the future...
  4. ncbi request reprint Epidemic obesity: are genetic factors involved via increased rates of assortative mating?
    J Hebebrand
    Department of Child and Adolescent Psychiatry of the Philips University of Marburg, Germany
    Int J Obes Relat Metab Disord 24:345-53. 2000
    ..We speculate that the recent upsurge in social stigmatization of obese individuals underlies the hypothesized increase in assortative mating...
  5. ncbi request reprint No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 109:402-5. 2001
    ..35; underweight: 0.32). Similarly, genotype frequencies did not differ between the groups. We concluded that the 825-T allele of the GNB3 does not play a major role in weight regulation in German children, adolescents and young adults...
  6. doi request reprint Body weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair study
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    J Clin Pharm Ther 35:207-11. 2010
    ..We aim to study this further by including patients treated with the atypical antipsychotics olanzapine or risperidone as well as opposite-sex sib pairs...
  7. ncbi request reprint No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity
    A Hinney
    Department of Child and Adolescent Psychiatry, Clinical Research Group, University of Marburg, Germany e
    Am J Med Genet 88:594-7. 1999
    ..1. An influence of alleles of the DRD4 on the development of AN, underweight, or extreme early onset obesity was not detected. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:594-597, 1999...
  8. ncbi request reprint Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    J Psychiatr Res 35:339-45. 2001
    ..Together with other published findings in adults, these results suggest an increased prevalence of obesity among young patients with schizophrenia and especially among patients chronically treated with atypical antipsychotics...
  9. ncbi request reprint Association and linkage of allelic variants of the dopamine transporter gene in ADHD
    S Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:923-33. 2007
    ..Future studies are required to assess if variation at this locus also explains other positive linkage results obtained for chromosome 5p...
  10. ncbi request reprint Further support for linkage of extreme obesity to the obese gene in a study group of obese children and adolescents
    H Roth
    Clinical Research Group, Institute of Human Genetics, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 105:341-4. 1997
    ..015 for the 214 bp allele of D7S1875 (corrected p-value = 0.03) and 0.215 for the 145 bp allele of D7S504 (corrected p-value = 0.43). These findings substantiate the evidence for linkage of extreme obesity to OB...
  11. ncbi request reprint Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder
    S Friedel
    Clinical Research Group, Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University of Marburg, 35039 Marburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 132:96-9. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  12. ncbi request reprint No evidence for involvement of the promoter polymorphism -866 G/A of the UCP2 gene in childhood-onset obesity in humans
    N Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Marburg, Germany
    Exp Clin Endocrinol Diabetes 111:73-6. 2003
    ..Allele and genotype frequencies did not differ between the extremely obese and never-obese subjects. In conclusion, we cannot confirm the results of ) in our young sample...
  13. ncbi request reprint A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 11:196-205. 2006
    ..Despite differences in ethnicity, ascertainment and phenotyping schemes, linkage results in ADHD appear remarkably consistent...
  14. ncbi request reprint No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD
    B G Schimmelmann
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 114:523-6. 2007
    ..We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in our sample...
  15. ncbi request reprint Clozapine/olanzapine-induced recurrence or deterioration of binge eating-related eating disorders
    S Gebhardt
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    J Neural Transm 114:1091-5. 2007
    ..To explore the association between eating disorders (EDs) prior to the use of clozapine/olanzapine (pre-clozapine/olanzapine EDs) and after initiation of these antipsychotics (post-clozapine/olanzapine EDs)...
  16. ncbi request reprint Independent confirmation of a major locus for obesity on chromosome 10
    A Hinney
    Department of Child and Adolescent Psychiatry, University of Marburg, FRG
    J Clin Endocrinol Metab 85:2962-5. 2000
    ..05. The linkage results confirm the presence of a major susceptibility locus for obesity in a region near the centromere on chromosome 10...
  17. ncbi request reprint Genetic predisposition to obesity in bulimia nervosa: a mutation screen of the melanocortin-4 receptor gene
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Germany
    Mol Psychiatry 7:647-51. 2002
    ..Our findings suggest that overweight is a risk factor for BN in clinically ascertained patients. For the first time a genotype predisposing to obesity has been detected in an extremely obese patient with BN...
