Detlef K Bartsch

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. ncbi A RET double mutation in the germline of a kindred with FMTC
    D K Bartsch
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 108:128-32. 2000
  2. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
  3. ncbi RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
  4. ncbi Familial pancreatic cancer syndromes
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Baldiger Strasse, Marburg 35033, Germany
    Endocrinol Metab Clin North Am 35:417-30, xi. 2006
  5. ncbi Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas
    D Bartsch
    Department of Surgery, Philipps University Marburg, Germany
    Cancer Lett 139:43-9. 1999
  6. pmc CDKN2A germline mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Institute of Biometrics and Medical Epidemiology, Philipps University, Marburg, Germany
    Ann Surg 236:730-7. 2002
  7. ncbi Familial pancreatic cancer
    D K Bartsch
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Germany
    Br J Surg 90:386-7. 2003
  8. ncbi Prevalence of familial pancreatic cancer in Germany
    Detlef K Bartsch
    National Case Collection of Familial Pancreatic Cancer, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Cancer 110:902-6. 2004
  9. ncbi Low frequency of p16(INK4a) alterations in insulinomas
    D K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Digestion 62:171-7. 2000
  10. ncbi Update of familial pancreatic cancer in Germany
    D K Bartsch
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Pancreatology 1:510-6. 2001

Detail Information

Publications103 found, 100 shown here

  1. ncbi A RET double mutation in the germline of a kindred with FMTC
    D K Bartsch
    Department of Surgery, Philipps University of Marburg, Germany
    Exp Clin Endocrinol Diabetes 108:128-32. 2000
    ....
  2. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
    ..To evaluate the outcome of an aggressive surgical approach for duodenopancreatic neuroendocrine tumors (PETs) associated with multiple endocrine neoplasia type 1 (MEN1)...
  3. ncbi RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
    ..04) than patients with the wild-type genotype. Our results suggest that RNASEL variants Glu265X and Arg462Gln may contribute to the tumorigenesis of sporadic and familial pancreatic cancer, which has to be proven in large scale studies...
  4. ncbi Familial pancreatic cancer syndromes
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Baldiger Strasse, Marburg 35033, Germany
    Endocrinol Metab Clin North Am 35:417-30, xi. 2006
    ....
  5. ncbi Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas
    D Bartsch
    Department of Surgery, Philipps University Marburg, Germany
    Cancer Lett 139:43-9. 1999
    ..In addition, another, yet unidentified, tumor suppressor gene(s) may be linked with the frequent LOH of 18q21 in primary pancreatic adenocarcinomas...
  6. pmc CDKN2A germline mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Institute of Biometrics and Medical Epidemiology, Philipps University, Marburg, Germany
    Ann Surg 236:730-7. 2002
    ..To evaluate the prevalence of mutations in the CDKN2A gene encoding p16 and p14 in familial pancreatic cancer (FPC)...
  7. ncbi Familial pancreatic cancer
    D K Bartsch
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Germany
    Br J Surg 90:386-7. 2003
  8. ncbi Prevalence of familial pancreatic cancer in Germany
    Detlef K Bartsch
    National Case Collection of Familial Pancreatic Cancer, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Cancer 110:902-6. 2004
    ..This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer...
  9. ncbi Low frequency of p16(INK4a) alterations in insulinomas
    D K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Digestion 62:171-7. 2000
    ..In this study the role of p16(INK4a) in the tumorigenesis of insulinomas was evaluated...
  10. ncbi Update of familial pancreatic cancer in Germany
    D K Bartsch
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Pancreatology 1:510-6. 2001
    ..Therefore, a German case collection for FPC was established in July 1999 to collect and evaluate data on FPC families...
  11. doi Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
    ..8-11.4%) were thus identified in 70 German FPC families, indicating that the prevalence of BRCA2 mutations in the German FPC population is less frequent than previously reported...
  12. doi Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 42:637-46. 2012
    ..The efficacy of this therapeutic approach remains to be revised by in vivo and clinical application...
  13. doi Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
    ..This study was made to evaluate long-term results of an aggressive surgical approach for pancreaticoduodenal neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1)...
  14. doi Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Pancreas 40:213-21. 2011
    ..Reports focusing on calcitonin-secreting PET (CTsPETs) are very rare. This study aimed to define a CTsPET-associated syndrome in regard to chemical, anatomical, and developmental aspects...
