Oliver Pfaar

Summary

Country: Germany

Publications

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  3. ncbi request reprint Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
    Am J Rhinol Allergy 24:220-5. 2010
  4. doi request reprint [Cluster immunotherapy of persistent allergic rhinoconjunctivitis. Safety aspects of induction therapy with mite depot allergen preparations]
    O Pfaar
    HNO Universitätsklinik, Mannheim
    HNO 57:1099-105. 2009
  5. doi request reprint Safety of two cluster schedules for subcutaneous immunotherapy in allergic rhinitis or asthma patients sensitized to inhalant allergens
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden DE 65189, Germany
    Int Arch Allergy Immunol 150:102-8. 2009
  6. doi request reprint Pathophysiology of itching and sneezing in allergic rhinitis
    Oliver Pfaar
    Center for Allergy and Rhinology, Wiesbaden, Germany
    Swiss Med Wkly 139:35-40. 2009
  7. doi request reprint [Specific immunotherapy for allergic rhinitis. Current methods and innovative developments]
    O Pfaar
    Zentrum für Rhinologie und Allergologie der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
    HNO 56:764-75. 2008
  8. ncbi request reprint Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial
    Oliver Pfaar
    Rhinology and Allergology Center, Wiesbaden, Germany
    Ann Allergy Asthma Immunol 100:256-63. 2008
  9. ncbi request reprint [Application of humanized Anti-IgE antibodies (omalizumab). A new principle in the treatment of allergic diseases in ENT medicine]
    O Pfaar
    Zentrum für Rhinologie und Allergologie Wiesbaden der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
    HNO 55:981-90; quiz 991-2. 2007
  10. ncbi request reprint Treatment of hypertrophic palatine tonsils using bipolar radiofrequency-induced thermotherapy (RFITT.)
    O Pfaar
    Department of Otorhinolaryngology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Acta Otolaryngol 127:1176-81. 2007

