Detlef K Bartsch

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi request reprint Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
    D K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    Fam Cancer 12:89-96. 2013
  2. doi request reprint Familial pancreatic cancer--current knowledge
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35041 Marburg, Germany
    Nat Rev Gastroenterol Hepatol 9:445-53. 2012
  3. doi request reprint Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 42:637-46. 2012
  4. doi request reprint Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
  5. doi request reprint Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
  6. doi request reprint Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
  7. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
  8. ncbi request reprint RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
  9. doi request reprint Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Pancreas 40:213-21. 2011
  10. doi request reprint Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010

Detail Information

Publications54

  1. doi request reprint Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
    D K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    Fam Cancer 12:89-96. 2013
    ..In the setting of FPC, the presence of multiple small "imaging" BD-IPMNs may indicate the presence of high-grade PanIN lesions elsewhere in the pancreas...
  2. doi request reprint Familial pancreatic cancer--current knowledge
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35041 Marburg, Germany
    Nat Rev Gastroenterol Hepatol 9:445-53. 2012
    ..This Review focuses on the clinical phenotype of FPC, its histopathological characteristics, known underlying genetic changes and associated genetic counselling and screening...
  3. doi request reprint Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 42:637-46. 2012
    ..The efficacy of this therapeutic approach remains to be revised by in vivo and clinical application...
  4. doi request reprint Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
    ..8-11.4%) were thus identified in 70 German FPC families, indicating that the prevalence of BRCA2 mutations in the German FPC population is less frequent than previously reported...
  5. doi request reprint Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
    ..This study was made to evaluate long-term results of an aggressive surgical approach for pancreaticoduodenal neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1)...
  6. doi request reprint Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
    ..However, routine bilateral cervical thymectomy (BCT) is still discussed, although controversially...
  7. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
    ..To evaluate the outcome of an aggressive surgical approach for duodenopancreatic neuroendocrine tumors (PETs) associated with multiple endocrine neoplasia type 1 (MEN1)...
  8. ncbi request reprint RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
    ..04) than patients with the wild-type genotype. Our results suggest that RNASEL variants Glu265X and Arg462Gln may contribute to the tumorigenesis of sporadic and familial pancreatic cancer, which has to be proven in large scale studies...
  9. doi request reprint Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Pancreas 40:213-21. 2011
    ..Reports focusing on calcitonin-secreting PET (CTsPETs) are very rare. This study aimed to define a CTsPET-associated syndrome in regard to chemical, anatomical, and developmental aspects...
  10. doi request reprint Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..Based on these findings, the strategy for further follow-up and treatment could be modified accordingly...
  11. doi request reprint Reoperations for primary hyperparathyroidism--improvement of outcome over two decades
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstraße, 35043 Marburg, Germany
    Langenbecks Arch Surg 398:99-106. 2013
    ....
  12. doi request reprint The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Gut 59:630-7. 2010
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of these drugs...
  13. doi request reprint Clinical impact of TP53 alterations in adrenocortical carcinomas
    Jens Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 397:209-16. 2012
    ..To evaluate the role of somatic TP53 mutations and to correlate somatic and germline mutations with results of immunostaining, a large cohort of ACC patients was analyzed...
  14. doi request reprint Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors
    Katja Maschuw
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1181-6. 2011
    ..The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up...
  15. doi request reprint Transoral thyroid and parathyroid surgery--development of a new transoral technique
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Germany
    Surgery 150:108-15. 2011
    ..We previously described a transoral access for (para-)thyroid resection in pigs. To proceed with the first clinical trials, we evaluated the safety of the new technique...
  16. doi request reprint Initial parathyroid surgery in 606 patients with renal hyperparathyroidism
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 36:318-26. 2012
    ..The aim of the present study was to evaluate the outcome of different surgical procedures for patients on permanent dialysis who underwent initial parathyroidectomy for renal hyperparathyroidism (rHPT)...
  17. doi request reprint Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 16:613-22. 2009
    ..The expression pattern of Pdx1, Shh, and PP in resected metastases can help to locate an otherwise undetected primary gastrinoma...
  18. ncbi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  19. ncbi request reprint Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Volker Fendrich
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University, Marburg, Germany
    Pancreas 30:e40-5. 2005
    ..In the present study, the involvement of TIMP3 in the tumorigenesis of 34 pancreatic adenocarcinomas was evaluated...
  20. doi request reprint Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, Philipps University, Marburg, Germany
    Ann Surg 257:308-14. 2013
    ..To evaluate the outcome of pancreaticoduodenectomy (PD) versus non-PD resections for the treatment of gastrinoma in multiple endocrine neoplasia type 1...
  21. ncbi request reprint No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cancer Lett 214:63-8. 2004
    ..No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer...
  22. doi request reprint Multimodal treatment of sporadic and inherited neuroendocrine tumors of the thymus
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Surgery 144:780-5. 2008
    ..Approximately 180 cases have been reported since their first description. NETT reveal an aggressive behavior leading to rapid local invasion and metastatic spread. An aggressive surgical approach may achieve long-term survival...
  23. doi request reprint Neuroendocrine pancreatic tumors are risk factors for pancreatic fistula after pancreatic surgery
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Dig Surg 28:263-9. 2011
    ..In the present study, we evaluated the risk of PF in a large study population of patients with neuroendocrine pancreatic tumors (NPT), pancreatic cancer (PC), and chronic pancreatitis (CP)...
  24. doi request reprint Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value
    Jens Waldmann
    Department of General Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    World J Surg 33:1208-18. 2009
    ..However, recommendations for screening modalities and intervals are based mostly on nonprospective data...
  25. doi request reprint Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstrasse, Marburg 35037, Germany
    Endocrine 35:347-55. 2009
    ..Polymorphisms of the RET gene are common (17%) and occur in familial and sporadic PC. Multiple genetic alterations including mutations, polymorphisms and intronic variants are more frequently observed in malignant PC...
  26. ncbi request reprint Prevalence of familial pancreatic cancer in Germany
    Detlef K Bartsch
    National Case Collection of Familial Pancreatic Cancer, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Cancer 110:902-6. 2004
    ..This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer...
  27. doi request reprint Surgical treatment of gastrointestinal neuroendocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Langenbecks Arch Surg 396:299-311. 2011
    ..Nonfunctional tumors do not secrete a hormone resulting in a clinical syndrome...
  28. doi request reprint German national case collection for familial pancreatic cancer (FaPaCa): ten years experience
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Fam Cancer 10:323-30. 2011
    ..Focused research projects can be conducted most efficiently, when data of different FPC registries are combined...
  29. doi request reprint Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Germany
    Ann Surg 253:546-52. 2011
    ..In this study, we address the role of the Hh pathway in tumor progression of murine islet cell tumors...
  30. doi request reprint Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Eur J Endocrinol 160:695-703. 2009
    ..In this study, we examined the expression of the EMT markers Snail, Twist and E-cadherin in normal parathyroid glands and benign and malignant parathyroid diseases...
  31. pmc LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer
    Emily P Slater
    Department of Surgery, Philipps University, Marburg, Germany
    Transl Oncol 6:99-103. 2013
    ..Although this preliminary finding needs to be validated in a large series of individuals at high risk for FPC, serum measurement of LCN2 and TIMP1 might be a promising screening tool...
  32. ncbi request reprint Familial pancreatic cancer
    Harald Rieder
    Institute of Clinical Genetics, Marburg, Germany
    Fam Cancer 3:69-74. 2004
    ..This may allow the application of invasive screening methods for the identification of early PC or, even better, its precursor lesions in high-risk individuals, providing the option of timely curative pancreatectomy...
  33. doi request reprint Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas
    Jens Waldmann
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg Oncol 16:1997-2005. 2009
    ..Twist, a target genes of Snail, is known to promote the development of distant metastases in mice. Increasing evidence suggests that EMT plays a pivotal role in tumor progression and metastatic spread...
  34. pmc Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Neoplasia 13:180-6. 2011
    ..Currently, no reliable, noninvasive imaging technique (e.g., ultrasound, computed tomography, magnet resonance imaging) exists to verify PanINs...
  35. doi request reprint Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 254:818-23; discussion 823. 2011
    ..Blockade of aberrant hedgehog activation has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with a new orally bioavailable Smoothened (Smo) antagonist LDE225 have not been examined...
  36. doi request reprint Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense?
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    World J Surg 36:2598-604. 2012
    ....
  37. doi request reprint Surgical management of pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University, Marburg, Germany
    Nat Rev Clin Oncol 6:419-28. 2009
    ..This Review describes the current status of surgical treatment for pancreatic endocrine tumors, and discusses the new developments in this field...
  38. ncbi request reprint Peripyloric lymph node metastasis is a rare condition in carcinoma of the pancreatic head
    Berthold Gerdes
    Department of Surgery, Philipps University of Marburg, Marburg, Germany
    Pancreas 31:88-92. 2005
    ..The aim of this prospective study was to identify the frequency of peripyloric and perigastric lymph node metastases in ductal adenocarcinoma of the pancreatic head (PC)...
  39. pmc An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 244:845-51; discussion 852-3. 2006
    ..To evaluate the outcome of reoperations in patients with duodenopancreatic neuroendocrine tumors (PETs) in a tertiary referral center...