  15. ncbi Tumor-suppressing pathways in cystic pancreatic tumors
    Berthold Gerdes
    Department of General Surgery, Philipps University of Marburg, Germany
    Pancreas 26:42-8. 2003
    ..Serous and mucinous cystic pancreatic tumors have different clinical behavior. We evaluated whether they also have genotypic differences by analyses of the tumor suppressor genes, p16INK4a, p53, and DPC4...
  16. doi Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..Based on these findings, the strategy for further follow-up and treatment could be modified accordingly...
  17. doi Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
    ..However, routine bilateral cervical thymectomy (BCT) is still discussed, although controversially...
  18. doi Pretherapeutic drug evaluation by tumor xenografting in anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Res 185:676-83. 2013
    ..Results of preclinical investigations are often of limited transferability to clinical tumor biology. Individualized multimodal treatment regimens, including novel growth-inhibiting drugs, might be a future option...
  19. doi Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 16:613-22. 2009
    ..The expression pattern of Pdx1, Shh, and PP in resected metastases can help to locate an otherwise undetected primary gastrinoma...
  20. ncbi Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Volker Fendrich
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University, Marburg, Germany
    Pancreas 30:e40-5. 2005
    ..In the present study, the involvement of TIMP3 in the tumorigenesis of 34 pancreatic adenocarcinomas was evaluated...
  21. doi Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstrasse, Marburg 35037, Germany
    Endocrine 35:347-55. 2009
    ..Polymorphisms of the RET gene are common (17%) and occur in familial and sporadic PC. Multiple genetic alterations including mutations, polymorphisms and intronic variants are more frequently observed in malignant PC...
  22. pmc Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors
    Volker Fendrich
    Department of Surgery, University Hospital Giessen and Marburg, Baldinger Strasse, 35043 Marburg, Germany
    ScientificWorldJournal 2012:529151. 2012
    ..As a single therapy Sorafenib significantly improved survival in the late treatment group. Conclusion. Sorafenib may provide a new paradigm for the therapy of islet cell tumors...
  23. doi Reoperations for primary hyperparathyroidism--improvement of outcome over two decades
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstraße, 35043 Marburg, Germany
    Langenbecks Arch Surg 398:99-106. 2013
    ....
  24. doi Clinical impact of TP53 alterations in adrenocortical carcinomas
    Jens Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 397:209-16. 2012
    ..To evaluate the role of somatic TP53 mutations and to correlate somatic and germline mutations with results of immunostaining, a large cohort of ACC patients was analyzed...
  25. doi Initial parathyroid surgery in 606 patients with renal hyperparathyroidism
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 36:318-26. 2012
    ..The aim of the present study was to evaluate the outcome of different surgical procedures for patients on permanent dialysis who underwent initial parathyroidectomy for renal hyperparathyroidism (rHPT)...
  26. doi Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors
    Katja Maschuw
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1181-6. 2011
    ..The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up...
  27. ncbi Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors
    Anja Wild
    Department of Surgery, Philipps University Marburg, 35043 Marburg, Germany
    J Clin Endocrinol Metab 88:1367-73. 2003
    ..02). These data suggest a possibly important role of TIMP-3 in the tumorigenesis of human PETs, especially in the development of metastases, which has to be further evaluated in large-scale studies...
  28. ncbi Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  29. doi Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, Philipps University, Marburg, Germany
    Ann Surg 257:308-14. 2013
    ..To evaluate the outcome of pancreaticoduodenectomy (PD) versus non-PD resections for the treatment of gastrinoma in multiple endocrine neoplasia type 1...
  30. doi Neuroendocrine pancreatic tumors are risk factors for pancreatic fistula after pancreatic surgery
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Dig Surg 28:263-9. 2011
    ..In the present study, we evaluated the risk of PF in a large study population of patients with neuroendocrine pancreatic tumors (NPT), pancreatic cancer (PC), and chronic pancreatitis (CP)...
  31. doi The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Gut 59:630-7. 2010
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of these drugs...
  32. ncbi Familial pancreatic cancer
    Harald Rieder
    Institute of Clinical Genetics, Marburg, Germany
    Fam Cancer 3:69-74. 2004
    ..This may allow the application of invasive screening methods for the identification of early PC or, even better, its precursor lesions in high-risk individuals, providing the option of timely curative pancreatectomy...
