Research Topics
Genomes and Genes | Robert FinkingSummaryAffiliation: Philipps University Country: Germany Publications
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Publications
Biosynthesis of nonribosomal peptides1Robert Finking
Philipps Universitat Marburg, Fachbereich Chemie Biochemie, Hans Meerwein Strasse, 35043 Marburg, Germany
Annu Rev Microbiol 58:453-88. 2004....
Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wallJuergen J May
Philipps Universitat Marburg, Fachbereich Chemie Biochemie, Marburg, Germany
FEBS J 272:2993-3003. 2005..We also performed in vivo studies and determined a significant inhibition of growth for different Bacillus subtilis strains when the inhibitor is used in combination with vancomycin...
Nonribosomal peptides: from genes to productsDirk Schwarzer
, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse, 35043 Marburg, Germany
Nat Prod Rep 20:275-87. 2003..In addition, possibilities and limitations for prediction of structural features of uncharacterized NRPSs and approaches for their engineering are discussed...
Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4'-phosphopantetheinyl transferases AcpS and SfpMohammad Reza Mofid
, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse, D-35032 Marburg, Germany
J Biol Chem 277:17023-31. 2002..Nevertheless, hTycA is recognized by the next proline-activating elongation module TycB1 in vitro, and the dipeptide is formed and released as diketopiperazine...
Aminoacyl adenylate substrate analogues for the inhibition of adenylation domains of nonribosomal peptide synthetasesRobert Finking
Fachbereich Chemie/Biochemie, , Hans-Meerwein-Strasse, 35032 Marburg, Germany
Chembiochem 4:903-6. 2003
Mutational analysis of peptidyl carrier protein and acyl carrier protein synthase unveils residues involved in protein-protein recognitionRobert Finking
, Fachbereich Chemie/Biochemie, Hans-Meerwein-Strasse, D-35032 Marburg, Germany
Biochemistry 43:8946-56. 2004..These altered PCPs were still capable of serving their designated function in NRPS modules, and selective use of AcpS or Sfp leads to production of two different products by a trimodular NRPS...
