Theo Pelzer

Summary

Country: Germany

Publications

  1. doi request reprint The estrogen receptor-α is required and sufficient to maintain physiological glucose uptake in the mouse heart
    Paula Anahi Arias-Loza
    Department of Internal Medicine, University of Wuerzburg, Oberduerrbacher Str 6, D 97080 Wuerzburg, Germany
    Hypertension 60:1070-7. 2012
  2. ncbi request reprint Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty rats
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Germany
    Biochem Biophys Res Commun 329:726-32. 2005
  3. ncbi request reprint Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Circulation 111:1492-8. 2005
  4. ncbi request reprint The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 67:604-12. 2005
  5. ncbi request reprint Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, Wurzburg, Germany
    Cardiovasc Res 77:774-81. 2008
  6. doi request reprint Medroxyprogesterone acetate aggravates oxidative stress and left ventricular dysfunction in rats with chronic myocardial infarction
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Germany
    Toxicol Pathol 39:867-78. 2011
  7. ncbi request reprint Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Hypertension 48:579-86. 2006
  8. ncbi request reprint Both estrogen receptor subtypes, alpha and beta, attenuate cardiovascular remodeling in aldosterone salt-treated rats
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Wurzburg, Germany
    Hypertension 50:432-8. 2007
  9. pmc Differential effects of 17beta-estradiol and of synthetic progestins on aldosterone-salt-induced kidney disease
    Paula Anahi Arias-Loza
    Department of Medicine, University of Wurzburg, Germany
    Toxicol Pathol 37:969-82. 2009
  10. doi request reprint Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability
    Melanie Muehlfelder
    Department of Medicine, University of Wuerzburg, Germany
    Biochem Biophys Res Commun 423:850-6. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint The estrogen receptor-α is required and sufficient to maintain physiological glucose uptake in the mouse heart
    Paula Anahi Arias-Loza
    Department of Internal Medicine, University of Wuerzburg, Oberduerrbacher Str 6, D 97080 Wuerzburg, Germany
    Hypertension 60:1070-7. 2012
    ..In conclusion, systemic activation of ERα is sufficient, and its expression is required to maintain physiological glucose uptake in the murine heart, which is likely to contribute to known cardioprotective estrogen effects...
  2. ncbi request reprint Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty rats
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Germany
    Biochem Biophys Res Commun 329:726-32. 2005
    ....
  3. ncbi request reprint Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Circulation 111:1492-8. 2005
    ..The present study was undertaken to determine the role of ERbeta in the development of chronic heart failure after experimental myocardial infarction (MI)...
  4. ncbi request reprint The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 67:604-12. 2005
    ..Therefore, we analyzed myocardial hypertrophy as well as cardiac function and gene expression in ovariectomized, spontaneously hypertensive rats (SHR) treated with the subtype-selective ERalpha agonist 16alpha-LE2 or 17beta-estradiol...
  5. ncbi request reprint Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, Wurzburg, Germany
    Cardiovasc Res 77:774-81. 2008
    ....
  6. doi request reprint Medroxyprogesterone acetate aggravates oxidative stress and left ventricular dysfunction in rats with chronic myocardial infarction
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Germany
    Toxicol Pathol 39:867-78. 2011
    ..These results support the interpretation that adding MPA to an E2 treatment complicates cardiovascular injury damage post-MI and therefore contributes to explain the adverse outcome of prospective clinical studies...
  7. ncbi request reprint Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats
    Virginija Jazbutyte
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Hypertension 48:579-86. 2006
    ..These observations contribute to explain the lower efficiency of estrogen substitution in senescent SHRs...
  8. ncbi request reprint Both estrogen receptor subtypes, alpha and beta, attenuate cardiovascular remodeling in aldosterone salt-treated rats
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Wurzburg, Germany
    Hypertension 50:432-8. 2007
    ..Nonfeminizing ERbeta agonists such as 8beta-VE2 have a therapeutic potential in the treatment of hypertensive heart disease...
  9. pmc Differential effects of 17beta-estradiol and of synthetic progestins on aldosterone-salt-induced kidney disease
    Paula Anahi Arias-Loza
    Department of Medicine, University of Wurzburg, Germany
    Toxicol Pathol 37:969-82. 2009
    ..Elevated mineralocorticoid levels and female sex hormones have been shown to confer opposing effects on renal injury, but their combined effects are still unknown...
  10. doi request reprint Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability
    Melanie Muehlfelder
    Department of Medicine, University of Wuerzburg, Germany
    Biochem Biophys Res Commun 423:850-6. 2012
    ..In conclusion, estrogens attenuate the detrimental vascular effects of excessive MR activation at least in part by preventing the depletion of intracellular NADPH levels...
  11. ncbi request reprint Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR
    Julian Widder
    Medizinische Klinik der Julius Maximilians Universität, Wurzburg, Germany
    Hypertension 42:991-6. 2003
    ..The novel selective ERalpha agonist Cpd1471 prevented these pathophysiological changes to a similar extent as E2. Thus, the pharmacological principle of selective ERalpha activation mediates positive vascular effects...
  12. doi request reprint Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system
    Paula Anahi Arias-Loza
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Gend Med 5:S34-45. 2008
    ....
  13. ncbi request reprint Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Hypertension 48:994-1001. 2006
    ..Novel progestins, such as drospirenone, confer superior effects compared with medroxyprogesterone acetate in a model of aldosterone-induced heart disease because of its antimineralocorticoid properties...
  14. ncbi request reprint Oestrogen action on the myocardium in vivo: specific and permissive for angiotensin-converting enzyme inhibition
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    J Hypertens 20:1001-6. 2002
    ....
  15. doi request reprint Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria
    Virginija Jazbutyte
    Laboratory of Molecular Cardiology, Department of Medicine, University Clinics Wuerzburg, Josef Schneider Strasse 2, D20, 97080 Wuerzburg, Germany
    Biochem Biophys Res Commun 384:450-4. 2009
    ..GST pull-down experiments confirmed the interaction of ERalpha and 17beta-HSD10. These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity...
  16. doi request reprint Estrogen and estrogen receptors in cardiovascular oxidative stress
    Paula Anahi Arias-Loza
    Department of Internal Medicine I, University Hospital of Wurzburg, Wurzburg, Germany
    Pflugers Arch 465:739-46. 2013
    ..The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury...
  17. pmc Impact of thoracic surgery on cardiac morphology and function in small animal models of heart disease: a cardiac MRI study in rats
    Peter Nordbeck
    Department of Internal Medicine I Cardiology, University Hospital Wurzburg, Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 8:e68275. 2013
    ....