  33. doi Multimodal treatment of sporadic and inherited neuroendocrine tumors of the thymus
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Surgery 144:780-5. 2008
    ..Approximately 180 cases have been reported since their first description. NETT reveal an aggressive behavior leading to rapid local invasion and metastatic spread. An aggressive surgical approach may achieve long-term survival...
  34. doi Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value
    Jens Waldmann
    Department of General Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    World J Surg 33:1208-18. 2009
    ..However, recommendations for screening modalities and intervals are based mostly on nonprospective data...
  35. doi Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Eur J Endocrinol 160:695-703. 2009
    ..In this study, we examined the expression of the EMT markers Snail, Twist and E-cadherin in normal parathyroid glands and benign and malignant parathyroid diseases...
  36. doi Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas
    Jens Waldmann
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg Oncol 16:1997-2005. 2009
    ..Twist, a target genes of Snail, is known to promote the development of distant metastases in mice. Increasing evidence suggests that EMT plays a pivotal role in tumor progression and metastatic spread...
  37. ncbi Low frequency of CHEK2 mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Städtische Kliniken Bielefeld Mitte, Teutoburgerstrasse 50, D 33604, Bielefeld, Germany
    Fam Cancer 5:305-8. 2006
    ..Given the low expected mutation rate of up to 1.4% for CHEK2 * 1100delC in the European population our data are suggestive for possible contribution of CHEK2 mutations to a small subset of FPC...
  38. doi German national case collection for familial pancreatic cancer (FaPaCa): ten years experience
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Fam Cancer 10:323-30. 2011
    ..Focused research projects can be conducted most efficiently, when data of different FPC registries are combined...
  39. doi Surgical treatment of gastrointestinal neuroendocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Langenbecks Arch Surg 396:299-311. 2011
    ..Nonfunctional tumors do not secrete a hormone resulting in a clinical syndrome...
  40. doi Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Germany
    Ann Surg 253:546-52. 2011
    ..In this study, we address the role of the Hh pathway in tumor progression of murine islet cell tumors...
  41. pmc p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb
    Berthold Gerdes
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University of Marburg, Marburg, Germany
    Ann Surg 235:51-9. 2002
    ..To identify the prognostic relevance of the G1/S cell cycle regulator genes p16INK4a, p53, MDM2, and Rb in patients with resected ductal pancreatic cancer (PC)...
  42. doi Clinical and genetic analysis of 18 pancreatic carcinoma/melanoma-prone families
    D K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Clin Genet 77:333-41. 2010
    ..More PC/melanoma-prone families need to be analysed to clarify whether such families represent variations of the FAMMM-PC syndrome or two distinct hereditary cancer syndromes...
  43. ncbi The calcitonin levels can sometimes mislead parathyroid surgeons in patients with chronic kidney disease and renal hyperparathyroidism: report of a case
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Today 43:429-33. 2013
    ..The thresholds for calcitonin levels need to be better defined in affected patients to determine the optimal extent of surgical resection...
  44. pmc LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer
    Emily P Slater
    Department of Surgery, Philipps University, Marburg, Germany
    Transl Oncol 6:99-103. 2013
    ..Although this preliminary finding needs to be validated in a large series of individuals at high risk for FPC, serum measurement of LCN2 and TIMP1 might be a promising screening tool...
  45. doi Familial pancreatic cancer--current knowledge
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35041 Marburg, Germany
    Nat Rev Gastroenterol Hepatol 9:445-53. 2012
    ..This Review focuses on the clinical phenotype of FPC, its histopathological characteristics, known underlying genetic changes and associated genetic counselling and screening...
  46. doi Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 254:818-23; discussion 823. 2011
    ..Blockade of aberrant hedgehog activation has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with a new orally bioavailable Smoothened (Smo) antagonist LDE225 have not been examined...
  47. pmc Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Neoplasia 13:180-6. 2011
    ..Currently, no reliable, noninvasive imaging technique (e.g., ultrasound, computed tomography, magnet resonance imaging) exists to verify PanINs...
  48. ncbi Chromosome 22q in pancreatic endocrine tumors: identification of a homozygous deletion and potential prognostic associations of allelic deletions
    Anja Wild
    Department of General Surgery, Philipps University of Marburg, Baldingerstrasse, Marburg Lahn 35043, Germany
    Eur J Endocrinol 147:507-13. 2002
    ..A variety of human tumors frequently show allelic deletions of chromosome 22q, suggesting that inactivation of one or more tumor suppressor genes in this region is important for their tumorigenesis...
