Holger Garn

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi request reprint Epidemiological and immunological evidence for the hygiene hypothesis
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str 2, 35043 Marburg, Germany
    Immunobiology 212:441-52. 2007
  2. ncbi request reprint Specific aspects of flow cytometric analysis of cells from the lung
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University of Marburg, Hans Meerwein Str, 35043 Marburg, Germany
    Exp Toxicol Pathol 57:21-4. 2006
  3. ncbi request reprint Autosensitization as a pathomechanism in asthma
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Strasse 2, D 35043, Marburg, Germany
    Ann N Y Acad Sci 1107:417-25. 2007
  4. pmc Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str, 35043 Marburg, Germany
    Respir Res 7:4. 2006
  5. doi request reprint Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 121:910-916.e5. 2008
  6. ncbi request reprint Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Hans Meerwein Strasse, 35033 Marburg, Germany
    J Immunol 178:7805-13. 2007
  7. ncbi request reprint Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ
    Andree Schmidt
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, and Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
    J Leukoc Biol 81:186-94. 2007
  8. pmc A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation
    Sebastian Kerzel
    Department of Pediatrics, Philipps University, Marburg, Germany
    Int Arch Allergy Immunol 156:247-58. 2011
  9. doi request reprint Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymes
    Tanja Dicke
    Sterna Biologicals GmbH and Co KG, Marburg, Germany
    Nucleic Acid Ther 22:117-26. 2012
  10. ncbi request reprint NO2-induced airway inflammation is associated with progressive airflow limitation and development of emphysema-like lesions in C57bl/6 mice
    Michael Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Exp Toxicol Pathol 56:341-50. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Epidemiological and immunological evidence for the hygiene hypothesis
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str 2, 35043 Marburg, Germany
    Immunobiology 212:441-52. 2007
    ..These processes start already in utero and prenatal as well as early postnatal developmental stages seem to represent a certain "window of opportunity" for allergy-preventing environmental influences...
  2. ncbi request reprint Specific aspects of flow cytometric analysis of cells from the lung
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University of Marburg, Hans Meerwein Str, 35043 Marburg, Germany
    Exp Toxicol Pathol 57:21-4. 2006
    ....
  3. ncbi request reprint Autosensitization as a pathomechanism in asthma
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Strasse 2, D 35043, Marburg, Germany
    Ann N Y Acad Sci 1107:417-25. 2007
    ....
  4. pmc Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats
    Holger Garn
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Biomedical Research Center, Hans Meerwein Str, 35043 Marburg, Germany
    Respir Res 7:4. 2006
    ..So far it is unclear, whether a functional shift in the already present AM population or the occurrence of a new, phenotypically different AM population is responsible for these observations...
  5. doi request reprint Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Medical Faculty, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 121:910-916.e5. 2008
    ..DNAzymes represent a new class of antisense molecules that combines the specificity of DNA base pairing with an inherent RNA-cleaving enzymatic activity...
  6. ncbi request reprint Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10
    Serdar Sel
    Department of Clinical Chemistry and Molecular Diagnostics, Hans Meerwein Strasse, 35033 Marburg, Germany
    J Immunol 178:7805-13. 2007
    ..These data indicate that TLR-3 or TLR-7 activation by viral TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10...
  7. ncbi request reprint Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ
    Andree Schmidt
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, and Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
    J Leukoc Biol 81:186-94. 2007
    ..In conclusion, the cellular infiltrate in lung allografts is dominated by macrophages, which exhibit an unusual phenotype and a strong capacity for mitotic self-renewal...
  8. pmc A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation
    Sebastian Kerzel
    Department of Pediatrics, Philipps University, Marburg, Germany
    Int Arch Allergy Immunol 156:247-58. 2011
    ..Objective: We now sought to determine whether the confinement to a single D(H) gene segment alone leads to a reduced allergic phenotype...
  9. doi request reprint Absence of unspecific innate immune cell activation by GATA-3-specific DNAzymes
    Tanja Dicke
    Sterna Biologicals GmbH and Co KG, Marburg, Germany
    Nucleic Acid Ther 22:117-26. 2012
    ..Consequently, use of GATA-3-specific DNAzymes may represent a novel and highly specific approach for the treatment of allergic diseases...