  40. doi request reprint Outcome in patients with long-term treatment in a surgical intensive care unit
    Nina Weiler
    Department of Surgery, Philipps University Marburg, Baldingerstraße, Marburg, Germany
    Langenbecks Arch Surg 397:995-9. 2012
    ..This study aimed to evaluate the outcome of patients with abdominal, thoracic or vascular operations and long-term intensive care unit (ICU) treatment...
  41. doi request reprint Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Oncol 97:592-5. 2008
    ..To investigate the appearance of multiple primary malignancies in patients with sporadic neuroendocrine pancreatic tumors (NEPTs)...
  42. ncbi request reprint Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 28:1317-22. 2004
    ..e., for staging. Detection of PETs at an early stage by an aggressive screening program using EUS may lead to prompt surgical intervention and improved prognosis of MEN-1 PETs...
  43. doi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  44. doi request reprint Development of a formula to predict parathyroid carcinoma in patients with primary hyperparathyroidism
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstraße, 35043 Marburg, Germany
    World J Surg 36:2605-11. 2012
    ..Unfortunately, no reliable preoperative criteria have yet been assessed to indicate a high likelihood of PC. Thus, the aim of the present study was to develop a formula to indicate preoperatively the presence of PC...
  45. pmc CDKN2A germline mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Institute of Biometrics and Medical Epidemiology, Philipps University, Marburg, Germany
    Ann Surg 236:730-7. 2002
    ..To evaluate the prevalence of mutations in the CDKN2A gene encoding p16 and p14 in familial pancreatic cancer (FPC)...
  46. doi request reprint Outcome of surgery for primary hyperaldosteronism
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstraße 1, 35043, Marburg, Germany
    World J Surg 35:2422-7. 2011
    ..Patients who underwent laparoscopic adrenalectomy at the authors' department were followed to identify clinical parameters that predict resolution of hypertension...
  47. doi request reprint Targeting the proteasome as a promising therapeutic strategy in thyroid cancer
    Annette Wunderlich
    Department of Surgery, University Hospital of Giessen and Marburg, Philipps University of Marburg, Marburg, Germany
    J Surg Oncol 105:357-64. 2012
    ..Here we investigated the effects of bortezomib on TC in vitro. Further, the study aimed to evaluate its potential for TC treatment in vivo...
  48. ncbi request reprint Duodenal somatostatinoma associated with Von Recklinghausen's disease
    Volker Fendrich
    Department of Surgery, Philipps-University Marburg, Baldingerstrasse, D-35043 Marburg, Germany
    J Hepatobiliary Pancreat Surg 11:417-21. 2004
    ..Small tumors arising in the duodenum may be treated with local excision, whereas larger tumors should be treated by total excision, which may entail a partial pancreatoduodenectomy...
  49. ncbi request reprint The calcitonin levels can sometimes mislead parathyroid surgeons in patients with chronic kidney disease and renal hyperparathyroidism: report of a case
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Today 43:429-33. 2013
    ..The thresholds for calcitonin levels need to be better defined in affected patients to determine the optimal extent of surgical resection...
  50. ncbi request reprint Chromosome 22q in pancreatic endocrine tumors: identification of a homozygous deletion and potential prognostic associations of allelic deletions
    Anja Wild
    Department of General Surgery, Philipps-University of Marburg, Baldingerstrasse, Marburg/Lahn 35043, Germany
    Eur J Endocrinol 147:507-13. 2002
    ..78; P<0.0001). CONCLUSIONS: These findings are suggestive for novel tumor suppressor gene loci at chromosome 22q that might contribute to the pathogenesis of PETs, especially to the development of distant metastases...
  51. doi request reprint An economic comparison of surgical and medical therapy in patients with secondary hyperparathyroidism--the German perspective
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Marburg, Germany
    Surgery 148:1091-9. 2010
    ..Limitations of resources in public health systems demand detailed analyses of accruing costs. The aim of this study was to compare the costs of these new treatment modalities to surgery...
  52. ncbi request reprint Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target
    Dorothee Karhoff
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 85:45-53. 2007
    ..In addition, we explored the effect of suppressing B-Raf kinase by the recently developed inhibitor BAY43-9006 (Sorafinib) on growth, apoptosis and MAPK activation neuroendocrine cell lines...
  53. doi request reprint Transoral thyroid and parathyroid surgery
    Elias Karakas
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Endosc 24:1261-7. 2010
    ..Moreover, minimally invasive procedures have found their way into thyroid and parathyroid surgery. Our goal was to develop a new access for thyroid and parathyroid resection via an entirely transoral approach...
  54. ncbi request reprint Adrenal involvement in multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 26:891-6. 2002
    ..The lesions are often small and nonfunctional and can therefore be managed by close surveillance; others have significant malignant potential and should be considered for surgery when they are 3 cm or larger...