  18. doi request reprint Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention
    A L Volckmar
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    Exp Clin Endocrinol Diabetes 121:334-7. 2013
    ..The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention...
  19. ncbi request reprint Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm 111:817-25. 2004
    ..We did not detect transmission disequilibrium of the investigated polymorphisms in OCD. Hence, these polymorphisms do not play a major role in the genetic predisposition to early onset OCD...
  20. ncbi request reprint Molecular genetic aspects of attention-deficit/hyperactivity disorder
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Neurosci Biobehav Rev 28:625-41. 2004
    ..The molecular results mentioned above are presented and discussed in detail, thus providing both clinicians and geneticists with an overview of the current research status of this important child and adolescent psychiatric disorder...
  21. ncbi request reprint Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, FRG
    J Clin Endocrinol Metab 84:1483-6. 1999
    ..Whereas our data support the evidence for dominantly inherited obesity as revealed by the three obese probands with haplo-insufficiency, the functional significance of the missense mutations remains to be determined...
  22. ncbi request reprint A prospective study of serum ghrelin levels in patients treated with clozapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 112:1411-6. 2005
    ..Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain...
  23. ncbi request reprint Prospective 10-year follow-up in adolescent anorexia nervosa--course, outcome, psychiatric comorbidity, and psychosocial adaptation
    B Herpertz-Dahlmann
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Germany
    J Child Psychol Psychiatry 42:603-12. 2001
    ..Those who achieve complete recovery from the eating disorder have a good chance of overcoming other psychiatric disorders and to adapt to social requirements...
  24. ncbi request reprint No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Pharmacogenomics J 7:275-81. 2007
    ..In conclusion, we have not identified a novel binding site of the two investigated atypical AP that could contribute to the induced weight gain...
  25. ncbi request reprint Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes
    A Hinney
    Department of Child and Adolescent Psychiatry, University of Marburg, FRG
    J Clin Endocrinol Metab 83:3737-41. 1998
    ..We conclude that the POMC gene harbors several different polymorphisms and mutations, none of which can readily be associated with the phenotypes under study...
  26. ncbi request reprint Perspectives: molecular genetic research in human obesity
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Obes Rev 4:139-46. 2003
    ..We recommend that the procedure via which a consensus is reached as to what constitutes a true positive association finding requires formalization...
  27. doi request reprint Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites
    M Föcker
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg Essen, Wickenburgstr 21, 45147 Essen, Germany
    J Psychiatr Res 46:1600-9. 2012
    ..Further studies are warranted to distinguish between state and trait related alterations and to establish diagnostic sensitivity and specificity of the thus altered metabolites...
  28. ncbi request reprint Candidate gene polymorphisms in eating disorders
    A Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Str 6, D 35033, Marburg, Germany
    Eur J Pharmacol 410:147-159. 2000
    ..This kind of approach has already been initiated for anorexia nervosa. Genetic research on eating disorders will hopefully lead to new pharmacological treatment strategies...
  29. ncbi request reprint Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia
    J Hebebrand
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Hans Sachs Strasse 6, 35033 Marburg, Germany
    Physiol Behav 79:25-37. 2003
    ..In the first and second parts of our review, we will summarize the relevant findings pertaining to hyperactivity in AN patients and in the rat model, respectively. We conclude with a synopsis and implications for future research...
  30. ncbi request reprint Social class, parental education, and obesity prevalence in a study of six-year-old children in Germany
    A Lamerz
    Department of Child and Adolescent Psychiatry, University Hospital Aachen, Neuenhofer Weg 21, Aachen, Germany
    Int J Obes (Lond) 29:373-80. 2005
    ..To assess the association between socioeconomic status (SES) and childhood obesity, and which factor in particular stands out in relation to obesity...
  31. ncbi request reprint Reproductive function during weight gain in anorexia nervosa. Leptin represents a metabolic gate to gonadotropin secretion
    K Holtkamp
    Department of Child and Adolescent Psychiatry, Technical University of Aachen, Germany
    J Neural Transm 110:427-35. 2003
    ..Once this is exceeded other biological mechanisms seem to be important for the complete recovery of the reproductive function and the resumption of menses...
