Research Topics
| A PetersSummaryCountry: Germany Publications
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Detail Information
Publications
The selfish brain: competition for energy resourcesA Peters
Department of Internal Medicine, University of Luebeck, Ratzeburger Allee 160, D 23538 Germany
Neurosci Biobehav Rev 28:143-80. 2004..In this 'Selfish Brain Theory', the neocortex and limbic system play a central role in the pathogenesis of diseases such as anorexia nervosa and obesity...- The energy request of inflammationA Peters
Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
Endocrinology 147:4550-2. 2006 - [Metabolic syndrome. Origin within the central nervous system?]A Peters
Medizinische Klinik I, Universitatsklinikum Schleswig Holstein, Campus Lubeck, 23538 Lubeck, Deutschland
Internist (Berl) 48:134-43. 2007..We have reviewed the literature from this new perspective, putting the brain as the focal midpoint of all metabolic activity... - The principle of homeostasis in the hypothalamus-pituitary-adrenal system: new insight from positive feedbackA Peters
Department of Internal Medicine I, Endocrinology, University of Luebeck, 23538 Luebeck, Germany
Am J Physiol Regul Integr Comp Physiol 293:R83-98. 2007..Current knowledge suggests that this principle of homeostasis could also apply to other biological systems... - Causes of obesity: looking beyond the hypothalamusA Peters
Department of Internal Medicine 1, University of Luebeck, 23538 Luebeck, Germany
Prog Neurobiol 81:61-88. 2007..Obesity develops in the long term... - Adaptation of cognitive function to hypoglycemia in healthy menB Fruehwald-Schultes
Department of Internal Medicine, University of Luebeck, Germany
Diabetes Care 23:1059-66. 2000..The effects of antecedent hypoglycemia on hypoglycemia-induced cognitive dysfunction are less well established... 
Blocking AMPA receptor signalling by caroverine infusion does not affect counter-regulation of hypoglycaemia in healthy menJ Klement
Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
Diabetologia 52:1192-6. 2009..We hypothesised that blocking the AMPA receptor by caroverine in healthy men would impair their perception of neuroglycopenia and thereby diminish hormonal counter-regulation as well as symptoms of hypoglycaemia, as a model of stress...- Protective effect of insulin against hypoglycemia-associated counterregulatory failureB Fruehwald-Schultes
Department of Internal Medicine I, University of Luebeck, Germany
J Clin Endocrinol Metab 84:1551-7. 1999..05). In conclusion, the present study clearly demonstrates that even a single episode of mild hypoglycemia reduces neuroendocrine counterregulation 18-24 h later. Insulin has a moderate protective effect on subsequent counterregulation... - Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitary-adrenal secretory activity in humansB Fruehwald-Schultes
Department of Internal Medicine I, University of Luebeck, Germany
J Clin Endocrinol Metab 84:3041-6. 1999..1 mmol/L; P < 0.05). Our results demonstrate that insulin acutely stimulates the HPA secretory activity in humans. The pattern suggests an effect of insulin at both peripheral and central levels of the HPA axis... - Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humansB Fruehwald-Schultes
Department of Internal Medicine I, Medical University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
Int J Obes Relat Metab Disord 25:S38-40. 2001..Here, the question has been posed as to whether hyperinsulinemia increases HPA secretory activity... - Antecedent hypoglycaemia attenuates vascular endothelial growth factor response to subsequent hypoglycaemia in healthy menV Merl
Department of Internal Medicine I, University of Leubeck, Germany
Diabet Med 22:1278-81. 2005..The origin of increased systemic VEGF concentration during hypoglycaemia and its physiological role remains to be defined... - Serum adiponectin concentrations during a 72-hour fast in over- and normal-weight humansV Merl
Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
Int J Obes (Lond) 29:998-1001. 2005..Thus, adiponectin appears to reflect primarily long-term changes in body weight with little evidence for a dependence on short-term regulatory influences... - Plasma glucagon decreases during night-time sleep in Type 1 diabetic patients and healthy control subjectsK Jauch-Chara
Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
Diabet Med 24:684-7. 2007..The dynamics of spontaneous glucagon release have rarely been assessed. We monitored spontaneous glucagon release in T1DM patients and healthy subjects during a 7-h period of night-time sleep... - Improving influence of insulin on cognitive functions in humansW Kern
Department of Internal Medicine I, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Neuroendocrinology 74:270-80. 2001..e., patients with Alzheimer's disease or diabetes mellitus... - Losartan attenuates symptomatic and hormonal responses to hypoglycemia in humansE Deininger
Medical Clinic I, Department of Clinical Neuroendocrinology, Institute for Pharmacology, Medical University Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany
Clin Pharmacol Ther 70:362-9. 2001..At present, for patients who are unaware of hypoglycemia and who require antihypertensive or nephroprotective treatment, we would recommend caution concerning treatment with losartan... - Metformin does not adversely affect hormonal and symptomatic responses to recurrent hypoglycemiaB Fruehwald-Schultes
Department of Internal Medicine I, University of Luebeck, D 23538 Luebeck, Germany
J Clin Endocrinol Metab 86:4187-92. 2001..015). The data indicate that metformin does not adversely affect hormonal and symptomatic responses to hypoglycemia. This finding appears to be relevant with regard to the safety of the combination of metformin with insulin therapy... - Hypoglycemia, but not insulin, acutely decreases LH and T secretion in menK M Oltmanns
Department of Internal Medicine I, Medical University of Luebeck, D-23538 Luebeck, Germany
J Clin Endocrinol Metab 86:4913-9. 2001..e. increased release of dehydroepiandrosterone) may add to the suppressive effect of hypoglycemia on gonadal steroidogenesis... - Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy menB Schultes
Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
Psychoneuroendocrinology 30:149-61. 2005..Together results indicate an adaptation to recurrent hypoglycemia for signs of controlled stimulus processing presumably involving hippocampo-prefrontocortical circuitry, while earlier automatic stages of processing appear to be spared... - High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetesC Hubold
Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
Int J Obes (Lond) 30:1356-61. 2006..Based on the crucial role of VEGF on brain glucose supply, we hypothesized that higher VEGF concentrations are associated with lower food intake and body mass in humans... - Influence of hypo- and hyperglycaemia on plasma leptin concentrations in healthy women and in women with polycystic ovary syndromeA K Ludwig
Department of Gynaecology and Obstetrics, University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Hum Reprod 22:1555-61. 2007..It is not yet known whether the long-term insulin resistance as found in PCOS patients alters the leptin response to hypo- and hyperglycaemia... - The selfish brain: competition for energy resourcesH L Fehm
Medizinische Klinik I, Universitat Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Prog Brain Res 153:129-40. 2006..This explains why these therapies are disappointing in the long run. New therapeutic strategies based on the "selfish brain theory" will be discussed... - Mood and cognitive functions during acute euglycaemia and mild hyperglycaemia in type 2 diabetic patientsI Pais
Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
Exp Clin Endocrinol Diabetes 115:42-6. 2007..We examined mood and cognitive functions in patients with T2DM during acute euglycaemia in comparison with moderate hyperglycaemia... - Sleep loss and the development of diabetes: a review of current evidenceB Schultes
Departments of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
Exp Clin Endocrinol Diabetes 113:563-7. 2005..Here, we provide a short overview of the current epidemiological and experimental evidence for a potential contribution of sleep loss to the development of diabetes... - NMDA receptor blockade by memantine does not prevent adaptation to recurrent hypoglycaemia in healthy menJ Klement
Department of Internal Medicine I, University of Lubeck, Lubeck, Germany
Diabetes Obes Metab 15:310-5. 2013..If so, attenuation should be prevented by blocking glutamatergic N-methyl-D-aspartate (NMDA) receptors... - Glucocorticoids and melanocortins in the regulation of body weight in humansH L Fehm
Medizinische Klinik I und Institut für Neuroendokrinologie, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Horm Metab Res 36:360-4. 2004..Thereby, the hippocampal structures determine the setpoint for bodyweight regulation. Novel approaches to treatment of obesity must aim at manipulating these brain structures... - [Role of the hippocampus in obesity and metabolic syndrome]H L Fehm
Medizinische Klinik I,
Nervenarzt 78:584-5. 2007 - The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemiaB Fruehwald-Schultes
Department of Internal Medicine I, University of Luebeck, Germany
Int J Obes Relat Metab Disord 26:510-6. 2002..Here, we hypothesised that a reduction of insulin sensitivity, ie insulin resistance, will diminish the stimulatory effect of insulin on leptin secretion as a consequence of decreased insulin-mediated glucose uptake... - Chronic fentanyl application induces adrenocortical insufficiencyK M Oltmanns
Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
J Intern Med 257:478-80. 2005..After 1 week, HPA axis function was markedly improved. We conclude that opiate medication may inhibit - in a life-threatening way - the organism's ability to respond to physical, emotional or metabolic stressors... - Brain size, body size and longevityA Peters
Medical Clinic 1, University of Luebeck, Luebeck, Germany
Int J Obes (Lond) 34:1349-52. 2010.... 
