A Peters

Summary

Country: Germany

Publications

  1. ncbi request reprint The selfish brain: competition for energy resources
    A Peters
    Department of Internal Medicine, University of Luebeck, Ratzeburger Allee 160, D 23538 Germany
    Neurosci Biobehav Rev 28:143-80. 2004
  2. ncbi request reprint The energy request of inflammation
    A Peters
    Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
    Endocrinology 147:4550-2. 2006
  3. ncbi request reprint [Metabolic syndrome. Origin within the central nervous system?]
    A Peters
    Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Deutschland
    Internist (Berl) 48:134-43. 2007
  4. ncbi request reprint The principle of homeostasis in the hypothalamus-pituitary-adrenal system: new insight from positive feedback
    A Peters
    Department of Internal Medicine I, Endocrinology, University of Luebeck, 23538 Luebeck, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R83-98. 2007
  5. ncbi request reprint Causes of obesity: looking beyond the hypothalamus
    A Peters
    Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
    Prog Neurobiol 81:61-88. 2007
  6. ncbi request reprint Adaptation of cognitive function to hypoglycemia in healthy men
    B Fruehwald-Schultes
    Department of Internal Medicine, University of Luebeck, Germany
    Diabetes Care 23:1059-66. 2000
  7. doi request reprint Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy men
    J Klement
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetologia 52:1192-6. 2009
  8. ncbi request reprint Protective effect of insulin against hypoglycemia-associated counterregulatory failure
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Germany
    J Clin Endocrinol Metab 84:1551-7. 1999
  9. ncbi request reprint Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humans
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Germany
    J Clin Endocrinol Metab 84:3041-6. 1999
  10. ncbi request reprint Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humans
    B Fruehwald-Schultes
    Department of Internal Medicine I, Medical University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Int J Obes Relat Metab Disord 25:S38-40. 2001