  32. ncbi request reprint A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity
    E Rettenbacher
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Germany
    Exp Clin Endocrinol Diabetes 115:7-12. 2007
    ..Functionally relevant mutations in the melanocortin-4 receptor gene ( MC4R) currently display the most common major gene/allele effect on extreme obesity...
  33. doi request reprint The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents
    N Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Horm Metab Res 44:75-7. 2012
    ..As the length (1 year as compared to 3 months) and mode of treatment (hypocaloric diet in adults vs. physical activity plus balanced meals) of the interventions varied, these parameters might have influenced the inconsistent results...
  34. ncbi request reprint Spectrum of binge eating symptomatology in patients treated with clozapine and olanzapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Federal Republic of Germany
    J Neural Transm 110:111-21. 2003
    ..For future research in this field we suggest a novel DSM-IV research classification "Medication-induced eating disorders"...
  35. ncbi request reprint 5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders
    S Walitza
    Department of Child and Adolescent Psychiatry, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 7:1054-7. 2002
    ..05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD...
  36. ncbi request reprint Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents
    H Roth
    Institute of Human Genetics, University of Marburg, Germany
    Hum Genet 103:540-6. 1998
    ....
  37. doi request reprint Genetic aspects in attention-deficit/hyperactivity disorder
    O Albayrak
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Essen, Germany
    J Neural Transm 115:305-15. 2008
    ..This article comprehensively reviews the latest findings on the genetics of ADHD...
  38. ncbi request reprint Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occurring polymorphisms and association analysis in body weight regulation
    F Oeffner
    Institute of Human Genetics, Philipps University of Marburg, Bahnhofstr 7a, 35037 Marburg, Germany
    Int J Obes Relat Metab Disord 25:767-9. 2001
    ..NDN, which codes for the human necdin protein, is a candidate gene for Prader-Willi syndrome (PWS). One feature of this neurogenetic disorder is hyperphagia resulting in extreme obesity observed later in development...
  39. ncbi request reprint Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations
    J Hebebrand
    Department of Child and Adolescent Psychiatry of the Philipps University of Marburg, Germany
    Mol Psychiatry 9:796-800. 2004
    ..In particular, we found no evidence for an increased rate of binge-eating behavior in obese carriers of MC4R variants. Our findings do not support the strong association between BED and MC4R carrier status...
  40. ncbi request reprint Sample size calculations for linkage analysis using extreme sib pairs based on segregation analysis with the quantitative phenotype body weight as an example
    A Ziegler
    Clinical Research Group Medical Center for Methodology and Health Research, Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Germany
    Genet Epidemiol 15:577-93. 1998
    ..We illustrate this approach by using previously published segregation analyses of body weight despite the fact that the assumptions imposed by these analyses do not hold up for this quantitative phenotype...
  41. ncbi request reprint [Eating disorders in children and adolescents]
    J Hebebrand
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Philipps Universitat Marburg
    MMW Fortschr Med 145:31-6. 2003
    ..Anorexia and bulimia affect mainly adolescents. Anorexia is associated with a number of mental and somatic comorbidities that need to be considered for the diagnosis and treatment...
  42. ncbi request reprint [Is topiramate effective for weight loss in neuroleptic-induced obesity? 2 case reports]
    M Schüler-Springorum
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Philipps Universitat Marburg
    Z Kinder Jugendpsychiatr Psychother 30:51-8. 2002
    ..This finding raises the interesting question of whether both mood and body weight can be stabilized in patients who have gained weight while being treated with neuroleptics for one of the disorders mentioned above...
  43. doi request reprint German validation of the Conners Adult ADHD Rating Scales-self-report (CAARS-S) I: factor structure and normative data
    H Christiansen
    Philipps University Marburg, Department of Clinical Psychology, Marburg, Germany
    Eur Psychiatry 26:100-7. 2011
    ..To date, the Conners Adult ADHD Rating Scales (CAARS) are the international standard for questionnaire assessment of ADHD. The current study evaluates a German version of the CAARS self-report (CAARS-S)...
