Volker Fendrich

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi request reprint Surgical treatment of gastrointestinal neuroendocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Langenbecks Arch Surg 396:299-311. 2011
  2. ncbi request reprint [Gastrointestinal stromal tumors: diagnostics and therapy]
    V Fendrich
    Klinik für Visceral, Thorax und Gefäßchirurgie, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Baldingerstraße, 35043, Marburg, Deutschland
    Chirurg 85:545-56. 2014
  3. pmc A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
    Vera Amrilleva
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Case Rep Gastroenterol 2:238-43. 2008
  4. pmc Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival
    J Waldmann
    Department of Surgery, Philipps Universitat Marburg, Marburg, Germany
    Br J Cancer 99:1900-7. 2008
  5. doi request reprint Familial pancreatic cancer-status quo
    Volker Fendrich
    National Case Collection of Familial Pancreatic Cancer of the Deutsche Krebshilfe FaPaCa, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Int J Colorectal Dis 29:139-45. 2014
  6. ncbi request reprint Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany Electronic address
    Pancreatology 13:502-7. 2013
  7. doi request reprint Chemoprevention of pancreatic cancer-one step closer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Langenbecks Arch Surg 397:495-505. 2012
  8. doi request reprint The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Gut 59:630-7. 2010
  9. pmc Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Neoplasia 13:180-6. 2011
  10. doi request reprint Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Germany
    Ann Surg 253:546-52. 2011

Collaborators

Detail Information

Publications73

  1. doi request reprint Surgical treatment of gastrointestinal neuroendocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Langenbecks Arch Surg 396:299-311. 2011
    ..Nonfunctional tumors do not secrete a hormone resulting in a clinical syndrome...
  2. ncbi request reprint [Gastrointestinal stromal tumors: diagnostics and therapy]
    V Fendrich
    Klinik für Visceral, Thorax und Gefäßchirurgie, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Baldingerstraße, 35043, Marburg, Deutschland
    Chirurg 85:545-56. 2014
    ..This leads to a significant improvement in progression-free survival compared to a 1-year therapy, and more important to an improvement in overall survival...
  3. pmc A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome
    Vera Amrilleva
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Case Rep Gastroenterol 2:238-43. 2008
    ..The patient remained cured after a follow-up of more than three years. The present case illustrates that, although rare, WDHA syndrome may be associated with a pancreatic polypeptide-secreting endocrine tumor of the pancreas...
  4. pmc Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival
    J Waldmann
    Department of Surgery, Philipps Universitat Marburg, Marburg, Germany
    Br J Cancer 99:1900-7. 2008
    ..19). In conclusion, we describe for the first time that Snail is expressed in a large subset of ACCs. Furthermore, Snail expression is associated with decreased survival, advanced disease and higher risk of developing distant metastases...
  5. doi request reprint Familial pancreatic cancer-status quo
    Volker Fendrich
    National Case Collection of Familial Pancreatic Cancer of the Deutsche Krebshilfe FaPaCa, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Int J Colorectal Dis 29:139-45. 2014
    ..Although the major gene defect has not yet been identified, some important germline mutations in the BRCA2-, PALB2-, and ATM-genes are causative in some FPC families...
  6. ncbi request reprint Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany Electronic address
    Pancreatology 13:502-7. 2013
    ..Recent evidence suggests that statins have potential chemopreventive abilities. In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of this drug...
  7. doi request reprint Chemoprevention of pancreatic cancer-one step closer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Langenbecks Arch Surg 397:495-505. 2012
    ..Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals...
  8. doi request reprint The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Gut 59:630-7. 2010
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of these drugs...
  9. pmc Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Neoplasia 13:180-6. 2011
    ..Currently, no reliable, noninvasive imaging technique (e.g., ultrasound, computed tomography, magnet resonance imaging) exists to verify PanINs...
  10. doi request reprint Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Germany
    Ann Surg 253:546-52. 2011
    ..In this study, we address the role of the Hh pathway in tumor progression of murine islet cell tumors...
  11. ncbi request reprint Management of sporadic and multiple endocrine neoplasia type 1 gastrinomas
    V Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Bielefeld, Germany
    Br J Surg 94:1331-41. 2007
    ..Gastrinomas are functional endocrine duodenopancreatic tumours and are responsible for Zollinger-Ellison syndrome (ZES). Clinical presentation, localization techniques and operative management were reviewed...