Detail Information

Publications38

  1. ncbi request reprint The selfish brain: competition for energy resources
    A Peters
    Department of Internal Medicine, University of Luebeck, Ratzeburger Allee 160, D 23538 Germany
    Neurosci Biobehav Rev 28:143-80. 2004
    ..In this 'Selfish Brain Theory', the neocortex and limbic system play a central role in the pathogenesis of diseases such as anorexia nervosa and obesity...
  2. ncbi request reprint The energy request of inflammation
    A Peters
    Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
    Endocrinology 147:4550-2. 2006
  3. ncbi request reprint [Metabolic syndrome. Origin within the central nervous system?]
    A Peters
    Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Deutschland
    Internist (Berl) 48:134-43. 2007
    ..We have reviewed the literature from this new perspective, putting the brain as the focal midpoint of all metabolic activity...
  4. ncbi request reprint The principle of homeostasis in the hypothalamus-pituitary-adrenal system: new insight from positive feedback
    A Peters
    Department of Internal Medicine I, Endocrinology, University of Luebeck, 23538 Luebeck, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R83-98. 2007
    ..Current knowledge suggests that this principle of homeostasis could also apply to other biological systems...
  5. ncbi request reprint Causes of obesity: looking beyond the hypothalamus
    A Peters
    Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
    Prog Neurobiol 81:61-88. 2007
    ..Obesity develops in the long term...
  6. ncbi request reprint Adaptation of cognitive function to hypoglycemia in healthy men
    B Fruehwald-Schultes
    Department of Internal Medicine, University of Luebeck, Germany
    Diabetes Care 23:1059-66. 2000
    ..The effects of antecedent hypoglycemia on hypoglycemia-induced cognitive dysfunction are less well established...
  7. doi request reprint Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy men
    J Klement
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Diabetologia 52:1192-6. 2009
    ..We hypothesised that blocking the AMPA receptor by caroverine in healthy men would impair their perception of neuroglycopenia and thereby diminish hormonal counter-regulation as well as symptoms of hypoglycaemia, as a model of stress...
  8. ncbi request reprint Protective effect of insulin against hypoglycemia-associated counterregulatory failure
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Germany
    J Clin Endocrinol Metab 84:1551-7. 1999
    ..05). In conclusion, the present study clearly demonstrates that even a single episode of mild hypoglycemia reduces neuroendocrine counterregulation 18-24 h later. Insulin has a moderate protective effect on subsequent counterregulation...
  9. ncbi request reprint Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humans
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Germany
    J Clin Endocrinol Metab 84:3041-6. 1999
    ..1 mmol/L; P < 0.05). Our results demonstrate that insulin acutely stimulates the HPA secretory activity in humans. The pattern suggests an effect of insulin at both peripheral and central levels of the HPA axis...
  10. ncbi request reprint Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humans
    B Fruehwald-Schultes
    Department of Internal Medicine I, Medical University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Int J Obes Relat Metab Disord 25:S38-40. 2001
    ..Here, the question has been posed as to whether hyperinsulinemia increases HPA secretory activity...
  11. ncbi request reprint Antecedent hypoglycaemia attenuates vascular endothelial growth factor response to subsequent hypoglycaemia in healthy men
    V Merl
    Department of Internal Medicine I, University of Leubeck, Germany
    Diabet Med 22:1278-81. 2005
    ..Many counter-regulatory hormones show a reduced response after antecedent hypoglycaemia. We therefore investigated whether this decrease in responsiveness with repetitive hypoglycaemia also pertains to VEGF...
  12. ncbi request reprint Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humans
    V Merl
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Int J Obes (Lond) 29:998-1001. 2005
    ..However, until now it is not known how the secretion of adiponectin is regulated in response to acute metabolic changes. Here, we assessed the influence of complete fasting for 72 h on serum adiponectin levels...
  13. ncbi request reprint Plasma glucagon decreases during night-time sleep in Type 1 diabetic patients and healthy control subjects
    K Jauch-Chara
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabet Med 24:684-7. 2007
    ..The dynamics of spontaneous glucagon release have rarely been assessed. We monitored spontaneous glucagon release in T1DM patients and healthy subjects during a 7-h period of night-time sleep...
  14. ncbi request reprint Improving influence of insulin on cognitive functions in humans
    W Kern
    Department of Internal Medicine I, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Neuroendocrinology 74:270-80. 2001
    ..e., patients with Alzheimer's disease or diabetes mellitus...
  15. ncbi request reprint Losartan attenuates symptomatic and hormonal responses to hypoglycemia in humans
    E Deininger
    Medical Clinic I, Department of Clinical Neuroendocrinology, Institute for Pharmacology, Medical University Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany
    Clin Pharmacol Ther 70:362-9. 2001
    ..At present, for patients who are unaware of hypoglycemia and who require antihypertensive or nephroprotective treatment, we would recommend caution concerning treatment with losartan...
  16. ncbi request reprint Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemia
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 86:4187-92. 2001
    ..015). The data indicate that metformin does not adversely affect hormonal and symptomatic responses to hypoglycemia. This finding appears to be relevant with regard to the safety of the combination of metformin with insulin therapy...
  17. ncbi request reprint Hypoglycemia, but not insulin, acutely decreases LH and T secretion in men
    K M Oltmanns
    Department of Internal Medicine I, Medical University of Luebeck, D-23538 Luebeck, Germany
    J Clin Endocrinol Metab 86:4913-9. 2001
    ..e. increased release of dehydroepiandrosterone) may add to the suppressive effect of hypoglycemia on gonadal steroidogenesis...
  18. ncbi request reprint Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy men
    B Schultes
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Psychoneuroendocrinology 30:149-61. 2005
    ..Together results indicate an adaptation to recurrent hypoglycemia for signs of controlled stimulus processing presumably involving hippocampo-prefrontocortical circuitry, while earlier automatic stages of processing appear to be spared...
  19. ncbi request reprint High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetes
    C Hubold
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Int J Obes (Lond) 30:1356-61. 2006
    ..Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans...
  20. ncbi request reprint Influence of hypo- and hyperglycaemia on plasma leptin concentrations in healthy women and in women with polycystic ovary syndrome