  44. pmc Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder
    I Jarick
    Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany
    Mol Psychiatry 19:115-21. 2014
    ..3 × 10(-2)). Our results suggest that copy number variants at the PARK2 locus contribute to the genetic susceptibility of ADHD. Mutations and CNVs in PARK2 are known to be associated with Parkinson disease. ..
  45. ncbi request reprint Topiramate, nutrition and weight change: a prospective study
    K M Klein
    Interdisciplinary Epilepsy Centre, Department of Neurology, Philipps University Marburg, Rudolf Bultmann Str 8, 35033 Marburg, Germany
    J Neurol Neurosurg Psychiatry 79:590-3. 2008
    ..To evaluate prospectively the relationship between appetite, food composition, nutritional habits and weight loss following administration of topiramate (TPM) and to identify predictors for TPM induced weight loss...
  46. ncbi request reprint Objective measurement of hyperactivity, impulsivity, and inattention in children with hyperkinetic disorders before and after treatment with methylphenidate
    P Heiser
    Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Hans Sachs Strasse 6, 35037 Marburg, Germany
    Eur Child Adolesc Psychiatry 13:100-4. 2004
    ....
  47. ncbi request reprint The need to revise the diagnostic criteria for anorexia nervosa
    J Hebebrand
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 111:827-40. 2004
    ..We propose alternative criteria which allow a better integration of biologically derived hypotheses addressing the nosology and the symptomatology of AN...
  48. ncbi request reprint The role of leptin in anorexia nervosa: clinical implications
    J Hebebrand
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 12:23-35. 2007
    ..The fact that hypoleptinaemia can induce hyperactivity in a rat model for AN has led to a series of studies in AN patients, which support the notion that application of leptin to severely hyperactive patients might prove beneficial...
  49. ncbi request reprint Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs
    K Meidtner
    Technical University Munich, Freising Weihenstephan 85350, Germany
    Anim Genet 37:245-7. 2006
    ..In one Piétrain founder animal, we detected an additional non-synonymous missense variant Arg236His. Thus, the MC4R gene could be a useful marker for increased growth in the relatively slow-growing Piétrain breed...
  50. ncbi request reprint Practical considerations on the use of extreme sib-pairs for obesity
    A Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, 23538 Lubeck, Germany
    Methods Inf Med 45:419-23. 2006
    ..We hypothesized that the low weight of most sibs who were seemingly discordant to the obese index proband was influenced by other environmental and/or genetic factors like restrained eating or psychiatric disorders...
  51. ncbi request reprint Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample
    P Heiser
    Department of Child and Adolescent Psychiatry and Psychotherapy, Philipps University, Marburg, Germany
    J Neural Transm 114:513-21. 2007
    ..We cannot rule out the possibility that other variations in the investigated genes contribute to the etiology of ADHD...
  52. pmc The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals
    E H Young
    MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Int J Obes (Lond) 31:1437-41. 2007
    ..Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger studies are needed, however, to confirm this relation...
  53. ncbi request reprint A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
    M C Ochoa
    Department of Physiology and Nutrition, University Clinic, University of Navarra, Pamplona Navarra, Spain
    Clin Endocrinol (Oxf) 66:652-8. 2007
    ..In addition, functional assays were performed for a novel MC4R mutation...
  54. ncbi request reprint Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa
    M Gabrovsek
    Medical Centre for Molecular Biology, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Am J Med Genet B Neuropsychiatr Genet 124:68-72. 2004
    ..Overall we found no support for the hypothesis that the Val158 allele of COMT gene is associated with AN in our combined European sample...
  55. ncbi request reprint No association of sequence variants in the neuropeptide Y2 receptor (NPY2R) gene with early onset obesity in Germans
    H J Wang
    Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, PR China
    Horm Metab Res 39:840-4. 2007
    ..50). In conclusion, we did not find evidence for an involvement of genetic variation in the NPY2R in early onset obesity in German samples...