  12. doi request reprint Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Oncol 97:592-5. 2008
    ..To investigate the appearance of multiple primary malignancies in patients with sporadic neuroendocrine pancreatic tumors (NEPTs)...
  13. ncbi request reprint [Diagnosis and surgical management of neureondocrine pancreatic tumours]
    V Fendrich
    Universitätsklinikum Giessen und Marburg, Klinik für Visceral, Thorax und Gefasschirurgie, Marburg, Deutschland
    Zentralbl Chir 135:210-7. 2010
    ..An aggressive surgical approach leads to cure in patients with benign tumours, and may achieve long-term survival in patients with malignant NPTs...
  14. doi request reprint Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Eur J Endocrinol 160:695-703. 2009
    ..In this study, we examined the expression of the EMT markers Snail, Twist and E-cadherin in normal parathyroid glands and benign and malignant parathyroid diseases...
  15. ncbi request reprint Surgical management of pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University, Marburg, Germany
    Nat Rev Clin Oncol 6:419-28. 2009
    ..This Review describes the current status of surgical treatment for pancreatic endocrine tumors, and discusses the new developments in this field...
  16. ncbi request reprint Minimally invasive surgery for pancreatic endocrine tumours
    V Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Br J Surg 94:1187-8. 2007
  17. doi request reprint Neuroendocrine pancreatic tumors are risk factors for pancreatic fistula after pancreatic surgery
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Dig Surg 28:263-9. 2011
    ..In the present study, we evaluated the risk of PF in a large study population of patients with neuroendocrine pancreatic tumors (NPT), pancreatic cancer (PC), and chronic pancreatitis (CP)...
  18. ncbi request reprint [Zollinger-Ellison syndrome]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 76:217-26. 2005
    ..If the source of gastrin secretion can be regionalized to the pancreatic head by a preoperative SASI angiography, a pylorus-preserving partial pancreaticoduodenectomy might be the treatment of choice...
  19. ncbi request reprint Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Volker Fendrich
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University, Marburg, Germany
    Pancreas 30:e40-5. 2005
    ..In the present study, the involvement of TIMP3 in the tumorigenesis of 34 pancreatic adenocarcinomas was evaluated...
  20. ncbi request reprint [Hyperaldosteronism persisting after subtotal adrenalectomy]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 74:473-7. 2003
    ..Total adrenalectomy is the standard procedure. In contrast to bilateral adrenal diseases (e.g., MEN II pheochromocytomas), there is no consensus about the effect of subtotal adrenalectomy...
  21. ncbi request reprint [Surgical research in Germany--an international comparison]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg, Baldingerstrasse, Marburg, Germany
    Chirurg 81:328-33. 2010
    ..If the situation is to be improved all factors have to be evaluated and, if possible, changed. Overall, German surgeons are underrepresented as readers and authors in the scientific market, which is mostly in the English language...
  22. pmc An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 244:845-51; discussion 852-3. 2006
    ..To evaluate the outcome of reoperations in patients with duodenopancreatic neuroendocrine tumors (PETs) in a tertiary referral center...
  23. doi request reprint Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 254:818-23; discussion 823. 2011
    ..Blockade of aberrant hedgehog activation has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with a new orally bioavailable Smoothened (Smo) antagonist LDE225 have not been examined...
  24. ncbi request reprint [Operative management and long-term survival in patients with neuroendocrine tumors of the pancreas--experience with 144 patients]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 132:195-200. 2007
    ..To evaluate the outcome of patients with pancreatic endocrine tumors (PETs) in a tertiary referral centre...
  25. doi request reprint Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 16:613-22. 2009
    ..The expression pattern of Pdx1, Shh, and PP in resected metastases can help to locate an otherwise undetected primary gastrinoma...
  26. ncbi request reprint [Diagnosis and surgical treatment of insulinoma--experiences in 40 cases]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 129:941-6. 2004
    ..It was the aim of this study to analyse and evaluate our group of patients with regard to preoperative tumor localization and overall surgical results...
  27. doi request reprint Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
    ..This study was made to evaluate long-term results of an aggressive surgical approach for pancreaticoduodenal neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1)...
  28. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
    ..To evaluate the outcome of an aggressive surgical approach for duodenopancreatic neuroendocrine tumors (PETs) associated with multiple endocrine neoplasia type 1 (MEN1)...
