Genomes and Genes
Affiliation: Philipps University
- Autosensitization as a pathomechanism in asthmaHolger Garn
Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Strasse 2, D 35043, Marburg, Germany
Ann N Y Acad Sci 1107:417-25. 2007....
- Epidemiological and immunological evidence for the hygiene hypothesisHolger Garn
Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str 2, 35043 Marburg, Germany
Immunobiology 212:441-52. 2007..These processes start already in utero and prenatal as well as early postnatal developmental stages seem to represent a certain "window of opportunity" for allergy-preventing environmental influences...
- Specific aspects of flow cytometric analysis of cells from the lungHolger Garn
Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University of Marburg, Hans Meerwein Str, 35043 Marburg, Germany
Exp Toxicol Pathol 57:21-4. 2006....
- Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed ratsHolger Garn
Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str, 35043 Marburg, Germany
Respir Res 7:4. 2006..So far it is unclear, whether a functional shift in the already present AM population or the occurrence of a new, phenotypically different AM population is responsible for these observations...
- Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzymeSerdar Sel
Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Marburg, Germany
J Allergy Clin Immunol 121:910-916.e5. 2008..DNAzymes represent a new class of antisense molecules that combines the specificity of DNA base pairing with an inherent RNA-cleaving enzymatic activity...
- Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10Serdar Sel
Department of Clinical Chemistry and Molecular Diagnostics, Hans Meerwein Strasse, 35033 Marburg, Germany
J Immunol 178:7805-13. 2007..These data indicate that TLR-3 or TLR-7 activation by viral TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10...
- A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammationSebastian Kerzel
Department of Pediatrics, Philipps University, Marburg, Germany
Int Arch Allergy Immunol 156:247-58. 2011..Objective: We now sought to determine whether the confinement to a single D(H) gene segment alone leads to a reduced allergic phenotype...
- Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situAndree Schmidt
Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, and Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
J Leukoc Biol 81:186-94. 2007..In conclusion, the cellular infiltrate in lung allografts is dominated by macrophages, which exhibit an unusual phenotype and a strong capacity for mitotic self-renewal...
- Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymesTanja Dicke
Sterna Biologicals GmbH and Co KG, Marburg, Germany
Nucleic Acid Ther 22:117-26. 2012..Consequently, use of GATA-3-specific DNAzymes may represent a novel and highly specific approach for the treatment of allergic diseases...
- NO2-induced airway inflammation is associated with progressive airflow limitation and development of emphysema-like lesions in C57bl/6 miceMichael Wegmann
Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
Exp Toxicol Pathol 56:341-50. 2005..Thus, NO2-exposed mice may serve as a model to investigate pathophysiological mechanisms that contribute to the development of human COPD...
- Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthmaMichael Wegmann
Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University Marburg, Baldingerstrasse, Marburg, Germany
Am J Respir Cell Mol Biol 36:61-7. 2007..Therefore, antagonizing CCR-3 represents a new approach toward a promising asthma therapy...
- Shift toward an alternatively activated macrophage response in lungs of NO2-exposed ratsHolger Garn
Institute of Immunology, Department of Pathology, Laboratory of Lung Cell Biology, Philipps University Marburg, Marburg, Germany
Am J Respir Cell Mol Biol 28:386-96. 2003..In conclusion, a priming toward development of the alternatively activated macrophage phenotype occurred in the lungs of rats following nitrogen dioxide inhalation...
- Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbesStephanie Brand
Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
J Allergy Clin Immunol 128:618-25.e1-7. 2011..Epigenetic regulation is an important mechanism by which environmental factors might interact with genes involved in allergy and asthma development...
- DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthmaStephanie Brand
Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Marburg, Germany
J Allergy Clin Immunol 129:1602-10.e6. 2012..However, the contribution to the development of a chronic inflammatory phenotype remains still unclear...
- Impaired superoxide radical production by bronchoalveolar lavage cells from NO(2)-exposed ratsChristoph Olker
Institute of Immunology, Philipps University of Marburg, Germany
Free Radic Biol Med 37:977-87. 2004..In conclusion, concomitant occurrence of reduced production and increased scavenging of superoxide radicals resulted in the drastically impaired release of these radicals from BAL cells of NO(2)-exposed rats...
- Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78Melanie L Conrad
Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35043 Marburg, Germany
J Exp Med 206:2869-77. 2009..lwoffii F78-exposed mothers. These data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny...
- Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activityOlivia M Merkel
Department of Pharmaceutics and Biopharmacy, Philipps Universitat, Marburg, Germany
Mol Pharm 7:969-83. 2010....
- IL-24 is expressed by rat and human macrophagesHolger Garn
Institute of Immunology, Philipps University, Marburg, Germany
Immunobiology 205:321-34. 2002..In conclusion, our data show that IL-24 expression is induced in stimulated and infected rat and human macrophages, however, more insights into the functions of IL-24 are necessary to define its physiological relevance...
- The immunological basis of the hygiene hypothesisHarald Renz
Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Germany
Chem Immunol Allergy 91:30-48. 2006..These novel immunoregulatory events may explain the hygiene hypothesis by an interaction of environmental factors with innate immune mechanisms and various subtypes of T-cell responses...
- Induction of epidermal fatty acid binding protein in intravascular monocytes of renal allograftsVeronika Grau
Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany
Transplantation 75:685-8. 2003..E-FABP might regulate monocyte activation and may represent a promising target for a therapeutic intervention in allograft rejection...
- Long term iNOS expression in thoracic lymph nodes of silicotic ratsAnke Friedetzky
Institute of Immunology, Philipps University, Marburg, Germany
Immunobiology 205:219-30. 2002..Our observations support the hypothesis that the mutual activation of lymphocytes and macrophages is a central process in the development of chronic silicosis...
- Development and regulation of immune responses to food antigens in pre- and postnatal lifeHarald Renz
Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Faculty of Medicine, Philipps University, Marburg, Germany
Nestle Nutr Workshop Ser Pediatr Program 64:139-51; discussion 151-5, 251-7. 2009..Epigenetic regulation represents an important novel mechanism in this regard. This concept opens new avenues for the development of preventive strategies to avoid inappropriate immune responses against food antigens...
- Differences in mRNA expression, protein content, and enzyme activity of superoxide dismutases in type II pneumocytes of acute and chronic lung injuryRenate Hochscheid
Division of Pneumology, Department of Internal Medicine, Philipps University of Marburg, Baldingerstrasse, Marburg D 35033, Germany
Free Radic Res 36:759-67. 2002..We conclude that during acute and chronic lung injury in type II pneumocytes expression and protein synthesis of CuZnSOD and MnSOD are regulated differently...
- Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory propertiesKay Vogel
Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008..Because of their small size and thereby their potential for deposition in lower airways of small children, bacterial spores may be candidates for such allergy-protective effects...
- Allergic airway inflammation inhibits pulmonary antibacterial host defenseChristoph Beisswenger
Department of Internal Medicine, Division for Pulmonary Diseases, , Germany
J Immunol 177:1833-7. 2006..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
- The course of allergen-induced leukocyte infiltration in human and experimental asthmaMarek Lommatzsch
Department of Pneumology, Clinic of Internal Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
J Allergy Clin Immunol 118:91-7. 2006....
- Epidermal fatty acid-binding protein is increased in rat lungs following in vivo treatment with keratinocyte growth factorVeronika Grau
Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, University of Giessen Lung Center, Justus Liebig University Giessen, Rudolf Buchheim Str 7, D 35385 Giessen, Germany
Int J Biochem Cell Biol 38:279-87. 2006..The increase in epidermal fatty acid-binding protein gene expression associated with type II cell hyperplasia might contribute to the molecular mechanisms mediating lung protection by keratinocyte growth factor...
- Anti-acids lead to immunological and morphological changes in the intestine of BALB/c mice similar to human food allergyIsabella Pali-Schöll
Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Exp Toxicol Pathol 60:337-45. 2008..Therefore, this medication leads to sensitization against food with changes typical for food allergy also in the intestine...
- Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective propertiesJennifer Debarry
Division of Innate Immunity, Research Center Borstel, Leibniz Center for Medicine, and Biosciences, Borstel, Germany
J Allergy Clin Immunol 119:1514-21. 2007....
- Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspringIsabella Schöll
Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel1090 Vienna, Austria
FASEB J 21:1264-70. 2007..From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants...