Detlef K Bartsch

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. pmc Total versus near-total thyroidectomy in Graves' disease and their outcome on postoperative transient hypoparathyroidism: study protocol for a randomized controlled trial?
    Katja Maschuw
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg GmbH Location Marburg, Baldingerstrasse, Marburg, D 35043, Germany
    Trials 13:234. 2012
  2. pmc Design and current status of CONTINT: continuous versus interrupted abdominal wall closure after emergency midline laparotomy - a randomized controlled multicenter trial [NCT00544583]
    Nuh N Rahbari
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    Trials 13:72. 2012
  3. doi request reprint Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
    D K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    Fam Cancer 12:89-96. 2013
  4. doi request reprint Familial pancreatic cancer--current knowledge
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35041 Marburg, Germany
    Nat Rev Gastroenterol Hepatol 9:445-53. 2012
  5. doi request reprint Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
  6. doi request reprint Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 42:637-46. 2012
  7. doi request reprint Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
  8. ncbi request reprint Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
  9. doi request reprint Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
  10. ncbi request reprint Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Volker Fendrich
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University, Marburg, Germany
    Pancreas 30:e40-5. 2005

Collaborators

Detail Information

Publications69

  1. pmc Total versus near-total thyroidectomy in Graves' disease and their outcome on postoperative transient hypoparathyroidism: study protocol for a randomized controlled trial?
    Katja Maschuw
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg GmbH Location Marburg, Baldingerstrasse, Marburg, D 35043, Germany
    Trials 13:234. 2012
    ....
  2. pmc Design and current status of CONTINT: continuous versus interrupted abdominal wall closure after emergency midline laparotomy - a randomized controlled multicenter trial [NCT00544583]
    Nuh N Rahbari
    Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany
    Trials 13:72. 2012
    ..The present randomized controlled trial evaluates the efficacy and safety of two commonly applied abdominal wall closure strategies in patients undergoing primary emergency midline laparotomy...
  3. doi request reprint Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
    D K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    Fam Cancer 12:89-96. 2013
    ..In the setting of FPC, the presence of multiple small "imaging" BD-IPMNs may indicate the presence of high-grade PanIN lesions elsewhere in the pancreas...
  4. doi request reprint Familial pancreatic cancer--current knowledge
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35041 Marburg, Germany
    Nat Rev Gastroenterol Hepatol 9:445-53. 2012
    ..This Review focuses on the clinical phenotype of FPC, its histopathological characteristics, known underlying genetic changes and associated genetic counselling and screening...
  5. doi request reprint Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families
    Emily P Slater
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Fam Cancer 9:335-43. 2010
    ..8-11.4%) were thus identified in 70 German FPC families, indicating that the prevalence of BRCA2 mutations in the German FPC population is less frequent than previously reported...
  6. doi request reprint Combined inhibition of cellular pathways as a future therapeutic option in fatal anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 42:637-46. 2012
    ..The efficacy of this therapeutic approach remains to be revised by in vivo and clinical application...
  7. doi request reprint Long-term results of surgery for pancreatic neuroendocrine neoplasms in patients with MEN1
    Caroline L Lopez
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1187-96. 2011
    ..This study was made to evaluate long-term results of an aggressive surgical approach for pancreaticoduodenal neuroendocrine neoplasms (pNENs) in patients with multiple endocrine neoplasia type 1 (MEN1)...
  8. ncbi request reprint Microarray analysis reveals differential expression of benign and malignant pheochromocytoma
    Jens Waldmann
    Department of Surgery, Philipps Universitat Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 17:743-56. 2010
    ..Based on these findings, the strategy for further follow-up and treatment could be modified accordingly...
  9. doi request reprint Frequency of ectopic and supernumerary intrathymic parathyroid glands in patients with renal hyperparathyroidism: analysis of 461 patients undergoing initial parathyroidectomy with bilateral cervical thymectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 35:1260-5. 2011
    ..However, routine bilateral cervical thymectomy (BCT) is still discussed, although controversially...
  10. ncbi request reprint Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas
    Volker Fendrich
    Department of Visceral, Thoracic, and Vascular Surgery, Philipps University, Marburg, Germany
    Pancreas 30:e40-5. 2005
    ..In the present study, the involvement of TIMP3 in the tumorigenesis of 34 pancreatic adenocarcinomas was evaluated...
  11. doi request reprint Calcitonin-secreting pancreatic endocrine tumors: systematic analysis of a rare tumor entity
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Germany
    Pancreas 40:213-21. 2011
    ..Reports focusing on calcitonin-secreting PET (CTsPETs) are very rare. This study aimed to define a CTsPET-associated syndrome in regard to chemical, anatomical, and developmental aspects...