  49. ncbi Peripyloric lymph node metastasis is a rare condition in carcinoma of the pancreatic head
    Berthold Gerdes
    Department of Surgery, Philipps University of Marburg, Marburg, Germany
    Pancreas 31:88-92. 2005
    ..The aim of this prospective study was to identify the frequency of peripyloric and perigastric lymph node metastases in ductal adenocarcinoma of the pancreatic head (PC)...
  50. doi Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense?
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    World J Surg 36:2598-604. 2012
    ....
  51. doi Outcome in patients with long-term treatment in a surgical intensive care unit
    Nina Weiler
    Department of Surgery, Philipps University Marburg, Baldingerstraße, Marburg, Germany
    Langenbecks Arch Surg 397:995-9. 2012
    ..This study aimed to evaluate the outcome of patients with abdominal, thoracic or vascular operations and long-term intensive care unit (ICU) treatment...
  52. doi Surgical management of pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University, Marburg, Germany
    Nat Rev Clin Oncol 6:419-28. 2009
    ..This Review describes the current status of surgical treatment for pancreatic endocrine tumors, and discusses the new developments in this field...
  53. pmc An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 244:845-51; discussion 852-3. 2006
    ..To evaluate the outcome of reoperations in patients with duodenopancreatic neuroendocrine tumors (PETs) in a tertiary referral center...
  54. doi Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Oncol 97:592-5. 2008
    ..To investigate the appearance of multiple primary malignancies in patients with sporadic neuroendocrine pancreatic tumors (NEPTs)...
  55. ncbi Duodenal somatostatinoma associated with Von Recklinghausen's disease
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    J Hepatobiliary Pancreat Surg 11:417-21. 2004
    ..Small tumors arising in the duodenum may be treated with local excision, whereas larger tumors should be treated by total excision, which may entail a partial pancreatoduodenectomy...
  56. ncbi Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 28:1317-22. 2004
    ..e., for staging. Detection of PETs at an early stage by an aggressive screening program using EUS may lead to prompt surgical intervention and improved prognosis of MEN-1 PETs...
  57. ncbi Prevalence of multiple endocrine neoplasia type 1 in young patients with apparently sporadic primary hyperparathyroidism or pancreaticoduodenal endocrine tumours
    P Langer
    Department of General Surgery, Philipps University Marburg, Marburg, Germany
    Br J Surg 90:1599-603. 2003
    ....
  58. doi Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer
    Lars Plassmeier
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043, Marburg, Germany
    Langenbecks Arch Surg 398:989-96. 2013
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemotherapeutic potential of aspirin as an adjuvant agent to gemcitabine...
  59. doi Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  60. doi Development of a formula to predict parathyroid carcinoma in patients with primary hyperparathyroidism
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstraße, 35043 Marburg, Germany
    World J Surg 36:2605-11. 2012
    ..Unfortunately, no reliable preoperative criteria have yet been assessed to indicate a high likelihood of PC. Thus, the aim of the present study was to develop a formula to indicate preoperatively the presence of PC...
  61. ncbi Adrenal involvement in multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 26:891-6. 2002
    ..The lesions are often small and nonfunctional and can therefore be managed by close surveillance; others have significant malignant potential and should be considered for surgery when they are 3 cm or larger...
  62. doi Outcome of surgery for primary hyperaldosteronism
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstraße 1, 35043, Marburg, Germany
    World J Surg 35:2422-7. 2011
    ..Patients who underwent laparoscopic adrenalectomy at the authors' department were followed to identify clinical parameters that predict resolution of hypertension...
  63. ncbi Adrenal involvement in multiple endocrine neoplasia type 1: results of 7 years prospective screening
    J Waldmann
    Department of General Surgery, Philipps University, Marburg, Germany
    Langenbecks Arch Surg 392:437-43. 2007
    ..Prevalence in recent studies varies between 9 and 45%. A genotype-phenotype correlation has been described as well as the development of adrenocortical carcinomas. Long-term prospective data are still lacking...
  64. doi Differentiation between thyroidal and ectopic calcitonin secretion in patients with coincidental thyroid nodules and pancreatic tumors - a report of two cases
    R Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Exp Clin Endocrinol Diabetes 118:520-3. 2010
    ..On the basis of these case reports, the diagnostic work flow and management in case of clearly elevated calcitonin levels are described and discussed...