Collaborators

Detail Information

Publications32

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  3. ncbi request reprint Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden, Germany
    Am J Rhinol Allergy 24:220-5. 2010
    ..Clinical efficacy of specific immunotherapy (SIT) with depigmented, polymerized allergen extracts is well documented in placebo-controlled trials, and safety data are encouraging although further data are required...
  4. doi request reprint [Cluster immunotherapy of persistent allergic rhinoconjunctivitis. Safety aspects of induction therapy with mite depot allergen preparations]
    O Pfaar
    HNO Universitätsklinik, Mannheim
    HNO 57:1099-105. 2009
    ..In cluster SIT, 2-3 injections per treatment day are applied resulting in an accelerated achievement of the maintenance dose...
  5. doi request reprint Safety of two cluster schedules for subcutaneous immunotherapy in allergic rhinitis or asthma patients sensitized to inhalant allergens
    O Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, An den Quellen 10, Wiesbaden DE 65189, Germany
    Int Arch Allergy Immunol 150:102-8. 2009
    ..Subcutaneous immunotherapy (SCIT) usually requires a long titration phase, which can be associated with various adverse events (AEs)...
  6. doi request reprint Pathophysiology of itching and sneezing in allergic rhinitis
    Oliver Pfaar
    Center for Allergy and Rhinology, Wiesbaden, Germany
    Swiss Med Wkly 139:35-40. 2009
    ..Further, the role of neuropeptides and neurotrophins with regard to neuronal and immune cell activation which might play a key role in the future treatment of allergic rhinitis are discussed...
  7. doi request reprint [Specific immunotherapy for allergic rhinitis. Current methods and innovative developments]
    O Pfaar
    Zentrum für Rhinologie und Allergologie der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
    HNO 56:764-75. 2008
    ....
  8. ncbi request reprint Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial
    Oliver Pfaar
    Rhinology and Allergology Center, Wiesbaden, Germany
    Ann Allergy Asthma Immunol 100:256-63. 2008
    ..Sublingual immunotherapy (SLIT) is increasingly being used for the treatment of allergic rhinitis, but there are conflicting study results demonstrating clinically relevant efficacy...
  9. ncbi request reprint [Application of humanized Anti-IgE antibodies (omalizumab). A new principle in the treatment of allergic diseases in ENT medicine]
    O Pfaar
    Zentrum für Rhinologie und Allergologie Wiesbaden der HNO Universitätsklinik Mannheim, An den Quellen 10, 65183 Wiesbaden
    HNO 55:981-90; quiz 991-2. 2007
    ..Further areas of applications in ENT medicine could be anticipated in other IgE-related illnesses, such as allergic rhinitis, food allergies, laryngitis and chronic allergy-related rhinosinusitis...
  10. ncbi request reprint Treatment of hypertrophic palatine tonsils using bipolar radiofrequency-induced thermotherapy (RFITT.)
    O Pfaar
    Department of Otorhinolaryngology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Acta Otolaryngol 127:1176-81. 2007
    ..Radiofrequency volume reduction of palatine tonsils is a gentle and safe treatment method in selected patients, which should carefully be considered as an alternative to tonsillectomy or tonsillotomy...
  11. ncbi request reprint Eicosanoids, aspirin-intolerance and the upper airways--current standards and recent improvements of the desensitization therapy
    O Pfaar
    Center for Rhinology and Allergy, Wiesbaden, Germany
    J Physiol Pharmacol 57:5-13. 2006
    ..Recently, the intravenous route for the inititial increment desensitization has been described which might offer new therapeutical possibilities in the treatment of ASA-intolerant patients...
  12. ncbi request reprint [Diagnosis and treatment of insect venom allergy. An important allergic issue for the ear, nose and throat specialist]
    O Pfaar
    Zentrum für Rhinologie und Allergologie Wiesbaden
    HNO 53:1099-115. 2005
    ..The important dose-increase phase can be performed using conventional, cluster, rush or ultra-rush schedules. Specific immunotherapy is successful in nearly 90% to 100% of patients after 3-5 years of treatment...
  13. doi request reprint Clinical outcome measures of specific immunotherapy
    Oliver Pfaar
    Center for Rhinology and Allergology, Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 9:208-13. 2009
    ..In particular, it focuses on primary and secondary outcome measurements and reviews the advantages and disadvantages of each method...
  14. ncbi request reprint [The value and possibilities of immunotherapy in the treatment of allergic rhinitis]
    O Pfaar
    Zentrum für Allergologie und Rhinologie Wiesbaden
    MMW Fortschr Med 148:28-32. 2006
    ..For sublingual therapy, too, questions about the impact on asthma development, new sensitizations and long-term outcomes have not yet been fully clarified...
  15. ncbi request reprint Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements
    Oliver Pfaar
    Center for Allergy and Rhinology, Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 6:161-6. 2006
    ..In particular, it focuses on current standards and recent improvements in aspirin desensitization. Recent publications on various desensitization protocols and routes of administration are discussed...
  16. ncbi request reprint [Olfactory testing: diagnostic methods for investigating the sense of smell]
    O Pfaar
    Zentrum für Rhinologie und Allergologie, Wiesbaden
    MMW Fortschr Med 148:34-6. 2006
    ..For testing smell in the demented, comatose or simulating patient, the measurement of chemosensory evoked potentials (CSEP) is an established method...
  17. ncbi request reprint [Cluster immunotherapy in allergic rhinoconjunctivitis: review of a new therapeutic approach]
    O Pfaar
    Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Germany
    Hautarzt 57:875-80. 2006
    ..As far as safety goes, cluster immunotherapy is an interesting alternative for the dose-increase period. In addition, recent studies reveal that clinical benefits appear sooner with cluster immunotherapy...
  18. ncbi request reprint [Bronchial asthma--what is of importance for the ENT-specialist?]
    O Pfaar