  12. ncbi request reprint RNASEL germline variants are associated with pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Philipps University, Marburg, Germany
    Int J Cancer 117:718-22. 2005
    ..04) than patients with the wild-type genotype. Our results suggest that RNASEL variants Glu265X and Arg462Gln may contribute to the tumorigenesis of sporadic and familial pancreatic cancer, which has to be proven in large scale studies...
  13. pmc Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Surgery, Division of Endocrinology, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Ann Surg 242:757-64, discussion 764-6. 2005
    ..To evaluate the outcome of an aggressive surgical approach for duodenopancreatic neuroendocrine tumors (PETs) associated with multiple endocrine neoplasia type 1 (MEN1)...
  14. ncbi request reprint Relevance of bilateral cervical thymectomy in patients with renal hyperparathyroidism: analysis of 161 patients undergoing reoperative parathyroidectomy
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    World J Surg 37:2155-61. 2013
    ..The aim of this study was to evaluate how often reoperation might have been avoidable if an appropriate cervical thymectomy had been performed during initial surgery...
  15. doi request reprint Mutations and polymorphisms in the SDHB, SDHD, VHL, and RET genes in sporadic and familial pheochromocytomas
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstrasse, Marburg 35037, Germany
    Endocrine 35:347-55. 2009
    ..Polymorphisms of the RET gene are common (17%) and occur in familial and sporadic PC. Multiple genetic alterations including mutations, polymorphisms and intronic variants are more frequently observed in malignant PC...
  16. doi request reprint The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Gut 59:630-7. 2010
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of these drugs...
  17. doi request reprint Reoperations for primary hyperparathyroidism--improvement of outcome over two decades
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstraße, 35043 Marburg, Germany
    Langenbecks Arch Surg 398:99-106. 2013
    ....
  18. doi request reprint Clinical impact of TP53 alterations in adrenocortical carcinomas
    Jens Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 397:209-16. 2012
    ..To evaluate the role of somatic TP53 mutations and to correlate somatic and germline mutations with results of immunostaining, a large cohort of ACC patients was analyzed...
  19. doi request reprint Impact of CT-based diagnostic imaging on management and outcome of nonfunctioning pancreatic tumors
    Katja Maschuw
    Department of Surgery, Philipps University Marburg, Baldingerstraße, 35043, Marburg, Germany
    Langenbecks Arch Surg 396:1181-6. 2011
    ..The aim of this study was to assess the impact of improved imaging on these features in a tertiary referral centre within a 20-year follow-up...
  20. doi request reprint Transoral thyroid and parathyroid surgery--development of a new transoral technique
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Germany
    Surgery 150:108-15. 2011
    ..We previously described a transoral access for (para-)thyroid resection in pigs. To proceed with the first clinical trials, we evaluated the safety of the new technique...
  21. doi request reprint Initial parathyroid surgery in 606 patients with renal hyperparathyroidism
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Baldingerstrasse, 35043, Marburg, Germany
    World J Surg 36:318-26. 2012
    ..The aim of the present study was to evaluate the outcome of different surgical procedures for patients on permanent dialysis who underwent initial parathyroidectomy for renal hyperparathyroidism (rHPT)...
  22. doi request reprint Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 16:613-22. 2009
    ..The expression pattern of Pdx1, Shh, and PP in resected metastases can help to locate an otherwise undetected primary gastrinoma...
  23. ncbi request reprint Outcome of surgery for ileojejunal neuroendocrine tumors
    Nils Habbe
    Department of Surgery, University Hospital Marburg, Baldingerstraße, 35043, Marburg, Germany
    Surg Today 43:1168-74. 2013
    ..Neuroendocrine tumors (NET) of the ileum/jejunum are rare and may require different treatment options to provide long-term survival. The purpose of the study was to evaluate the outcome of surgery for ileojejunal NET...
  24. ncbi request reprint Prevalence of familial pancreatic cancer in Germany
    Detlef K Bartsch
    National Case Collection of Familial Pancreatic Cancer, Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Int J Cancer 110:902-6. 2004
    ..This prevalence is lower than so far postulated in the literature. There were no significant clinical differences between the familial and sporadic form of pancreatic cancer...
  25. ncbi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  26. doi request reprint Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, Philipps University, Marburg, Germany
    Ann Surg 257:308-14. 2013
    ..To evaluate the outcome of pancreaticoduodenectomy (PD) versus non-PD resections for the treatment of gastrinoma in multiple endocrine neoplasia type 1...
  27. ncbi request reprint No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma
    Robert Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cancer Lett 214:63-8. 2004
    ..No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer...