Synapses are lost during aging in the primate prefrontal cortexA Peters
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118 2526, USA
Neuroscience 152:970-81. 2008..The synapse loss is also considered in light of earlier studies, which show that the frequency of spontaneous excitatory synaptic responses is reduced with age in layers 2/3 neurons...- Comparison of classifiers applied to confocal scanning laser ophthalmoscopy dataW Adler
Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University Erlangen Nuremberg, Waldstrasse 6, 91054 Erlangen, Germany
Methods Inf Med 47:38-46. 2008..Comparison of classification methods using data of one clinical study. The tuning of hyperparameters is assessed as part of the methods by nested-loop cross-validation... - Systemic inflammation, genetic susceptibility and lung functionJ Sunyer
Centre for Environmental Epidemiological Research and Municipal Institute of Medical Research, Universitat Pompeu Fabra, CIBERESP, Barcelona, Spain
Eur Respir J 32:92-7. 2008..Applying a Mendelian randomisation approach, the study supports a causal association between low-grade general inflammation and airway diseases... - The neuroendocrine control of glucose allocationA Peters
Medical Clinic 1, Medical University of Luebeck, Germany
Exp Clin Endocrinol Diabetes 110:199-211. 2002..This novel viewpoint of "brain glucose" control may shed new light on the pathogenesis of the metabolic syndrome and type 2 diabetes... - Metabolic stress during hypoglycaemia clamp assessed by microdialysisL Bahlmann
Department of Anesthesiology, Medical University of Luebeck, Lubeck, Germany
Minerva Anestesiol 71:711-6. 2005..It was the aim to perform subcutaneous and blood microdialysis during hypoglycaemic clamp experiments in 12 healthy young men to reveal basis data for critical care microdialysis practice... - [Rehabilitation score for patients with type 2 Diabetes mellitus: An instrument to standardize assessment of the need for rehabilitation]B Dodt
Medizinische Klinik I des Universitätsklinikums Lübeck, Germany
Rehabilitation (Stuttg) 41:237-48. 2002..Based on this rehabilitation score, 19 % of cases in a preliminary evaluation of 79 patients with type 2 diabetes showed a need for medical rehabilitation therapy... - Increased asthma medication use in association with ambient fine and ultrafine particlesS von Klot
GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
Eur Respir J 20:691-702. 2002..The results suggest that reported asthma medication use and symptoms increase in association with particulate air pollution and gaseous pollutants such as nitrogen dioxide... - [Obesity and osteoporosis]H Friebe
Reha Klinik Aukammtal, Wiesbaden
Orthopade 34:645-51. 2005..As a consequence, increasing lean body mass while reducing fat mass seems to be the most effective way to prevent both atherosclerosis and osteoporosis... - [SF-36 Health Survey in Rehabilitation Research. Findings from the North German Network for Rehabilitation Research, NVRF, within the rehabilitation research funding program]M Bullinger
Arbeitsgruppe Lebensqualitätsforschung bei Erwachsenen und Kindern, Institut und Poliklinik für Medizinische Psychologie, Zentrum fur Psychosoziale Medizin, Universitatsklinikum Hamburg Eppendorf
Rehabilitation (Stuttg) 42:218-25. 2003..g. SCL-90-R) could be found. Summarizing, the SF-36/SF-12 can be recommended for use in rehabilitation research. Analyses regarding sensitivity should be conducted in future studies...