    Zentrum für Rhinologie und Allergologie, Wiesbaden
    Laryngorhinootologie 85:834-44; quiz 845-6. 2006
    ..This article gives a detailed overview on these topics and the current guidelines...
  19. doi request reprint Immunologic effect and tolerability of intra-seasonal subcutaneous immunotherapy with an 8-day up-dosing schedule to 10,000 standardized quality-units: a double-blind, randomized, placebo-controlled trial
    Oliver Pfaar
    Center for Rhinology and Allergology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Wiesbaden, Germany
    Clin Ther 34:2072-81. 2012
    ..However, because subjects often present to physicians with allergy symptoms during the pollen season, "within-season" initiation of specific immunotherapy is of special interest...
  20. doi request reprint Accelerated up-dosing of subcutaneous immunotherapy with a registered allergoid grass pollen preparation
    Oliver Pfaar
    Center for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Dusseldorf, Germany
    Int Arch Allergy Immunol 160:420-4. 2013
    ..In addition, for patients with multiple pollen allergies, patients coming near the beginning of pollen season, and patients who wish to up-dose faster, an accelerated induction regimen would be helpful...
  21. doi request reprint Safety aspects of Cluster immunotherapy with semi-depot allergen extracts in seasonal allergic rhinoconjunctivitis
    Oliver Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim, Germany
    Eur Arch Otorhinolaryngol 267:245-50. 2010
    ..With respect to safety aspects, this accelerated dosage schedule could turn into an interesting alternative for dosage increase during subcutaneous immunotherapy (SCIT)...
  22. ncbi request reprint Aspirin desensitization: useful treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) in aspirin-exacerbated respiratory disease (AERD)?
    Ludger Klimek
    Center for Rhinology and Allergology, An den Quellen 10, 65183, Wiesbaden, Germany
    Curr Allergy Asthma Rep 14:441. 2014
    ..For application, the nasal, bronchial, oral and intravenous routes have been described. Aspirin desensitization has been proven to be efficacious and safe and was able to reduce the need for other medications in AERD patients. ..
  23. doi request reprint Cluster protocols in SCIT: enough evidence for practical use?
    Oliver Pfaar
    Centre for Rhinology and Allergology Wiesbaden of the Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, D 65183 Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 10:188-93. 2010
    ..The review provides a comprehensive evaluation of Cluster schedules in subcutaneous-specific immunotherapy (SCIT) in terms of the safety profile and onset of clinical and immunological effects...
  24. doi request reprint Sublingual allergen-specific immunotherapy adjuvanted with monophosphoryl lipid A: a phase I/IIa study
    Oliver Pfaar
    Department of Otorhinolaryngology, University Hospital Mannheim, Center for Rhinology and Allergology, Wiesbaden, Germany
    Int Arch Allergy Immunol 154:336-44. 2011
    ..This is the first reported study of adjuvanted SLIT...
  25. doi request reprint Aspirin intolerance: does desensitization alter the course of the disease?
    L Klimek
    Center for Rhinology and Allergy, An den Quellen 10, D 65183 Wiesbaden, Germany
    Immunol Allergy Clin North Am 29:669-75. 2009
    ..Apart from surgical or pharmacologic therapy, ASA-desensitization therapy is the treatment of choice. Various desensitization protocols and routes of administration are discussed...
  26. doi request reprint A comparison of immunotherapy delivery methods for allergen immunotherapy
    Ludger Klimek
    Allergy Center, An den Quellen 10, D 65183 Wiesbaden, Germany
    Expert Rev Clin Immunol 9:465-74; quiz 475. 2013
    ..Allergic diseases are among the most common diseases in humans. Besides allergen avoidance, allergen-specific immunotherapy is the only causative treatment option. During recent years, many innovations of this therapy have emerged...
  27. ncbi request reprint Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions
    Oliver Pfaar
    Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, D 01307 Dresden, Germany
    Chem Senses 31:27-31. 2006
    ..This might become a valuable model of hyposmia for future investigations...
  28. ncbi request reprint Patient-reported outcomes and quality-of-life questionnaires in the assessment of rhinoconjunctivitis in childhood
    Désirée Larenas-Linnemann
    aHospital Médica Sur, Mexico DF, Mexico bDepartment of Otorhinolaryngology, Head and Neck Surgery, Center for Rhinology and Allergology, University Hospital Mannheim, Wiesbaden, Germany
    Curr Opin Allergy Clin Immunol 14:192-9. 2014
    ..Clinical trials using allergen immunotherapy (AIT), the sole causal treatment of allergies, are being conducted, but discussions on optimal patient-related outcomes (PROs) are still ongoing...
  29. doi request reprint Adjuvants for immunotherapy
    Oliver Pfaar
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany
    Curr Opin Allergy Clin Immunol 12:648-57. 2012
    ..This article gives an overview about the current state of preclinical and clinical studies using different kinds of adjuvants and their effect on allergen-specific immunotherapy (SIT)...
  30. doi request reprint [Specific immunotherapy with depigmented allergoids]
    L Klimek
    Zentrum für Rhinologie und Allergologie, An den Quellen 10, 65183, Wiesbaden, Deutschland
    HNO 58:51-6. 2010
    ..Recent data suggest that the modified polymerized allergoids allow a safe rush titration in a few days or even in 1 day (ultra-rush titration)...
  31. ncbi request reprint Assessment of olfactory function after septoplasty: a longitudinal study
    O Pfaar
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Germany
    Rhinology 42:195-9. 2004
    ..Aim of the study was to evaluate septoplasty-related changes of lateralised olfactory function during both early and late postoperative periods in comparison to the preoperative situation...
  32. doi request reprint Allergological approach to drug hypersensitivity reactions
    Bernhard Przybilla
    Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universität Frauenlobstr 9 1180337 Munich, Germany
    J Dtsch Dermatol Ges 6:240-3. 2008