  28. doi request reprint Neuroendocrine pancreatic tumors are risk factors for pancreatic fistula after pancreatic surgery
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Dig Surg 28:263-9. 2011
    ..In the present study, we evaluated the risk of PF in a large study population of patients with neuroendocrine pancreatic tumors (NPT), pancreatic cancer (PC), and chronic pancreatitis (CP)...
  29. ncbi request reprint Multimodal treatment of sporadic and inherited neuroendocrine tumors of the thymus
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Surgery 144:780-5. 2008
    ..Approximately 180 cases have been reported since their first description. NETT reveal an aggressive behavior leading to rapid local invasion and metastatic spread. An aggressive surgical approach may achieve long-term survival...
  30. doi request reprint Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value
    Jens Waldmann
    Department of General Surgery, Philipps University Marburg, Baldingerstrasse, 35033, Marburg, Germany
    World J Surg 33:1208-18. 2009
    ..However, recommendations for screening modalities and intervals are based mostly on nonprospective data...
  31. doi request reprint Pretherapeutic drug evaluation by tumor xenografting in anaplastic thyroid cancer
    Annette Wunderlich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Res 185:676-83. 2013
    ..Results of preclinical investigations are often of limited transferability to clinical tumor biology. Individualized multimodal treatment regimens, including novel growth-inhibiting drugs, might be a future option...
  32. doi request reprint Surgical treatment of gastrointestinal neuroendocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, Marburg, Germany
    Langenbecks Arch Surg 396:299-311. 2011
    ..Nonfunctional tumors do not secrete a hormone resulting in a clinical syndrome...
  33. doi request reprint Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Germany
    Ann Surg 253:546-52. 2011
    ..In this study, we address the role of the Hh pathway in tumor progression of murine islet cell tumors...
  34. doi request reprint German national case collection for familial pancreatic cancer (FaPaCa): ten years experience
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Fam Cancer 10:323-30. 2011
    ..Focused research projects can be conducted most efficiently, when data of different FPC registries are combined...
  35. doi request reprint Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Eur J Endocrinol 160:695-703. 2009
    ..In this study, we examined the expression of the EMT markers Snail, Twist and E-cadherin in normal parathyroid glands and benign and malignant parathyroid diseases...
  36. ncbi request reprint Aspirin prolongs survival and reduces the number of Foxp3+ regulatory T cells in a genetically engineered mouse model of pancreatic cancer
    Lars Plassmeier
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043, Marburg, Germany
    Langenbecks Arch Surg 398:989-96. 2013
    ..In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemotherapeutic potential of aspirin as an adjuvant agent to gemcitabine...
  37. doi request reprint Expression of hedgehog signalling pathway in anaplastic thyroid cancer
    Ulrike Hinterseher
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Endocrine 45:439-47. 2014
    ..Aberrant activation of this pathway might be involved in the aggressive biology of anaplastic cancer and further evaluation regarding a possible clinical impact of pathway inhibition is warranted...
  38. ncbi request reprint Simvastatin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany Electronic address
    Pancreatology 13:502-7. 2013
    ..Recent evidence suggests that statins have potential chemopreventive abilities. In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of this drug...
  39. ncbi request reprint The calcitonin levels can sometimes mislead parathyroid surgeons in patients with chronic kidney disease and renal hyperparathyroidism: report of a case
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Today 43:429-33. 2013
    ..The thresholds for calcitonin levels need to be better defined in affected patients to determine the optimal extent of surgical resection...
  40. pmc LCN2 and TIMP1 as Potential Serum Markers for the Early Detection of Familial Pancreatic Cancer
    Emily P Slater
    Department of Surgery, Philipps University, Marburg, Germany
    Transl Oncol 6:99-103. 2013
    ..Although this preliminary finding needs to be validated in a large series of individuals at high risk for FPC, serum measurement of LCN2 and TIMP1 might be a promising screening tool...
  41. ncbi request reprint Familial pancreatic cancer
    Harald Rieder
    Institute of Clinical Genetics, Marburg, Germany
    Fam Cancer 3:69-74. 2004
    ..This may allow the application of invasive screening methods for the identification of early PC or, even better, its precursor lesions in high-risk individuals, providing the option of timely curative pancreatectomy...
  42. doi request reprint Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 254:818-23; discussion 823. 2011
    ..Blockade of aberrant hedgehog activation has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with a new orally bioavailable Smoothened (Smo) antagonist LDE225 have not been examined...
  43. doi request reprint Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomas
    Jens Waldmann
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg Oncol 16:1997-2005. 2009
    ..Twist, a target genes of Snail, is known to promote the development of distant metastases in mice. Increasing evidence suggests that EMT plays a pivotal role in tumor progression and metastatic spread...
