D Pfander

Summary

Country: Germany

Publications

  1. pmc Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints
    Kolja Gelse
    Division of Orthopaedic Rheumatology, University of Erlangen Nuremberg, Rathsberger Strasse 57, Erlangen 91054, Germany
    Arthritis Res Ther 10:R111. 2008
  2. ncbi request reprint Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments
    David Pfander
    Department of Orthopaedic Rehabilitation, Medical Park Bad Rodach, Bad Rodach, Germany
    Curr Opin Rheumatol 19:457-62. 2007
  3. pmc The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis
    David Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 8:104. 2006
  4. pmc Hypoxia and HIF-1alpha in osteoarthritis
    David Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, Im Waldkrankenhaus St Marien, University of Erlangen Nuremberg, Rathsbergerstr 57, 91054 Erlangen, Germany
    Int Orthop 29:6-9. 2005
  5. pmc Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis
    D Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 63:240-4. 2004
  6. pmc Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage
    D Pfander
    Department of Orthopaedic Surgery, University of Erlangen Nuernberg, Germany
    Ann Rheum Dis 59:448-54. 2000
  7. pmc Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints
    D Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery im Waldkrankenhaus St Marien, University of Erlangen Nuernberg, Erlangen, Germany
    Ann Rheum Dis 60:1070-3. 2001
  8. pmc Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes
    D Pfander
    Department of Orthopedic Surgery, Division of Orthopedic Rheumatology, University of Erlangen Nuernberg, Erlangen, Germany
    Am J Pathol 159:1777-83. 2001
  9. ncbi request reprint Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes
    C Grimmer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:4084-94. 2007
  10. ncbi request reprint [Talonavicular arthrodesis for the rheumatoid foot]
    H D Carl
    Orthopädisch Rheumatologische Abteilung, Friedrich Alexander Universitat Erlangen Nurnberg, Im Waldkrankenhaus St Marien, Rathsberger Strasse 57, 91054 Erlangen
    Z Rheumatol 65:633-6, 638-9. 2006

