Astrid Dempfle

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi Gene-environment interactions for complex traits: definitions, methodological requirements and challenges
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
    Eur J Hum Genet 16:1164-72. 2008
  2. pmc Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    BMC Proc 1:S73. 2007
  3. ncbi Meta-analysis of linkage studies for complex diseases: an overview of methods and a simulation study
    A Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    Ann Hum Genet 68:69-83. 2004
  4. ncbi Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
  5. ncbi Data adaptive interim modification of sample sizes for candidate-gene association studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Germany
    Hum Hered 56:56-62. 2003
  6. pmc Genome scan for body mass index and height in the Framingham Heart Study
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstrasse 3, Marburg, 35037 Germany
    BMC Genet 4:S91. 2003
  7. pmc TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer
    Carola Seifart
    Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Germany
    Dis Markers 21:157-65. 2005
  8. ncbi Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication
    Thomas Wündisch
    Klinik für Hämatologie, Onkologie und Immunologie, Klinikum der Philipps Universität, Marburg, Germany
    J Clin Oncol 23:8018-24. 2005
  9. ncbi Hypoxia-inducible factor and vascular endothelial growth factor are expressed more frequently in embolized than in nonembolized cerebral arteriovenous malformations
    Ulrich Sure
    Neurochirurgische Klinik, Philipps University, Marburg, Germany
    Neurosurgery 55:663-9; discussion 669-70. 2004
  10. ncbi A novel type of autosomal recessive syndactyly: clinical and molecular studies in a family of Pakistani origin
    Sajid Malik
    Zentrum für Humangenetik, Philipps Universitat Marburg, Marburg, Germany
    Am J Med Genet A 126:61-7. 2004

Collaborators

Detail Information

Publications19

  1. doi Gene-environment interactions for complex traits: definitions, methodological requirements and challenges
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
    Eur J Hum Genet 16:1164-72. 2008
    ..Advantages and disadvantages of different epidemiological study designs are given and sample size requirements are exemplified. These issues as well as a critical appraisal of common methodological concerns are finally discussed...
  2. pmc Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    BMC Proc 1:S73. 2007
    ..The previously reported R620W single-nucleotide polymorphism was identified using logistic regression, but the haplotype-based methods did not provide any precise location information...
  3. ncbi Meta-analysis of linkage studies for complex diseases: an overview of methods and a simulation study
    A Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    Ann Hum Genet 68:69-83. 2004
    ..The weighting methods explicitly take those differences into account and have more power in the simulated scenarios than the other methods...
  4. ncbi Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
    ..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population...
  5. ncbi Data adaptive interim modification of sample sizes for candidate-gene association studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Germany
    Hum Hered 56:56-62. 2003
    ..One would therefore wish to reassess the sample size during the course of a study...
  6. pmc Genome scan for body mass index and height in the Framingham Heart Study
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstrasse 3, Marburg, 35037 Germany
    BMC Genet 4:S91. 2003
    ..Two variance-components approaches (SOLAR and MERLIN-VC) and one regression method (MERLIN-REGRESS) were applied to the data...
  7. pmc TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer
    Carola Seifart
    Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Germany
    Dis Markers 21:157-65. 2005
    ..The functional IL-10-1082 polymorphism correlates with altered IL-10 levels and might influence lung cancer susceptibility by altered inflammatory responses in the airways...
  8. ncbi Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication
    Thomas Wündisch
    Klinik für Hämatologie, Onkologie und Immunologie, Klinikum der Philipps Universität, Marburg, Germany
    J Clin Oncol 23:8018-24. 2005
    ..We tracked the long-term stability of remissions in this prospective, multicenter trial...
  9. ncbi Hypoxia-inducible factor and vascular endothelial growth factor are expressed more frequently in embolized than in nonembolized cerebral arteriovenous malformations
    Ulrich Sure
    Neurochirurgische Klinik, Philipps University, Marburg, Germany
    Neurosurgery 55:663-9; discussion 669-70. 2004
    ..In addition, we investigated hypoxia-inducible factor-1 alpha as a possible protein operative during neoangiogenesis of cerebral AVMs...
  10. ncbi A novel type of autosomal recessive syndactyly: clinical and molecular studies in a family of Pakistani origin
    Sajid Malik
    Zentrum für Humangenetik, Philipps Universitat Marburg, Marburg, Germany
    Am J Med Genet A 126:61-7. 2004
    ..We show that the phenotype in our family is not linked to chromosomal regions 2q34-q36, 2q31, and 6q22-q23 encompassing loci for syndactyly types I, II, and III...
  11. ncbi Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Hum Hered 54:210-7. 2002
    ....
  12. pmc Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
    Am J Hum Genet 74:572-81. 2004
    ..The respective protective effect against obesity implies that variation in the MC4R gene entails both loss and gain of function...
  13. ncbi [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]
    Benno Graf Schimmelmann
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitat Duisburg Essen, Rheinische Kliniken Essen, Virchowstrasse 174, DE 45147 Essen
    Z Kinder Jugendpsychiatr Psychother 34:425-33. 2006
    ..The understanding of ADHD's neurobiology may be advanced by new technologies, such as SNP-based genome scans performed with gene chips comprising 10,000-1,000,000 SNPs, as well as using more sophisticated animal model designs...
  14. ncbi Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
    Hai Jun Wang
    Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
    J Clin Endocrinol Metab 89:157-62. 2004
    ..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups...
  15. ncbi Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder
    Naoe Okamura
    Department of Pharmacology, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1444-8. 2007
    ..These results provide evidence for a gender-specific effect of NPSR in the pathogenesis of panic disorder...
  16. ncbi Gene by environment interactions
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, 600 South Euclid, St Louis, MO 63110, USA
    Genet Epidemiol 31:S68-74. 2007
    ..A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant)...
  17. pmc Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulation
    Armin O Schmitt
    Institute for Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany
    J Zhejiang Univ Sci B 8:777-81. 2007
    ..We furthermore detected statistically significant association between hundreds of deletion sites and fat weight at the age of eight weeks...
  18. ncbi Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  19. ncbi Children with idiopathic short stature are poor eaters and have decreased body mass index
    Stefan A Wudy
    Department of General Pediatrics, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
    Pediatrics 116:e52-7. 2005
    ..In children with idiopathic short stature (ISS), studies investigating body mass index (BMI) or parameters of satiety regulation are scarce, and studies analyzing eating behavior are lacking...