    A K Ludwig
    Department of Gynaecology and Obstetrics, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Hum Reprod 22:1555-61. 2007
    ..It is not yet known whether the long-term insulin resistance as found in PCOS patients alters the leptin response to hypo- and hyperglycaemia...
  21. ncbi request reprint The selfish brain: competition for energy resources
    H L Fehm
    Medizinische Klinik I, Universitat Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Prog Brain Res 153:129-40. 2006
    ..This explains why these therapies are disappointing in the long run. New therapeutic strategies based on the "selfish brain theory" will be discussed...
  22. ncbi request reprint Mood and cognitive functions during acute euglycaemia and mild hyperglycaemia in type 2 diabetic patients
    I Pais
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Exp Clin Endocrinol Diabetes 115:42-6. 2007
    ..We examined mood and cognitive functions in patients with T2DM during acute euglycaemia in comparison with moderate hyperglycaemia...
  23. ncbi request reprint Sleep loss and the development of diabetes: a review of current evidence
    B Schultes
    Departments of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Exp Clin Endocrinol Diabetes 113:563-7. 2005
    ..Here, we provide a short overview of the current epidemiological and experimental evidence for a potential contribution of sleep loss to the development of diabetes...
  24. doi request reprint NMDA receptor blockade by memantine does not prevent adaptation to recurrent hypoglycaemia in healthy men
    J Klement
    Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
    Diabetes Obes Metab 15:310-5. 2013
    ..If so, attenuation should be prevented by blocking glutamatergic N-methyl-d-aspartate (NMDA) receptors...
  25. ncbi request reprint Glucocorticoids and melanocortins in the regulation of body weight in humans
    H L Fehm
    Medizinische Klinik I und Institut für Neuroendokrinologie, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Horm Metab Res 36:360-4. 2004
    ..Thereby, the hippocampal structures determine the setpoint for bodyweight regulation. Novel approaches to treatment of obesity must aim at manipulating these brain structures...
  26. ncbi request reprint [Role of the hippocampus in obesity and metabolic syndrome]
    H L Fehm
    Medizinische Klinik I, Universitat Lubeck
    Nervenarzt 78:584-5. 2007
  27. ncbi request reprint The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia
    B Fruehwald-Schultes
    Department of Internal Medicine I, University of Luebeck, Germany
    Int J Obes Relat Metab Disord 26:510-6. 2002
    ..Here, we hypothesised that a reduction of insulin sensitivity, ie insulin resistance, will diminish the stimulatory effect of insulin on leptin secretion as a consequence of decreased insulin-mediated glucose uptake...
  28. ncbi request reprint Chronic fentanyl application induces adrenocortical insufficiency
    K M Oltmanns
    Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
    J Intern Med 257:478-80. 2005
    ..After 1 week, HPA axis function was markedly improved. We conclude that opiate medication may inhibit - in a life-threatening way - the organism's ability to respond to physical, emotional or metabolic stressors...
  29. doi request reprint Brain size, body size and longevity
    A Peters
    Medical Clinic 1, University of Luebeck, Luebeck, Germany
    Int J Obes (Lond) 34:1349-52. 2010
    ....
  30. pmc Synapses are lost during aging in the primate prefrontal cortex
    A Peters
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2526, USA
    Neuroscience 152:970-81. 2008
    ..The synapse loss is also considered in light of earlier studies, which show that the frequency of spontaneous excitatory synaptic responses is reduced with age in layers 2/3 neurons...
  31. ncbi request reprint Comparison of classifiers applied to confocal scanning laser ophthalmoscopy data
    W Adler
    Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University Erlangen Nuremberg, Waldstrasse 6, 91054 Erlangen, Germany
    Methods Inf Med 47:38-46. 2008
    ..Comparison of classification methods using data of one clinical study. The tuning of hyperparameters is assessed as part of the methods by nested-loop cross-validation...
  32. doi request reprint Systemic inflammation, genetic susceptibility and lung function
    J Sunyer
    Centre for Environmental Epidemiological Research and Municipal Institute of Medical Research, Universitat Pompeu Fabra, CIBERESP, Barcelona, Spain
    Eur Respir J 32:92-7. 2008
    ..Applying a Mendelian randomisation approach, the study supports a causal association between low-grade general inflammation and airway diseases...
  33. ncbi request reprint The neuroendocrine control of glucose allocation
    A Peters
    Medical Clinic 1, Medical University of Luebeck, Germany
    Exp Clin Endocrinol Diabetes 110:199-211. 2002
    ..This novel viewpoint of "brain glucose" control may shed new light on the pathogenesis of the metabolic syndrome and type 2 diabetes...
  34. ncbi request reprint Metabolic stress during hypoglycaemia clamp assessed by microdialysis
    L Bahlmann
    Department of Anesthesiology, Medical University of Luebeck, Lubeck, Germany
    Minerva Anestesiol 71:711-6. 2005
    ..It was the aim to perform subcutaneous and blood microdialysis during hypoglycaemic clamp experiments in 12 healthy young men to reveal basis data for critical care microdialysis practice...
  35. ncbi request reprint [Rehabilitation score for patients with type 2 Diabetes mellitus: An instrument to standardize assessment of the need for rehabilitation]
    B Dodt
    Medizinische Klinik I des Universitätsklinikums Lübeck, Germany
    Rehabilitation (Stuttg) 41:237-48. 2002
    ..Based on this rehabilitation score, 19 % of cases in a preliminary evaluation of 79 patients with type 2 diabetes showed a need for medical rehabilitation therapy...
  36. ncbi request reprint Increased asthma medication use in association with ambient fine and ultrafine particles
    S von Klot
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Respir J 20:691-702. 2002
    ..The results suggest that reported asthma medication use and symptoms increase in association with particulate air pollution and gaseous pollutants such as nitrogen dioxide...
  37. ncbi request reprint [Obesity and osteoporosis]
    H Friebe
    Reha Klinik Aukammtal, Wiesbaden
    Orthopade 34:645-51. 2005
    ..As a consequence, increasing lean body mass while reducing fat mass seems to be the most effective way to prevent both atherosclerosis and osteoporosis...
  38. ncbi request reprint [SF-36 Health Survey in Rehabilitation Research. Findings from the North German Network for Rehabilitation Research, NVRF, within the rehabilitation research funding program]
    M Bullinger
    Arbeitsgruppe Lebensqualitätsforschung bei Erwachsenen und Kindern, Institut und Poliklinik für Medizinische Psychologie, Zentrum fur Psychosoziale Medizin, Universitatsklinikum Hamburg Eppendorf
    Rehabilitation (Stuttg) 42:218-25. 2003
    ..g. SCL-90-R) could be found. Summarizing, the SF-36/SF-12 can be recommended for use in rehabilitation research. Analyses regarding sensitivity should be conducted in future studies...