  56. ncbi request reprint Several mutations in the melanocortin 4 receptor gene are associated with obesity in Chinese children and adolescents
    C L Wang
    Department of Endocrinology, The Children s Hospital of Zhejiang University School of Medicine, Hangzhou, China
    J Endocrinol Invest 29:894-8. 2006
    ..To screen mutations in the melanocortin 4 receptor (MC4R) in obese and normal-weight Chinese children and adolescents...
  57. doi request reprint TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children
    C L Roth
    Paediatric Endocrinology, Seattle Children s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
    Horm Metab Res 40:713-7. 2008
    ....
  58. ncbi request reprint Serum leptin and body weight in females with anorexia and bulimia nervosa
    W Kopp
    Department of Psychosomatics, Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Horm Metab Res 30:272-5. 1998
    ..This dynamic aspect is important specifically in patients with anorexia nervosa during therapeutically induced weight gain...
  59. ncbi request reprint [Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population]
    U A Zakel
    Center of Child and Adolescent Medicine, Justus Liebig University of Giessen, Giessen, Germany
    Klin Padiatr 217:244-9. 2005
    ..The prevalence of childhood obesity is steadily increasing. Weight regulation and food intake are subject to complex regulatory mechanisms. The leptinergic-melanocortinergic system is known to be of major importance...
  60. ncbi request reprint The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, Neuenhofer Weg 21, D 52074, Aachen, Germany
    J Psychiatr Res 37:165-9. 2003
    ..001) and lg10 leptin level at admission (P=0.002). In conclusion, we confirmed weight gain induced hyperleptinemia in AN. Further research is required to assess if this phenomenon contributes to renewed weight loss...
  61. ncbi request reprint Identification of a deletion variant in the gene encoding the human alpha(2A)-adrenergic receptor
    A Hamann
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitat Heidelberg, Germany
    Eur J Endocrinol 144:291-5. 2001
    ..This study was undertaken to assess whether variants in the alpha(2A)-adrenergic receptor gene are associated with body weight...
  62. ncbi request reprint Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 87:4587-94. 2002
    ..Furthermore, determinations of sOB-R and FLI are additional valuable tools to investigate the leptin axis during growth and sexual maturation...
  63. ncbi request reprint A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 27:385-8. 2003
    ..Hence, MC4R is involved in the most common monogenic form of human obesity described so far...
  64. ncbi request reprint No evidence for a direct effect of clozapine on fat-cell formation and production of leptin and other fat-cell-derived factors
    H Hauner
    Mol Psychiatry 8:258-9. 2003
  65. ncbi request reprint Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents
    F Oeffner
    Institute of Human Genetics, Philipps University of Marburg, Germany
    Acta Diabetol 37:93-101. 2000
    ..02). These results suggest a contribution of NMB or a gene in its close vicinity to genetic weight control in humans...
  66. ncbi request reprint The 5-HT(2A) -1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres
    P Gorwood
    CHU Louis Mourier, Assistance Publique des Hopitaux de Paris, 178, rue des Renouillers 92701 Colombes cedex, France
    Mol Psychiatry 7:90-4. 2002
    ..Previous results may have been exposed to stratification bias (which we controlled by the TDT method) and/or the risk of type 1 error (from which we were less exposed because of the sample size)...
  67. ncbi request reprint Overweight and obesity in children with Attention-Deficit/Hyperactivity Disorder
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Germany
    Int J Obes Relat Metab Disord 28:685-9. 2004
    ..The aim of our study was to assess if the prevalence of overweight and obesity is lower in a population of boys with ADHD in comparison with the German healthy male reference population of the same age...
  68. ncbi request reprint High serum leptin levels subsequent to weight gain predict renewed weight loss in patients with anorexia nervosa
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, Neuenhofer Weg 21, D 52074 Aachen, Germany
    Psychoneuroendocrinology 29:791-7. 2004
    ..In conclusion, high serum leptin levels at discharge from inpatient treatment may indicate a risk for renewed weight loss and an unfavorable 1 yr outcome in AN...
  69. ncbi request reprint Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects
    A Hamann
    Medizinische Kernklinik und Poliklinik, Universitats Krankenhaus Eppendorf, Hamburg, Germany
    Eur J Endocrinol 141:90-2. 1999
    ..We conclude from our data that these two variants in the PPARgamma2 gene are unlikely to contribute to the high prevalence of early-onset obesity...