Collaborators

Detail Information

Publications16

  1. pmc Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints
    Kolja Gelse
    Division of Orthopaedic Rheumatology, University of Erlangen Nuremberg, Rathsberger Strasse 57, Erlangen 91054, Germany
    Arthritis Res Ther 10:R111. 2008
    ..The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1 alpha by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of osteoarthritis in murine knee joints...
  2. ncbi request reprint Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments
    David Pfander
    Department of Orthopaedic Rehabilitation, Medical Park Bad Rodach, Bad Rodach, Germany
    Curr Opin Rheumatol 19:457-62. 2007
    ..This review summarizes the current knowledge about hypoxia and hypoxia-inducible factor-1 (HIF-1) for chondrocyte survival, energy generation and matrix synthesis of articular chondrocytes during cartilage homeostasis and disease...
  3. pmc The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis
    David Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 8:104. 2006
    ..With this commentary we aim to briefly discuss the recently published literature in this field...
  4. pmc Hypoxia and HIF-1alpha in osteoarthritis
    David Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, Im Waldkrankenhaus St Marien, University of Erlangen Nuremberg, Rathsbergerstr 57, 91054 Erlangen, Germany
    Int Orthop 29:6-9. 2005
    ..Thus, we assume that chondrocytes are depending on the adaptive functions of HIF-1alpha in order to maintain ATP levels and thereby matrix synthesis during the course of osteoarthritis...
  5. pmc Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis
    D Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Ann Rheum Dis 63:240-4. 2004
    ....
  6. pmc Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage
    D Pfander
    Department of Orthopaedic Surgery, University of Erlangen Nuernberg, Germany
    Ann Rheum Dis 59:448-54. 2000
    ..Therefore, to localise TSP-1 and its receptors immunohistochemistry and in situ hybridisation were used...
  7. pmc Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints
    D Pfander
    Division of Orthopaedic Rheumatology, Department of Orthopaedic Surgery im Waldkrankenhaus St Marien, University of Erlangen Nuernberg, Erlangen, Germany
    Ann Rheum Dis 60:1070-3. 2001
    ..To determine the levels of vascular endothelial growth factor (VEGF) mRNA and protein expression in normal and osteoarthritic (OA) human articular cartilage, and whether VEGF expression alters during the progression of OA...
  8. pmc Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes
    D Pfander
    Department of Orthopedic Surgery, Division of Orthopedic Rheumatology, University of Erlangen Nuernberg, Erlangen, Germany
    Am J Pathol 159:1777-83. 2001
    ..These results suggest that the expression of early (proliferating cell nuclear antigen, syndecan-3) and late differentiation markers (annexin VI, alkaline phosphatase) is activated in chondrocytes of osteoarthritic cartilage...
  9. ncbi request reprint Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes
    C Grimmer
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 56:4084-94. 2007
    ....
  10. ncbi request reprint [Talonavicular arthrodesis for the rheumatoid foot]
    H D Carl
    Orthopädisch Rheumatologische Abteilung, Friedrich Alexander Universitat Erlangen Nurnberg, Im Waldkrankenhaus St Marien, Rathsberger Strasse 57, 91054 Erlangen
    Z Rheumatol 65:633-6, 638-9. 2006
    ..Talonavicular joint fusion has been successfully applied for the surgical treatment of the rheumatoid foot. Several fixation techniques have been suggested for this purpose, however, with high rates of non-union...
  11. pmc Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels
    Claudia Grimmer
    Division of Orthopedic Rheumatology, Department of Orthopedic Surgery im Waldkrankenhaus St Marien, University of Erlangen Nuremberg, Rathsbergerstrasse 57, D 91054 Erlangen, Germany
    Am J Pathol 169:491-502. 2006
    ....
  12. ncbi request reprint [Meeting report of the "Arthrosis Research in Germany" Professional Seminar of the Arthrosis Research Society 26/27 September 2003 in Erlangen]
    D Pfander
    Abteilung für Orthopädische Rheumatologie der Friedrich Alexander Universität Erlangen Nürnberg, Rathsbergerstr 57, 91054 Erlangen, Germany
    Z Rheumatol 63:88-9. 2004
  13. ncbi request reprint HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes
    David Pfander
    Division of Orthopedic Rheumatology, Department of Orthopedic Surgery, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Cell Sci 116:1819-26. 2003
    ..In summary, our results clearly demonstrate the importance of HIF-1alpha in maintenance of anaerobic glycolysis, and thereby extracellular matrix synthesis, of epiphyseal chondrocytes...
  14. ncbi request reprint [The influence of laser irradiation of low-power density on an experimental cartilage damage in rabbit knee-joints: an in vivo investigation considering macroscopic, histological and immunohistochemical changes]
    David Pfander
    Orthopadische Klinik, Friederich Alexander Universität Erlangen Nürnberg, Rathsberger Strasse 57, 91054 Erlangen, Deutschland
    Biomed Tech (Berl) 51:131-8. 2006
    ..Thus, it could be demonstrated in vivo that an arthrotic process decelerates through the influence of laser light of low-energy densities...
  15. ncbi request reprint Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
    David Pfander
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Development 131:2497-508. 2004
    ..This is the first study reporting the novel and intriguing findings that pVHL has a crucial role in endochondral bone development and is necessary for normal chondrocyte proliferation in vivo...
  16. ncbi request reprint Functional differences between growth plate apoptotic bodies and matrix vesicles
    Thorsten Kirsch
    Department of Orthopaedics, Musculoskeletal Research Laboratories, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Bone Miner Res 18:1872-81. 2003
    ..Therefore, different therapeutic approaches must be chosen to inhibit pathological mineralization depending on the mechanism of mineralization (matrix vesicles versus apoptotic bodies)...