  65. ncbi Management of sporadic and multiple endocrine neoplasia type 1 gastrinomas
    V Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Bielefeld, Germany
    Br J Surg 94:1331-41. 2007
    ..Gastrinomas are functional endocrine duodenopancreatic tumours and are responsible for Zollinger-Ellison syndrome (ZES). Clinical presentation, localization techniques and operative management were reviewed...
  66. ncbi German national case collection of familial pancreatic cancer - clinical-genetic analysis of the first 21 families
    H Rieder
    Institut für Klinische Genetik, Philipps Universitat, Marburg, Germany
    Onkologie 25:262-6. 2002
    ..In order to evaluate the characteristics of familial PC, a German national case collection for familial pancreas cancer (FaPaCa) was established...
  67. ncbi [Multiple endocrine neoplasia type 1. Surgical therapy of primary hyperparathyroidism]
    P Langer
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Chirurg 75:900-6. 2004
    ..A prospective randomized trial is needed to compare stPTX including cervical thymectomy vs tPTX+T. A genotype-phenotype correlation could not be identified...
  68. ncbi Multiple primaries in pancreatic cancer patients: indicator of a genetic predisposition?
    B Gerdes
    Department of General Surgery, Philipps University of Marburg, D 35033 Marburg, Germany
    Int J Epidemiol 29:999-1003. 2000
    ..To evaluate inherited predisposition in pancreatic cancer we compared the clinical data of pancreatic cancer patients with and without multiple primaries as well as the frequency of malignancies among their relatives...
  69. ncbi [Diagnosis and surgical treatment of insulinoma--experiences in 40 cases]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 129:941-6. 2004
    ..It was the aim of this study to analyse and evaluate our group of patients with regard to preoperative tumor localization and overall surgical results...
  70. ncbi Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients?
    B Gerdes
    Department of General Surgery, Philipps University of Marburg, Germany
    Pancreas 21:369-75. 2000
    ..The genetic investigation of patients with accumulation of different cancers even without a positive family history may be a new approach for the understanding of the relation of different cancers...
  71. ncbi Familial ACTH-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia clinically affecting only female family members
    C Nies
    Department of General Surgery, Klinik für Visceral, Thorax und Gefässchirurgue, Philipps University Marburg, Germany
    Exp Clin Endocrinol Diabetes 110:277-83. 2002
    ....
  72. doi [Hereditary pancreatic cancer]
    N Habbe
    Klinik für Visceral, Thorax und Gefasschirurgie, Universitätsklinikum Giessen und Marburg, Standort Marburg, Baldingerstrasse, 35043, Marburg
    Chirurg 79:1029-37. 2008
    ..In case of the diagnosis of a PC or high-grade precursor lesions, a prophylactic extension of the resection can be considered, since patients with hereditary PC often develop multifocal pancreatic lesions...
  73. ncbi Natural course of small, asymptomatic neuroendocrine pancreatic tumours in multiple endocrine neoplasia type 1: an endoscopic ultrasound imaging study
    P H Kann
    Division of Endocrinology and Diabetology, Department of Surgery, Phillipp s University, Marburg, Germany
    Endocr Relat Cancer 13:1195-202. 2006
    ..However, faster growing tumours and patients with rapidly progressive disease can be observed. Risk for obvious metastatic disease from asymptomatic neuroendocrine pancreatic tumours<15 mm in MEN1 seems to be low...
  74. doi [Transoral partial parathyroidectomy]
    E Karakas
    Klinik für Visceral, Thorax und Gefasschirurgie, Universitätsklinikum Giessen Marburg GmbH, Standort Marburg, Deutschland
    Chirurg 81:1020-5. 2010
    ....
  75. doi Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer
    P Langer
    Department of General Surgery, Philipps University Marburg, Germany
    Gut 58:1410-8. 2009
    ..Familial pancreatic cancer (FPC) accounts for approximately 3% of all pancreatic cancer (PC) cases. It has been suggested that high-risk individuals (HRIs) should be offered a screening programme...
  76. ncbi Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors
    E P Slater
    Department of Surgery, Philipps University Marburg, Germany
    Eur J Endocrinol 154:587-98. 2006
    ..The comparative analysis by cDNA microarrays of gene-expression patterns of benign and malignant adrenocortical tumors allows us to identify new tumor-suppressor genes and proto-oncogenes underlying adrenocortical tumorigenesis...