  29. ncbi request reprint Clinical impact of TP53 alterations in adrenocortical carcinomas
    Jens Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 397:209-16. 2012
    ..To evaluate the role of somatic TP53 mutations and to correlate somatic and germline mutations with results of immunostaining, a large cohort of ACC patients was analyzed...
  30. ncbi request reprint Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..Based on these findings, the strategy for further follow-up and treatment could be modified accordingly...
  31. doi request reprint Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas
    Jens Waldmann
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg Oncol 16:1997-2005. 2009
    ..Twist, a target genes of Snail, is known to promote the development of distant metastases in mice. Increasing evidence suggests that EMT plays a pivotal role in tumor progression and metastatic spread...
  32. doi request reprint Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Pancreas 40:213-21. 2011
    ..Reports focusing on calcitonin-secreting PET (CTsPETs) are very rare. This study aimed to define a CTsPET-associated syndrome in regard to chemical, anatomical, and developmental aspects...
  33. pmc Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors
    Volker Fendrich
    Department of Surgery, University Hospital Giessen and Marburg, Baldinger Strasse, 35043 Marburg, Germany
    ScientificWorldJournal 2012:529151. 2012
    ..As a single therapy Sorafenib significantly improved survival in the late treatment group. Conclusion. Sorafenib may provide a new paradigm for the therapy of islet cell tumors...
  34. doi request reprint Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors
    Katja Maschuw
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1181-6. 2011
    ..The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up...
  35. doi request reprint Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
    ..8-11.4%) were thus identified in 70 German FPC families, indicating that the prevalence of BRCA2 mutations in the German FPC population is less frequent than previously reported...
  36. ncbi request reprint Outcome of surgery for ileojejunal neuroendocrine tumors
    Nils Habbe
    Department of Surgery, University Hospital Marburg, Baldingerstraße, 35043, Marburg, Germany
    Surg Today 43:1168-74. 2013
    ..Neuroendocrine tumors (NET) of the ileum/jejunum are rare and may require different treatment options to provide long-term survival. The purpose of the study was to evaluate the outcome of surgery for ileojejunal NET...
  37. doi request reprint Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, Philipps University, Marburg, Germany
    Ann Surg 257:308-14. 2013
    ..To evaluate the outcome of pancreaticoduodenectomy (PD) versus non-PD resections for the treatment of gastrinoma in multiple endocrine neoplasia type 1...
  38. doi request reprint Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value
    Jens Waldmann
    Department of General Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    World J Surg 33:1208-18. 2009
    ..However, recommendations for screening modalities and intervals are based mostly on nonprospective data...
  39. ncbi request reprint Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors
    Anja Wild
    Department of Surgery, Philipps University Marburg, 35043 Marburg, Germany
    J Clin Endocrinol Metab 88:1367-73. 2003
    ..02). These data suggest a possibly important role of TIMP-3 in the tumorigenesis of human PETs, especially in the development of metastases, which has to be further evaluated in large-scale studies...
  40. ncbi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  41. ncbi request reprint Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 28:1317-22. 2004
    ..e., for staging. Detection of PETs at an early stage by an aggressive screening program using EUS may lead to prompt surgical intervention and improved prognosis of MEN-1 PETs...
  42. ncbi request reprint Low frequency of CHEK2 mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Städtische Kliniken Bielefeld Mitte, Teutoburgerstrasse 50, D 33604, Bielefeld, Germany
    Fam Cancer 5:305-8. 2006
    ..Given the low expected mutation rate of up to 1.4% for CHEK2 * 1100delC in the European population our data are suggestive for possible contribution of CHEK2 mutations to a small subset of FPC...
  43. doi request reprint German national case collection for familial pancreatic cancer (FaPaCa): ten years experience
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Fam Cancer 10:323-30. 2011
    ..Focused research projects can be conducted most efficiently, when data of different FPC registries are combined...
  44. ncbi request reprint Multimodal treatment of sporadic and inherited neuroendocrine tumors of the thymus
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Surgery 144:780-5. 2008
    ..Approximately 180 cases have been reported since their first description. NETT reveal an aggressive behavior leading to rapid local invasion and metastatic spread. An aggressive surgical approach may achieve long-term survival...
  45. ncbi request reprint Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer
    Lars Plassmeier
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043, Marburg, Germany
    Langenbecks Arch Surg 398:989-96. 2013
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemotherapeutic potential of aspirin as an adjuvant agent to gemcitabine...