  44. pmc Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Neoplasia 13:180-6. 2011
    ..Currently, no reliable, noninvasive imaging technique (e.g., ultrasound, computed tomography, magnet resonance imaging) exists to verify PanINs...
  45. ncbi request reprint Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 28:1317-22. 2004
    ..e., for staging. Detection of PETs at an early stage by an aggressive screening program using EUS may lead to prompt surgical intervention and improved prognosis of MEN-1 PETs...
  46. ncbi request reprint Familial pancreatic cancer syndromes
    Nils Habbe
    Department of Surgery, Philipps University Marburg, Baldiger Strasse, Marburg 35033, Germany
    Endocrinol Metab Clin North Am 35:417-30, xi. 2006
    ....
  47. ncbi request reprint Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors
    Anja Wild
    Department of Surgery, Philipps University Marburg, 35043 Marburg, Germany
    J Clin Endocrinol Metab 88:1367-73. 2003
    ..02). These data suggest a possibly important role of TIMP-3 in the tumorigenesis of human PETs, especially in the development of metastases, which has to be further evaluated in large-scale studies...
  48. doi request reprint Cryopreservation of parathyroid tissue after parathyroid surgery for renal hyperparathyroidism: does it really make sense?
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
    World J Surg 36:2598-604. 2012
    ....
  49. ncbi request reprint Peripyloric lymph node metastasis is a rare condition in carcinoma of the pancreatic head
    Berthold Gerdes
    Department of Surgery, Philipps University of Marburg, Marburg, Germany
    Pancreas 31:88-92. 2005
    ..The aim of this prospective study was to identify the frequency of peripyloric and perigastric lymph node metastases in ductal adenocarcinoma of the pancreatic head (PC)...
  50. ncbi request reprint Surgical management of pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University, Marburg, Germany
    Nat Rev Clin Oncol 6:419-28. 2009
    ..This Review describes the current status of surgical treatment for pancreatic endocrine tumors, and discusses the new developments in this field...
  51. pmc An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    Ann Surg 244:845-51; discussion 852-3. 2006
    ..To evaluate the outcome of reoperations in patients with duodenopancreatic neuroendocrine tumors (PETs) in a tertiary referral center...
  52. doi request reprint Outcome in patients with long-term treatment in a surgical intensive care unit
    Nina Weiler
    Department of Surgery, Philipps University Marburg, Baldingerstraße, Marburg, Germany
    Langenbecks Arch Surg 397:995-9. 2012
    ..This study aimed to evaluate the outcome of patients with abdominal, thoracic or vascular operations and long-term intensive care unit (ICU) treatment...
  53. doi request reprint Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Marburg, Germany
    J Surg Oncol 97:592-5. 2008
    ..To investigate the appearance of multiple primary malignancies in patients with sporadic neuroendocrine pancreatic tumors (NEPTs)...
  54. doi request reprint Development of a formula to predict parathyroid carcinoma in patients with primary hyperparathyroidism
    Elias Karakas
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Baldingerstraße, 35043 Marburg, Germany
    World J Surg 36:2605-11. 2012
    ..Unfortunately, no reliable preoperative criteria have yet been assessed to indicate a high likelihood of PC. Thus, the aim of the present study was to develop a formula to indicate preoperatively the presence of PC...
  55. doi request reprint Shortness: an unknown phenotype of multiple endocrine neoplasia type 1
    Caroline L Lopez
    Department of Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Eur J Endocrinol 169:133-7. 2013
    ....
  56. pmc CDKN2A germline mutations in familial pancreatic cancer
    Detlef K Bartsch
    Department of Surgery, Institute of Biometrics and Medical Epidemiology, Philipps University, Marburg, Germany
    Ann Surg 236:730-7. 2002
    ..To evaluate the prevalence of mutations in the CDKN2A gene encoding p16 and p14 in familial pancreatic cancer (FPC)...
  57. doi request reprint Outcome of surgery for primary hyperaldosteronism
    Jens Waldmann
    Department of Surgery, University Hospital Giessen and Marburg, Baldingerstraße 1, 35043, Marburg, Germany
    World J Surg 35:2422-7. 2011
    ..Patients who underwent laparoscopic adrenalectomy at the authors' department were followed to identify clinical parameters that predict resolution of hypertension...
  58. doi request reprint Enucleation and limited pancreatic resection provide long-term cure for insulinoma in multiple endocrine neoplasia type 1
    Detlef K Bartsch
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 98:290-8. 2013
    ..To assess the characteristics and long-term outcome after surgery in patients with multiple endocrine neoplasia type 1 (MEN1)-associated insulinoma...