  77. ncbi Small neuroendocrine pancreatic tumors in multiple endocrine neoplasia type 1 (MEN1): least significant change of tumor diameter as determined by endoscopic ultrasound (EUS) imaging
    P H Kann
    Endocrinology and Diabetology, Philipp s University Medical School, Marburg, Germany
    Exp Clin Endocrinol Diabetes 114:361-5. 2006
    ..9 %; tumors > 5 mm: 12.3 %). In conclusion, endosonographic imaging enables the measurement of small PETs with an acceptable reproducibility. Changes of tumor diameter of more than 20 % have to be taken as statistically significant...
  78. doi [Minimally invasive resection of neuroendocrine pancreatic tumors]
    P Langer
    Klinik für Visceral, Thorax und Gefasschirurgie, Universitätsklinikum Giessen und Marburg GmbH, Standort Marburg, Baldingerstrasse, Marburg, Germany
    Chirurg 80:105-12. 2009
    ..Neither sporadic and MEN1-associated gastrinomas nor the very rare glucagonomas and vasoactive intestinal peptide-producing tumors (vipomas), which are often large and malignant, should also be tackled laparoscopically...
  79. doi PALB2 mutations in European familial pancreatic cancer families
    E P Slater
    German National Case Collection of Familial Pancreatic Cancer FaPaCa, Department of Surgery, Philipps University, Marburg, Germany
    Clin Genet 78:490-4. 2010
    ..Therefore, PALB2 mutations might be causative for FPC in a small subset of European families, especially in those with an additional occurrence of breast cancer...
  80. doi [Diagnosis and surgical management of neureondocrine pancreatic tumours]
    V Fendrich
    Universitätsklinikum Giessen und Marburg, Klinik für Visceral, Thorax und Gefasschirurgie, Marburg, Deutschland
    Zentralbl Chir 135:210-7. 2010
    ..An aggressive surgical approach leads to cure in patients with benign tumours, and may achieve long-term survival in patients with malignant NPTs...
  81. ncbi [Zollinger-Ellison syndrome]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Chirurg 76:217-26. 2005
    ..If the source of gastrin secretion can be regionalized to the pancreatic head by a preoperative SASI angiography, a pylorus-preserving partial pancreaticoduodenectomy might be the treatment of choice...
  82. doi Surgery for multiple endocrine neoplasia type 1-associated primary hyperparathyroidism
    J Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Br J Surg 97:1528-34. 2010
    ..It is uncertain which operative procedure provides the best outcome with regard to long-term normocalcaemia...
  83. ncbi [Operative management and long-term survival in patients with neuroendocrine tumors of the pancreas--experience with 144 patients]
    V Fendrich
    Klinik für Visceral, Thorax und Gefasschirurgie, Philipps Universitat Marburg
    Dtsch Med Wochenschr 132:195-200. 2007
    ..To evaluate the outcome of patients with pancreatic endocrine tumors (PETs) in a tertiary referral centre...
  84. doi Outcome of surgery for ileojejunal neuroendocrine tumors
    Nils Habbe
    Department of Surgery, University Hospital Marburg, Baldingerstraße, 35043, Marburg, Germany
    Surg Today 43:1168-74. 2013
    ..Neuroendocrine tumors (NET) of the ileum/jejunum are rare and may require different treatment options to provide long-term survival. The purpose of the study was to evaluate the outcome of surgery for ileojejunal NET...
  85. doi Targeting the proteasome as a promising therapeutic strategy in thyroid cancer
    Annette Wunderlich
    Department of Surgery, University Hospital of Giessen and Marburg, Philipps University of Marburg, Marburg, Germany
    J Surg Oncol 105:357-64. 2012
    ..Here we investigated the effects of bortezomib on TC in vitro. Further, the study aimed to evaluate its potential for TC treatment in vivo...
  86. ncbi Prospective controlled trial of a standardized meal stimulation test in the detection of pancreaticoduodenal endocrine tumours in patients with multiple endocrine neoplasia type 1
    P Langer
    Department of General Surgery, Philipps-University, Marburg, Germany
    Br J Surg 88:1403-7. 2001
    ..The expensive and time-consuming meal test can be excluded from MEN 1 screening programmes...
  87. doi Relevance of bilateral cervical thymectomy in patients with renal hyperparathyroidism: analysis of 161 patients undergoing reoperative parathyroidectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    World J Surg 37:2155-61. 2013
    ..The aim of this study was to evaluate how often reoperation might have been avoidable if an appropriate cervical thymectomy had been performed during initial surgery...