  46. ncbi request reprint Reduced complication rate after modified binding purse-string-mattress sutures pancreatogastrostomy versus duct-to-mucosa pancreaticojejunostomy
    Kristin Heeger
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany Electronic address
    Surgeon 11:246-52. 2013
    ..The present study compares postoperative complications after duct-to-mucosa pancreaticojejunostomy with a modified binding purse-string-mattress sutures pancreatogastrostomy in a teaching hospital...
  47. doi request reprint Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstrasse, Marburg 35037, Germany
    Endocrine 35:347-55. 2009
    ..Polymorphisms of the RET gene are common (17%) and occur in familial and sporadic PC. Multiple genetic alterations including mutations, polymorphisms and intronic variants are more frequently observed in malignant PC...
  48. pmc LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer
    Emily P Slater
    Department of Surgery, Philipps University, Marburg, Germany
    Transl Oncol 6:99-103. 2013
    ..Although this preliminary finding needs to be validated in a large series of individuals at high risk for FPC, serum measurement of LCN2 and TIMP1 might be a promising screening tool...
  49. doi request reprint Outcome in patients with long-term treatment in a surgical intensive care unit
    Nina Weiler
    Department of Surgery, Philipps University Marburg, Baldingerstraße, Marburg, Germany
    Langenbecks Arch Surg 397:995-9. 2012
    ..This study aimed to evaluate the outcome of patients with abdominal, thoracic or vascular operations and long-term intensive care unit (ICU) treatment...
  50. ncbi request reprint Duodenal somatostatinoma associated with Von Recklinghausen's disease
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    J Hepatobiliary Pancreat Surg 11:417-21. 2004
    ..Small tumors arising in the duodenum may be treated with local excision, whereas larger tumors should be treated by total excision, which may entail a partial pancreatoduodenectomy...
  51. ncbi request reprint Chronic pancreatitis and systemic inflammatory response syndrome prevent impact of chemotherapy with gemcitabine in a genetically engineered mouse model of pancreatic cancer
    Richard F Knoop
    Department of Surgery, Philipp University Marburg, Germany
    Neoplasia 16:463-70. 2014
    ..So far, no studies have evaluated the correlation between chronic pancreatitis, systemic inflammatory response syndrome, and the loss of chemotherapeutic benefit...
  52. doi request reprint Increased rate of clinically relevant pancreatic fistula after deep enucleation of small pancreatic tumors
    Kristin Heeger
    Department of Surgery, Philipps University, Baldingerstraße, D 35043, Marburg, Germany
    Langenbecks Arch Surg 399:315-21. 2014
    ..This study evaluates the outcome of enucleations with regard to their distance to the MPD...
  53. doi request reprint Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions
    Albrecht Neesse
    Department of Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany
    Gut 62:1034-43. 2013
    ..Here, we investigate the potential of targeting claudin-4 with a naturally occurring ligand to visualise pancreatic cancer and its precursor lesions in vitro and in vivo by near-infrared imaging approaches...
  54. ncbi request reprint RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
    ..04) than patients with the wild-type genotype. Our results suggest that RNASEL variants Glu265X and Arg462Gln may contribute to the tumorigenesis of sporadic and familial pancreatic cancer, which has to be proven in large scale studies...
  55. ncbi request reprint [Minimal-invasive operative treatment of organic hyperinsulinism]
    P Langer
    Klinik für Visceral, Thorax und Gefasschirurgie, Klinikum der Philipps Universität, 35043 Marburg
    Dtsch Med Wochenschr 130:514-8. 2005
    ..On the occasion of two cases, this report describes the laparoscopic treatment of these rare tumors...
  56. doi request reprint Enucleation and limited pancreatic resection provide long-term cure for insulinoma in multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 98:290-8. 2013
    ..To assess the characteristics and long-term outcome after surgery in patients with multiple endocrine neoplasia type 1 (MEN1)-associated insulinoma...
  57. doi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  58. ncbi request reprint Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target
    Dorothee Karhoff
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 85:45-53. 2007
    ..In addition, we explored the effect of suppressing B-Raf kinase by the recently developed inhibitor BAY43-9006 (Sorafinib) on growth, apoptosis and MAPK activation neuroendocrine cell lines...
  59. ncbi request reprint Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters!
    Katja Schlosser
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    World J Surg 31:1947-53. 2007
    ..The mechanism by which graft function deteriorates is unknown. We reviewed our experience in regard to the operative procedures and postoperative outcome...