  10. ncbi request reprint NO2-induced airway inflammation is associated with progressive airflow limitation and development of emphysema-like lesions in C57bl/6 mice
    Michael Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Exp Toxicol Pathol 56:341-50. 2005
    ..Thus, NO2-exposed mice may serve as a model to investigate pathophysiological mechanisms that contribute to the development of human COPD...
  11. ncbi request reprint Shift toward an alternatively activated macrophage response in lungs of NO2-exposed rats
    Holger Garn
    Institute of Immunology, Department of Pathology, Laboratory of Lung Cell Biology, Philipps University Marburg, Marburg, Germany
    Am J Respir Cell Mol Biol 28:386-96. 2003
    ..In conclusion, a priming toward development of the alternatively activated macrophage phenotype occurred in the lungs of rats following nitrogen dioxide inhalation...
  12. ncbi request reprint Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma
    Michael Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Hospital of the Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Am J Respir Cell Mol Biol 36:61-7. 2007
    ..Therefore, antagonizing CCR-3 represents a new approach toward a promising asthma therapy...
  13. doi request reprint Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes
    Stephanie Brand
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 128:618-25.e1-7. 2011
    ..Epigenetic regulation is an important mechanism by which environmental factors might interact with genes involved in allergy and asthma development...
  14. doi request reprint DNA methylation of TH1/TH2 cytokine genes affects sensitization and progress of experimental asthma
    Stephanie Brand
    Institute for Laboratory Medicine and Pathobiochemistry, Philipps University of Marburg, Marburg, Germany
    J Allergy Clin Immunol 129:1602-10.e6. 2012
    ..However, the contribution to the development of a chronic inflammatory phenotype remains still unclear...
  15. pmc Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
    Melanie L Conrad
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35043 Marburg, Germany
    J Exp Med 206:2869-77. 2009
    ..lwoffii F78-exposed mothers. These data establish a direct relationship between maternal bacterial exposures, functional maternal TLR signaling, and asthma protection in the progeny...
  16. ncbi request reprint Impaired superoxide radical production by bronchoalveolar lavage cells from NO(2)-exposed rats
    Christoph Olker
    Institute of Immunology, Philipps University of Marburg, Germany
    Free Radic Biol Med 37:977-87. 2004
    ..In conclusion, concomitant occurrence of reduced production and increased scavenging of superoxide radicals resulted in the drastically impaired release of these radicals from BAL cells of NO(2)-exposed rats...
  17. pmc Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity
    Olivia M Merkel
    Department of Pharmaceutics and Biopharmacy, Philipps Universitat, Marburg, Germany
    Mol Pharm 7:969-83. 2010
    ....
  18. ncbi request reprint IL-24 is expressed by rat and human macrophages
    Holger Garn
    Institute of Immunology, Philipps University, Marburg, Germany
    Immunobiology 205:321-34. 2002
    ..In conclusion, our data show that IL-24 expression is induced in stimulated and infected rat and human macrophages, however, more insights into the functions of IL-24 are necessary to define its physiological relevance...
  19. doi request reprint Effect of barrier microbes on organ-based inflammation
    Holger Garn
    Institute of Laboratory Medicine, Philipps Universität Marburg, Marburg, Germany
    J Allergy Clin Immunol 131:1465-78. 2013
    ..In this article the recent epidemiologic, clinical, and experimental evidence for this interaction is discussed...
  20. ncbi request reprint The immunological basis of the hygiene hypothesis
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Philipps University Marburg, Germany
    Chem Immunol Allergy 91:30-48. 2006
    ..These novel immunoregulatory events may explain the hygiene hypothesis by an interaction of environmental factors with innate immune mechanisms and various subtypes of T-cell responses...
  21. doi request reprint Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation
    Alexander Visekruna
    Institute for Medical Microbiology and Hygiene, University of Marburg, Marburg, Germany
    Eur J Immunol 43:606-18. 2013
    ..Thus, our data point to the existence of Tc9 cells and to their supportive function in Th2-dependent airway inflammation, suggesting that these cells might be a therapeutic target in allergic disorders...