  88. doi An economic comparison of surgical and medical therapy in patients with secondary hyperparathyroidism--the German perspective
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Marburg, Germany
    Surgery 148:1091-9. 2010
    ..Limitations of resources in public health systems demand detailed analyses of accruing costs. The aim of this study was to compare the costs of these new treatment modalities to surgery...
  89. ncbi Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target
    Dorothee Karhoff
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 85:45-53. 2007
    ..In addition, we explored the effect of suppressing B-Raf kinase by the recently developed inhibitor BAY43-9006 (Sorafinib) on growth, apoptosis and MAPK activation neuroendocrine cell lines...
  90. ncbi p16(INK4a) alterations in chronic pancreatitis-indicator for high-risk lesions for pancreatic cancer
    B Gerdes
    Department of General Surgery, Philipps University of Marburg, Baldingerstrasse, 35033 Marburg, Germany
    Surgery 129:490-7. 2001
    ..Therefore, p16(INK4a) alterations, especially promoter methylation, might indicate high-risk precursors in chronic pancreatitis that might progress to cancer...
  91. ncbi Successful treatment of solid-pseudopapillary tumor of the pancreas with multiple liver metastases
    I Hassan
    Department of Surgery, Institute of Theoretical Surgery, Philipps University of Marburg, Marburg, Germany
    Pancreatology 5:289-94. 2005
    ..The patient is disease free after a follow-up of 18 months after resection of the primary tumor, suggesting that an aggressive surgical treatment might also be justified for metastasized SPT...
  92. doi Transoral thyroid and parathyroid surgery
    Elias Karakas
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Endosc 24:1261-7. 2010
    ..Moreover, minimally invasive procedures have found their way into thyroid and parathyroid surgery. Our goal was to develop a new access for thyroid and parathyroid resection via an entirely transoral approach...
  93. ncbi A novel insulinoma tumor suppressor gene locus on chromosome 22q with potential prognostic implications
    A Wild
    Department of General Surgery, Philipps University of Marburg, D 35043 Marburg, Germany
    J Clin Endocrinol Metab 86:5782-7. 2001
    ..The distinct pattern of allelic loss identified in this chromosomal region appears to be an attractive candidate marker for further evaluation with regard to the discrimination between benign and malignant insulinomas...
  94. ncbi Surgical aspects of gastrinoma in multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Klinik für Allgemein und Viszeralchirurgie der Städt Kliniken Bielefeld Mitte, Bielefeld, Germany
    Wien Klin Wochenschr 119:602-8. 2007
    ..The article discusses the available data on treatment strategies of MEN1 associated ZES...
  95. ncbi Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University, Halle Saale, Germany
    Clin Endocrinol (Oxf) 67:613-22. 2007
    ..This study was conducted to examine whether carriers of out-of-frame/truncating and in-frame MEN1 mutations differ in age-related tumour penetrance...
  96. ncbi BRCA2 germline mutations in familial pancreatic carcinoma
    Stephan A Hahn
    Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Germany
    J Natl Cancer Inst 95:214-21. 2003
    ..To study these relationships in more detail, we examined whether BRCA2 germline mutations are associated with familial pancreatic cancer...
  97. ncbi Evaluation of the 4q32-34 locus in European familial pancreatic cancer
    Julie Earl
    Division of Surgery and Oncology, University of Liverpool, Liverpool, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1948-55. 2006
    ..The 4q32-34 region has been previously identified as a potential locus for FPC in a large American family...
  98. ncbi No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cancer Lett 214:63-8. 2004
    ..No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer...
  99. ncbi Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background
    Sven Eisold
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    Cancer 100:1978-86. 2004
    ..A gene responsible for familial pancreatic carcinoma has not been identified to date...
  100. ncbi Pancreatic cancer and basal-cell carcinoma
    Mercedes Sina-Frey
    Lancet 361:180. 2003
  101. ncbi Genetics of hereditary pancreatic carcinoma
    Stephan A Hahn
    Department of Internal Medicine, Knappschaftskrankenhaus University of Bochum, Zentrum für Klinische Forschung, Labor für Molekulare Gastroenterologische Onkologie, Universitatsstrasse 150, 44780 Bochum, Germany
    Clin Lab Med 25:117-33. 2005
    ..It is hoped that these genetic studies will aid the development of clinical management strategies for pancreatic carcinoma prevention...