B Nieswandt

Summary

Affiliation: Philipp Klee-Institute of Clinical Pharmacology
Country: Germany

Publications

  1. ncbi Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, Wuppertal, Germany
    Blood 96:2520-7. 2000
  2. pmc Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    J Exp Med 193:459-69. 2001
  3. ncbi Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, Arrenbergerstrasse 20, 42117 Wuppertal, Germany
    Blood 97:3829-35. 2001
  4. pmc Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
  5. ncbi Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha
    W Bergmeier
    Department of Molecular Oncology, General Surgery, Witten/Herdecke University, Arrenbergerstr. 20, Haus 10, 42117 Wuppertal, Germany
    J Biol Chem 276:25121-6. 2001
  6. ncbi Evidence for two distinct epitopes within collagen for activation of murine platelets
    V Schulte
    Department of Molecular Oncology, General Surgery, Witten/Herdecke University, 42117 Wuppertal, Germany
    J Biol Chem 276:364-8. 2001
  7. ncbi Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, 42283 Wuppertal, Germany
    J Biol Chem 275:23998-4002. 2000
  8. ncbi Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation
    S Moog
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Blood 98:1038-46. 2001
  9. ncbi The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism
    G Kauffenstein
    INSERM U.311, , 10 rue Spielmann, 67065 Strasbourg Cedex, France
    FEBS Lett 505:281-90. 2001
  10. ncbi A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1
    P Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    FEBS Lett 542:53-9. 2003

Collaborators

Detail Information

Publications13

  1. ncbi Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, Wuppertal, Germany
    Blood 96:2520-7. 2000
    ....
  2. pmc Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    J Exp Med 193:459-69. 2001
    ....
  3. ncbi Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, Arrenbergerstrasse 20, 42117 Wuppertal, Germany
    Blood 97:3829-35. 2001
    ..Together, these results provide evidence for a cross-talk between (dimerized) GPVI and Gi-coupled receptors during collagen-induced platelet aggregation. (Blood. 2001;97:3829-3835)..
  4. pmc Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
    ..These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential...
  5. ncbi Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha
    W Bergmeier
    Department of Molecular Oncology, General Surgery, Witten/Herdecke University, Arrenbergerstr. 20, Haus 10, 42117 Wuppertal, Germany
    J Biol Chem 276:25121-6. 2001
    ..These results demonstrate that rhodocytin induces platelet activation by mechanisms that are fundamentally different from those induced by collagen...
  6. ncbi Evidence for two distinct epitopes within collagen for activation of murine platelets
    V Schulte
    Department of Molecular Oncology, General Surgery, Witten/Herdecke University, 42117 Wuppertal, Germany
    J Biol Chem 276:364-8. 2001
    ..The possibility that this response is mediated by a receptor that is not coupled to FcR gamma-chain is excluded on the grounds that aggregation is absent in platelets from FcR gamma-chain-deficient mice...
  7. ncbi Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, 42283 Wuppertal, Germany
    J Biol Chem 275:23998-4002. 2000
    ..These results strongly suggest that GPVI is the collagen receptor responsible for platelet activation in mice and demonstrate that the association with the FcRgamma chain is critical for its expression and function...
  8. ncbi Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation
    S Moog
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Blood 98:1038-46. 2001
    ..In conclusion, GPV binds to collagen and appears to be required for normal platelet responses to this agonist. (Blood. 2001;98:1038-1046)..
  9. ncbi The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism
    G Kauffenstein
    INSERM U.311, , 10 rue Spielmann, 67065 Strasbourg Cedex, France
    FEBS Lett 505:281-90. 2001
    ....
  10. ncbi A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1
    P Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    FEBS Lett 542:53-9. 2003
    ....
  11. ncbi Platelets in atherothrombosis: lessons from mouse models
    B Nieswandt
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    J Thromb Haemost 3:1725-36. 2005
    ..This review will summarize key findings made by these approaches and discuss them in the context of human disease...
  12. ncbi Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation
    N Chouchakova
    Departments of Clinical Immunology and Functional Anatomy, Medical School Hannover, Hannover, Germany
    J Immunol 166:5193-200. 2001
    ....
  13. ncbi Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides
    M P Gratacap
    Pharmakologisches Institut, Universitat Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany
    J Biol Chem 276:47906-13. 2001
    ..Cyclic AMP and cGMP differentially interfere with -induced Rho and Rac activation at least in part by selective effects on the regulation of individual G-proteins through the TXA(2) receptor...