  70. pmc Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys
    I M Heid
    J Med Genet 42:e21. 2005
    ..69, p = 0.03). However, evidence in a large population based study in a homogeneous population and a significant estimate of the change in quantitative measures of obesity is still lacking...
  71. pmc Major differences in prevalence of overweight according to nationality in preschool children living in Germany: determinants and public health implications
    J Kuepper-Nybelen
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Arch Dis Child 90:359-63. 2005
    ..To investigate the prevalence of overweight according to nationality in preschool children living in Germany, and to establish the determinants responsible for differences in body mass index...
  72. ncbi request reprint Genes, lifestyles and obesity
    A Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    Int J Obes Relat Metab Disord 28:S29-36. 2004
    ..To review the role of genes and lifestyle factors, particularly dietary habits and physical activity patterns, in obesity risk as well as their potential interactions...
  73. ncbi request reprint [Body height, body weight and body mass index of German military recruits. Historical retrospect and current status]
    U Jaeger
    ,
    Anthropol Anz 59:251-73. 2001
    ..Especially the over-proportional increase of the number of conscripts in the higher body-weight-classes requires a further continuous analysis of the available mustering data...
  74. ncbi request reprint Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents
    J Tafel
    Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitatsklinikum Heidelberg, 69115 Heidelberg, Germany
    Diabetes Obes Metab 6:452-5. 2004
    ..We therefore investigated the possible association of polymorphisms in the beta-adrenergic receptor genes with early onset obesity...
  75. pmc Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index
    A Dempfle
    J Med Genet 41:795-800. 2004
  76. ncbi request reprint Serum leptin, gonadotropin, and testosterone concentrations in male patients with anorexia nervosa during weight gain
    M Wabitsch
    Department of Pediatrics and Institute of Biomedical Technology, University of Ulm, Ulm D-89075, Germany
    J Clin Endocrinol Metab 86:2982-8. 2001
    ..002). In conclusion, these data suggest that leptin might also play an important role in the regulation of the hypothalamo-pituitary-gonadal axis and fertility in underweight males as has previously been shown in underweight females...
  77. ncbi request reprint Association between an agouti-related protein gene polymorphism and anorexia nervosa
    T Vink
    Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    Mol Psychiatry 6:325-8. 2001
    ..These results implicate that antagonism of the MC4-r might be considered as pharmacotherapy for patients with AN...
  78. ncbi request reprint Spousal resemblance in the Canadian population: implications for the obesity epidemic
    P T Katzmarzyk
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Int J Obes Relat Metab Disord 26:241-6. 2002
    ..To determine the extent of the spousal resemblance for adiposity and leanness in the Canadian population...
  79. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder
    S Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Mol Psychiatry 10:1126-32. 2005
    ..064). Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes...
  80. ncbi request reprint Does obesity surgery improve psychosocial functioning? A systematic review
    S Herpertz
    Clinic of Psychosomatic Medicine and Psychotherapy, University of Essen, Essen, Germany
    Int J Obes Relat Metab Disord 27:1300-14. 2003
    ....
  81. ncbi request reprint [Relevance of the melanocortinergic system for body weight regulation]
    M Raab
    Klinische Forschergruppe, Klinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters der Philipps Universität Marburg
    Dtsch Med Wochenschr 128:447-52. 2003
  82. ncbi request reprint Do psychosocial variables predict weight loss or mental health after obesity surgery? A systematic review
    S Herpertz
    Department of Psychosomatic Medicine and Psychotherapy, Westfälische Klinik Dortmund, Ruhr University Bochum, Marsbruchstrasse 179, 44287 Dortmund, Germany
    Obes Res 12:1554-69. 2004
    ..This systematic review included all controlled and noncontrolled trials of the last 2 decades with either a retrospective or prospective design and a follow-up period of at least 1 year...
  83. ncbi request reprint Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Hum Mol Genet 3:2207-12. 1994
    ..Some of these symptoms might be related to the absence of functional DRD4 protein...