  60. doi request reprint [Minimally invasive resection of neuroendocrine pancreatic tumors]
    P Langer
    Klinik für Visceral, Thorax und Gefasschirurgie, Universitätsklinikum Giessen und Marburg GmbH, Standort Marburg, Baldingerstrasse, Marburg, Germany
    Chirurg 80:105-12. 2009
    ..Neither sporadic and MEN1-associated gastrinomas nor the very rare glucagonomas and vasoactive intestinal peptide-producing tumors (vipomas), which are often large and malignant, should also be tackled laparoscopically...
  61. doi request reprint Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer
    P Langer
    Department of General Surgery, Philipps University Marburg, Germany
    Gut 58:1410-8. 2009
    ..Familial pancreatic cancer (FPC) accounts for approximately 3% of all pancreatic cancer (PC) cases. It has been suggested that high-risk individuals (HRIs) should be offered a screening programme...
  62. doi request reprint [Perineal hernia. A rare complication following abdominoperineal rectal amputation]
    S Zimmer
    Klinik für Viszeral, Thorax und Gefasschirurgie, Universität Giessen und Marburg, Standort Marburg, Baldingerstrasse, 35033 Marburg, Deutschland
    Chirurg 80:462, 464-5. 2009
    ..Surgical repair can be done either through a transabdominal approach or transperineally. Long-term results show that both methods are feasible in this situation. We report the third case of perineal hernia in German literature...
  63. doi request reprint Familial pancreatic cancer: current status
    Peter Langer
    Philipps University Hospital, Department of General Surgery, Baldingerstraße, D 35043 Marburg, Germany 49 6421 2866442 49 6421 2868995
    Expert Opin Med Diagn 1:193-201. 2007
    ..The first data on the prospective screening of high-risk individuals have demonstrated that precursor lesions of PC can be identified, but false-positive findings do occur...
  64. ncbi request reprint Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening
    J Waldmann
    Department of General Surgery, Philipps University, Marburg, Germany
    Langenbecks Arch Surg 392:437-43. 2007
    ..Prevalence in recent studies varies between 9 and 45%. A genotype-phenotype correlation has been described as well as the development of adrenocortical carcinomas. Long-term prospective data are still lacking...
  65. doi request reprint Expression of hedgehog signalling pathway in anaplastic thyroid cancer
    Ulrike Hinterseher
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 45:439-47. 2014
    ..Aberrant activation of this pathway might be involved in the aggressive biology of anaplastic cancer and further evaluation regarding a possible clinical impact of pathway inhibition is warranted...
  66. doi request reprint RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling
    Melanie Tariki
    Philipps University, Institute of Molecular Biology and Tumor Research IMT, Emil Mannkopff Str 2, 35037 Marburg, Germany
    Cell Signal 25:2668-75. 2013
    ..Taken together, we propose that factors modulating the nucleo-cytoplasmic distribution of SUFU impact on the normal function of this tumor suppressing protein. ..
  67. ncbi request reprint Transabdominal preperitoneal versus totally extraperitoneal repair of inguinal hernia: a meta-analysis of randomized studies
    Stavros A Antoniou
    Department of General and Visceral Surgery, Center for Minimally Invasive Surgery, Hospital Neuwerk, Mönchengladbach, Germany
    Am J Surg 206:245-252.e1. 2013
    ..The aim of the present study was to comparatively evaluate the outcomes of laparoscopic transabdominal preperitoneal inguinal hernia repair and totally extraperitoneal repair...
  68. pmc Liver-specific therapies for metastases of neuroendocrine pancreatic tumors
    Volker Fendrich
    Volker Fendrich, Nils Habbe, Detlef Klaus Bartsch, Department of Surgery, Philipps University, Marburg D 35043, Germany
    World J Hepatol 2:367-73. 2010
    ..Liver resection, transplantation and many different therapeutic approaches are discussed in this special review...
  69. pmc Palladin mutation causes familial pancreatic cancer: absence in European families
    Emily Slater
    PLoS Med 4:e164. 2007
  70. pmc An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2725-35. 2008
    ....
  71. pmc Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 67:2187-96. 2007
    ....
  72. ncbi request reprint Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum
    Volker Fendrich
    Department of Pathology, John Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Endocr Relat Cancer 14:865-74. 2007
    ..In conclusion, we describe for the first time that Snail and SHH are overexpressed in a large subset of NETs of the ileum. Aberrant activation of these pathways might be involved in invasion and metastatic spread in NETs...