  59. doi request reprint Increased rate of clinically relevant pancreatic fistula after deep enucleation of small pancreatic tumors
    Kristin Heeger
    Department of Surgery, Philipps University, Baldingerstraße, D 35043, Marburg, Germany
    Langenbecks Arch Surg 399:315-21. 2014
    ..This study evaluates the outcome of enucleations with regard to their distance to the MPD...
  60. ncbi request reprint Duodenal somatostatinoma associated with Von Recklinghausen's disease
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    J Hepatobiliary Pancreat Surg 11:417-21. 2004
    ..Small tumors arising in the duodenum may be treated with local excision, whereas larger tumors should be treated by total excision, which may entail a partial pancreatoduodenectomy...
  61. doi request reprint Targeting the proteasome as a promising therapeutic strategy in thyroid cancer
    Annette Wunderlich
    Department of Surgery, University Hospital of Giessen and Marburg, Philipps University of Marburg, Marburg, Germany
    J Surg Oncol 105:357-64. 2012
    ..Here we investigated the effects of bortezomib on TC in vitro. Further, the study aimed to evaluate its potential for TC treatment in vivo...
  62. pmc Airtightness of lung parenchyma without a closing suture after atypical resection using the Nd:YAG Laser LIMAX 120
    Andreas Kirschbaum
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany
    Interact Cardiovasc Thorac Surg 18:92-5. 2014
    ..However, the lung tissue may be restricted by the sutures once it is re-ventilated. Thus, it was analysed whether the lung parenchyma is airtight after laser resection without suturing the defect...
  63. ncbi request reprint Chromosome 22q in pancreatic endocrine tumors: identification of a homozygous deletion and potential prognostic associations of allelic deletions
    Anja Wild
    Department of General Surgery, Philipps University of Marburg, Baldingerstrasse, Marburg Lahn 35043, Germany
    Eur J Endocrinol 147:507-13. 2002
    ..A variety of human tumors frequently show allelic deletions of chromosome 22q, suggesting that inactivation of one or more tumor suppressor genes in this region is important for their tumorigenesis...
  64. doi request reprint An economic comparison of surgical and medical therapy in patients with secondary hyperparathyroidism--the German perspective
    Ralph Schneider
    Department of Visceral, Thoracic and Vascular Surgery, Philipps University, Marburg, Germany
    Surgery 148:1091-9. 2010
    ..Limitations of resources in public health systems demand detailed analyses of accruing costs. The aim of this study was to compare the costs of these new treatment modalities to surgery...
  65. ncbi request reprint Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target
    Dorothee Karhoff
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany
    Neuroendocrinology 85:45-53. 2007
    ..In addition, we explored the effect of suppressing B-Raf kinase by the recently developed inhibitor BAY43-9006 (Sorafinib) on growth, apoptosis and MAPK activation neuroendocrine cell lines...
  66. pmc Comparison of local tissue damage: monopolar cutter versus Nd:YAG laser for lung parenchyma resection. An experimental study
    Andreas Kirschbaum
    Visceral, Thoracic and Vascular Surgery Clinic, University Hospital Giessen and Marburg GmbH, Marburg, Germany
    Interact Cardiovasc Thorac Surg 18:1-6. 2014
    ..The aim of this experimental study was to investigate which instrument causes less lung-tissue damage at the same power output...
  67. doi request reprint Transabdominal preperitoneal versus totally extraperitoneal repair of inguinal hernia: a meta-analysis of randomized studies
    Stavros A Antoniou
    Department of General and Visceral Surgery, Center for Minimally Invasive Surgery, Hospital Neuwerk, Mönchengladbach, Germany
    Am J Surg 206:245-252.e1. 2013
    ..The aim of the present study was to comparatively evaluate the outcomes of laparoscopic transabdominal preperitoneal inguinal hernia repair and totally extraperitoneal repair...
  68. doi request reprint Transoral thyroid and parathyroid surgery
    Elias Karakas
    Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany
    Surg Endosc 24:1261-7. 2010
    ..Moreover, minimally invasive procedures have found their way into thyroid and parathyroid surgery. Our goal was to develop a new access for thyroid and parathyroid resection via an entirely transoral approach...
  69. ncbi request reprint Adrenal involvement in multiple endocrine neoplasia type 1
    Peter Langer
    Department of Surgery, Philipps University Hospital, Baldingerstrasse, D 35043 Marburg, Germany
    World J Surg 26:891-6. 2002
    ..The lesions are often small and nonfunctional and can therefore be managed by close surveillance; others have significant malignant potential and should be considered for surgery when they are 3 cm or larger...