  22. ncbi request reprint Long term iNOS expression in thoracic lymph nodes of silicotic rats
    Anke Friedetzky
    Institute of Immunology, Philipps University, Marburg, Germany
    Immunobiology 205:219-30. 2002
    ..Our observations support the hypothesis that the mutual activation of lymphocytes and macrophages is a central process in the development of chronic silicosis...
  23. ncbi request reprint Induction of epidermal fatty acid binding protein in intravascular monocytes of renal allografts
    Veronika Grau
    Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany
    Transplantation 75:685-8. 2003
    ..E-FABP might regulate monocyte activation and may represent a promising target for a therapeutic intervention in allograft rejection...
  24. pmc β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma
    Anton Volkov
    Institute for Medical Microbiology and Hygiene, Philipps University of Marburg, Marburg, Germany
    PLoS ONE 8:e60565. 2013
    ..Here, we present novel evidence for the requirement of the β5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma. The unexpected role of β5i in OVA asthma remains to be clarified...
  25. doi request reprint Development and regulation of immune responses to food antigens in pre- and postnatal life
    Harald Renz
    Department of Clinical Chemistry and Molecular Diagnostics, Biomedical Research Center BMFZ, Faculty of Medicine, Philipps University, Marburg, Germany
    Nestle Nutr Workshop Ser Pediatr Program 64:139-51; discussion 151-5, 251-7. 2009
    ..Epigenetic regulation represents an important novel mechanism in this regard. This concept opens new avenues for the development of preventive strategies to avoid inappropriate immune responses against food antigens...
  26. ncbi request reprint Differences in mRNA expression, protein content, and enzyme activity of superoxide dismutases in type II pneumocytes of acute and chronic lung injury
    Renate Hochscheid
    Division of Pneumology, Department of Internal Medicine, Philipps University of Marburg, Baldingerstrasse, Marburg D 35033, Germany
    Free Radic Res 36:759-67. 2002
    ..We conclude that during acute and chronic lung injury in type II pneumocytes expression and protein synthesis of CuZnSOD and MnSOD are regulated differently...
  27. doi request reprint Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
    Kay Vogel
    Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 122:307-12, 312.e1-8. 2008
    ..Because of their small size and thereby their potential for deposition in lower airways of small children, bacterial spores may be candidates for such allergy-protective effects...
  28. ncbi request reprint Allergic airway inflammation inhibits pulmonary antibacterial host defense
    Christoph Beisswenger
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Germany
    J Immunol 177:1833-7. 2006
    ..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
  29. ncbi request reprint The course of allergen-induced leukocyte infiltration in human and experimental asthma
    Marek Lommatzsch
    Department of Pneumology, Clinic of Internal Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    J Allergy Clin Immunol 118:91-7. 2006
    ....
  30. ncbi request reprint Epidermal fatty acid-binding protein is increased in rat lungs following in vivo treatment with keratinocyte growth factor
    Veronika Grau
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, University of Giessen Lung Center, Justus Liebig University Giessen, Rudolf Buchheim Str 7, D 35385 Giessen, Germany
    Int J Biochem Cell Biol 38:279-87. 2006
    ..The increase in epidermal fatty acid-binding protein gene expression associated with type II cell hyperplasia might contribute to the molecular mechanisms mediating lung protection by keratinocyte growth factor...
  31. doi request reprint Anti-acids lead to immunological and morphological changes in the intestine of BALB/c mice similar to human food allergy
    Isabella Pali-Schöll
    Department of Pathophysiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Exp Toxicol Pathol 60:337-45. 2008
    ..Therefore, this medication leads to sensitization against food with changes typical for food allergy also in the intestine...
  32. pmc Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring
    Isabella Schöll
    Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel1090 Vienna, Austria
    FASEB J 21:1264-70. 2007
    ..From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants...
  33. ncbi request reprint Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties
    Jennifer Debarry
    Division of Innate Immunity, Research Center Borstel, Leibniz Center for Medicine, and Biosciences, Borstel, Germany
    J Allergy Clin Immunol 119:1514-21. 2007
    ....