Research Topics
Genomes and GenesSpecies | Astrid DempfleSummaryAffiliation: Philipps University Country: Germany Publications
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Detail Information
Publications
Gene-environment interactions for complex traits: definitions, methodological requirements and challengesAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
Eur J Hum Genet 16:1164-72. 2008..Advantages and disadvantages of different epidemiological study designs are given and sample size requirements are exemplified. These issues as well as a critical appraisal of common methodological concerns are finally discussed...
Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritisAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
BMC Proc 1:S73. 2007..The previously reported R620W single-nucleotide polymorphism was identified using logistic regression, but the haplotype-based methods did not provide any precise location information...
Meta-analysis of linkage studies for complex diseases: an overview of methods and a simulation studyA Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
Ann Hum Genet 68:69-83. 2004..The weighting methods explicitly take those differences into account and have more power in the simulated scenarios than the other methods...- Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studiesAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
Hum Mol Genet 15:2772-83. 2006..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population... - Data adaptive interim modification of sample sizes for candidate-gene association studiesAndre Scherag
Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Germany
Hum Hered 56:56-62. 2003..One would therefore wish to reassess the sample size during the course of a study... - Genome scan for body mass index and height in the Framingham Heart StudyFrank Geller
Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstrasse 3, Marburg, 35037 Germany
BMC Genet 4:S91. 2003..Two variance-components approaches (SOLAR and MERLIN-VC) and one regression method (MERLIN-REGRESS) were applied to the data... - TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancerCarola Seifart
Department of Internal Medicine, Division of Respiratory Medicine, Philipps University of Marburg, Germany
Dis Markers 21:157-65. 2005..The functional IL-10-1082 polymorphism correlates with altered IL-10 levels and might influence lung cancer susceptibility by altered inflammatory responses in the airways... - Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradicationThomas Wündisch
Klinik für Hämatologie, Onkologie und Immunologie, Klinikum der Philipps Universität, Marburg, Germany
J Clin Oncol 23:8018-24. 2005..We tracked the long-term stability of remissions in this prospective, multicenter trial... - Hypoxia-inducible factor and vascular endothelial growth factor are expressed more frequently in embolized than in nonembolized cerebral arteriovenous malformationsUlrich Sure
Neurochirurgische Klinik, Philipps University, Marburg, Germany
Neurosurgery 55:663-9; discussion 669-70. 2004..In addition, we investigated hypoxia-inducible factor-1 alpha as a possible protein operative during neoangiogenesis of cerebral AVMs... - Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studiesAndre Scherag
Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Hum Hered 54:210-7. 2002.... - A novel type of autosomal recessive syndactyly: clinical and molecular studies in a family of Pakistani originSajid Malik
Zentrum für Humangenetik, Philipps Universitat Marburg, Marburg, Germany
Am J Med Genet A 126:61-7. 2004..We show that the phenotype in our family is not linked to chromosomal regions 2q34-q36, 2q31, and 6q22-q23 encompassing loci for syndactyly types I, II, and III... - Melanocortin-4 receptor gene variant I103 is negatively associated with obesityFrank Geller
Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
Am J Hum Genet 74:572-81. 2004..The respective protective effect against obesity implies that variation in the MC4R gene entails both loss and gain of function... - [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]Benno Graf Schimmelmann
Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitat Duisburg Essen, Rheinische Kliniken Essen, Virchowstrasse 174, DE 45147 Essen
Z Kinder Jugendpsychiatr Psychother 34:425-33. 2006..The understanding of ADHD's neurobiology may be advanced by new technologies, such as SNP-based genome scans performed with gene chips comprising 10,000-1,000,000 SNPs, as well as using more sophisticated animal model designs... - Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal statureHai Jun Wang
Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
J Clin Endocrinol Metab 89:157-62. 2004..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups... - Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorderNaoe Okamura
Department of Pharmacology, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:1444-8. 2007..These results provide evidence for a gender-specific effect of NPSR in the pathogenesis of panic disorder... - Gene by environment interactionsROBERT C CULVERHOUSE
Department of Medicine, Washington University School of Medicine, 600 South Euclid, St Louis, MO 63110, USA
Genet Epidemiol 31:S68-74. 2007..A related but distinct goal is to characterize an interaction (e.g. to determine if the interaction is significant)... - Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulationArmin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Invalidenstrasse 42, 10115, Berlin, Germany
J Zhejiang Univ Sci B 8:777-81. 2007..We furthermore detected statistically significant association between hundreds of deletion sites and fat weight at the age of eight weeks... - Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral centerChristian P Jacob
Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center... - Children with idiopathic short stature are poor eaters and have decreased body mass indexStefan A Wudy
Department of General Pediatrics, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
Pediatrics 116:e52-7. 2005..In children with idiopathic short stature (ISS), studies investigating body mass index (BMI) or parameters of satiety regulation are scarce, and studies analyzing eating behavior are lacking...